Abstract: A TAT-FXN fusion polypeptide useful in treating subjects diagnosed with Friedrich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.

Abstract: A TAT-FXN fusion polypeptide useful in treating subjects diagnosed with Friedrich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.

Abstract: Methods to assess a pediatric subject having a single ventricle heart include identifying a difference between concentration levels of metabolic biomarkers and reference concentration levels and then assessing the pediatric subject based on the identified differences.

Abstract: A system for stimulating oil or gas production from a wellbore includes a hydraulic fracturing pump unit having one or more hydraulic fracturing pumps driven by one or more electrical fracturing motors, a variable frequency drive (VFD) controlling the electrical fracturing motors, a fracturing pump blower unit driven by a blower motor, and a fracturing pump lubrication unit having a lubrication pump driven by a lubrication motor and a cooling fan driven by a cooling motor. The system may further include a blender unit and a hydration unit. A system control unit may control the operational parameters of the system.

Abstract: A TAT-FXN fusion polypeptide useful in treating subjects diagnosed with Friedrich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.

Abstract: A dry product additive system includes a skid, a hopper, a pickup funnel, a feeder system, a supply pump, and an eductor assembly. The feeder system may be configured to transport product from the hopper to the pickup funnel. The eductor assembly including a suction inlet, a motive inlet, and an outlet. The suction inlet may be coupled to the pickup funnel by a suction hose. The motive inlet may be coupled to the supply pump by a motive fluid hose.

Abstract: An integrated fracturing system includes a fracturing pump, an electric motor positioned to drive the fracturing pump, a variable frequency drive positioned to provide variable frequency power to the electric motor, a master controller, and a diagnostic sensor. The master controller is positioned to provide energize and speed commands to the VFD. The diagnostic sensor is coupled to the electric motor positioned to measure diagnostic data. The diagnostic sensor is in communication with the master controller.

Abstract: An oral care kit comprising an oral care implement having a first reservoir containing a first oral care agent comprising a first whitening reagent that includes triacetin; and a container having a second reservoir containing a second oral care agent, the second oral care agent comprising a catalytic enzyme and a second whitening reagent that includes peroxide forming compound.

Abstract: A dry product additive system includes a skid, a hopper, a pickup funnel, a feeder system, a supply pump, and an eductor assembly. The feeder system may be configured to transport product from the hopper to the pickup funnel. The eductor assembly including a suction inlet, a motive inlet, and an outlet. The suction inlet may be coupled to the pickup funnel by a suction hose. The motive inlet may be coupled to the supply pump by a motive fluid hose.

Abstract: A method includes supplying a plurality of generators, each generator in electrical communication with a switchgear with each switchgear in data communication with a generator data management system. The method also includes supplying a plurality of electrically driven fracturing pumps with each electrically driven fracturing pump in data communication with pump data management system. Further, the method includes supplying a load shedding system, the load shedding system in data communication with the generator data management system and a pump control system, the pump control system in data communication with the pump data management system. The method includes determining which pumps should have speed reduced by the load shedding system and reducing the speed of the pumps determined by the load shedding system using the pump control system.

Abstract: A Transactivator of Transcription-frataxin (TAT-FXN) fusion polypeptide useful in treating subjects diagnosed with Friedreich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.

Abstract: A system for stimulating oil or gas production from a wellbore includes a hydraulic fracturing pump unit having one or more hydraulic fracturing pumps driven by one or more electrical fracturing motors, a variable frequency drive (VFD) controlling the electrical fracturing motors, a fracturing pump blower unit driven by a blower motor, and a fracturing pump lubrication unit having a lubrication pump driven by a lubrication motor and a cooling fan driven by a cooling motor. The system may further include a blender unit and a hydration unit. A system control unit may control the operational parameters of the system.

Abstract: An enzymatically produced ?-glucan oligomer/polymer compositions is provided. The enzymatically produced ?-glucan oligomer/polymers can be derivatized into ?-glucan ether compounds. The ?-glucan oligomers/polymers and the corresponding ?-glucan ethers are cellulose and/or protease resistant, making them suitable for use in fabric care and laundry care applications. Methods for the production and use of the present compositions are also provided.

Abstract: Tissue expanders and methods of use. In some embodiments the tissue expanders are adapted to reduce wear on one or more components.

Abstract: An abdominal closure method and device is disclosed where the device generally includes a first tissue securement member configured for securement to a first tissue region and a second tissue securement member configured for securement to a second tissue region. The first and second tissue securement members are coupled to the connecting member and the connecting member is positionable at a distance from the first and second tissue regions. Additionally, one or more biasing elements may be connected to the first and second tissue securement members to approximate the first and second tissue regions towards one another via respective securement members.

Abstract: An oral care composition including an enzyme and an anhydrous matrix that at least partially stabilizes the enzyme. The anhydrous matrix includes a source of hydrogen peroxide, an acyl donor, a non-aqueous anhydrous liquid, and a thickener.

Abstract: An enzymatically produced ?-glucan oligomer/polymer compositions is provided. The enzymatically produced ?-glucan oligomer/polymers can be derivatized into ?-glucan ether compounds. The ?-glucan oligomers/polymers and the corresponding ?-glucan ethers are cellulose and/or protease resistant, making them suitable for use in fabric care and laundry care applications. Methods for the production and use of the present compositions are also provided.

Abstract: A TAT-FXN fusion polypeptide useful in treating subjects diagnosed with Friedrich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.

Abstract: A method includes supplying a plurality of generators, each generator in electrical communication with a switchgear with each switchgear in data communication with a generator data management system. The method also includes supplying a plurality of electrically driven fracturing pumps with each electrically driven fracturing pump in data communication with pump data management system. Further, the method includes supplying a load shedding system, the load shedding system in data communication with the generator data management system and a pump control system, the pump control system in data communication with the pump data management system. The method includes determining which pumps should have speed reduced by the load shedding system and reducing the speed of the pumps determined by the load shedding system using the pump control system.

Abstract: A system for stimulating oil or gas production from a wellbore includes a hydraulic fracturing pump unit having one or more hydraulic fracturing pumps driven by one or more electrical fracturing motors, a variable frequency drive (VFD) controlling the electrical fracturing motors, a fracturing pump blower unit driven by a blower motor, and a fracturing pump lubrication unit having a lubrication pump driven by a lubrication motor and a cooling fan driven by a cooling motor. The system may further include a blender unit and a hydration unit. A system control unit may control the operational parameters of the system.