Patents by Inventor Mark Pratt

Mark Pratt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090181939
    Abstract: Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB1 receptors, such as obesity, wherein: R1 is aryl or heteroaryl; R2 is alkyl, aryl or heteroaryl; R3 is alkyl, aryl, heteroaryl, NR9R10, OR15, or NR16C(O)R17; Y is C?O, C?S, SO2, or (CR7R8)p; m=1 or 2; n=1 or 2; and p=1, 2, 3 or 4, R7 to R17 being as defined in the specification; wherein if —Y—R3 is C(O)NH(alkyl) then: R1 and/or R2 is selected from heteroaryl; and/or m and/or n is 2; and/or R11 and/or R12 is lower alkyl, or a pharmaceutically acceptable salt or prodrug thereof.
    Type: Application
    Filed: March 19, 2009
    Publication date: July 16, 2009
    Applicant: VERNALIS RESEARCH LIMITED.
    Inventors: James Edward Paul Davidson, Jonathan Mark Bentley, Claire Elizabeth Dawson, Kerry Harrison, Howard Langham Mansell, Alan Leslie Pither, Robert Mark Pratt, Jonathan Richard Anthony Roffey, Victoria Jane Ruston
  • Patent number: 7504522
    Abstract: Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB1 receptors such as obesity: Formula (I) wherein: R1 and R2 are independently selected from aryl; and R3 is hydrogen or alkyl; or a pharmaceutically acceptable salt or prodrug thereof, wherein at least one of R1 and R2 has a non-hydrogen substituent in the ortho-position(s) thereof relative to the point of attachment to the [—CH—O—] group.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: March 17, 2009
    Assignee: Vernalis Research Limited
    Inventors: James Edward Paul Davidson, Claire Elizabeth Dawson, Kerry Harrison, Howard Langham Mansell, Robert Mark Pratt, Sukhjit Sohal, Victoria Jane Ruston
  • Patent number: 7452894
    Abstract: Use of a compound of formula (I) wherein R1 is selected from alkyl, aryl, alkoxy, aryloxy, 0thioalkyl, thioaryl, CN, halo, NR5R6, NR4COR5, NR4CONR5R6, NR4CO2R7 and NR4SO2R7; R2 is selected from N, O or S-containing heteroaryl groups, wherein the heteroaryl group is attached via an unsaturated carbon atom which is adjacent to one or two N, O or S-heteroatom(s), other than ortho, ortho-disubstituted heteroaryl groups; R3 is selected from H, alkyl, COR8, CONR9R10, CONR8NR9R10, CO2R11 and SO2R11; R4, R5 and R6 are independently selected from H, alkyl and aryl or where R5 and R6 are in an (NR5R6) group then R5 and R6 may be linked to form a heterocyclic ring; R7 is selected from alkyl and aryl; R8, R9 and R10 are independently selected from H, alkyl and aryl, or R9 and R10 may be linked to form a heterocyclic ring, or where R8, R9 and R10 are in a (CONR8NR9R10) group, R8 and R9 may be linked to form a heterocyclic group; and R11, is selected from alkyl and aryl, or a pharmaceutically acceptable salt thereof or pro
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: November 18, 2008
    Assignee: Vernalis Research Limited
    Inventors: Roger John Gillespie, Joanne Lerpiniere, Claire Elizabeth Dawson, Suneel Gaur, Robert Mark Pratt, Gemma Caroline Stratton, Scott Murray Weiss
  • Publication number: 20080153820
    Abstract: A compound of formula (I), wherein X is S or O; R1 is selected from H, alkyl, aryl, hydroxy, alkoxy, aryloxy, thioalkyl, thioaryl, halogen, CN, COR5, CO2R5, CONR5R7, CONR5NR6R7, NR6R7, NR5CONR6R7, NR5COR6, NR5CO2R8, and NR5SO2R8; R2 is selected from aryl attached via an unsaturated carbon atom; R3 is selected from H, alkyl, hydroxy, alkoxy, halogen, CN and NO2; R3 is selected from H, alkyl, aryl, hydroxy, alkoxy, aryloxy, thioalkyl, thioaryl, halogen, CN, NO2, COR5, CO2R5, CONR6R7, CONR5NR6R7, NR6R7, NR5CONR6R7, NR5COR6, NR5CO2R8 and NR5SO2R8; R5, R6 and R7 are independently selected from H, alkyl and aryl or where R6 and R7 are in an (NR6R7) group, R6 and R7 may be linked to form a heterocyclic group, or where R5, R6 and R7 are in a (CONR5NR6R7) group, R5 and R6 may be linked to form a heterocyclic group; and R8 is selected from alkyl and aryl, or a pharmaceutically acceptable salt thereof or prodrug thereof, and the use thereof in therapy and in the treatment or prevention of a disorder in which the blockin
    Type: Application
    Filed: February 22, 2008
    Publication date: June 26, 2008
    Inventors: Roger John Gillespie, Joanne Lerpiniere, Claire Elizabeth Dawson, Suneel Gaur, Robert Mark Pratt
  • Patent number: 7384949
