Abstract: Irinotecan phospholipid liposomes with improved storage stability are provided. with related methods of treatment and manufacture. The irinotecan liposomes can have reduced formation of lyso-phosphatidylcholine (lyso-PC) during storage, and prior to administration to a patient.

Abstract: Methods of making an enhanced bioactive PRP implant include supplying a centrifuge container with a collagen-based scaffold pre-inserted onto a moveable filter within the vial. A centrifuge process for creating the PRP implant is followed, resulting in a PRP/collagen implant combination. Other biologics may be added to the container instead of or in addition to the collagen-based scaffold. Additionally, methods of fixing the PRP implant into place at the point of a tear or wound include applying the PRP implant adjacent to or within a meniscal tear, or underneath or on top of a rotator cuff tear. Suture or staples may then be routed either through or over the PRP implant to hold the implant in place.

Abstract: Irinotecan phospholipid liposomes with improved storage stability are provided, with related methods of treatment and manufacture. The irinotecan liposomes can have reduced formation of lyso-phosphatidylcholine (lyso-PC) during storage, and prior to administration to a patient.

Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.

Abstract: A checkout system includes a checkout station having a housing, a customer interface and a customer unloading station. A point-of-sale system has a microprocessor and memory operatively associated with one another to identify products being purchased, payments tendered therefor and to store transaction information locally at the checkout station or remotely from the checkout station. The microprocessor has programming configured to allow an item to be scanned by a product identification scanner, and an attendant command module.

Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.

Abstract: A checkout system includes a checkout station having a housing, a customer interface and a customer unloading station. A point-of-sale system has a microprocessor and memory operatively associated with one another to identify products being purchased, payments tendered therefor and to store transaction information locally at the checkout station or remotely from the checkout station. The microprocessor has programming configured to allow an item to be scanned by a product identification scanner, and an attendant command module.

Abstract: Improved checkout systems, apparatuses and methods for managing electronic coupons include a checkout kiosk, a point-of-sale system and a microprocessor with an electronic rules engine. The electronic rules engine is configured to allow application of electronic coupons to customer accounts internally to the point-of-sale system. Redemption of the electronic coupons is allowed by the consumer at the kiosk without a scan-able artifact.

Abstract: This invention relates to treating gastrointestinal dysfunction with erythropoietin (EPO) or its analog.

Abstract: A checkout system includes a checkout station having a housing, a customer interface and a customer unloading station. A point-of-sale system has a microprocessor and memory operatively associated with one another to identify products being purchased, payments tendered therefor and to store transaction information locally at the checkout station or remotely from the checkout station. The microprocessor has programming configured to allow an item to be scanned by a product identification scanner, and an attendant command module.

Abstract: This invention relates to treating gastrointestinal dysfunction with erythropoietin (EPO) or its analog.

Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.

Abstract: A checkout system includes a checkout station having a housing, a customer interface and a customer unloading station. A point-of-sale system has a microprocessor and memory operatively associated with one another to identify products being purchased, payments tendered therefor and to store transaction information locally at the checkout station or remotely from the checkout station. The microprocessor has programming configured to allow an item to be scanned by a product identification scanner, and an attendant command module.

Abstract: A checkout system includes a checkout station having a housing, an attendant work station, a customer unloading station and an exceptions processing subsystem. A point-of-sale system has a microprocessor and memory operatively associated with one another to identify products being purchased, payments tendered therefor and to store transaction information locally at the checkout station or remotely from the checkout station. The microprocessor has programming configured to allow an item to be scanned by a product identification scanner and in communication with the exceptions processing subsystem. The attendant work station may include an exceptions handling display: Check out methods and apparatus are also disclosed.

Abstract: Compositions and methods of treating a subject with an acute traumatic injury are disclosed. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a potassium channel blocker. The potassium channel blocker can include 4-aminopyridine, a derivative thereof, or a combination thereof. The pharmaceutical composition can be administered with an additional therapeutic agent such as an anticonvulsant. The methods can be used for treating acute traumatic injury to an excitable tissue. The methods can restore at least a portion of lost motor function or sensory function, enhance repair and regeneration of stem or progenitor cells such as to promote neural cell generation, enhance cell survival, reduce scarring, decreases sox9 expression, chondroitin sulfate proteoglycan expression, and other markers of tissue damage, decreases lesion size, decreases oxidative damage, or combinations thereof.

Abstract: This invention relates to treating gastrointestinal dysfunction with erythropoietin (EPO) or its analog.

Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.

Abstract: A checkout system includes a checkout station having a housing, a customer interface and a customer unloading station. A point-of-sale system has a microprocessor and memory operatively associated with one another to identify products being purchased, payments tendered therefor and to store transaction information locally at the checkout station or remotely from the checkout station. The microprocessor has programming configured to allow an item to be scanned by a product identification scanner, and an attendant command module.

Abstract: Compositions and methods of treating a subject with cancer are described. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound with the dual characteristics or restoring function of the c-Cbl ubiquitin ligase in cancer cells and in also worsening sublethal lysosomal dysfunction, preferably in combination with an agent capable of making cancer cells more oxidized. The pharmaceutical composition can be administered with an additional therapeutic agent or agents such as an agent that represents an accepted standard of care for the treatment of a particular type being treated. The methods can be used for treating a wide variety of different kinds of cancers, such as brain tumors, breast cancers, melanomas, breast cancers and lymphomas.

Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.