Abstract: This invention relates to a lubricating composition comprising or resulting from the admixing of: base oil, detergent, and one or more metal alkanoates having a quaternary carbon atom at the 2 position, the 2? position, or both the 2 and 2? positions, where the lubricating composition preferably has an adhesive wear of 100 hours or more, a foam volume of 70 ml or less at 24° C., and 50 ml or less at 93.5° C., and, optionally, a total base number of 7 mgKOH/g or more.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z5 (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity 10 is implicated.

Abstract: A picture frame comprising a picture carrier portion and a frame portion, the frame portion for formation of a frame and comprising frame members with: a side member hingedly connected via a first hinge connection to the picture carrier portion; a back member hingedly connected via a second hinge connection to the side member, wherein in an assembled configuration: the side member forms an side of the frame; the back member forms a back of the frame and is inclined relative the carrier portion to extend from the side member to the picture carrier portion.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z?? (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: An exercise device includes a resistance unit having a connecting gear. It further includes a cable. It further includes an arm that routes the cable to an actuator. The arm is rotatable relative to the resistance unit about the connecting gear, the arm having a central axis. The arm includes a control that mechanically disengages a locking mechanism from the connecting gear. The control is activated by an activation force substantially directed either toward the central axis of the arm, along a length of the arm, or about the central axis. The activation force is mechanically converted into linear force along the arm that disengages the locking mechanism from the connecting gear.

Abstract: A book assembly system comprising: a cover arrangement, having a support member for supporting a binder arrangement in an assembled configuration; a binder arrangement, having: a spine bar for carrying picture members, the spine bar having a spine portion interposing first and second holding portions, wherein the support member is arrangeable in the assembled configuration with: a corresponding side portion to adjoin the spine portion of the spine bar, and; corresponding first and second interconnecting portions to adjoin the respective first and second holding portions of the spine.

Abstract: A picture frame comprising a picture carrier portion and a frame portion, the picture carrier portion to carry a picture member; the frame portion comprising frame members with: an outer side member hingedly connected at a first hinge connection to the picture carrier portion; a back member hingedly connected at a second hinge connection to the outer side member, and an inner side member hingedly connected at a third hinge connection to the back member, wherein in an assembled position: the outer side member forms an outer side of the frame, the back member forms a back of the frame, and; the inner side member forms an inner side of the frame, wherein a connection system is arranged to lock the inner side member to the picture carrier portion.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z?? (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: The invention enables digital music content to be downloaded to and used on a portable wireless computing device. An application running on the wireless device has been automatically adapted to parameters associated with the wireless device without end-user input (e.g. the application has been configured in dependence on the device OS and firmware, related bugs, screen size, pixel number, security models, connection handling, memory etc., This application enables an end-user to browse and search music content on a remote server using a wireless network; to download music content from that remote server using the wireless network and to playback and manage that downloaded music content. The application also includes a digital rights management system that enables unlimited legal downloads of different music tracks to the device and also enables any of those tracks stored on the device to be played so long as a subscription service has not terminated.

Abstract: A new and improved Folded Collinear Dipole (FCD) Antenna eliminates a coaxial feed and provides a folded ½ wave top element that is basically two ½ wave elements in parallel above a ?th wave coil isolator another ¼ wave element that is on top of another ¼ wave element that is shielded by a brass feed tube and the bottom element is insulated with a PTFE tube. This is all stacked on top of an RF 50-ohm fitting (Typically an “N” female). A cover/protection tube “G” is made from “cross-linked polyethylene” tubing to increase performance of this antenna as it is nearly invisible to the RF signal and does not attenuate the signal which would reduce overall performance found today in most sleeved monopole antennas. The Vinyl cap protectors are used for mainly two functions, on the main larger sleeve it keeps out any atmospheric conditions including intruders such as insects. The feed tube cap insulates and keeps the element centered into the feed tube assembly.

Abstract: An exercise device includes a resistance unit having a connecting gear. It further includes a cable. It further includes an arm that routes the cable to an actuator. The arm is rotatable relative to the resistance unit about the connecting gear, the arm having a central axis. The arm includes a control that mechanically disengages a locking mechanism from the connecting gear. The control is activated by an activation force substantially directed either toward the central axis of the arm, along a length of the arm, or about the central axis. The activation force is mechanically converted into linear force along the arm that disengages the locking mechanism from the connecting gear.

