Patents by Inventor Mark W. Orme

Mark W. Orme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carboline derivatives as PDE5 inhibitors
    Patent number: 6984641
    Abstract: Selective inhibitors of cGMP-specific PDE, and use of the compounds and salts and solvates thereof as therapeutic agents, are disclosed.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: January 10, 2006
    Assignee: Lilly Icos LLC.
    Inventors: Mark W. Orme, Jason S. Sawyer, Alain C. Daugan, Agnes Bombrun, Françoise Gellibert, Lisa M. Schultze, Raymond F. Brown, Romain L. Gosmini
  • Hexahydropyrazino[1'2';1,6]pyrido[3,4-b]indole-1,4-diones for the treatment of cardiovascular disorders and erectile dysfunction
    Patent number: 6962918
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: November 8, 2005
    Assignee: Lilly Icos LLC.
    Inventors: Mark W. Orme, Lisa M. Schultze, Jason Scott Sawyer, Alain Claude-Marie Daugan, Raymond Brown
  • Condensed pyrazindione derivatives as PDE inhibitors
    Patent number: 6960587
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: November 1, 2005
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Lisa M. Schultze, Jason Scott Sawyer
  • Pyrazino[1?,2?:1,6]pyrido[3,4b]indole derivatives
    Patent number: 6911542
    Abstract: Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: June 28, 2005
    Assignee: Lilly Icos LLC.
    Inventors: Mark W. Orme, Jason Scott Sawyer, Lisa M. Schultze, Alain Claude-Marie Daugan, Francoise Gellibert
  • Condensed pyrazindione derivatives
    Patent number: 6903099
    Abstract: Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: June 7, 2005
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Jason Scott Sawyer, Lisa M. Schultze
  • Indole derivatives as PDE5-inhibitors
    Patent number: 6878711
    Abstract: Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: April 12, 2005
    Assignee: Lilly Icos LLC
    Inventors: Mark W. Orme, Jason Scott Sawyer, Lisa M. Schultze
  • Derivatives of 2,3,6,7,12,12a-hexahydropyrazino-[1?,2?:1,6]pyrido[3,4b]-indole-1,4-dione
    Patent number: 6872721
    Abstract: Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: March 29, 2005
    Assignee: Lilly ICOS LLC
    Inventors: Mark W. Orme, Jason Scott Sawyer, Alain Claude-Marie Daugan
  • Condensed pyridoindole derivatives
    Patent number: 6858620
    Abstract: Compounds of general structural formula (I), and use of the compounds or salts or solvates thereof as therapeutic agents, are disclosed
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: February 22, 2005
    Assignee: Lilly ICOS, LLC
    Inventors: Mark W. Orme, Jason Scott Sawyer, Alain Claude-Marie Daugan, Romain Luc Marie Gosmini, Lisa M. Schultze
  • Condensed pyridoindole derivatives
    Patent number: 6838456
    Abstract: Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: January 4, 2005
    Assignee: Lilly ICOS LLC
    Inventors: Mark W. Orme, Jason Scott Sawyer, Alain Claude-Marie Daugan, Françoise Gellibert, Romain Luc Marie Gosmini
  • Cyclic GMP-specific phosphodiesterase inhibitors
    Patent number: 6825197
    Abstract: Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: November 30, 2004
    Assignee: Lilly ICOS LLC
    Inventors: Mark W. Orme, Jason Scott Sawyer
  • Tetracyclic compounds as pde5-inhibitors
    Publication number: 20040162291
    Abstract: Compounds of structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Application
    Filed: November 25, 2003
    Publication date: August 19, 2004
    Inventors: Mark W. Orme, Jason S. Sawyer, Lisa M. Schultze
  • Pyrazino 1',2':1,6 pyrido 3,4-b indole1,4-dione derivatives
    Publication number: 20040152705
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as thereapeutic agents. In particular, the invention relates to compounds that are potent and selective inhibitors of cyclic guanosine 3′, 5′-monophosphate specific phosphodiesterase (cGMP-specific PDE), in particular PDE5, and have utility in a variety of therapeutic areas wherein such inhibition is considered beneficial, including the treatment of cardiovascular disorders and erectile dysfunction.
    Type: Application
    Filed: November 24, 2003
    Publication date: August 5, 2004
    Inventors: Mark W. Orme, Jason S. Sawyer, Lisa M. Schultze
  • Chemical compounds
    Publication number: 20040147542
    Abstract: Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents as inhibitors of phosphodiesterase 5 cardiovascular disorders.
    Type: Application
    Filed: February 9, 2004
    Publication date: July 29, 2004
    Inventors: Jason S. Sawyer, Mark W. Orme, James D. Copp
  • Chemical compounds
    Publication number: 20040122035
    Abstract: Compounds of the general structural formula 1
    Type: Application
    Filed: February 12, 2004
    Publication date: June 24, 2004
    Inventors: Mark W. Orme, Jason S Sawyer, Agnes Bombrun, Romain L Gosmini, Anne Bouillot, Nerina Dodic, Michael Sierra
  • Chemical compounds
    Publication number: 20040038978
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Application
    Filed: April 9, 2003
    Publication date: February 26, 2004
    Inventors: Mark W. Orme, Lisa M. Schultze, Jason Scott Sawyer
  • Chemical compounds
    Publication number: 20030236263
    Abstract: Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Application
    Filed: February 27, 2003
    Publication date: December 25, 2003
    Inventors: Mark W. Orme, Lisa M. Schultze, Jason Scott Sawyer, Alain Claude-Marie Daugan, Raymond Brown
  • Chemical compounds
    Publication number: 20030225092
    Abstract: Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Application
    Filed: December 3, 2002
    Publication date: December 4, 2003
    Inventors: Mark W. Orme, Jason Scott Sawyer, Alain Claude-Marie Daugan
  • Compositions and methods for treating bone deficit conditions
    Patent number: 6649631
    Abstract: Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: November 18, 2003
    Assignees: The Board of Regents of the University of Texas System, ZymoGenetics Corporation, OsteoScreen
    Inventors: Mark W. Orme, Nand Baindur, Kirk G. Robbins, Scott M. Harris, Maria Kontoyianni, Laurence H. Hurley, Sean M. Kerwin, Gregory Mundy, Charles Petrie
  • Chemical compounds
    Publication number: 20030207906
    Abstract: Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Application
    Filed: February 28, 2003
    Publication date: November 6, 2003
    Inventors: Mark W. Orme, Jason Scott Sawyer, Alain Claude-Marie Daugan, Francoise Gellibert, Romain Luc Marie Gosmini
  • Fused heterocyclic derivatives as phosphodiesterase inhibitors
    Publication number: 20030207867
    Abstract: Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Application
    Filed: January 15, 2003
    Publication date: November 6, 2003
    Inventors: Mark W. Orme, Jason Scott Sawyer, Lisa M Schultze