Abstract: The present disclosure provides ?-diketones or analogs thereof, that activate Wnt/?-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

Abstract: An apparatus includes a processor to: present prompts guiding selection of first subset terms for estimation of variants of an experiment design based on a model thereof, and second subset terms for estimation using Bayesian modification; monitor for selections of term; in response to each change in the first subset terms, determine whether all first subset terms can be estimated based on the model; in response to the first subset including too many terms, present an indication of too many terms being selected for estimation based on the model; in response to the first subset including fewer terms than can be estimated based on the model, present an indication that more terms could be selected for estimation based on the model; and for each variant of the experiment design, estimate each first subset term based on the model, and estimate each second subset term using Bayesian modification.

Abstract: An apparatus includes a processor to: generate variants of an experiment design based on varied parameters; for each variant, estimate terms based on the model, and derive an optimality value; present a table of the variants including a column for each varied parameter and a column for the optimality value, a row for each variant, and a bar graph for each column depicting a distribution of the values therein; present function controls operable to select a function to perform on row(s) of the table in response to selection of a bar of a bar graph of a column; in response to selection of a function, change the current function to the selected function; and in response to a selection of a bar of a bar graph of a column, perform the current function on row(s) based on instances of the value associated with selected bar.

Abstract: A hemodialysis machine comprising a fluid pathway for delivering a dialysate solution, wherein the fluid pathway comprises a pre-dialysis pathway and a post-dialysis pathway, a dialyser for dialysing patient's blood using the dialysate solution, the dialyser connected between the pre-dialysis pathway and the post-dialysis pathway, a first sensor system configured to sense a characteristic of the dialysate solution at a first location on the pre-dialysis pathway, a second sensor system configured to sense a characteristic of the dialysate solution at a second location on the post-dialysis pathway, and a control system configured to make a comparative analysis of the measurements taken by the first sensor and the second sensor for monitoring the composition of the dialysate solution.

Abstract: Provided are compositions and methods for treating osteoarthritis including intra-articular administration of a compound of Formula (I) including amorphous and polymorph forms thereof.

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: A disinfectant composition useful in shrimp aquaculture and a process for using such a disinfectant, in which there is a composition containing a) 25 to 87 wt. % of KHSO5 containing triple salt b) 1 to 20 wt. % of at least one H2N(CH2)nSO3H compound with n being 0, 1, 2 or 3, c) 1 to 8 wt. % of a surfactant d) 1 to 60 wt. % of a C2-C10 aliphatic dicarboxylic acid, optionally substituted with a hydroxyl and/or carboxylic group and e) 10 to 30 wt. % alkali metal phosphate.

Abstract: The present application discloses a compound which is which activates Wnt/?-catenin signaling and thus treats or prevents diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

Abstract: Indazole compounds for treating various diseases and pathologies are provided. More particularly, the use of an indazole compound or analogs thereof, in the treatment of inflammatory diseases or disorders is provided.

Abstract: Provided are compositions and methods for treating osteoarthritis including intra-articular administration of a compound of Formula (I) including amorphous and polymorph forms thereof.

Abstract: A composition containing a) 25 to 87 wt. % of KHSO5 containing triple salt b) 1 to 20 wt. % of at least one H2N(CH2)nSO3H compound with n being 0, 1, 2 or 3, c) 1 to 8 wt. % of a surfactant d) 1 to 60 wt. % of a C2-C10 aliphatic dicarboxylic acid, optionally substituted with a hydroxyl and/or carboxylic group and e) 10 to 30 wt. % alkali metal phosphate.

Abstract: The present disclosure provides ?-diketones or analogs thereof, that activate Wnt/?-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

Abstract: The invention relates to a method for detection of analyte interaction with a channel molecule held in a membrane, comprising the optical detection of a modification in the flux of a signal molecule as it passes through the channel molecule by the action of a membrane potential, wherein the modification in the flux is caused by at least partial blockage of the channel molecule by the analyte. The invention further relates to bilayer arrays, components, methods of manufacture and use.

Abstract: A dialysis machine which monitors the pressure of blood entering and leaving a patient's body using several sensors (37, 39) and adapts the pressure of a dialysate solution feed to compensate for compliances in the dialysate fluid flow path. As a consequence, better flow balance is maintained throughout dialysis treatment leading to a more uniform removal of waste materials from the blood.

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Indazole compounds for treating various diseases and pathologies are provided. More particularly, the use of an indazole compound or analogs thereof, in the treatment of inflammatory diseases or disorders is provided.

Abstract: Provided are compositions and methods for treating osteoarthritis including intra-articular administration of a compound of Formula (I) including amorphous and polymorph forms thereof.

Abstract: The invention relates to a dialysis machine capable of performing ultrafiltration without the need for a dedicated ultrafiltration pump. The system uses a pair of membrane flow balance pumps wherein the operation and/or the volume flow rate of the pumps can be modified during operation to bring about a net movement of dialysate either into or from the dialyser. The direction of flow of the dialysate in the dialyzer is reversible and the dialyzer can comprise two dialysate inlets, one at each end, and two dialysate outlets, one at each end.

Abstract: The invention relates to a method for detection of analyte interaction with a channel molecule held in a membrane, comprising the optical detection of a modification in the flux of a signal molecule as it passes through the channel molecule by the action of a membrane potential, wherein the modification in the flux is caused by at least partial blockage of the channel molecule by the analyte. The invention further relates to bilayer arrays, components, methods of manufacture and use.

Abstract: Provided are compositions and methods for treating osteoarthritis including intra-articular administration of a compound of Formula (I) including amorphous and polymorph forms thereof.