Abstract: A marine outboard engine for a watercraft has a stern bracket for mounting the marine outboard engine to the watercraft, a swivel bracket pivotally connected to the stern bracket about a generally horizontal tilt/trim axis, and a drive unit pivotally connected to the swivel bracket about a steering axis. The steering axis is generally perpendicular to the tilt/trim axis. A hydraulic actuator is operatively connected to the stern bracket and the swivel bracket for pivoting the swivel bracket and the drive unit relative to the stern bracket about the tilt/trim axis. A pump is mounted to the swivel bracket. The pump is pivotable about the tilt/trim axis together with the swivel bracket. The pump is fluidly connected to the hydraulic actuator to supply hydraulic fluid to the hydraulic actuator.

Abstract: Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective amount of a composition comprising an agent that promotes remyelination of the peripheral nerve. Also provided are methods of determining whether a peripheral nerve injury has a capacity for recovery. The methods include selecting a subject with a peripheral nerve injury, administering to the subject a first dose of a composition comprising and agent that promote remyelination and detecting after the first dose one or more characteristics of peripheral nerve recovery, the presence of one or more characteristics of peripheral nerve recovery indicating a peripheral nerve injury has a capacity for recovery and the absence of characteristics of peripheral nerve recovery indicating a peripheral nerve injury without a capacity for recovery.

Abstract: Provided herein are compositions, kits and methods related to the treatment of one or more lysosomal storage diseases (LSDs) in a subject and methods of identifying agents that are useful for the treatment of one or more LSDs. The compositions, kits, and methods are based on the novel discovery that agents effective for treating LSD must have two characteristics: they must inhibit cell death and reduce suppression of cell division caused by toxic substances that accumulate in LSD. Exemplary agents include polypeptides (e.g., IGF-1, VEGF) and small molecules (e.g., chlorotrianisene, clofoctal, colforsin, and tulobuterol).

Abstract: A drive unit has an engine, an operatively connected driveshaft, a transmission, and a propeller shaft connected to a rotor outside a gear case. A plate, extending above the rotor, is adapted to slidingly receive along a joint axis, an accessory having an accessory joint element which is one of a channel and a protrusion. Extending parallel to the joint axis along a plate joint surface, which is one of a first surface facing away from the rotor and a second surface facing toward the rotor, is a plate joint element, which is the other of the channel and the protrusion, adapted to slidingly interlock with the accessory joint element to thereby prevent displacement thereof in a first direction parallel to the plate joint surface and perpendicular to the joint axis, and in a second direction normal to the plate joint surface. An accessory attachment method is also disclosed.

Abstract: A marine outboard engine for a watercraft has a stern bracket for mounting the marine outboard engine to the watercraft, a swivel bracket pivotally connected to the stern bracket about a generally horizontal tiltitrim axis, and a drive unit pivotally connected to the swivel bracket about a steering axis. The steering axis is generally perpendicular to the tilt/trim axis. An actuator is operatively connected to the stern bracket and the swivel bracket for pivoting the swivel bracket and the drive unit relative to the stern bracket about the tilt/trim axis. A pump is mounted to the swivel bracket. The pump is pivotable about the tilt/trim axis together with the swivel bracket. The pump is fluidly connected to the actuator to supply hydraulic fluid to the actuator.

Abstract: A stern bracket for mounting a drive unit to a watercraft including a transom. The drive unit is pivotable with respect to the stern bracket about a tilt axis. The stern bracket includes a support member for fixing the drive unit to the transom and a water deflector. The water deflector comprises a mounting bracket attached to the support member and a deflection plate connected to the mounting bracket. The deflection plate, disposed at a vertical position lower than the tilt axis, extends between the transom and the drive unit mounted to the stern bracket mounted to the transom. A left deflection wing, connected to at least one of the deflection plate and the mounting bracket, extends downward and laterally outward therefrom. A right deflection wing, connected to at least one of the deflection plate and the mounting bracket, extends downward and laterally outward therefrom. A watercraft is also disclosed.

Abstract: A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM? glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5? fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.

