Abstract: A method of performing a dialysis treatment includes using a pump and a dialysate supply line to transport peritoneal dialysis fluid, the supply line having a proximal end into which peritoneal dialysis fluid is supplied and from which spend dialysate is withdrawn, and a distal end which is connected to a patient's peritoneal access. The method further includes generating proximal and distal pressure signals using pressure detectors located at both the proximal and distal ends, respectively, of said supply line. During a drain cycle in which spent dialysate is pumped from the patient, the method includes, responsively to the proximal and distal pressure signals, detecting a characteristic of a pressure difference between the distal and proximal ends whose magnitude is determined by a predicted change in dialysate properties, and responsively to the characteristic, generating a signal indicating the change in dialysate properties.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: An automated peritoneal dialysis system provides various features including prescription-driven dialysis fluid preparation, an integrated disposable fluid circuit, and sensor capabilities that allow accurate filing and draining control with high safety margins. Features include a peritoneal fluid circuit with a pressure sensor at either end and methods and devices for using the pressure signals. Other features and embodiments are disclosed.

Abstract: A medical treatment system is configured to output a predefined test pattern and to receive the signal by way of a microphone in order to test the volume and quality of the audio output in order to ensure the output audio signals effective to wake a sleeping patient. The failure of a processor to confirm the volume and fidelity of the audio output as well as the timeliness of the test pattern causes the processor to deny the resumption of a treatment and to generate an error signal.

Abstract: A proportioning system includes a solute container filled with dry solutes, a source of water, a container of electrolyte concentrate, a fluid circuit connecting the solute container to the source of water and the container of electrolyte concentrate, the fluid circuit having an empty mixing container, a controller configured to transfer water from the source of water to the solute container through the fluid circuit so as to prepare a solute concentrate solution in the solute container. The controller is configured to transfer fluid from the container of electrolyte concentrate to a mixing container as well as a solute concentrate from the solute container to the mixing container and further adding water to said mixing container to form a medicament therein.

Abstract: A treatment device system includes a treatment machine for performing a therapy on a patient, the treatment machine including at least one fluid conveyor and a controller, the controller having a first memory, to cause the at least one fluid conveyor to produce a therapeutic fluid by mixing purified water and at least one concentrate. The system also includes a water purifier with an internal central controller, in fluid communication with and providing the purified water to the treatment machine. A wired or wireless control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier, the controller of the treatment machine transmitting data via the control line to the internal central controller of the water purifier for control of the water purifier, the data provided based on at least one of the operator inputs received via the user interface.

Abstract: A treatment device system includes a treatment machine for generating a custom dialysis solution and including at least one fluid conveyor, the treatment machine having a controller, the controller having a first memory, configured to produce the custom dialysis solution by causing the at least one fluid conveyor to mix purified water and at least one concentrate. The system also includes a user interface and a water purifier in fluid communication with and providing the purified water to the treatment machine, the water purifier including an internal central controller, the internal central controller having a second memory, to control preparation of the purified water. A server is communicatively coupled with the treatment machine and a control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier.

Abstract: A treatment device system includes a peritoneal dialysis treatment machine for performing a therapy on a patient, the treatment machine including at least one fluid conveyor and a controller, the controller having a first memory, to cause the at least one fluid conveyor to produce a peritoneal dialysis solution by mixing purified water and at least one concentrate. The system also includes a water purifier in fluid communication with and providing the purified water to the treatment machine. A wired or wireless control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier, wherein the controller of the treatment machine transmits data via the control line to the internal central controller of the water purifier for control of the water purifier, the data provided based on at least one of the operator inputs received via the user interface.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: Methods, device, and systems for preparing peritoneal dialysis fluid and/or administering a peritoneal dialysis treatment are disclosed. In embodiments, peritoneal dialysis fluid is prepared at a point of use automatically using a daily sterile disposable fluid circuit and one or more long-term concentrate containers that are changed only after multiple days (e.g. weekly). The daily disposable may have concentrate containers that are initially empty and are filled from the long-term concentrate containers once per day at the beginning of a treatment.