Abstract: The present invention relates to processes for the preparation of certain compounds that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) activity, and their synthetic intermediates.

Abstract: The invention enables digital music content to be downloaded to and used on a portable wireless computing device. An application running on the wireless device has been automatically adapted to parameters associated with the wireless device without end-user input (e.g. the application has been configured in dependence on the device OS and firmware, related bugs, screen size, pixel number, security models, connection handling, memory etc. This application enables an end-user to browse and search music content on a remote server using a wireless network; to download music content from that remote server using the wireless network and to playback and manage that downloaded music content. The application also includes a digital rights management system that enables unlimited legal downloads of different music tracks to the device and also enables any of those tracks stored on the device to be played so long as a subscription service has not terminated.

Abstract: A timber-concrete composite floor or roof system connector that provides high slip modulus stiffness and resiliency through a combination of mechanical and adhesive connections to a timber substrate, ductile structural behavior under ultimate loading, and an integrated method for chair support of concrete slab reinforcing members during wet concrete placement.

Abstract: A method of controlling a concentration or range of concentrations of a liquid or gas in an enclosure is provided. The method includes positioning an injection station within the enclosure, the injection station includes a liquid or gas source, a sprayer assembly and a system that delivers the liquid or gas from the liquid or gas source to the sprayer assembly. A concentration level of the liquid or gas in the environment surrounding the injection station is monitored using a sensor and the sensor providing a signal indicative of the concentration level to a controller. The controller controls the flow of the liquid or gas to the sprayer assembly based on the signal.

Abstract: The invention enables digital music content to be downloaded to and used on a portable wireless computing device. An application running on the wireless device has been automatically adapted to parameters associated with the wireless device without end-user input (e.g. the application has been configured in dependence on the device OS and firmware, related bugs, screen size, pixel number, security models, connection handling, memory etc. This application enables an end-user to browse and search music content on a remote server using a wireless network; to download music content from that remote server using the wireless network and to playback and manage that downloaded music content. The application also includes a digital rights management system that enables unlimited legal downloads of different music tracks to the device and also enables any of those tracks stored on the device to be played so long as a subscription service has not terminated.

Abstract: The invention enables digital music content to be downloaded to and used on a portable wireless computing device. An application running on the wireless device has been automatically adapted to parameters associated with the wireless device without end-user input (e.g. the application has been configured in dependence on the device OS and firmware, related bugs, screen size, pixel number, security models, connection handling, memory etc. This application enables an end-user to browse and search music content on a remote server using a wireless network; to download music content from that remote server using the wireless network and to playback and manage that downloaded music content. The application also includes a digital rights management system that enables unlimited legal downloads of different music tracks to the device and also enables any of those tracks stored on the device to be played so long as a subscription service has not terminated.

Abstract: An exercise device includes a resistance unit having a connecting gear. It further includes a cable. It further includes an arm that routes the cable to an actuator. The arm is rotatable relative to the resistance unit about the connecting gear, the arm having a central axis. The arm includes a control that mechanically disengages a locking mechanism from the connecting gear. The control is activated by an activation force substantially directed either toward the central axis of the arm, along a length of the arm, or about the central axis. The activation force is mechanically converted into linear force along the arm that disengages the locking mechanism from the connecting gear.

Abstract: A wearable device (10) has an internal antenna (22, 24) within a housing (20), and an external conductor patch (30) over which the housing (20) is mounted. The conductor patch (30) has an area greater than the area of an internal ground plane (22) of the antenna (22, 24).

Abstract: This invention relates to a lubricating composition comprising or resulting from the admixing of: base oil, detergent, and one or more metal alkanoates having a quaternary carbon atom at the 2 position, the 2? position, or both the 2 and 2? positions, where the lubricating composition preferably has an adhesive wear of 100 hours or more, a foam volume of 70 ml or less at 24° C., and 50 ml or less at 93.5° C., and, optionally, a total base number of 7 mgKOH/g or more.