Abstract: A bound collection of leaves having a spine and a method of its manufacture are disclosed. Each leaf of a first plurality of leaves of the bound collection includes a first pattern of tabs by which that leaf is bound. The tabs of the first pattern are distributed along a binding axis of that leaf that is parallel to a spine axis of the spine. Each leaf of a second plurality of leaves of the bound collection includes a second pattern of tabs different than the first pattern by which that leaf is bound. The tabs of the second pattern are distributed along a binding axis of that leaf that is parallel to the spine axis. Each tab of the first pattern and second pattern of tabs extends in a direction orthogonal to the binding axis from within an unbound region to a binding-side edge of that leaf.

Abstract: Presented herein are techniques for assessing one or more outcomes associated with implantation of one or more electrodes into the inner ear of a recipient.

Abstract: A system for automated horseshoeing. The system is a three cell concept generally including a tool change area, a gluing area and a modification area. The system generally include a platform for a horse to stand thereon wherein all working components are contained below. The system is configured so that a horse can stand on said platform and the working components move from hoof to hoof thereby allowing the horse to remain in a neutral standing position during the entire shoeing process without having to bend it's ankle. The automated horseshoeing process of the present specification is entirely monitored by a farrier.

Abstract: Techniques are provided for implementing a persistent memory storage tier to manage persistent memory of a node. The persistent memory is managed by the persistent memory storage tier at a higher level within a storage operating system storage stack than a level at which a storage file system of the node is managed. The persistent memory storage tier intercepts an operation targeting the storage file system. The persistent memory storage tier retargets the operation from targeting the storage file system to targeting the persistent memory. The operation is transmitted to the persistent memory.

Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

Abstract: An inkjet printer has a print assembly and a print material feed system comprising a first circulation circuit and a second circulation circuit, the first circulation circuit fluidly coupled between the second circulation circuit and the print assembly.

Abstract: Described herein are compositions and methods for the delivery of microbial therapeutics useful for the treatment of disorders related to intestinal dysbiosis.

Abstract: An inductive sensor device includes at least one die mounted in or on a substrate, a redistribution layer (RDL) region formed over the at least one die and including multiple RDL metal layers, and at least one inductive coil formed in the RDL region and including at least one conductive coil element formed in at least one RDL metal layer of the multiple RDL metal layers, wherein the at least one die includes sensor circuitry connected to the at least one inductive coil to perform sensor measurements.

Abstract: A bound collection of leaves having a spine and a method of its manufacture are disclosed. Each leaf of a first plurality of leaves of the bound collection includes a first pattern of tabs by which that leaf is bound. The tabs of the first pattern are distributed along a binding axis of that leaf that is parallel to a spine axis of the spine. Each leaf of a second plurality of leaves of the bound collection includes a second pattern of tabs different than the first pattern by which that leaf is bound. The tabs of the second pattern are distributed along a binding axis of that leaf that is parallel to the spine axis. Each tab of the first pattern and second pattern of tabs extends in a direction orthogonal to the binding axis from within an unbound region to a binding-side edge of that leaf.

Abstract: Systems and computer-implemented methods of generating recipient-facilitated blockchain transactions. A recipient device transmits a recipient outpoint to a sender device. The sender device returns a partially-complete transaction containing the recipient outpoint as a recipient input to the partially-complete transaction and containing at least one sender input.

Abstract: Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with an ENPP1 inhibitor compound to inhibit the cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor compound is cell impermeable. ENPP1 inhibitor compounds can act extracellularly to block the degradation of cGAMP. Also provided are pharmaceutical compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of an ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject in conjunction with administering an ENPP1 inhibitor to the subject. The radiation therapy can be administered in the subject methods at a dosage and/or frequency effective to reduce radiation damage to the subject, but still instigate an immune response.

Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

Abstract: An inkjet printer has a print assembly and a print material feed system comprising a first circulation circuit and a second circulation circuit, the first circulation circuit fluidly coupled between the second circulation circuit and the print assembly.

Abstract: Microsphere formulations comprising asenapine are provided. Methods for making and using the microsphere formulations are also provided.

Abstract: Techniques are provided for implementing a file system format for persistent memory. A node, comprising persistent memory, receives an operation comprising a file identifier and file system instance information. A list of file system info objects are evaluated to identify a file system info object matching the file system instance information. An inofile, identified by the file system info object as being associated with inodes of files within an instance of the file system targeted by the operation, is traversed to identify an inode matching the file identifier. If the inode comprises an indicator that the file is tiered into the persistent memory, then the inode it utilized to facilitate execution of the operation upon the persistent memory. Otherwise, the operation is routed to a storage file system tier for execution by a storage file system upon storage associated with the node.

Abstract: Techniques are provided for implementing a persistent memory storage tier to manage persistent memory of a node. The persistent memory is managed by the persistent memory storage tier at a higher level within a storage operating system storage stack than a level at which a storage file system of the node is managed. The persistent memory storage tier intercepts an operation targeting the storage file system. The persistent memory storage tier retargets the operation from targeting the storage file system to targeting the persistent memory. The operation is transmitted to the persistent memory.

Abstract: A CPU includes a processor die and a substrate. The processor die includes first signal contacts, power contacts, and ground contacts. The processor die is affixed and electrically coupled to the substrate on a first surface of the substrate. The substrate routes the first signal contacts to associated second signal contacts on a second surface of the substrate. The substrate further routes a subset of the power contacts to a power pad on the first surface of the substrate, and routes a subset of the ground contacts to a ground pad on the first surface of the substrate.

Abstract: A genus of compounds encompassed by formula (III) and their use is disclosed: The compounds activate Ppargc1a and, as a consequence, are useful for treating a variety of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Huntington's disease, frontotemporal degeneration, dementia with Lewy bodies, motor neuron diseases, and a demyelinating disease.

Abstract: A method for communicating information related to a diagnostic analyzer includes receiving user identification information from a portable computer. A user associated with the user identification information operates the diagnostic analyzer. First diagnostic analyzer information is retrieved from at least one database that relates analyzer information to the user of the diagnostic analyzer. The first diagnostic analyzer information is related to the diagnostic analyzer. The first diagnostic analyzer information is communicated to the portable computer. Second diagnostic analyzer information from the diagnostic analyzer is retrieved. The second diagnostic analyzer information is generated by the diagnostic analyzer. The first and the second diagnostic analyzer information is communicated to the portable computer. The portable computer is configured to display the first and the second diagnostic analyzer related information.

Abstract: Presented herein are techniques to control the spread of current beyond, in an apical direction, a predetermined location/point in the cochlea. As a result, the techniques presented herein create a protected apical zone at an apical side of the predetermined location for undisturbed acoustic temporal coding (i.e., an apical region of the cochlea in which the voltage fields from delivered current signals are nulled, minimized, or otherwise controlled in order to eliminate, reduce, or otherwise limit electro-acoustic interactions that could negatively affect remaining low-frequency hair cells).