Abstract: The invention relates to a compound of formula (I) wherein A, R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: A method of flow testing multiple zones in a wellbore includes lowering a tool string into the wellbore. The tool string includes an inflatable packer or plug and an electric pump. The method further includes operating the pump, thereby inflating the packer or plug and isolating a first zone from one or more other zones; monitoring flow from the first zone; deflating the packer or plug; moving the tool string in the wellbore; and operating the pump, thereby inflating the packer or plug and isolating a second zone from one or more other zones; and monitoring flow from the second zone. The zones are monitored in one trip.

Abstract: There are provided methods and apparatus for synchronized stream packing of packets that differ contextually between A/V streams in a parallel presentation. A method includes the step of identifying sub-picture/subtitle packets and/or audio packets having arrival timestamps and/or presentation timestamps that match an arrival timestamp and/or a presentation timestamp, respectively, of video packets. The method also includes the step of packing a Video Object Unit (VOBU) and/or a Transport Stream (TS) with the identified sub-picture/subtitle and audio packets and the video packets having the matching timestamps.

Abstract: There are provided methods and apparatus for synchronized stream packing of packets that differ contextually between A/V streams in a parallel presentation. A method includes the step of identifying sub-picture/subtitle packets and/or audio packets having arrival timestamps and/or presentation timestamps that match an arrival timestamp and/or a presentation timestamp, respectively, of video packets. The method also includes the step of packing a Video Object Unit (VOBU) and/or a Transport Stream (TS) with the identified sub-picture/subtitle and audio packets and the video packets having the matching timestamps.

Abstract: The present invention relates to piperidine sulphonamide derivatives of formula wherein Ar1, Ar2, R1, R2, m and n are as defined in the description and claims, or pharmaceutically suitable acid addition salts thereof. The compounds of formula I are orexin receptor antagonists and the related compounds can be useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder or sleep disorders associated with neurological diseases.

Abstract: This invention relates to compounds of the formula wherein A, B and R1 to R7 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as medicaments for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.

Abstract: The present invention is concerned with spiro-dihydrotetraazabenzoazulenes, i.e. spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes of formula I wherein R1, R2, R3, X, Y, Z, m and n are as described herein. The compounds according to the invention act as V1a receptor modulators and are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.

Abstract: This invention relates to compounds of the formula wherein A, B and R1 to R7 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as medicaments for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.

Abstract: An optical article for playback in a player includes a first file comprising a first control logic; and a second file comprising a second control logic. The first file is configured to direct the player to play a first content data stored on the optical article, when the first control logic is read by the player. The player is directed to read the second file if the player cannot read the first file. The second file is configured to direct the player to play a second content data stored on the article when the second control logic is read by the player. The optical article includes a mark containing an optical state change material disposed on at least a portion of the first file, wherein the mark is in one of a first optical state or a second optical state, and wherein the first control logic can be read only when the mark is in the second optical state.

Abstract: A monitoring system for multiple medical ventilators is provided. In one aspect, the monitoring system includes a memory that includes instructions, and a processor. The processor is configured to execute the instructions to receive data for a plurality of medical ventilators, and identify a configuration for each of the plurality of medical ventilators from the received data for the plurality of medical ventilators. The processor is also configured to execute the instructions to associate each patient with a respective one of the plurality of medical ventilators, determine an identification and status for each patient associated with one of the plurality of medical ventilators, and provide, for display, information indicative of the configuration of each of the plurality of medical ventilators and indicative of the identification and status of each patient associated with one of the plurality of medical ventilators. Methods and machine-readable media are also provided.

Abstract: A method for ventilator suction management. The method includes accessing data associated with a patient, wherein the patient is associated with a ventilator; analyzing the data; and determining that suction is needed on the patient based on the analyzed data.

Abstract: A method for modifying ventilator operation based on patient orientation. The method comprising monitoring patient orientation of a patient, wherein the patient is associated with a ventilator; and modifying ventilator operation of the ventilator based on the patient orientation.

Abstract: A method for logging ventilator data. The method includes logging the ventilator data, wherein the ventilator data is associated with a ventilator; and providing access to the logged ventilator data for use by a medical entity.

Abstract: Accessing ventilator data; and generating a patient billing record based on the ventilator data and/or managing ventilation inventory based on the use of ventilator consumables.

Abstract: The present invention relates to piperidine sulphonamide derivatives of formula wherein Ar1, Ar2, R1, R2, m and n are as defined in the description and claims, or pharmaceutically suitable acid addition salts thereof. The compounds of formula I are orexin receptor antagonists and the related compounds can be useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder or sleep disorders associated with neurological diseases.

Abstract: An ostomy body side member with a sealing member is provided. The sealing member has a fixed base member defining an opening having a first diameter and a resilient sealing element comprising a stoma receiving orifice defining an inner boundary. The inner boundary of the stoma receiving orifice has a second diameter that is smaller than the first diameter of the frame. The sealing member is also provided with at least one adjustment member coupled between the fixed base member and the resilient sealing element. Furthermore, an alignment member for adjusting the tension of the at least one adjustment member is provided thereby allowing the diametrical dimension of the stoma sealing orifice to be adjusted from a first diameter to a second diameter.

Abstract: A sealing wafer for use in an ostomy appliance is provided. The sealing wafer has an attachment platform with a distal surface capable of being attached to an ostomy bag, a proximal surface facing towards the user during use, and an opening having an inner boundary defining a stoma receiving opening. The sealing wafer further includes a fixed base member attached to the attachment platform and a rotating member arranged to rotate relative to the fixed base member. A sealing member is coupled between the fixed base member and the rotating member for providing a seal around a stoma and defining a stoma sealing orifice. When the rotating member is rotated relative to the base member, this rotation causes an increased or a decreased tension to be applied to the sealing member so that the diametrical dimensions of the stoma sealing orifice change from a first diameter to a second diameter.

Abstract: An optical article comprising a first file encoded on the optical article comprising data structure information; a second file encoded on the optical article comprising a backup of the first file; wherein at least one of the first file or the second file must be fully readable for the player to read the data on the optical article; and a mark disposed on at least a portion of the optical article where the first file is encoded and at least a portion of the optical article where the second file is encoded; wherein the mark comprises an optical state change material; wherein the optical state change material undergoes a change in its optical state when exposed to an activation signal selected from one or more of a laser, thermal energy, infrared rays, X-rays, gamma rays, microwaves, visible light, ultraviolet light, ultrasound waves, radio frequency waves, electrical energy, chemical energy, magnetic energy, and mechanical energy; wherein the optical article is transformed from a pre-activated state to an activ

Abstract: This invention relates to dihydropyrimidinones of the formula wherein X and R1 to R7 are as defined in the description, as well as pharmaceutically acceptable salts thereof. These compounds are BACE2 inhibitors and can be used as medicaments for the treatment or prevention of diseases such as diabetes.

Abstract: A method for contextualizing ventilator data. The method includes accessing ventilator data, wherein the ventilator data is generated by a ventilator, accessing context data, and associating the ventilator data with the context data such that the ventilator data is contextualized.