Abstract: A ventilation management system stores an initial configuration profile including a set of operating parameters for operating one or more respective ventilation devices. The system receives first ventilator data from a first ventilation device at a first location, and second ventilator data from a second ventilation device at a second location, the first and second ventilation devices being configured to operate based on the initial configuration profile, wherein the received first ventilator data comprises one or more current operating parameters of the first ventilation device, or physiological data obtained from a patient associated with the first ventilation device. The system modifies the initial configuration profile for use by the first ventilation device based on the received first ventilation data and provides the modified configuration profile to the first ventilation device.

Abstract: The invention relates to compound of formula (I) wherein R1 to R3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: A cable for transmitting electricity may include a core including a first conductive material, a core shield surrounding the core, an insulation layer surrounding the core shield, the insulation layer comprising a material providing electrical insulating properties, an insulation shield surrounding the insulation layer; and at least one of the following at least partially surrounding the insulation shield: (a) a bedding layer including a first semi-conductive material, (b) a tape layer including a metallic tape intercalated with an insulating tape, and (c) a protection layer.

Abstract: A releasable clamping device is provided. The device includes a plurality of wedge members that slidably are disposed upon a carrier, with an input disposed in conjunction with a first wedge member. The input interacts with a projection and when the input is moved the first wedge members slides along the carrier. Motion of the first wedge member causes vertical motion of the second and fourth wedge members, which in combination cause the thickness of the releasable clamping device to increase, which frictionally retains the carrier and associated components thereon (such as a PCB) within a housing. The input may be moved in an opposite direction which causes the first wedge member to slide along the carrier in an opposite direction and causes the second and fourth wedge members to vertically move toward the carrier thereby narrowing the overall thickness of the device to allow removal of the carrier.

Abstract: Techniques for state-based provisioning of image data streams are described herein. In some examples, a plurality of image data streams, such as video streams, may be captured from one or more electronically presented content items. Upon being captured, the image data streams may be transmitted to an image data streaming service, such as a video streaming service, for transmission to spectators or other viewers. In addition to the image data, state data associated with the image data streams may also be transmitted to the image data streaming service. The state data may include information that describes the contents of the image data streams. In some examples, the image data streaming service may use the state data to provision the image data streams, for example to determine one or more image data streams that match a viewer's interest and to transmit those streams to the viewer.

Abstract: Techniques for state-based provisioning of image data streams are described herein. In some examples, a plurality of image data streams, such as video streams, may be captured from one or more electronically presented content items. Upon being captured, the image data streams may be transmitted to an image data streaming service, such as a video streaming service, for transmission to spectators or other viewers. In addition to the image data, state data associated with the image data streams may also be transmitted to the image data streaming service. The state data may include information that describes the contents of the image data streams. In some examples, the image data streaming service may use the state data to provision the image data streams, for example to determine one or more image data streams that match a viewer's interest and to transmit those streams to the viewer.

Abstract: A labeling device for a syringe that includes a first labeling subsystem adapted to print a first label having machine readable information and a second labeling subsystem adapted to print a second label having human readable information is disclosed. The first labeling subsystem includes a label applicator adapted to automatically apply the first label to a portion of the syringe. The first labeling subsystem includes a syringe clamp assembly that securely holds the syringe while the label applicator automatically applies a first label to the syringe. The second labeling subsystem includes a removal device adapted to automatically remove a backing material from the second label.

Abstract: Systems and methods for indicating that a boundary is crossed during execution of a video game are described. One of the methods includes generating, by a camera, a field-of-view, the field-of-view encompassing a plurality of boundaries that define a volume. The method further includes capturing, by the camera, one or more images of a head-mounted display (HMD) within the field-of-view. The method includes identifying, by a processor, a position of the HMD in a real-world environment from the one or more images. The method includes determining, by the processor, whether the HMD at the position has crossed one of the boundaries. The method includes generating one or more video frames including a guard rail upon determining that the HMD has crossed the one of the boundaries and sending the one or more video frames to the HMD for display.