Abstract: A pressure measurement system includes a pressure pod with two chambers separated by a diaphragm such that a deformation/movement of the diaphragm is indicative of a difference between the pressures of the two chambers. Such deformation/movement is detected by a device that has no physical contact with the diaphragm, for example, by an optical detector that detects a change in the shape of the diaphragm or a movement of a protrusion on the diaphragm.

Abstract: Fluid channel sealing devices, frangible seals, fluid circuits, associated controllers and methods of using the same are provided for controlling fluid distribution using a reconfigurable blocking element having first and second portions to establish a first configuration free of any open channels such that fluid is prevented from flowing through the channel and a second configuration where the first and second portions are separated to establish an open channel and allow fluid to pass.

Abstract: A peritoneal dialysis device includes a disposable tubing set that includes a fill line with a patient access connector at one end and a dialysis fluid receiving end opposite the patient access connector end. The device also includes a fill-side pressure measuring sensor attached at the fill end and forming a disposable component of the tubing set and a patient-side pressure measuring sensor located at the fluid receiving end. The patient-side and fill-side pressure measuring sensors are adapted for measuring pressure in the fill line at the respective ends thereof. The device also includes a controller configured to regulate a rate of flow in the fill line responsively to a signal from the at least the patient-side pressure measuring sensor.

Abstract: Methods, device, and systems for preparing peritoneal dialysis fluid and/or administering a peritoneal dialysis treatment are disclosed. In embodiments, peritoneal dialysis fluid is prepared at a point of use automatically using a daily sterile disposable fluid circuit and one or more long-term concentrate containers that are changed only after multiple days (e.g. weekly). The daily disposable may have concentrate containers that are initially empty and are filled from the long-term concentrate containers once per day at the beginning of a treatment.

Abstract: A treatment device system includes a treatment machine for performing a therapy on a patient, the treatment machine including at least one fluid conveyor and a controller, the controller having a first memory, to cause the at least one fluid conveyor to produce a therapeutic fluid by mixing purified water and at least one concentrate. The system also includes and a water purifier in fluid communication with and providing the purified water to the treatment machine. A wired or wireless control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier, wherein the controller of the treatment machine transmits data via the control line to the internal central controller of the water purifier for control of the water purifier, the data provided based on at least one of the operator inputs received via the user interface.

Abstract: A treatment device system includes a treatment machine for generating custom peritoneal dialysis solution and including at least one fluid conveyor, the treatment machine having a controller, the controller having a first memory, configured to produce a therapeutic fluid by causing the at least one fluid conveyor to mix purified water and at least one concentrate. The system also includes a user interface and a water purifier in fluid communication with and providing the purified water to the treatment machine, the water purifier including internal central controller, the internal central controller having a second memory, to control preparation of the purified water. A server is communicatively coupled with the treatment machine and a control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier.

Abstract: A treatment device system includes a treatment machine for performing a therapy on a patient, the treatment machine including at least one fluid conveyor and a controller, the controller having a first memory, to cause the at least one fluid conveyor to produce a therapeutic fluid by mixing purified water and at least one concentrate. The system also includes and a water purifier in fluid communication with and providing the purified water to the treatment machine. A wired or wireless control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier, wherein the controller of the treatment machine transmits data via the control line to the internal central controller of the water purifier for control of the water purifier, the data provided based on at least one of the operator inputs received via the user interface.

Abstract: Peritoneal dialysis admixing and/or treatment devices, methods, and systems are disclosed. The systems, methods, and devices provide high-level guarantees of sterility and employs relatively inexpensive disposable components to provide pumping. Disclosed systems, methods, and devices and features thereof are adapted for point of use generation of medicament. In particular admixing systems that employ independently-replaceable long term concentrate are disclosed. Features are directed to assurance of sterility and accurate admixing of water and concentrate to generate ready-to-use medicaments and other benefits.