Abstract: The present invention concerns the use of HYD1 peptides to reduce activated T-cell numbers and/or to promote bone preservation in vivo. The present invention concerns methods of treating a bone deficiency and/or an autoimmune disorder, comprising administering an effective amount of a HYD1 peptide. Another aspect of the invention concerns a pharmaceutical composition comprising a HYD1 peptide and another agent for treating a bone deficiency and/or another agent for treating an autoimmune disorder.

Abstract: Embodiments include a television appliance configured to display a selected on-screen viewing activity, and a client application. The client application is configured to maintain a list of contacts and allow a user of the media appliance to establish communication events with contacts via a network interface and packet-based network. The client application is further configured to receive a machine-readable data item via the network interface and packet-based network from a television appliance of one or more of said contacts, the machine-readable data item indicating a current television channel being viewed by the respective contact. In at least some embodiments, the client application may control operation of said user's television appliance in relation to the contact's television appliance based on the data item.

Abstract: Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.

Abstract: A method of transmitting video data comprising: establishing a bidirectional video channel between a first terminal and a second terminal in a packet-based communication network; beginning a live, face-to-face video call over the established channel by generating first video data from a video camera of the first terminal, transmitting the first video data to the second terminal for display on a screen of the second terminal, receiving second video data generated from a video camera of the second terminal, and displaying the second video data on a screen of the first terminal; generating third video data at the first terminal from a source other than the video camera of the first terminal; receiving a user selection at the first terminal; and in response to the user selection, transmitting the third video data to the second user over the established channel of the packet-based communication network.

Abstract: Techniques for displaying graphical representations of contacts are described. In accordance with one or more embodiments, a group of graphical representations of contacts is displayed at a first size in a display region. In response to a selection of a subgroup of the graphical representations, the subgroup of graphical representations is automatically resized to fit in the display region at a second size.

Abstract: A method of transmitting video data comprising: establishing a bidirectional video channel between a first terminal and a second terminal in a packet-based communication network; beginning a live, face-to-face video call over the established channel by generating first video data from a video camera of the first terminal, transmitting the first video data to the second terminal for display on a screen of the second terminal, receiving second video data generated from a video camera of the second terminal, and displaying the second video data on a screen of the first terminal; generating third video data at the first terminal from a source other than the video camera of the first terminal; receiving a user selection at the first terminal; and in response to the user selection, transmitting the third video data to the second user over the established channel of the packet-based communication network.

Abstract: A method of initiating a communication event via a packet-based communication network in a media appliance having a processor executing a communication client, comprising: retrieving a stored list comprising a plurality of contacts associated with a user of the communication client; generating a first two-dimensional contact grid comprising a first arrangement of entries; displaying the first contact grid on a display means such that each of a plurality of the entries comprises a graphical representation of a respective one of the plurality of contacts, wherein the graphical representations are sized so as to fit in the entries of the first contact grid; receiving a selection of a subset of the graphical representations in the first contact grid from a user of the communication client; generating a second contact grid comprising a second arrangement of entries corresponding to the selected subset; displaying the second contact grid on the display means in replacement of the first contact grid, such that each

Abstract: A media appliance and corresponding method, the media appliance comprising a video signal source such as a TV receiver, and signal processing apparatus for generating a corresponding sequence of frames for output to a screen. The appliance comprises a client application programmed to capture one of the frames and use the captured frame to generate an image to represent a user in relation to bidirectional communications over a packet-based network.

Abstract: A method of distributing availability information from a first user terminal to at least one further user terminal connected via a communication network, comprising: executing a communication client at the first user terminal; the communication client accessing schedule data stored on a storage means relating to a user of the first user terminal; the communication client analysing the schedule data to determine a current status of the user; mapping the current status of the user to a selected one of a group of predefined availability settings at the communication client; and transmitting a message comprising the selected availability setting over the communication network to the at least one further user terminal.

Abstract: A television receiver system and corresponding method, the television receiver system comprising: a television receiver for receiving broadcast television signals, signal processing apparatus operable to process the received television signals for output to a television screen, and a control device allowing a user to select a viewing activity by controlling the output to the television screen. The television receiver further comprises a memory storing a communication client application; and communications processing apparatus operable to execute the communication client application. The client application is programmed so as when executed to allow the user to establish bidirectional communications with one or more other users via a packet-based communication network, and to provide notifications to the user of incoming communication events from other users.

