Abstract: A blood treatment system with pressure sensors may be configured to control blood flow to and from the patient and use readings of the pressure sensors to determine a change in a pressure drop across a flow restriction in the blood circuit to estimate a condition of the machine or the patient, or outputting data responsive to the estimation. Further embodiments employ measurement of pressure drop to detect abnormal viscosity or viscosity variations in order to detect possible infection.

Abstract: A proportioning system includes a solute container filled with dry solutes, a source of water, a container of electrolyte concentrate, a fluid circuit connecting the solute container to the source of water and the container of electrolyte concentrate, the fluid circuit having an empty mixing container, a controller configured to transfer water from the source of water to the solute container through the fluid circuit so as to prepare a solute concentrate solution in the solute container. The controller is configured to transfer fluid from the container of electrolyte concentrate to a mixing container as well as a solute concentrate from the solute container to the mixing container and further adding water to said mixing container to form a medicament therein.

Abstract: A pressure measurement system includes a pressure pod with two chambers separated by a diaphragm such that a deformation/movement of the diaphragm is indicative of a difference between the pressures of the two chambers. Such deformation/movement is detected by a device that has no physical contact with the diaphragm, for example, by an optical detector that detects a change in the shape of the diaphragm or a movement of a protrusion on the diaphragm.

Abstract: A proportioning system includes a solute container filled with dry solutes, a source of water, a container of electrolyte concentrate, a fluid circuit connecting the solute container to the source of water and the container of electrolyte concentrate, the fluid circuit having an empty mixing container, a controller configured to transfer water from the source of water to the solute container through the fluid circuit so as to prepare a solute concentrate solution in the solute container. The controller is configured to transfer fluid from the container of electrolyte concentrate to a mixing container as well as a solute concentrate from the solute container to the mixing container and further adding water to said mixing container to form a medicament therein.

Abstract: Methods, device, and systems for preparing peritoneal dialysis fluid and/or administering a peritoneal dialysis treatment are disclosed. In embodiments, peritoneal dialysis fluid is prepared at a point of use automatically using a daily sterile disposable fluid circuit and one or more long-term concentrate containers that are changed only after multiple days (e.g. weekly). The daily disposable may have concentrate containers that are initially empty and are filled from the long-term concentrate containers once per day at the beginning of a treatment.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: Methods, device, and systems for preparing peritoneal dialysis fluid and/or administering a peritoneal dialysis treatment are disclosed. In embodiments, peritoneal dialysis fluid is prepared at a point of use automatically using a daily sterile disposable fluid circuit and one or more long-term concentrate containers that are changed only after multiple days (e.g. weekly). The daily disposable may have concentrate containers that are initially empty and are filled from the long-term concentrate containers once per day at the beginning of a treatment.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: A medical treatment system is configured to output a predefined test pattern and to receive the signal by way of a microphone in order to test the volume and quality of the audio output in order to ensure the output audio signals effective to wake a sleeping patient. The failure of a processor to confirm the volume and fidelity of the audio output as well as the timeliness of the test pattern causes the processor to deny the resumption of a treatment and to generate an error signal.

Abstract: A treatment device system includes a treatment machine for generating a custom peritoneal dialysis solution and has at least one fluid conveyor. The treatment machine has a controller with a first memory and is configured to produce the custom peritoneal dialysis solution by causing the fluid conveyor to mix purified water and at least one concentrate. A water purifier is in fluid communication with, and provides the purified water to, the treatment machine. The water purifier has an internal central controller to control preparation of the purified water, the internal central controller having a second memory. Further, the controller of the treatment machine transmits data, based on a prescription sent from a server to the treatment machine, via a wired or wireless control line to the internal central controller of the water purifier.