    Abstract: A compound of formula (I), wherein X is S or O; R1 is selected from H, alkyl, aryl, hydroxy, alkoxy, aryloxy, thioalkyl, thioaryl, halogen, CN, COR5, CO2R5, CONR6R7, CONR5NR6R7, NR6R7, NR5CONR6R7, NR5COR6, NR5CO2R8, and NR5SO2R8; R2 is selected from aryl attached via an unsaturated carbon atom; R3 is selected from H, alkyl, hydroxy, alkoxy, halogen, CN and NO2; R4 is selected from H, alkyl, aryl, hydroxy, alkoxy, aryloxy, thioalkyl, thioaryl, halogen, CN, NO2, COR5, CO2R5, CONR6R7, CONR5NR6R7, NR6R7, NR5CONR6R7, NR5COR6, NR5CO2R8 and NR5SO2R8; R5, R6 and R7 are independently selected from H, alkyl and aryl or where R6 and R7 are in an (NR6R7) group, R6 and R7 may be linked to form a heterocyclic group, or where R5, R6 and R7 are in a (CONR5NR6R7) group, R5 and R6 may be linked to form a heterocyclic group; and R8 is selected from alkyl and aryl, or a pharmaceutically acceptable salt thereof or prodrug thereof, and the use thereof in therapy and in the treatment or prevention of a disorder in which the blockin
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: June 10, 2008
    Assignee: Vernalis Research Limited
    Inventors: Roger John Gillespie, Joanne Lerpiniere, Claire Elizabeth Dawson, Suneel Gaur, Robert Mark Pratt
  • Publication number: 20080033677
    Abstract: An embodiment generally relates to a method of processing signals. The method includes providing for a plurality of filters, where each filter is configured to process an associated dye. The method also includes determining a residual error for at least one filter during dye amplification and modifying the at least one filter based on the residual error. The method further includes filtering subsequent signals associated with the modified at least one filter.
    Type: Application
    Filed: June 11, 2007
    Publication date: February 7, 2008
    Applicant: Applera Corporation
    Inventors: Austin Tomaney, David Holden, Mark Pratt, H. Kao
  • Patent number: 7323466
    Abstract: The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: January 29, 2008
    Assignees: Hoffman-La Roche Inc., Vernalis Research Limited
    Inventors: Jonathan Mark Bentley, Claire Elizabeth Dawson, Wolfgang Guba, Paul Hebeisen, Nathaniel Monck, Robert Mark Pratt, Hans Richter, Stephan Roever, Vicki Ruston
  • Publication number: 20060134662
    Abstract: Aspects of the present invention describe an apparatus and method for generating genotype calls for a sample. The genotyping initially models allelic signal response into an allelic model having one or more model parameters for an identified one or more sources of systematic variation. The model and parameters are then used to transform the allelic signals to a normalized normalized allelic space that serves to compensate for the one or more sources of systematic variation. By compensating for the systematic variation in this manner, the genotype for the sample is readily determined based upon its relationship to the representation of the allelic signals in normalized allelic space and in accordance with the allelic model.
    Type: Application
    Filed: October 25, 2005
    Publication date: June 22, 2006
    Inventors: Mark Pratt, David Holden
  • Patent number: 7022707
    Abstract: The present invention is a chemical compound of formula (I) or a pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R4, A1, A2 m and n are as described in the specification.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: April 4, 2006
    Assignees: Hoffman-La Roche Inc., Vernalis Research Limited
    Inventors: David Reginald Adams, Jonathan Mark Bentley, James Edward Paul Davidson, Claire Elizabeth Dawson, Ashley Roger George, Howard Langham Mansell, Patrizio Mattei, Jacques Mizrahi, Matthias Heinrich Nettekoven, Robert Mark Pratt, Stephan Roever, Jonathan Richard Anthony Roffey, Jean-Luc Specklin, Henri Stalder, Kerry Wilkinson
  • Publication number: 20060024690
    Abstract: A method of using a standard to correct for variability in sample handling, can comprise (a) adding a template of known concentration to an assay comprising a sample; (b) preamplifying the assay; (c) amplifying the assay; (d) collecting data during the amplifying; and (e) correcting the data using a comparison of data collected from the template to data collected from the sample.
