Abstract: Methods to assess a pediatric subject having a single ventricle heart include identifying a difference between concentration levels of metabolic biomarkers and reference concentration levels and then assessing the pediatric subject based on the identified differences.

Abstract: The described technology relates to electronic continuous trading systems, and matching data records representing inventories with variant characteristics such as, variant length, variant data types, etc. Example implementations provide for generating instrument descriptors that include unitary-valued attributes and set-valued attributes, and the use of both types of attributes in trade decision making.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: A battery system includes a battery cooling system, the battery cooling system including a battery chiller, battery pods in fluid connection with the battery chiller, and at least one chiller pump, the at least one chiller pump in fluid communication with the battery chiller and the battery pods. The battery system also includes a heat exchanger, the heat exchanger in fluid communication with the battery cooling system and an inverter loop. In addition the battery system includes the inverter loop including active front end rectifiers (AFE) and LCL filters (LCL), an inverter pump in communication with the AFE and the LCL, and a temperature sensing control valve adapted to stop or start flow of an inverter loop cooling fluid from reaching the heat exchanger.

Abstract: A system for stimulating oil or gas production from a wellbore includes a hydraulic fracturing pump unit having one or more hydraulic fracturing pumps driven by one or more electrical fracturing motors, a variable frequency drive (VFD) controlling the electrical fracturing motors, a fracturing pump blower unit driven by a blower motor, and a fracturing pump lubrication unit having a lubrication pump driven by a lubrication motor and a cooling fan driven by a cooling motor. The system may further include a blender unit and a hydration unit. A system control unit may control the operational parameters of the system.

Abstract: A TAT-FXN fusion polypeptide useful in treating subjects diagnosed with Friedrich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.

Abstract: A dry product additive system includes a skid, a hopper, a pickup funnel, a feeder system, a supply pump, and an eductor assembly. The feeder system may be configured to transport product from the hopper to the pickup funnel. The eductor assembly including a suction inlet, a motive inlet, and an outlet. The suction inlet may be coupled to the pickup funnel by a suction hose. The motive inlet may be coupled to the supply pump by a motive fluid hose.

Abstract: An orthodontic self-ligating bracket for orthodontic treatment of maloccluded teeth. The bracket includes a bracket body, a bracket door, and a spring mechanism retained by the bracket door. The bracket body has a base on the bottom side of the bracket body that is contoured to attach to a surface of a tooth, a bracket slot on the top side of the bracket body extending in a mesiodistal direction and configured to releasably retain an archwire, and a bracket groove on the top side of the bracket body extending in an occlusogingival direction towards the bracket slot. The spring mechanism includes one or more springs that are configured to contact the bracket door and the bracket body. The bracket door can thus be retained by and slidably engage the bracket body between an open position and a closed position. One or more additional active spring members may also be provided.

Abstract: An integrated fracturing system includes a fracturing pump, an electric motor positioned to drive the fracturing pump, a variable frequency drive positioned to provide variable frequency power to the electric motor, a master controller, and a diagnostic sensor. The master controller is positioned to provide energize and speed commands to the VFD. The diagnostic sensor is coupled to the electric motor positioned to measure diagnostic data. The diagnostic sensor is in communication with the master controller.

Abstract: An orthodontic self-ligating bracket for orthodontic treatment of maloccluded teeth. The bracket includes a bracket body, a bracket door, and a spring mechanism retained by the bracket door. The bracket body has a base on the bottom side of the bracket body that is contoured to attach to a surface of a tooth, a bracket slot on the top side of the bracket body extending in a mesiodistal direction and configured to releasably retain an archwire, and a bracket groove on the top side of the bracket body extending in an occlusogingival direction towards the bracket slot. The spring mechanism includes one or more springs that are configured to contact the bracket door and the bracket body. The bracket door can thus be retained by and slidably engage the bracket body between an open position and a closed position. One or more additional active spring members may also be provided.

Abstract: An oral care kit comprising an oral care implement having a first reservoir containing a first oral care agent comprising a first whitening reagent that includes triacetin; and a container having a second reservoir containing a second oral care agent, the second oral care agent comprising a catalytic enzyme and a second whitening reagent that includes peroxide forming compound.

