Abstract: Ventilation systems are provided. In one aspect, a ventilation system includes system includes a ventilation device that is configured to provide breathable air or gas mixture to a patient according to certain operating parameters, a memory that includes instructions, and a processor. The processor is configured to execute the instructions to receive, over a network, at least one of patient data, order data, configuration data, user data, or rules or protocols, and provide a modification of operating parameters of the ventilation device based on the received patient data, order data, configuration data, user data, or rules or protocols. Methods and machine-readable media are also provided.

Abstract: Ventilator management systems are provided. In one aspect, a ventilator management system includes a memory that includes an initial configuration profile configured to designate operating parameters for a ventilation device, and a processor. The processor is configured to receive ventilator data from the ventilation device, the ventilator data includes at least one of operating parameters of the ventilation device or physiological statistics of a patient associated with the ventilation device, and determine, based on the ventilator data, a modification to the initial configuration profile for the ventilation device. The processor is also configured to generate a modified configuration profile for the ventilation device based on the determined modification. Methods and machine-readable media are also provided.

Abstract: The present invention relates to a compound of formula (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein R1, R2, R3, L1, L2, L3, L4, L5 and n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, an protein misfolding disorders.

Abstract: A motor vehicle steering wheel assembly may include a ring-shaped member comprising a slot and an internal recess, wherein the slot and internal recess extend circumferentially about the ring-shaped member, the slot being provided in a surface of the ring-shaped member and forming an aperture into the internal recess; a support portion configured to be coupled to a vehicle support structure, the support portion extending through the slot; and a guide portion coupled to the support portion, the guide portion being slidably disposed in the internal recess such that the ring-shaped member is rotatable.

Abstract: The present invention relates to a compound of formula (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein R1, R2, R3, L1, L2, L3, L4, L5 and n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, and/or protein misfolding disorders.

Abstract: Systems and methods for indicating that a boundary is crossed during execution of a video game are described. One of the methods includes generating, by a camera, a field-of-view, the field-of-view encompassing a plurality of boundaries that define a volume. The method further includes capturing, by the camera, one or more images of a head-mounted display (HMD) within the field-of-view. The method includes identifying, by a processor, a position of the HMD in a real-world environment from the one or more images. The method includes determining, by the processor, whether the HMD at the position has crossed one of the boundaries. The method includes generating one or more video frames including a guard rail upon determining that the HMD has crossed the one of the boundaries and sending the one or more video frames to the HMD for display.

Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: Embodiments of the invention are directed toward systems and methods that execute legacy semiconductor applications using a non-legacy controller. In some embodiments a hardware abstraction layer and/or an emulator can be used to provide communication between a non-legacy operating system and legacy components including legacy applications. In some embodiments various methods and/or devices can be used to emulate and/or translate communications between legacy and non-legacy components.

Abstract: A proton beam therapy system with a cantilever gantry system and a moving floor system. The moving floor system includes a flexible moving floor and a track that is disposed vertically and affixed to an external wall. The track includes a lateral portion providing a linear lateral path for the part of the moving floor and non-lateral portions providing a vertical path for the excess of the floor. The non-lateral portions may be located above or below the lateral portion. During rotation of the cantilever gantry and when the beam nozzle is positioned under the patient table, an opening is maintained in the floor through which the beam nozzle protrudes. The opening follows the changing positions of the beam nozzle and moves in the floor plane in synchronization with the rotation of the gantry.

Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: A cleat for a boat includes a cam mounted to the boat, where the cam has a rotatable toothed surface for pressing against a line. The cleat also includes a guide mounted to the boat adjacent the cam, where the guide has a surface for directing the line above a top of the cam. In addition, the cleat has a slot formed in the surface of the guide, which permits the line to be moved into opposition with the rotatable toothed surface of the cam.

Abstract: The invention relates to a compound of formula (I) wherein A and R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: The invention relates to a compound of formula (I) wherein A and R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: A labeling device for a syringe that includes a first labeling subsystem adapted to print a first label having machine readable information and a second labeling subsystem adapted to print a second label having human readable information is disclosed. The first labeling subsystem includes a label applicator adapted to automatically apply the first label to a portion of the syringe. The first labeling subsystem includes a syringe clamp assembly that securely holds the syringe while the label applicator automatically applies a first label to the syringe. The second labeling subsystem includes a removal device adapted to automatically remove a backing material from the second label.

Abstract: A method for zeroing memory in computing systems where access to memory is non-uniform includes receiving, via a system call, a request to delete a memory region, forwarding the request to an intermediate software thread, and using the intermediate software thread to perform the request as a background process. The method further includes, upon receiving a message from the intermediate software thread, returning to a system caller, while performing the request, via the intermediate software thread, continues in the background.

Abstract: A steering assembly for a vehicle is provided. The steering assembly comprises a steering wheel and a steering wheel support, the steering wheel being movable relative to the steering wheel support from a driving orientation, in which orientation the vehicle is intended to be driven, and a work surface orientation in which the plane of a front surface of the steering wheel is more closely aligned with a longitudinal axis of the vehicle.

Abstract: The present invention relates to a compound of formula (I) wherein R1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.

Abstract: A labeling device for a syringe that includes a first labeling subsystem adapted to print a first label having machine readable information and a second labeling subsystem adapted to print a second label having human readable information is disclosed. The first labeling subsystem includes a label applicator adapted to automatically apply the first label to a portion of the syringe. The first labeling subsystem includes a syringe clamp assembly that securely holds the syringe while the label applicator automatically applies a first label to the syringe. The second labeling subsystem includes a removal device adapted to automatically remove a backing material from the second label.

Abstract: A cleat for a boat includes a cam mounted to the boat, where the cam has a rotatable toothed surface for pressing against a line. The cleat also includes a guide mounted to the boat adjacent the cam, where the guide has a surface for directing the line above a top of the cam. In addition, the cleat has a slot formed in the surface of the guide, which permits the line to be moved into opposition with the rotatable toothed surface of the cam.

Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 and n are defined as in the description and in the claims. The compound of formula (I) can be for treating.