    Type: Application
    Filed: March 22, 2005
    Publication date: February 2, 2006
    Inventors: H. Kao, Ian Harding, Kathleen Hayashibara, Achim Karger, Fiona Laird Hyland, Mark Oldham, Omead Ostadan, Mark Pratt, Junko Stevens, Austin Tomaney, Greg Young
  • Patent number: 6867889
    Abstract: A holographic optical element (HOE) device is mounted in wireless optical telecommunication system transceiver. The HOE device includes a developed emulsion material having an interference pattern recorded thereon, sandwiched between a pair of elements, such as a pair of clear glass plates. In operation, the HOE device uses the recorded interference pattern to diffract received light rays towards an optical processing unit of the system receiver. A transmitter unit can be positioned at least in part behind the HOE device. An opening in the emulsion material allows a light signal transmitted from the transmitter unit to be substantially unaffected by the recorded interference pattern. The transceiver can also include a spotting scope and an alignment beacon.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: March 15, 2005
    Assignee: Terabeam Corporation
    Inventors: Charles Gregory Amadon, Richard D. Rallison, Mark Pratt, David P. Bajorins, Lawrence Cooper Stapleton, Richard B. Riday, Harold Alexander Brown, William Joseph Lauby, Michael Thomas, Scott William Sparrold
  • Publication number: 20040235859
    Abstract: The present invention is a chemical compound of formula (I) 1
    Type: Application
    Filed: June 23, 2004
    Publication date: November 25, 2004
    Inventors: David Reginald Adams, Jonathan Mark Bentley, James Edward Paul Davidson, Claire Elizabeth Dawson, Ashley Roger George, Howard Langham Mansell, Patrizio Mattei, Jacques Mizrahi, Matthias Heinrich Nettekoven, Robert Mark Pratt, Stephan Roever, Jonathan Richard Anthony Roffey, Jean-Luc Specklin, Henri Stalder, Kerry Wilkinson
  • Publication number: 20040102459
    Abstract: Use of a compound of formula (I) wherein R1 is selected from alkyl, aryl, alkoxy, aryloxy, 0thioalkyl, thioaryl, CN, halo, NR5R6, NR4COR5, NR4CONR5R6, NR4CO2R7 and NR4SO2R7; R2 is selected from N, O or S-containing heteroaryl groups, wherein the heteroaryl group is attached via an unsaturated carbon atom which is adjacent to one or two N, O or S-heteroatom(s), other than ortho, ortho-disubstituted heteroaryl groups; R3 is selected from H, alkyl, COR8, CONR9R10, CONR8NR9R10, CO2R11 and SO2R11; R4, R5 and R6 are independently selected from H, alkyl and aryl or where R5 and R6 are in an (NR5R6) group then R5 and R6 may be linked to form a heterocyclic ring; R7 is selected from alkyl and aryl; R8, R9 and R10 are independently selected from H, alkyl and aryl, or R9 and R10 may be linked to form a heterocyclic ring, or where R8, R9 and R10 are in a (CONR8NR9R10) group, R8 and R9 may be linked to form a heterocyclic group; and R11, is selected from alkyl and aryl, or a pharmaceutically acceptable salt thereof or pro
    Type: Application
    Filed: November 13, 2003
    Publication date: May 27, 2004
    Inventors: Roger John Gillespie, Joanne Lerpiniere, Claire Elizabeth Dawson, Suneel Gaur, Robert Mark Pratt, Gemma Caroline Stratton, Scott Murray Weiss
  • Publication number: 20040097524
    Abstract: A compound of formula (I), wherein X is S or O; R1 is selected from H, alkyl, aryl, hydroxy, alkoxy, aryloxy, thioalkyl, thioaryl, halogen, CN, COR5, CO2R5, CONR6R7, CONR5NR6R7, NR6R7, NR5CONR6R7, NR5COR6, NR5CO2R8, and NR5SO2R8; R2 is selected from aryl attached via an unsaturated carbon atom; R3 is selected from H, alkyl, hydroxy, alkoxy, halogen, CN and NO2; R4 is selected from H, alkyl, aryl, hydroxy, alkoxy, aryloxy, thioalkyl, thioaryl, halogen, CN, NO2, COR5, CO2R5, CONR6R7, CONR5NR6R7, NR6R7, NR5CONR6R7, NR5COR6, NR5CO2R8 and NR5SO2R8; R5, R6 and R7 are independently selected from H, alkyl and aryl or where R6 and R7 are in an (NR6R7) group, R6 and R7 may be linked to form a heterocyclic group, or where R5, R6 and R7 are in a (CONR5NR6R7) group, R5 and R6 may be linked to form a heterocyclic group; and R8 is selected from alkyl and aryl, or a pharmaceutically acceptable salt thereof or prodrug thereof, and the use thereof in therapy and in the treatment or prevention of a disorder in which the blockin
    Type: Application
    Filed: November 4, 2003
    Publication date: May 20, 2004
    Inventors: Roger John Gillespie, Joanne Lerpiniere, Claire Elizabeth Dawson, Suneel Gaur, Robert Mark Pratt
  • Patent number: 6678079
    Abstract: A holographic optical element (HOE) device is mounted in wireless optical telecommunication system transceiver. The HOE device includes a developed emulsion material having an interference pattern recorded thereon, sandwiched between a pair of elements, such as a pair of clear glass plates. In operation, the HOE device uses the recorded interference pattern to diffract received light rays towards an optical processing unit of the system receiver. A transmitter unit can be positioned at least in part behind the HOE device. An opening in the emulsion material allows a light signal transmitted from the transmitter unit to be substantially unaffected by the recorded interference pattern. The transceiver can also include a spotting scope and an alignment beacon.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: January 13, 2004
