Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: A method for assessing a structure arranged in an electrolyte may include connecting an electric source between the structure and an earth, and imposing, on the structure, a primary current with at least three frequencies including a first frequency of a duration and an amplitude, a second frequency of a duration and an amplitude, and a third frequency of a duration and an amplitude, a series of currents with the first and second frequency being separated by a time gap. Fields of electric fields may be measured with an instrument having first, second, and third sensors and a positioning system. Each sensor May be configured to measure a field of an electromagnetic field along the structure for each of the frequencies. A primary field resulting from an electric current within the structure based on the measured field may be computed.

Abstract: This invention harvests some inertia from moving spheres to transfer thrust to the device. The invention has a track generally in the shape of a racetrack, that uses balls which are accelerated along the extended section of the racetrack toward the rear direction of the general forward motion produced by the device. The balls initial acceleration on the track produces a recoil adding to the forward motion of the device. This recoil is then counteracted via the ball traversing around the back of the U shaped race track, bleeding off some inertia. The balls continue around the rear track to the forward leg of the straight section where the excess inertia is bled off by friction means to add to the forward motion of the track. The balls, depleted of most of their inertia, continue around the front section and on to the acceleration means located on the rear facing leg and repeat the cycle.

Abstract: A laundry treating appliance can include a chassis defining an interior and having at least a front wall, with the front wall having a component access port providing access to an internal component of the laundry treating appliance. The laundry treating appliance can also have a panel coupled to the front wall, with the panel movable between a first position and a second position. The panel can also include a pocket handle.

Abstract: A laundry treating appliance can include a chassis defining an interior and having at least a front wall, with the front wall having a component access port providing access to an internal component of the laundry treating appliance. The laundry treating appliance can also have a panel coupled to the front wall, with the panel movable between a first position and a second position. The panel can also include a pocket handle.

Abstract: A laundry treating appliance can include a chassis defining an interior and having at least a front wall, with the front wall having a component access port providing access to an internal component of the laundry treating appliance. The laundry treating appliance can also have a panel coupled to the front wall, with the panel movable between a first position and a second position. The panel can also include a pocket handle.

Abstract: Systems and methods for the gas-phase production of carbon nanotube (CNT)-nanoparticle (NP) hybrid materials in a flow-through pyrolytic reactor specially adapted to integrate nanoparticles (NP) into CNT material at the nanoscale level, and the second generation CNT-NP hybrid materials produced thereby.

Abstract: A toenail clipping device that provides support for the foot and toes so the toenails can be clipped. The Circular Mounted Toenail Clipper provides a stationary platform for the foot and the clipper is mounted on a rotating bearing assembly. This assembly allows the user to easily position the toenail clipper in relation to the stationary foot by providing a guide for the clipper that allows multiple axis of movement. The toenail clipper is attached to a circular stage and guided through an elongated handle. The circular stage allows the user to rotate the toenail clipper around the active toenail that needs clipping making the task easy. The toenail clipper has a force multiplier incorporated into the elongated handle enabling easy and controllable cutting of toenails.

Abstract: Systems and methods for the gas-phase production of carbon nanotube (CNT)-nanoparticle (NP) hybrid materials in a flow-through pyrolytic reactor specially adapted to integrate nanoparticles (NP) into CNT material at the nanoscale level, and the second generation CNT-NP hybrid materials produced thereby.

Abstract: This invention relates to novel compounds according to Formula (III)(a) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), and to pharmaceutical compositions containing them.

Abstract: A sensor sleeve for use in detecting a failure in an article (e.g., a hydraulic hose), the sensor sleeve includes an insulator layer that separates two electrode layers. As such, the electrode layers deform to contact each other, which changes the impedance as measured across the electrode layers. The sensor sleeve is designed to change electrical impedance (resistance) due to fluid pressure initiating a hole through the sensor itself. The sensor sleeve will detect the fluid leak when the hole penetrates the sensor and brings the two elastic electrodes in contact with each other and/or the fluid, which when the fluid is conductive fluid, creates a signal path between the first electrode layer and the second electrode layer, which also changes the impedance as measured across the electrode layers.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: A wrist attachable device comprising an arm that can articulate. The arm is fastened to the wrist collar in a parallel axis with the wrist. This arm is designed with means to mount a tool or a measuring tape. The arm is designed to swing the attached tool into the palm of the hand attached to the arm band. Upon completion of the tool use, the arm is designed to return the tool to a home position further back on the wrist against the cuff and out of the way.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

Abstract: A sensor sleeve for use in detecting a failure in an article (e.g., a hydraulic hose), the sensor sleeve includes an insulator layer that separates two electrode layers. As such, the electrode layers deform to contact each other, which changes the impedance as measured across the electrode layers. The sensor sleeve is designed to change electrical impedance (resistance) due to fluid pressure initiating a hole through the sensor itself. The sensor sleeve will detect the fluid leak when the hole penetrates the sensor and brings the two elastic electrodes in contact with each other and/or the fluid, which when the fluid is conductive fluid, creates a signal path between the first electrode layer and the second electrode layer, which also changes the impedance as measured across the electrode layers.