Abstract: Systems provide enhanced cooling of tip regions of turbine blades. A cooling system includes a turbine blade with a root, a base, a tip, a leading edge, a trailing edge, an outer structure that includes a pressure side wall, a suction side wall and a tip cap at its tip. A core in the blade defines a leading channel that ejects cooling air through the leading edge. A primary tip flag channel ejects cooling air through the tip and the trailing edge. A secondary tip flag channel ejects cooling air through the trailing edge. The primary tip flag channel and the secondary tip flag channel promote cooling of the tip due to the locations in the tip area and their delivery of low temperature and high pressure cooling air thereto.

Abstract: Infant formula compositions and methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.

Abstract: Gas turbine engines and methods for reducing spool thrust in a combustor section thereof are provided. The engines include an impeller, a shaft coupled to the impeller, an inner cavity downstream of the impeller, a thrust bearing assembly mechanically coupled to the shaft, a seal assembly having a seal land, and a controller. The controller is configured to detect a loss of oil event to the thrust bearing assembly and, in response, actuate the seal assembly to move the seal land toward a downstream face of the impeller to form a continuous axial seal about the inner cavity, vent gases from the inner cavity to decrease pressure therein to an extent less than an operating gas pressure thereof, and maintain the axial seal and the pressure within the inner cavity and thereby reduce the axial loads on the shaft.

Abstract: Gas turbine engines and methods for reducing spool thrust in a combustor section thereof are provided. The engines include an impeller, a shaft coupled to the impeller, an inner cavity downstream of the impeller, a thrust bearing assembly mechanically coupled to the shaft, a seal assembly having a seal land, and a controller. The controller is configured to detect a loss of oil event to the thrust bearing assembly and, in response, actuate the seal assembly to move the seal land toward a downstream face of the impeller to form a continuous axial seal about the inner cavity, vent gases from the inner cavity to decrease pressure therein to an extent less than an operating gas pressure thereof, and maintain the axial seal and the pressure within the inner cavity and thereby reduce the axial loads on the shaft.

Abstract: Gas turbine engines and methods for reducing spool thrust in a turbine section thereof are provided. The engines include a turbine disk, a shaft coupled to the turbine disk, an inner cavity downstream of the turbine disk, a thrust bearing assembly mechanically coupled to the shaft, a seal assembly having a seal land, and a controller. The controller is configured to detect a loss of oil event to the thrust bearing assembly and, in response: actuate the seal assembly to move the seal land toward a downstream face of the turbine disk to form a continuous axial seal about the inner cavity, supply a pressurized gas to the inner cavity to increase pressure in therein to an extent greater than an operating pressure thereof, and maintain the axial seal and the pressure within the inner cavity and thereby reduce the axial loads on the shaft.

Abstract: Gas turbine engines and methods for reducing spool thrust in a turbine section thereof are provided. The engines include a turbine disk, a shaft coupled to the turbine disk, an inner cavity downstream of the turbine disk, a thrust bearing assembly mechanically coupled to the shaft, a seal assembly having a seal land, and a controller. The controller is configured to detect a loss of oil event to the thrust bearing assembly and, in response: actuate the seal assembly to move the seal land toward a downstream face of the turbine disk to form a continuous axial seal about the inner cavity, supply a pressurized gas to the inner cavity to increase pressure in therein to an extent greater than an operating pressure thereof, and maintain the axial seal and the pressure within the inner cavity and thereby reduce the axial loads on the shaft.

Abstract: A foot and knee protector device includes a support extending from a first end to a second end; a knee pad attached to the support and having one or more straps to secure around a leg of a user; a foot support attached to the support and having one or more straps to secure around a foot of the user; and a toe protector attached to the support via an extension, the toe protector extending past an end of the user's foot; the knee pad and the toe protector protect the user when in a kneeling position, the toe protector preventing the end of the user's foot or boot from coming into contact with a ground surface.