Abstract: A dry product additive system includes a skid, a hopper, a pickup funnel, a feeder system, a supply pump, and an eductor assembly. The feeder system may be configured to transport product from the hopper to the pickup funnel. The eductor assembly including a suction inlet, a motive inlet, and an outlet. The suction inlet may be coupled to the pickup funnel by a suction hose. The motive inlet may be coupled to the supply pump by a motive fluid hose.

Abstract: A method includes supplying a plurality of generators, each generator in electrical communication with a switchgear with each switchgear in data communication with a generator data management system. The method also includes supplying a plurality of electrically driven fracturing pumps with each electrically driven fracturing pump in data communication with pump data management system. Further, the method includes supplying a load shedding system, the load shedding system in data communication with the generator data management system and a pump control system, the pump control system in data communication with the pump data management system. The method includes determining which pumps should have speed reduced by the load shedding system and reducing the speed of the pumps determined by the load shedding system using the pump control system.

Abstract: A method of assembling a distalizer is provided. An arm is provided including a mesial element at one end of the arm, and a ball member at another end of the arm. The mesial element has a first base for attachment to a canine or bicuspid. A distal element is also provided having a second base for attachment to a molar. To assemble the distalizer, the ball member of the arm is enclosed in the distal element without deformation of the distal element. For instance, the ball member is inserted into a first portion of the distal element, and a second portion of the distal element is joined together with the first portion to form a receptacle for the ball member. The ball member is thus enclosed in the distal element without reducing an opening of a receptacle in the distal element. Thus, improved distalizer assembly and operation may result.

Abstract: A system for stimulating oil or gas production from a wellbore includes a hydraulic fracturing pump unit having one or more hydraulic fracturing pumps driven by one or more electrical fracturing motors, a variable frequency drive (VFD) controlling the electrical fracturing motors, a fracturing pump blower unit driven by a blower motor, and a fracturing pump lubrication unit having a lubrication pump driven by a lubrication motor and a cooling fan driven by a cooling motor. The system may further include a blender unit and a hydration unit. A system control unit may control the operational parameters of the system.

Abstract: An oral care composition including a hydrophobic phase and a hydrophilic phase is disclosed. The hydrophobic phase may include a source of hydrogen peroxide and an acyl donor, and the hydrophilic phase may include an enzyme having perhydrolytic activity that catalyzes the generation of peracetic acid between the source of hydrogen peroxide and the acyl donor.

Abstract: A Transactivator of Transcription-frataxin (TAT-FXN) fusion polypeptide useful in treating subjects diagnosed with Friedreich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.

Abstract: A system for stimulating oil or gas production from a wellbore includes a hydraulic fracturing pump unit having one or more hydraulic fracturing pumps driven by one or more electrical fracturing motors, a variable frequency drive (VFD) controlling the electrical fracturing motors, a fracturing pump blower unit driven by a blower motor, and a fracturing pump lubrication unit having a lubrication pump driven by a lubrication motor and a cooling fan driven by a cooling motor. The system may further include a blender unit and a hydration unit. A system control unit may control the operational parameters of the system.

Abstract: An orthodontic self-ligating bracket for orthodontic treatment of maloccluded teeth is provided that includes a bracket body and a bracket door including a coplanar spring. The bracket body has a base that is contoured to attach to a surface of a tooth, a archwire slot on the top side of the bracket body extending in a mesiodistal direction and configured to releasably retain an archwire, and a bracket groove on the top side of the bracket body extending in an occlusogingival direction towards the archwire slot. The coplanar spring includes a spring body and one or more legs that deflect in direction generally coplanar with a plane of motion of the bracket door. The one or more legs interact with one or more depressions in the bracket body to move and retain the bracket door on the bracket body.

Abstract: Aspects of a distalizer and method of assembling a distalizer are provided. The distalizer comprises an arm including a mesial element at one end of the arm, a ball member at another end of the arm, and a distal element which encloses the ball member without deformation of the distal element. The mesial element has a first base for attachment to a canine or bicuspid, and the distal element has a second base for attachment to a molar. To assemble the distalizer, the arm with the mesial element and the ball member is provided, and the ball member is enclosed in the distal element without deformation of the distal element. Alternatively, the mesial and distal elements are additively manufactured simultaneously with the arm including the ball member, and the ball member is enclosed in the distal element without deformation of the distal element during the additive manufacturing.