Patents by Inventor Mark W. Orme

Mark W. Orme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of VAP-1
    Patent number: 11787791
    Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: October 17, 2023
    Assignee: ACUCELA INC.
    Inventors: Mark W. Orme, Edison S. Zuniga, Vladimir A. Kuksa, Russell Stuart Craft, Eduardo Moreno Saveedra, Johannes Wilhelm Georg Meissner, Jacobus Antonius Joseph den Hartog, Albert Cornelis Dros
  • INHIBITORS OF VAP-1
    Publication number: 20230295140
    Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
    Type: Application
    Filed: May 24, 2023
    Publication date: September 21, 2023
    Inventors: Mark W. ORME, Edison S. ZUNIGA, Vladimir A. KUKSA, Russell Stuart CRAFT, Eduardo Moreno SAVEEDRA, Johannes Wilhelm Georg MEISSNER, Jacobus Antonius Joseph den HARTOG, Albert Cornelis DROS
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20230218549
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt’s Disease.
    Type: Application
    Filed: August 5, 2022
    Publication date: July 13, 2023
    Inventors: Ian L. SCOTT, Vladimir A. KUKSA, Mark W. ORME, Thomas L. LITTLE, JR., Anna GALL, Feng HONG
  • Alkoxy compounds for disease treatment
    Patent number: 11446261
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: September 20, 2022
    Assignee: Acucela Inc.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • INHIBITORS OF VAP-1
    Publication number: 20220024915
    Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
    Type: Application
    Filed: September 27, 2019
    Publication date: January 27, 2022
    Inventors: Mark W. ORME, Edison S. ZUNIGA, Vladimir A. KUKSA, Russell Stuart CRAFT, Eduardo Moreno SAVEEDRA, Johannes Wilhelm Georg MEISSNER, Jacobus Antonius Joseph den HARTOG, Albert Cornelis DROS
  • INHIBITORS OF VAP-1
    Publication number: 20210387975
    Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
    Type: Application
    Filed: September 27, 2019
    Publication date: December 16, 2021
    Inventors: Mark W. ORME, Edison S. ZUNIGA, Vladimir A. KUKSA, Russell Stuart CRAFT, Eduardo Moreno SAVEEDRA, Johannes Wilhelm Georg MEISSNER, Jacobus Antonius Joseph den HARTOG, Albert Cornelis DROS
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20210077427
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: May 1, 2020
    Publication date: March 18, 2021
    Inventors: Ian L. SCOTT, Vladimir A. KUKSA, Mark W. ORME, Thomas L. LITTLE, Jr., Anna GALL, Feng HONG
  • Alkoxy compounds for disease treatment
    Patent number: 10639286
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: May 5, 2020
    Assignee: ACUCELA INC.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20190183816
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: July 23, 2018
    Publication date: June 20, 2019
    Inventors: Ian L. SCOTT, Vladimir A. KUKSA, Mark W. ORME, Thomas L. LITTLE, JR., Anna GALL, Feng HONG
  • Styrenyl derivative compounds for treating ophthalmic diseases and disorders
    Patent number: 10201545
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: February 12, 2019
    Assignee: ACUCELA INC.
    Inventors: Ian Leslie Scott, Vladimir Aleksandrovich Kuksa, Anna Gall, Mark W. Orme, Jennifer Gage, Thomas L. Little, Jr., Qin Jiang, Lana Michele Rossiter, Kevin F. McGee, Jr., Ryo Kubota
  • Alkoxy compounds for disease treatment
    Patent number: 10188615
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: January 29, 2019
    Assignee: ACUCELA INC.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20180177746
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: August 8, 2017
    Publication date: June 28, 2018
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • Alkoxy compounds for disease treatment
    Patent number: 9737496
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: August 22, 2017
    Assignee: ACUCELA INC.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20170049722
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: September 8, 2016
    Publication date: February 23, 2017
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, JR., Anna Gall, Feng Hong
  • SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS
    Publication number: 20170022180
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: September 10, 2015
    Publication date: January 26, 2017
    Inventors: Vladimir A. Kuksa, Mark W. Orme, Feng Hong, Ryo Kubota
  • Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders
    Patent number: 9464033
    Abstract: Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: October 11, 2016
    Assignee: ACUCELA INC.
    Inventors: Ian Leslie Scott, Vladimir Aleksandrovich Kuksa, Mark W. Orme, Thomas Little, Anna Gall, Jennifer Gage, Feng Hong
  • Alkoxy compounds for disease treatment
    Patent number: 9458088
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: October 4, 2016
    Assignee: ACUCELA INC.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas L. Little, Jr., Anna Gall, Feng Hong
  • Amine derivative compounds for treating ophthalmic diseases and disorders
    Patent number: 9452153
    Abstract: Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: September 27, 2016
    Assignee: ACUCELA INC.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Feng Hong, Thomas L. Little, Jr., Ryo Kubota
  • Substituted heterocyclic compounds for disease treatment
    Patent number: 9447078
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted heterocyclic amine derivative compound and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: September 20, 2016
    Assignee: ACUCELA INC.
    Inventors: Vladimir A. Kuksa, Mark W. Orme, Feng Hong, Ryo Kubota
  • Styrenyl derivative compounds for treating ophthalmic diseases and disorders
    Patent number: 9421210
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: August 23, 2016
    Assignee: ACUCELA INC.
    Inventors: Ian Leslie Scott, Vladimir Aleksandrovich Kuska, Anna Gall, Mark W. Orme, Jennifer Gage, Thomas L. Little, Jr., Qin Jiang, Lana Michele Rossiter, Kevin F. McGee, Jr., Ryo Kubota