Abstract: A treatment device system includes a treatment machine for generating a custom peritoneal dialysis solution and has at least one fluid conveyor. The treatment machine has a controller with a first memory and is configured to produce the custom peritoneal dialysis solution by causing the fluid conveyor to mix purified water and at least one concentrate. A water purifier is in fluid communication with, and provides the purified water to, the treatment machine. The water purifier has an internal central controller to control preparation of the purified water, the internal central controller having a second memory. Further, the controller of the treatment machine transmits data, based on a prescription sent from a server to the treatment machine, via a wired or wireless control line to the internal central controller of the water purifier.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: Fluid channel sealing devices, frangible seals, fluid circuits, associated controllers and methods of using the same are provided for controlling fluid distribution using a reconfigurable blocking element having first and second portions to establish a first configuration free of any open channels such that fluid is prevented from flowing through the channel and a second configuration where the first and second portions are separated to establish an open channel and allow fluid to pass.

Abstract: Peritoneal dialysis admixing and/or treatment devices, methods, and systems are disclosed. The systems, methods, and devices provide high-level guarantees of sterility and employ relatively inexpensive disposable components to provide pumping. Disclosed systems, methods, and devices and features thereof are adapted for point of use generation of medicament. In particular, admixing systems that employ independently-replaceable long term concentrate are disclosed. Features are directed to assurance of sterility and accurate admixing of water and concentrate to generate ready-to-use medicaments and other benefits.

Abstract: A medical treatment system includes a disposable fluid circuit that includes a water inlet and a batch container arranged to hold a mixture, the mixture including water that is received from the water inlet and at least one concentrate. The fluid circuit also includes a drain line for draining fluid from the disposable fluid circuit, and a manifold with a plurality of fluid lines, the manifold connecting the water inlet, the batch container, a source of the at least one concentrate, and the drain line. A source of purified water supplies the purified water to the water inlet and a sensor detects a property of fluid in the disposable fluid circuit. A controller controls flowing of a first fluid followed by displacement by a second fluid causing the first fluid to flow to the sensor.

Abstract: Peritoneal dialysis admixing and/or treatment devices, methods, and systems are disclosed. The systems, methods, and devices provide high-level guarantees of sterility and employs relatively inexpensive disposable components to provide pumping. Disclosed systems, methods, and devices and features thereof are adapted for point of use generation of medicament. In particular admixing systems that employ independently-replaceable long term concentrate are disclosed. Features are directed to assurance of sterility and accurate admixing of water and concentrate to generate ready-to-use medicaments and other benefits.

Abstract: A pressure measurement system includes a pressure pod with two chambers separated by a diaphragm such that a deformation/movement of the diaphragm is indicative of a difference between the pressures of the two chambers. Such deformation/movement is detected by a device that has no physical contact with the diaphragm, for example, by an optical detector that detects a change in the shape of the diaphragm or a movement of a protrusion on the diaphragm.

Abstract: A medical treatment system includes a disposable fluid circuit that includes a water inlet and a batch container arranged to hold a mixture, the mixture including water that is received from the water inlet and at least one concentrate. The fluid circuit also includes a drain line for draining fluid from the disposable fluid circuit, and a manifold with a plurality of fluid lines, the manifold connecting the water inlet, the batch container, a source of the at least one concentrate, and the drain line. A source of purified water supplies the purified water to the water inlet and a sensor detects a property of fluid in the disposable fluid circuit. A controller controls flowing of a first fluid followed by displacement by a second fluid causing the first fluid to flow to the sensor.

Abstract: Methods, device, and systems for preparing peritoneal dialysis fluid and/or administering a peritoneal dialysis treatment are disclosed. In embodiments, peritoneal dialysis fluid is prepared at a point of use automatically using a daily sterile disposable fluid circuit and one or more long-term concentrate containers that are changed only after multiple days (e.g. weekly). The daily disposable may have concentrate containers that are initially empty and are filled from the long-term concentrate containers once per day at the beginning of a treatment.

Abstract: A blood treatment system with pressure sensors may be configured to control blood flow to and from the patient and use readings of the pressure sensors to determine a change in a pressure drop across a flow restriction in the blood circuit to estimate a condition of the machine or the patient, or outputting data responsive to the estimation. Further embodiments employ measurement of pressure drop to detect abnormal viscosity or viscosity variations in order to detect possible infection.