Abstract: Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.

Abstract: A user terminal comprising: a positioning system arranged to detect a geographical location of the user terminal; a transceiver for communicating with other user terminals via a communication network; and a communication processing apparatus coupled to the transceiver and positioning system. The communication processing apparatus is arranged to detect communication events occurring via the transceiver and communication network in relation to other user terminals, and to maintain a log of the communication events. Further, the communication processing apparatus is configured to organize the log in dependence on a geographical location detected by the positioning system.

Abstract: An integrated health record system comprises a platform including a processor coupled to a medical application. The system includes at least one input device coupled to the processor. The input device receives patient information of a patient via an electronic form and receives vital signs of the patient. The medical application integrates the patient information and the vital signs into an electronic health record (EHR) that corresponds to the patient. The medical application receives a sound file that includes information resulting from an examination of the patient, and translates the sound file into a document that comprises a clinical document architecture (CDA). The medical application parses the document and identifies a plurality of data components based on a correspondence to a plurality of data fields of the HER. The medical application populates each of the plurality of data fields with each of the data components.

Abstract: The present invention relates to novel substituted aryl sulfone intermediates and processes for preparing the same. An aspect of this invention relates to a process for making substituted aryl sulfone intermediates utilizing a one-pot deacylation-carbon/sulfur bond formation step. The invention also relates to a process for preparing intermediates that are used to make the compounds of formula I. Some of the advantages of the present invention include manufacturing flexibility and efficiency, high yield synthesis using a one pot deacylation and carbon-sulfur bond formation step of a thioester intermediate and the like. This and other aspects of the invention will be realized upon review of the specification as a whole.

Abstract: The present invention relates to novel substituted aryl sulfone intermediates and processes for preparing the same. An aspect of this invention relates to a process for making substituted aryl sulfone intermediates utilizing a one-pot deacylation-carbon/sulfur bond formation step. The invention also relates to a process for preparing intermediates that are used to make the compounds of formula I. Some of the advantages of the present invention include manufacturing flexibility and efficiency, high yield synthesis using a one pot deacylation and carbon-sulfur bond formation step of a thioester intermediate and the like. This and other aspects of the invention will be realized upon review of the specification as a whole.

Abstract: A method of establishing a communication event between a first user and a second user of a communication system; wherein the first user operates a user terminal executing an electronic game application; the method comprising the steps of: storing contact information for at least the second user of the communication system; associating the contact information of the second contact with one or more game objects in the electronic game application; receiving an input signal from the first user to interact with a game object displayed during execution of the electronic game application; and responsive to receiving the signal to interact with the game object, establishing a communication event between the first user of the game application and the second user of the communication system using the contact information associated with the game object.

Abstract: A method of initiating a communication event via a packet-based communication network in a media appliance having a processor executing a communication client, comprising: retrieving a stored list comprising a plurality of contacts associated with a user of the communication client; generating a first two-dimensional contact grid comprising a first arrangement of entries; displaying the first contact grid on a display means such that each of a plurality of the entries comprises a graphical representation of a respective one of the plurality of contacts, wherein the graphical representations are sized so as to fit in the entries of the first contact grid; receiving a selection of a subset of the graphical representations in the first contact grid from a user of the communication client; generating a second contact grid comprising a second arrangement of entries corresponding to the selected subset; displaying the second contact grid on the display means in replacement of the first contact grid, such that each

Abstract: A media appliance and corresponding method, the media appliance comprising a video signal source such as a TV receiver, and signal processing apparatus for generating a corresponding sequence of frames for output to a screen. The appliance comprises a client application programmed to capture one of the frames and use the captured frame to generate an image to represent a user in relation to bidirectional communications over a packet-based network.

Abstract: A method of distributing availability information from a first user terminal to at least one further user terminal connected via a communication network, comprising: executing a communication client at the first user terminal; the communication client accessing schedule data stored on a storage means relating to a user of the first user terminal; the communication client analysing the schedule data to determine a current status of the user; mapping the current status of the user to a selected one of a group of predefined availability settings at the communication client; and transmitting a message comprising the selected availability setting over the communication network to the at least one further user terminal.