Abstract: The present invention relates to inhibitors of the interaction between H. pylori HopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.

Abstract: The present invention relates to a method for treating cancer in a subject, comprising the step of administering to a subject in need thereof administering a therapeutically effective dose of a T cell capable of binding a neopeptide that is expressed by a tumor suppressor gene, wherein said neopeptide is derived from a frameshift product of a tumor suppressor gene and wherein the T cell binds to the neopeptide-MHC complex with a half-life (T1/2) of at least 50 s.

Abstract: The present invention relates to a method for providing a neopeptide-specific T cell, wherein the neopeptide-specific T cell forms a complex having a half-life (T½) of at least 50 s with a neopeptide-MHC monomer. The present invention further relates to a T cell obtainable by the method as well as a pharmaceutical composition comprising such T cells.

Abstract: The present invention relates to inhibitors of the interaction between H. pylori HopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.

Abstract: The present invention relates to inhibitors of the interaction between H. pylori IIopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.

Abstract: The present invention relates to inhibitors of the interaction between H. pylori IIopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.

Abstract: The present invention relates to immunogenic compositions and their use in the prevention or treatment of diseases or disorders caused by or associated with Helicobacter pylori, in particular H. pylori infection and gastroduodenal disorders caused by H. pylori. The present invention further relates to methods of detecting H. pylori infection in a subject.

Abstract: The present invention relates to immunogenic compositions and their use in the prevention or treatment of diseases or disorders caused by or associated with Helicobacter pylori, in particular H. pylori infection and gastroduodenal disorders caused by H. pylori. The present invention further relates to methods of detecting H. pylori infection in a subject.

Abstract: The present invention is related to a method for detecting H. pylori infection in a subject, wherein the method comprises detecting in a sample from the subject an immune response against FliD, wherein the immune response comprises an anti-FliD antibody.

Abstract: The present invention relates to a method for providing a neopeptide-specific T cell, wherein the neopeptide-specific T cell forms a complex having a half-life (T½) of at least 50 s with a neopeptide-MHC monomer. The present invention further relates to a T cell obtainable by the method as well as a pharmaceutical composition comprising such T cells.

Abstract: The present invention is related to a polypeptide comprising an amino acid sequence, whereby the amino acid sequence of the polypeptide is at least 80% identical to a stretch of consecutive amino acids of the region of HPGGT comprising an amino acid sequence corresponding to SEQ.ID.No. 1, whereby such region is defined by (a) amino acid positions 150 to 200 of the amino acid sequence according to SEQ.ID.No.1, or (b) amino acid positions 410 to 480 of the amino acid sequence according to SEQ.ID.No.1, and whereby the polypeptide is suitable to elicit an immune response which is capable of inhibiting the catalytic activity of HPGGT.

Abstract: The present invention is related to a method for detecting H. pylori infection in a subject, wherein the method comprises detecting in a sample from the subject an immune response against FliD, wherein the immune response comprises an anti-FliD antibody.

Abstract: A lighting device for a motor vehicle headlamp is described. The device includes a reflector for focusing light emitted by a light source. At the rear end of the reflector is an opening to receive at least a part of the light source, and a reflector neck that surrounds the opening and to which the light source is fastened in a defined position relative to a reflective surface of the reflector. A plurality of locking members are formed on the reflector which in the course of a rotary movement of the light source about the optical axis of the reflector or about an axis parallel thereto when the light source has been at least partly inserted in the reflector neck, engage in corresponding perforations formed in the fight source.

Abstract: The present invention is related to a polypeptide comprising an amino acid sequence, whereby the amino acid sequence of the polypeptide is at least 80% identical to a stretch of consecutive amino acids of the region of HPGGT comprising an amino acid sequence corresponding to SEQ.ID.No. 1, whereby such region is defined by (a) amino acid positions 150 to 200 of the amino acid sequence according to SEQ.ID.No. 1, or (b) amino acid positions 410 to 480 of the amino acid sequence according to SEQ.ID.No. 1, and whereby the polypeptide is suitable to elicit an immune response which is capable of inhibiting the catalytic activity of HPGGT.