Abstract: A marine outboard engine is described, having an engine disposed in a cowling. The engine has a cooling system. A first pump is disposed inside the cowling below a water line of the outboard engine. The first pump is continuously driven by the engine during operation of the engine. The first pump is a centrifugal pump having an inlet in fluid communication with an exterior of the marine outboard engine below the water line and an outlet in fluid communication with the cooling system. A second pump is disposed inside the cowling below the water line. The second pump has an inlet in fluid communication with an exterior of the marine outboard engine below the water line and an outlet in fluid communication with the cooling system. An electric motor is operatively connected to the second pump for selectively driving the second pump during operation of the engine.

Abstract: A propeller assembly has first and second propeller blades pivotably mounted on a propeller hub. The first and second propeller blades are pivotable with respect to the propeller hub about corresponding first and second pivot axes to vary a pitch of the first and second propeller blades. A support member has a first end at least partially disposed within the first propeller blade and a second end at least partially disposed within the second propeller blade. The first end has a first central longitudinal axis generally coaxial with the first pivot axis. The second end has a second central longitudinal axis generally coaxial with the second pivot axis. A gear case having a propeller and a marine outboard engine having a propeller are also disclosed.

Abstract: A marine outboard engine has upper and lower engine covers, a swivel bracket, a stern bracket, an engine, a driveshaft, a gear case, a propeller shaft, and a variable pitch propeller. A hydraulic system includes hydraulic steering, trim, and propeller pitch actuators, and at least one valve having at least one inlet, and first, second, and third outlets. The first, second, and third outlets fluidly communicate with the hydraulic steering, trim, and propeller pitch actuators respectively. A pump fluidly communicates with the at least one inlet of the at least one valve. A reservoir stores hydraulic fluid. A control unit controls the at least one valve to control a flow of hydraulic fluid through each of the first, second, and third outlets based at least in part on a signal received from a pressure sensor. Methods of controlling the hydraulic systems are also disclosed.

Abstract: A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM? glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5? fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.

Abstract: A marine outboard engine is disclosed which comprises a drive unit, a tilt/trim/steering subsystem and a stern bracket adapted for connection to an associated watercraft. The tilt/trim/steering subsystem connects the drive unit to the stern bracket and comprises a first rotary actuator carrying the drive unit for pivotal movement about a steering axis that extends generally vertically, and a second rotary actuator connected to the first rotary actuator and supporting the first rotary actuator and the drive unit for pivotal movement about a tilt/trim axis that extends generally horizontally.

Abstract: A marine outboard engine is described, having an engine disposed in a cowling. The engine has a cooling system. A first pump is disposed inside the cowling below a water line of the outboard engine. The first pump is continuously driven by the engine during operation of the engine. The first pump is a centrifugal pump having an inlet in fluid communication with an exterior of the marine outboard engine below the water line and an outlet in fluid communication with the cooling system. A second pump is disposed inside the cowling below the water line. The second pump has an inlet in fluid communication with an exterior of the marine outboard engine below the water line and an outlet in fluid communication with the cooling system. An electric motor is operatively connected to the second pump for selectively driving the second pump during operation of the engine.

Abstract: A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM? glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5? fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.

Abstract: Disclosed is a system for providing in vivo delivery of polynucleotides to mammalian prostate cells using an intravascular administration route. The polynucleotides are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the polynucleotide to the cell.

Abstract: Provided herein are compositions and methods for the treatment of central nervous system (CNS) lesions comprising administration of glial restricted precursor (GRP) derived astrocytes (GDAs).

Abstract: Methods and compositions related to a novel cellular pathway, the redox/Fyn/c-Cbl pathway, include a variety of aspects. Provided herein are agents that selectively interrupt the pathway and methods of using the same. Also provided are screening methods used to identify a pro-oxidation toxicant or other agents and stimuli that affect the redox/Fyn/c-Cbl pathway. Methods of testing oxidation levels by evaluating aspects of the pathway are also provided.

Abstract: A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM? glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5? fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.

Abstract: A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM? glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5? fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.

Abstract: Disclosed are compositions and methods for treating cancer that contain caspase inhibitors and/or antioxidant compositions. Formulations containing noncaspase inhibitor anti-cancer agents are also disclosed.