Abstract: A system for stimulating oil or gas production from a wellbore includes a hydraulic fracturing pump unit having one or more hydraulic fracturing pumps driven by one or more electrical fracturing motors, a variable frequency drive (VFD) controlling the electrical fracturing motors, a fracturing pump blower unit driven by a blower motor, and a fracturing pump lubrication unit having a lubrication pump driven by a lubrication motor and a cooling fan driven by a cooling motor. The system may further include a blender unit and a hydration unit. A system control unit may control the operational parameters of the system.

Abstract: Tissue expanders and methods of use. In some embodiments the tissue expanders are adapted to reduce wear on one or more components.

Abstract: An orthodontic self-ligating bracket for orthodontic treatment of maloccluded teeth is provided that includes a bracket body and a bracket door including a coplanar spring. The bracket body has a base that is contoured to attach to a surface of a tooth, a archwire slot on the top side of the bracket body extending in a mesiodistal direction and configured to releasably retain an archwire, and a bracket groove on the top side of the bracket body extending in an occlusogingival direction towards the archwire slot. The coplanar spring includes a spring body and one or more legs that deflect in direction generally coplanar with a plane of motion of the bracket door. The one or more legs interact with one or more depressions in the bracket body to move and retain the bracket door on the bracket body.

Abstract: A system for stimulating oil or gas production from a wellbore includes a hydraulic fracturing pump unit having one or more hydraulic fracturing pumps driven by one or more electrical fracturing motors, a variable frequency drive (VFD) controlling the electrical fracturing motors, a fracturing pump blower unit driven by a blower motor, and a fracturing pump lubrication unit having a lubrication pump driven by a lubrication motor and a cooling fan driven by a cooling motor. The system may further include a blender unit and a hydration unit. A system control unit may control the operational parameters of the system.

Abstract: Tissue expanders and methods of use. In some embodiments the tissue expanders are adapted to reduce wear on one or more components.

Abstract: An orthodontic self-ligating bracket for orthodontic treatment of maloccluded teeth. The bracket includes a bracket body, a bracket door, and a spring mechanism retained by the bracket door. The bracket body has a base on the bottom side of the bracket body that is contoured to attach to a surface of a tooth, a bracket slot on the top side of the bracket body extending in a mesiodistal direction and configured to releasably retain an archwire, and a bracket groove on the top side of the bracket body extending in an occlusogingival direction towards the bracket slot. The spring mechanism includes one or more springs that are configured to contact the bracket door and the bracket body. The bracket door can thus be retained by and slidably engage the bracket body between an open position and a closed position. One or more additional active spring members may also be provided.

Abstract: An orthodontic self-ligating bracket for orthodontic treatment of maloccluded teeth. The bracket includes a bracket body, a bracket door, and a spring mechanism retained by the bracket door. The bracket body has a base on the bottom side of the bracket body that is contoured to attach to a surface of a tooth, a bracket slot on the top side of the bracket body extending in a mesiodistal direction and configured to releasably retain an archwire, and a bracket groove on the top side of the bracket body extending in an occlusogingival direction towards the bracket slot. The spring mechanism includes one or more springs that are configured to contact the bracket door and the bracket body. The bracket door can thus be retained by and slidably engage the bracket body between an open position and a closed position. One or more additional active spring members may also be provided.

Abstract: An orthodontic self-ligating bracket for orthodontic treatment of maloccluded teeth is provided that includes a bracket body and a bracket door including a coplanar spring. The bracket body has a base that is contoured to attach to a surface of a tooth, a archwire slot on the top side of the bracket body extending in a mesiodistal direction and configured to releasably retain an archwire, and a bracket groove on the top side of the bracket body extending in an occlusogingival direction towards the archwire slot. The coplanar spring includes a spring body and one or more legs that deflect in direction generally coplanar with a plane of motion of the bracket door. The one or more legs interact with one or more depressions in the bracket body to move and retain the bracket door on the bracket body.

Abstract: Compositions and methods for screening for a disease or a disorder associated with a deficiency in frataxin in a subject using biomarkers for diseases or disorders associated with a deficiency in frataxin are disclosed. The compositions and methods include determining the acetylation status of mito-chondrial proteins. Also disclosed are methods of detecting progression of a disease or a disorder associated with a deficiency in frataxin in a subject and methods of monitoring effectiveness of a therapy for diseases or disorders associated with a deficiency in frataxin.