    Assignee: Terabeam Corporation
    Inventors: Charles Gregory Amadon, Richard D. Rallison, Mark Pratt, David P. Bajorins, Lawrence Cooper Stapleton, Richard B. Riday, Harold Alexander Brown, William Joseph Lauby, Michael Thomas, Scott William Sparrold
  • Patent number: 6608708
    Abstract: A holographic optical element (HOE) device is mounted in a receiver unit, such as a wireless optical telecommunication system receiver. The HOE device includes a developed emulsion material having an interference pattern recorded thereon, sandwiched between a pair of elements, such as a pair of clear glass plates. In operation, the HOE device uses the recorded interference pattern to diffract incident light rays towards an optical processing unit of the system receiver. The optical processing unit includes a photodetector that detects the diffracted light rays. The system receiver can include various other components and/or can have various configurations. In one configuration, a plurality of mirrors is used to control the direction of the light rays coming from the HOE device, and a collimating optical assembly collimates these light rays. A beam splitting optical assembly can be used to split the light rays into a tracking channel and a communication channel.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: August 19, 2003
    Assignee: Terabeam Corporation
    Inventors: Charles Gregory Amadon, Richard D. Rallison, John J. Schuster, Harold A. Brown, Mark Pratt
  • Publication number: 20030014316
    Abstract: A central monitoring station is linked to a plurality of remote terminals, such as payment terminals at a plurality of parking facilities. The central monitoring station and each remote terminal includes a two-way communication system in the form of a video camera and display, and audio speaker and microphone. The station and remote terminals are preferably linked through an Ethernet or Internet connection, although a hard-wired connection is also contemplated. The two-way communication system can be used by a customer at the remote terminal to achieve direct human interaction with an attendant at the remote central station to address problems occurring at the terminal. The communication system can also allow the attendant to manipulate the processor of each remote terminal to collect data, troubleshoot or override the function of the terminal.
    Type: Application
    Filed: July 11, 2001
    Publication date: January 16, 2003
    Inventors: Mark Pratt, David Harpold
  • Patent number: 6490070
    Abstract: A polarization of a light signal is modulated to provide polarization tracking in a wireless optical communication system. The light signal having the modulated polarization, such as a sinusoidally varying polarization, is transmitted from an optical transmitter having polarization-maintaining fiber. The light signal having the modulated polarization is received at an optical receiver. A portion of the light signal is directed to an analyzer that detects the modulated polarization and generates an amplitude-modulated light signal corresponding to the modulated polarization. The amplitude-modulated light signal is directed to a tracking detector, such as a quad cell detector, that generates an amplitude-modulated electronic signal corresponding to the amplitude-modulated light signal. The amplitude-modulated electronic signal can be subsequently used to control or perform tracking of the optical receiver.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: December 3, 2002
    Assignee: Terabeam Corporation
    Inventors: Jeffrey C. Adams, Mark Pratt, Micah J. Barclay
  • Patent number: 6483621
    Abstract: A transmitted light signal, such as laser light, is modulated by a data signal and by a tracking signal. The tracking signal has a modulation depth that is substantially smaller than a peak-to-peak amplitude of the light signal. At reception, the tracking signal is recovered from the modulated light signal and is used to determine an orientation of a receiver with respect to the transmitted light signal.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: November 19, 2002
    Assignee: Terabeam Corporation
    Inventors: Jeffrey C. Adams, Mark Pratt, Micah J. Barclay
  • Publication number: 20020143020
    Abstract: The present invention is a chemical compound of formula (I) 1
    Type: Application
    Filed: December 7, 2001
    Publication date: October 3, 2002
    Inventors: David Reginald Adams, Jonathan Mark Bentley, James Edward Paul Davidson, Claire Elizabeth Dawson, Ashley Roger George, Howard Langham Mansell, Patrizio Mattei, Jacques Mizrahi, Matthias Heinrich Nettekoven, Robert Mark Pratt, Stephan Roever, Jonathan Richard Anthony Roffey, Jean-Luc Specklin, Henri Stalder, Kerry Wilkinson