Abstract: Provided herein are methods and compositions related to treating and/or preventing liver related diseases and disorders and for improving liver health in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.

Abstract: Provided herein are crystalline forms of nicotinamide riboside chloride and methods of making the same. Also provided are compositions comprising the crystalline form of nicotinamide riboside chloride, and therapeutic methods employing the crystalline form of nicotinamide riboside chloride.

Abstract: Cryogenic analysis assemblies and methods are provided. The assemblies and/or methods can be configured for optical sample analysis. The assemblies and/or methods can include: an objective assembly operatively aligned with a sample support assembly, both the objective assembly and sample support assembly residing within a vacuum housing; wherein the objective assembly defines an objective mount housing an objective coupled to a mounting ring within a chamber below a heater assembly; and an insulative member between the objective mount and the mounting ring, the insulative member supporting the objective mount and thermally isolating the objective mount from the mounting ring.

Abstract: A rotor for a turbomachine and a method of manufacturing the same. The method includes providing a lug with a lug body and an interface material disposed on the lug body. The method also includes friction welding the lug to a hub member via the interface material to define a projected structure for an outer radial area of a disc assembly of the rotor. The projected structure is configured to support a first side of a rotor blade of the rotor in cooperation with a second projected structure of the disc assembly supporting a second side of the rotor blade. The lug body and the hub member are made from different materials.

Abstract: A turbine vane airfoil and a turbine nozzle that includes the turbine vane airfoil. The turbine vane airfoil includes an airfoil defining a chamber proximate a surface, and an impingement tube. The impingement tube includes a first wall and a second wall. The first wall defines a plurality of first apertures, and each has a first upstream surface portion opposite a first downstream surface portion. The second wall defines a plurality of second apertures, and each has a second upstream surface portion opposite a second downstream surface portion. Each of the first apertures cooperate with a respective one of the second apertures to direct a cooling fluid onto the surface, and the first downstream surface portion of at least one of the first apertures includes a first point that is collinear with a second point of the second downstream surface portion of the respective one of the second apertures.

Abstract: Provided herein are efficient and scalable methods for the synthesis of nicotinamide riboside from riboside triacetate. Also provided are compositions comprising nicotinamide riboside, and therapeutic methods employing nicotinamide riboside.

Abstract: Infant formula compositions and methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.

Abstract: Provided herein are efficient and scalable methods for the synthesis of nicotinamide riboside from riboside triacetate. Also provided are compositions comprising nicotinamide riboside, and therapeutic methods employing nicotinamide riboside.

Abstract: Provided herein are crystalline forms of nicotinamide riboside chloride and methods of making the same. Also provided are compositions comprising the crystalline form of nicotinamide riboside chloride, and therapeutic methods employing the crystalline form of nicotinamide riboside chloride.

Abstract: Methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.

Abstract: An impingement baffle for directing a cooling fluid onto a target surface includes a baffle body having a first end opposite a second end, and a first side opposite a second side. The second side is spaced a distance apart from the target surface, with the distance varying from the first end to the second end. The baffle body defines impingement holes that extend through the baffle body from the first side to the second side. The impingement holes are spaced apart along the baffle body to receive the cooling fluid. The impingement baffle includes tubular extensions coupled to the second side. Each tubular extension is in fluid communication with a respective one of the impingement holes to direct the cooling fluid onto the target surface. Each tubular extension extends for a length from the second side, and the length of each tubular extension is based on the distance.

Abstract: Architectures and techniques are presented that improve or optimize (e.g., within a factor of optimal) spare equipment allocation. Efficient spare equipment allocation is capable of satisfying many orthogonal or even conflicting goals such as reducing the cost of purchase and storage of the spare equipment while simultaneously seeking to reduce downtime due to failed equipment resulting from too sparse coverage by the spare equipment. A sparing procedure can identify depot nodes that are indicative of depot locations where a spare device is to be stored.

Abstract: Provided herein are methods and compositions related to treating and/or preventing liver related diseases and disorders and for improving liver health in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.