Abstract: The present invention relates to nucleoside derivatives having photolabile protective groups of general formula (I) in which R1=H, NO2, CN, OCH3, halogen, an alkyl, alkoxy or alkoxyalkyl residue having 1 to 4 C atoms or an optionally substituted aryl residue or an aliphatic acyl residue having 2 to 5 atoms, R2=H, NO2, CN, OCH3, halogen, an alkyl, alkoxy or alkoxyalkyl residue having 1 to 4 C atoms or an optionally substituted aryl residue or an aliphatic acyl residue having 2 to 5 atoms, R3=H, halogen, NO2, CN, OCH3, an alkyl, alkoxy or alkoxyalkyl residue having 1 to 4 C atoms or an optionally substituted aryl residue or aliphatic acyl residue having 2 to 5 C atoms, R4=H, halogen, NO2, CN, OCH3, an alkyl, alkoxy, or alkoxyalkyl residue having 1 to 4 C atoms or an optionally substituted aryl residue or aliphatic acyl residue having 2 to 5 atoms, R5=H, dimethoxytrityl or a protective group common in the chemistry of nucleotides or a functional group com

Abstract: The present invention relates to photolabile protective groups for synthesizing biopolymers, in particular nucleic acids.

Abstract: The invention relates to a process and a device for the light-controlled synthesis of biopolymers on surfaces. In this process, patterns of individual sequences (20) are produced by the imaging of an arrangement (1) of electrically individually controllable light diodes (2) onto the surfaces.

Abstract: The present invention relates to a method for the photolithographic synthesis of biochips in which photolabile protective groups of the 2-(2-nitrophenyl)ethyl type are used, whereby the irradiation step that is common in the photolithographic chip synthesis is carried out in the presence of a base, preferably a secondary or uerriary base.

Abstract: The present invention relates to a method for conrolling the quality of oligomer assays, which is characterized in that a phosphate unit is fused to certain array positions, said phosphate unit being linked to a signal-generating reporter group, the degree of oligomer synthesis is determined using the signal of the reporter group, and the reporter group is then split off again.

Abstract: The invention relates to a method for the determination of analytes using carrier chips comprising arrays of different receptors in immobilized form on the surface of said chips. The method is performed dynamically in several cycles. Information obtained in a previous cycle on the modification or alteration of said receptors is used in the following cycle.

Abstract: The invention relates to a process and an apparatus for the micrometering of extremely small quantities of liquid for the production of biopolymer arrays. The sample liquids to be analyzed are supplied by means of a supply device (1, 23), which can be connected to a stock of rinsing fluid (24). A reversible electric voltage (10) can be applied to the supply device (1, 23), enabling the electro-osmotic flow which arises to be used for the transport of the sample liquids onto a detection field (18).

Abstract: The present invention relates to a method for controlling the quality of oligomer arrays, which is characterized in that a phosphate unit is fused to certain array positions, said phosphate unit being linked to a signal-generating reporter group, the degree of oligomer synthesis is determined using the signal of the reporter group, and the reporter group is then split off again.

Abstract: The invention relates to a process and a device for the determination of the transfer of a sample substance in the production of biopolymer fields or biopolymer arrays onto the surface (4) of a specimen slide (3). The surface (4) of a specimen slide (3) comprises a conductive material (14) whose electrical connection to the feed device (1) via the sample liquid (12) serves as acknowledgement signal (8).

Abstract: The invention relates to a method and an apparatus for determining analytes by electronic detection using a microfluidic support.

Abstract: A process is described for preparing oligonucleotides by solid phase synthesis in which exocyclic amino groups present on nucleobases are protected with cyclic diacyl groups, which can be deprotected in the presence of a strong, nonnucleophilic base. Novel intermediates employing the cyclic diacyl protecting groups are also described.