Abstract: The present disclosure relates to an injection device for expelling of a number of preset or user-selectable doses of a medicament, the injection device comprising: an elongated housing extending along a longitudinal axis, and a rotatable member and a counterpart member each comprising a first mechanical code and a second mechanical code, respectively. For setting of a dose the rotatable member is rotatable relative to the housing and relative to the counterpart member. During setting of the dose the rotatable member is constrained along the longitudinal axis relative to the housing or relative to the counterpart member. For expelling of a dose one of the rotatable member and the counterpart member is displaceable along the longitudinal axis into an expelling position relative to the other one of the rotatable member and the counterpart member only when the first mechanical code is aligned with the second mechanical code.

Abstract: Airborne LiDAR bathymetry systems and methods of use are provided. The airborne LiDAR bathymetry system can collect topographic data and bathymetric data at high altitudes. The airborne LiDAR bathymetry system has a receiver system, a detector system, and a laser transmission system.

Abstract: A system, method, and computer-program product includes obtaining application configuration data; computing, via an execution of a designed experiment, a plurality of application usability tests based on the application configuration data; generating a computer-executable application based at least on the plurality of application usability tests; and deploying the computer-executable application to a target computing environment for execution by one or more users.

Abstract: Structures and related systems and methods for dose reduction in extreme ultraviolet (EUV) lithography. The structures can comprise a dose reducing layer, an adhesion layer, and a resist.

Abstract: The disclosure generally relates to the field of semiconductor substrate processing technology, and more particularly to methods for depositing layers of materials on substrates, to structures formed accordingly, and for systems for executing such methods and for forming such structures. Aspects relate to a layer deposition process comprising the steps of forming an extreme ultraviolet (EUV) photoresist underlayer on a surface of a substrate; providing a substrate within a reactor chamber; providing a precursor comprising Sn and/or In to the reactor chamber thereby adsorbing the precursor on the surface of the substrate; and forming an EUV photoresist underlayer on the surface of the substrate within the reactor chamber by exposing the precursor adsorbed on the surface to a plasma, wherein the plasma comprises H2 as reactant and a noble gas as carrier gas.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may receive an indication identifying whether a physical resource block (PRB) allocation boundary discontinuity is present. The UE may communicate using a precoding configuration applied based at least in part on the indication identifying whether the PRB allocation boundary discontinuity is present. Numerous other aspects are described.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: The invention relates to a method for detection of analyte interaction with a channel molecule held in a membrane, comprising the optical detection of a modification in the flux of a signal molecule as it passes through the channel molecule by the action of a membrane potential, wherein the modification in the flux is caused by at least partial blockage of the channel molecule by the analyte. The invention further relates to bilayer arrays, components, methods of manufacture and use.

Abstract: 4-Alkoxypyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 4-alkoxypyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Abstract: The invention provides methods of optically detecting an analyte in a medium as the analyte moves with respect to a nanopore. The analyte may be, for example, a biological molecule such as a polynucleotide or polypeptide. Systems and apparatuses for carrying our such methods are also provided.

Abstract: A computing device receives user input for a design of an experiment. The user input indicates respective factor identities for factors in the design of the experiment, respective response identities for responses to options for the factors in the design, and a user-defined objective for the one or more responses. Additionally, based on the user input, the computing device displays a subset of a set of multiple model types and a user-definable amount of design runs for the design. Each design run presents settings according to the design for each of the factors. The computing device also receives settings indicating a user-selected model type from the subset and a user-defined amount of design runs, and based on the settings, selects one or more design construction criteria for generating the design. The computing device then generates the design according to the design construction criteria.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a radio unit (RU) may receive, from a user equipment (UE), a demodulation reference signal (DMRS) associated with a channel. The RU may perform a channel estimation associated with the channel using the DMRS to obtain channel estimation information. The RU may transmit, to a distributed unit (DU), information that is based at least in part on the channel estimation information. Numerous other aspects are described.

Abstract: A dialysis system comprising a dialysis machine (100) having a main body portion, a water purification system, the water purification system being separate to the dialysis machine, and a liquid sanitizer (200). The liquid sanitizer (200) is provided within the main body portion of the dialysis machine. The liquid sanitizer (200) is fluidly connected between the dialysis machine (100) and the water purification system. The liquid sanitizer (200) has a heater (240) arranged to heat a volume of liquid, a temperature sensor arranged to sense the temperature of the volume of liquid and a liquid sanitizer controller (250). The dialysis system defines a first closed fluid circuit comprising the dialysis machine and the liquid sanitizer and a second closed fluid circuit comprising the water purification system, the dialysis machine and the liquid sanitizer. The liquid sanitizer (200) is configured to effect sanitization of the first closed fluid circuit and the second closed fluid circuit.

Abstract: The invention relates to a method for detection of analyte interaction with a channel molecule held in a membrane, comprising the optical detection of a modification in the flux of a signal molecule as it passes through the channel molecule by the action of a membrane potential, wherein the modification in the flux is caused by at least partial blockage of the channel molecule by the analyte. The invention further relates to bilayer arrays, components, methods of manufacture and use.

Abstract: Providing cognitive responses with an electronic message system includes predicting an urgency level corresponding to an electronic message received by the system based on detecting pre-defined features within the message and assigning a classification to the message based on the detected features. The message and corresponding urgency level can be mapped to a response action based on the classification assigned to the message. A notification of the response action and corresponding urgency level can be generated.

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: An apparatus includes a processor to: generate variants of an experiment design based on varied parameters; for each variant, estimate terms based on the model, and derive an optimality value; present a table of the variants including a column for each varied parameter and a column for the optimality value, a row for each variant, and a bar graph for each column depicting a distribution of the values therein; present function controls operable to select a function to perform on row(s) of the table in response to selection of a bar of a bar graph of a column; in response to selection of a function, change the current function to the selected function; and in response to a selection of a bar of a bar graph of a column, perform the current function on row(s) based on instances of the value associated with selected bar.

Abstract: A pump and valve arrangement (201), a dialysis system (10) comprising the pump and valve arrangement 201 and a method of operating a pump and valve arrangement (201). The pump and valve arrangement (201) has a dialyser having a semi-permeable membrane. The pump and valve arrangement (201) delivers dialysis fluid to and from the dialyser (12). The pump and valve arrangement (201) has a control system (450) configured to shuttle dialysis fluid between an inlet pump assembly and the dialyser (12) one or more times so as to agitate the surface of the semi-permeable membrane of the dialyser (12).