Abstract: Ventilation systems are provided. In one aspect, a ventilation system includes system includes a ventilation device that is configured to provide breathable air or gas mixture to a patient according to certain operating parameters, a memory that includes instructions, and a processor. The processor is configured to execute the instructions to receive, over a network, at least one of patient data, order data, configuration data, user data, or rules or protocols, and provide a modification of operating parameters of the ventilation device based on the received patient data, order data, configuration data, user data, or rules or protocols. Methods and machine-readable media are also provided.

Abstract: Ventilator management systems are provided. In one aspect, a ventilator management system includes a memory that includes an initial configuration profile configured to designate operating parameters for a ventilation device, and a processor. The processor is configured to receive ventilator data from the ventilation device, the ventilator data includes at least one of operating parameters of the ventilation device or physiological statistics of a patient associated with the ventilation device, and determine, based on the ventilator data, a modification to the initial configuration profile for the ventilation device. The processor is also configured to generate a modified configuration profile for the ventilation device based on the determined modification. Methods and machine-readable media are also provided.

Abstract: The present invention relates to a compound of formula (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein R1, R2, R3, L1, L2, L3, L4, L5 and n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, an protein misfolding disorders.

Abstract: A motor vehicle steering wheel assembly may include a ring-shaped member comprising a slot and an internal recess, wherein the slot and internal recess extend circumferentially about the ring-shaped member, the slot being provided in a surface of the ring-shaped member and forming an aperture into the internal recess; a support portion configured to be coupled to a vehicle support structure, the support portion extending through the slot; and a guide portion coupled to the support portion, the guide portion being slidably disposed in the internal recess such that the ring-shaped member is rotatable.

Abstract: The present invention relates to a compound of formula (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein R1, R2, R3, L1, L2, L3, L4, L5 and n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, and/or protein misfolding disorders.

Abstract: Systems and methods for indicating that a boundary is crossed during execution of a video game are described. One of the methods includes generating, by a camera, a field-of-view, the field-of-view encompassing a plurality of boundaries that define a volume. The method further includes capturing, by the camera, one or more images of a head-mounted display (HMD) within the field-of-view. The method includes identifying, by a processor, a position of the HMD in a real-world environment from the one or more images. The method includes determining, by the processor, whether the HMD at the position has crossed one of the boundaries. The method includes generating one or more video frames including a guard rail upon determining that the HMD has crossed the one of the boundaries and sending the one or more video frames to the HMD for display.

Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: Embodiments of the invention are directed toward systems and methods that execute legacy semiconductor applications using a non-legacy controller. In some embodiments a hardware abstraction layer and/or an emulator can be used to provide communication between a non-legacy operating system and legacy components including legacy applications. In some embodiments various methods and/or devices can be used to emulate and/or translate communications between legacy and non-legacy components.

Abstract: A proton beam therapy system with a cantilever gantry system and a moving floor system. The moving floor system includes a flexible moving floor and a track that is disposed vertically and affixed to an external wall. The track includes a lateral portion providing a linear lateral path for the part of the moving floor and non-lateral portions providing a vertical path for the excess of the floor. The non-lateral portions may be located above or below the lateral portion. During rotation of the cantilever gantry and when the beam nozzle is positioned under the patient table, an opening is maintained in the floor through which the beam nozzle protrudes. The opening follows the changing positions of the beam nozzle and moves in the floor plane in synchronization with the rotation of the gantry.

Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: A cleat for a boat includes a cam mounted to the boat, where the cam has a rotatable toothed surface for pressing against a line. The cleat also includes a guide mounted to the boat adjacent the cam, where the guide has a surface for directing the line above a top of the cam. In addition, the cleat has a slot formed in the surface of the guide, which permits the line to be moved into opposition with the rotatable toothed surface of the cam.

Abstract: The invention relates to a compound of formula (I) wherein A and R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.