Abstract: Methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.

Abstract: A turbine nozzle formed of a superalloy, and including: an annular end-wall including a pocket, the pocket defining an inner surface within the annular end-wall; a vane, the vane including an airfoil portion and a boss portion, the vane extending from the pocket such that the boss portion is enclosed within the pocket and the airfoil portion extends through the annular end-wall; and a seal within the pocket, the seal including one or more protrusions extending from the inner surface of the pocket and abutting the vane at one or both of the boss portion and the airfoil portion.

Abstract: Provided herein are methods and compositions related to treating and/or preventing liver related diseases and disorders and for improving liver health in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.

Abstract: Provided herein are methods and compositions related to treating and/or preventing multiple sclerosis in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.

Abstract: Provided herein are methods and compositions related to treating and/or preventing obesity and/or conditions associated with obesity in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: Data can be stored based on one or more indications and one or more other storage criteria. The indications can effectively indicate or identify a storage level for storing data in a multi-storage system. The indications, however, need not be the only basis for storing the data object in a multi-storage system as one or more other storage criteria can also be considered. As a result, the indication can be used to effectively influence data storage but other storage criteria can be used as well to prevent adverse effects caused by undue influence and to ensure the overall efficiency of the system. Also, the one or more other storage criteria can be evaluated or revaluated on a continual basis.

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: A rotor for a turbomachine and a method of manufacturing the same. The method includes providing a lug with a lug body and an interface material disposed on the lug body. The method also includes friction welding the lug to a hub member via the interface material to define a projected structure for an outer radial area of a disc assembly of the rotor. The projected structure is configured to support a first side of a rotor blade of the rotor in cooperation with a second projected structure of the disc assembly supporting a second side of the rotor blade. The lug body and the hub member are made from different materials.

Abstract: A turbine component includes a hot wall, a cold wall spaced apart from the hot wall and a conduit defined between the hot wall and the cold wall. A cooling system is defined in the conduit. The cooling system includes a plurality of cooling pins, each including a first end having a first cross-sectional area and a second end having a second cross-sectional area. Each cooling pin includes a body extending between the first end and the second end, with a pin leading edge defined along the body from the first end to the second end. The pin leading edge is defined by a first diameter and a pin trailing edge is defined by a second diameter. At least one first cooling pin has the first end coupled to the hot wall and the second end coupled to the cold wall with a fillet.

Abstract: A turbomachine includes a shroud and a rotor, which includes first and second blades. A first blade tip and a second blade tip respectively include a base and a first layer. The second blade tip also includes an abrasive second layer layered over the respective first layer. The first layer has a lower material hardness than the shroud. The second layer has a lower thermal stability than the shroud and the first layer. The rotor performs a grind operation and, subsequently, a post-grind operation. The second layer, in the grind operation, contacts and removes material from the shroud, and wears away, thereby revealing the first layer of the second blade tip for the post-grind operation. The first layer of the first blade tip is spaced apart with at least some radial clearance from the shroud in the grind and post-grind operations.

Abstract: The present invention relates to Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: Low primary amine (LPA) polyaspartic esters are provided which comprise a reaction product of an aliphatic diamine and an excess of a Michael addition receptor optionally, in the presence of a C1-C10 alcohol, wherein the low primary amine (LPA) polyaspartic ester has a monoaspartate content of less than 10%. The low primary amine (LPA) polyaspartic esters of the invention may find use in slow reactivity polyurea systems and react with polyisocyanates to produce polyurea coatings, adhesives, sealants, films, composites, castings, and paints.

Abstract: Search spaces for obtaining query execution plans for a query are identified. The search spaces are subdivided into sub-search spaces. Searches are initiated within the sub search spaces and plan costs for competing query execution plans are noted along with search costs associated with continuing to search the sub-search spaces. A decision is made based on the plan costs and search costs for utilizing search resources as to when to terminate the searching and to select the then-existing lowest cost query execution plan as an optimal query execution plan for executing the query.

Abstract: Provided herein are methods and compositions related to treating and/or preventing glaucoma in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside and/or pterostilbene.

Abstract: Methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.

Abstract: A method for generating a multi-layer predictive model includes collecting historical observable data from one or more pieces of equipment of a same type, wherein the historical observable data is collected at different hierarchical levels of the one or more pieces of equipment; collecting operational state indications of the pieces of equipment corresponding to the collected historical observable data; generating, from the collected historical observable data, a set of operational state models, wherein each operational state model corresponds to one of the different hierarchical levels; and generating, from outputs of the set of operational state models, a top-level operational model for the piece of equipment. The top-level operational model is operable to determine maintenance and replacement timing for the piece of equipment.

Abstract: Compounds, methods of editing a target genomic region(s), methods of repairing of a DNA break via a HDR pathway, methods of inhibiting or suppressing repair of a DNA break via a NHEJ pathway, and methods of modifying expression of a gene(s) or protein(s) comprise administering to one or more cells that include one or more target genomic regions, a genome editing system and a DNA protein-kinase (DNA-PK) inhibitor disclosed herein. Kits and compositions for editing a target gene comprise a genome editing system and a DNA-PK inhibitor disclosed herein.

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions, or disorders.