Abstract: The present invention is related to a polypeptide comprising an amino acid sequence, whereby the amino acid sequence of the polypeptide is at least 80% identical to a stretch of consecutive amino acids of the region of HPGGT comprising an amino acid sequence corresponding to SEQ. ID. No. 1, whereby such region is defined by (a) amino acid positions 150 to 200 of the amino acid sequence according to SEQ. ID. No. 1, or (b) amino acid positions 410 to 480 of the amino acid sequence according to SEQ. ID. No. 1, and whereby the polypeptide is suitable to elicit an immune response which is capable of inhibiting the catalytic activity of HPGGT.

Abstract: A high pressure discharge lamp (10), which is particularly a motor vehicle headlight, comprises a high pressure discharge burner (12) for emitting light supported by at least one leg (24), preferably three or four legs (24). By means of the legs (24) the burner (12) is mechanically connected to a socket (14) of the high pressure discharge lamp (10). According to the invention the legs (24) are part of a holder (16), which comprises further a ring (18) surrounding the socket (14), whereby the ring (18) is one-piece with the legs (24). Due to the design of the holder (16) as ring (18) with protruding legs (24) the heat of the burner (12) is conducted from the burner (12) via the legs (24) to the ring (18) by heat conduction. From the ring (18) the heat is led away to the environment by convection. This leads to a significant cooler Temperature of the holder (16) with respect to the burner (12), so that the material of the socket (14) needs not to be selected with respect to a good heat resistance.

Abstract: It is provided a burner for automotive lamps, particularly HID lamps, comprising a discharge vessel for generating light by means of a discharge arc. A glass body for protecting the discharge vessel comprises a shaft for being inserted into a socket. The shaft comprises at least one insulation pocket for receiving a rib of the socket and for insulating the first electrode outside the glass body. Due to the insulation pocket the glass body may provide an umbrella-like dielectric increasing the minimum necessary way for a high voltage discharge arc to the uncovered part of the first electrode at the proximal end of the shaft. Due to the improved insulation effect by means of the insulation pocket, the height of the shaft of the glass body may be significantly reduced leading to a reduced height of the burner without impairing the insulation of the burner.

Abstract: An apparatus for fastening a burner of a discharge lamp to a housing or plug portion including a sleeve clamped around an outer bulb of the burner, an annular base fastened to the housing or plug portion of the electronic ballast unit having tabs that are orientated in the direction of the center point of the annular base and are biased against the sleeve. The tabs are inclined at an angle through an opening of the base, so that in the mounted condition of the burner, they rest against the sleeve below a surface of the annular base.

Abstract: A lamp (10) for an automotive headlamp and a method for manufacturing such kind of a lamp (10) is provided, wherein the lamp (10) comprises a burner (12) for emitting light, a metal holder (20) connected to the burner (12) for supporting the burner (12), a first socket part (32) made from a heat-resistant plastic material, which is connected to the burner (12), and a second socket part (34), through which a part of the burner (12), which is connected to a first electrical pole (14), is led for connecting the burner (12) to a voltage source, wherein the second socket part (34) is arranged adjacent to the first socket part (32) such, that at least one insulating gap (42) for providing voltage resistance in mainly radial and/or axial direction is provided. Due to the first socket part (32) it is possible to receive the hot burner (12) by the socket without impairing the heat resistance, wherein the second socket part (34) may be made from a cheaper material.

Abstract: It is provided a burner (12) for automotive lamps (10), particularly HID lamps, comprising a discharge vessel (14) for generating light by means of a discharge arc. A first electrode (16) terminates in the discharge vessel (14). A second electrode (18) terminates in the discharge vessel (14) for generating the discharge arc in cooperation with the first electrode (16). A glass body (20) for protecting the discharge vessel (14) is provided. The glass body (20) comprises a shaft (22) for being inserted into a socket (24). The first electrode (16) is led through the shaft (22) out of the glass body (20) in a proximal direction (32) and the second electrode (18) is led spaced to the first electrode (16) outside the shaft (22) in proximal direction (32). The shaft (22) comprises at least one insulation pocket (26) for receiving a rib (36) of the socket (24) and for insulating the first electrode (16) outside the glass body (20).