Abstract: Compositions and methods for screening for a disease or a disorder associated with a deficiency in frataxin in a subject using biomarkers for diseases or disorders associated with a deficiency in frataxin are disclosed. The compositions and methods include determining the acetylation status of mitochondrial proteins. Also disclosed are methods of detecting progression of a disease or a disorder associated with a deficiency in frataxin in a subject and methods of monitoring effectiveness of a therapy for diseases or disorders associated with a deficiency in frataxin.

Abstract: Tissue expanders and methods of use. In some embodiments the tissue expanders are adapted to reduce wear on one or more components.

Abstract: A cardio-pulmonary compression board includes a board (10) configured for a patient. A leg (20) is pivotally connected to the board, and the leg includes a free end portion having a mechanical feature (35) configured to be received in a compression device to adjustably secure the compression device at a distance from the board in an operational position. A locking mechanism (32, 42) is configured to releasably maintain the leg in the operational position, which is transverse to a plane of the board.

Abstract: An orthodontic self-ligating bracket for orthodontic treatment of maloccluded teeth. The bracket includes a bracket body, a bracket door, and a spring mechanism retained by the bracket door. The bracket body has a base on the bottom side of the bracket body that is contoured to attach to a surface of a tooth, a bracket slot on the top side of the bracket body extending in a mesiodistal direction and configured to releasably retain an archwire, and a bracket groove on the top side of the bracket body extending in an occlusogingival direction towards the bracket slot. The spring mechanism includes one or more springs that are configured to contact the bracket door and the bracket body. The bracket door can thus be retained by and slidably engage the bracket body between an open position and a closed position. One or more additional active spring members may also be provided.

Abstract: A method by which an orthodontic appliance is automatically designed and manufactured from digital lower jaw and tooth shape data of a patient provides for the scanning of the mouth of a patient to produce a three-dimensional digitized model of the shapes of the patient's teeth and their positions in the patient's mouth. The appliance is automatically designed according to the final design, which also can be interactively modified and approved by the orthodontist, with the computer recalculating the effects on the treatment as a result of the doctor's changes. Brackets are fabricated as an integrated set, either by cutting slots therein or by building the brackets in layers. Three-dimensional custom jigs are automatically made to exactly position the brackets on a patient's teeth.

Abstract: A tissue expansion system including an implantable device that includes a compressed gas canister with a compressed gas disposed therein, and an expandable chamber, the compressed gas canister disposed within a cradle, wherein the cradle is disposed within the expandable chamber, wherein the cradle is directly secured to a posterior portion of the expandable chamber and the compressed gas canister is indirectly secured to the posterior portion of the expandable chamber, the compressed gas canister being movable within the cradle and relative to the posterior portion of the expandable chamber.

Abstract: Tissue expanders and methods of use. In some embodiments the tissue expanders are adapted to reduce wear on one or more components.

Abstract: A system for stimulating oil or gas production from a wellbore includes a hydraulic fracturing pump unit having one or more hydraulic fracturing pumps driven by one or more electrical fracturing motors, a variable frequency drive (VFD) controlling the electrical fracturing motors, a fracturing pump blower unit driven by a blower motor, and a fracturing pump lubrication unit having a lubrication pump driven by a lubrication motor and a cooling fan driven by a cooling motor. The system may further include a blender unit and a hydration unit. A system control unit may control the operational parameters of the system.

Abstract: Isolated transduced cells exhibiting FRDA characteristics in an inducible fashion are disclosed. Isolated transduced cells comprise an expression vector having a nucleic acid sequence encoding an shRNA for frataxin protein knockdown and a heterologous expression control sequence. Additionally, methods of screening for a candidate therapeutic agent for treating Friedreich's Ataxia using isolated transduced cells are disclosed. Further, a recombinant nucleic acid construct for frataxin knockdown is disclosed that comprises a nucleic acid encoding an shRNA operably linked to a heterologous expression control sequence and expressing an shRNA molecule in a dose-responsive fashion.

Abstract: The present disclosure relates generally to fusion proteins including gigaxonin coupled to a cell penetrant peptide. These fusion proteins can be used to treat GAN in a subject in need thereof. Administration of the fusion proteins allows for control of at least one of Galectin-1 (GAL-1) levels and phosphorylated vimentin protein levels, thereby mediating aggregation of vimentin and the formation of vimentin-free zones in cells.