Abstract: The present invention relates to a method for producing a water-erodible, water-soluble or water-dispersible active-ingredient-administering form, in which, firstly, a film suitable as an oral film-administering form is produced which contains the active ingredient and in which a surface of the film is activated in a subsequent step in order to generate a tacky surface, followed by rolling up the activated film to form a rolled-up laminate. The present invention also relates to rolled-up laminates produced according to this method. Corresponding laminates are very stable, such that they can be dispensed and cut, and are suitable on account of their area density, which is very high by comparison with conventional OTF products, for administering active ingredients which have to be given in larger amounts.

Abstract: A casting mold for producing a casting having a front and a rear side from a curable casting compound, having at least one first mold part with a front mold face that shapes the front side and a second mold part with a rear mold face that shapes the rear side, which mold parts conjointly delimit a casting cavity. Provided on the rear mold face is a first fastening interface and provided on an insert part, by way of which a through hole on the casting is to be formed, is a second fastening interface. The insert part in the case of a closed mold bears on the rear mold face as well as on the front mold face. The two fastening interfaces are releasably connectable to one another in such a manner that, when removing the second mold part from the cured casting, the first fastening interface is automatically released from the second fastening interface.

Abstract: The invention relates to an oral thin film comprising a matrix layer containing at least one polymer, wherein a microneedle system is applied to at least one surface of the oral thin film, a method for preparing such an oral thin film, a composite comprising such a thin film and an application aid, which comprises at least one polymer, for the oral thin film, wherein the oral thin film and the application aid are firmly joined to one another, a method for preparing the oral thin film, a method for preparing the composite, and the oral thin film and the composite for use as a medicinal product.

Abstract: The invention relates to a composite comprising an oral thin film and an application aid for said oral thin film, wherein the oral thin film and the application aid are firmly joined to each other, a method for its preparation, and the composite for use as a medicinal product.

Abstract: The present invention relates to an oral thin film comprising at least one polymer and at least one pharmaceutically active agent, wherein the concentration of the at least one pharmaceutically active agent in the oral thin film is greater than the saturation concentration of the at least one pharmaceutically active agent in the oral thin film, and wherein the oral thin film comprises at least one material which serves as crystal nucleus for the at least one pharmaceutically active agent, to a method for producing said oral thin film, and to the use of said oral thin film as a medicament.

Abstract: The invention relates to amorphous folate salt. The salt consists of a folate anion and an organic cation. The folate anion is selected from the group consisting of 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, (6S)-tetrahydrofolic acid, 5,10-Methylene-(6R)-tetrahydrofolic acid, and its oxidized derivatives JK12A and Mefox, and the cation is an organic compound selected from the group arginine, choline, acetylcholine, 1,1-dimethyl-biguanidin phenylethylbiguanidin, betaine-methylester and dimethylaminoethanol. The cation is an organic compound with a complementary pharmacological activity.

Abstract: A device for mechanical overload protection in a drive train of a machine tool, the drive train having an output side with an output shaft and an input side with a motor shaft. The output shaft is operatively connected to the motor shaft by way of a connector, the device for mechanical overload protection being formed by a press-fit connection between the connector-on the one side and the motor shaft or the output shaft on the other side. A method for producing such a device for mechanical overload protection in a machine tool is also provided. The peak torques in the drive train, which preferably occur for a short time, can be significantly reduced and the machine tool and its mechanical components can be protected from damage in the event of a blockage.

Abstract: Technologies and techniques for a modular instrument panel assembly for vehicle interiors, featuring enhanced mounting and update mechanisms. The assembly includes an outer instrument panel, a support bracket with vertical and horizontal sections, and a mounting bracket for secure attachment to the vehicle's dashboard. The support bracket incorporates multiple attachment points, reinforced ribs, and flanges for structural integrity. Spring-loaded alignment guides and locking mechanisms ensure precise alignment and secure attachment. The modular design allows for easy installation, removal, and customization of electronic and mechanical components.

Abstract: The present invention relates to an oral thin film comprising at least one cellulose derivative and at least one pharmaceutically active agent, the at least one pharmaceutically active agent having a water solubility of at most 50 g/L at 20° C. and a pH of 6 to 7 and being contained in the oral thin film in an amount of at least 20 wt. % in relation to the total weight of the oral thin film, and to a method for production of said oral thin film, and use thereof as a medicament.

Abstract: An example operation may include one or more of executing a first processing element among a sequence of processing elements within a data processing pipeline on input data to generate a first output, transferring the first output and context associated with the first processing element from the first processing element to a second processing element among the sequence of processing elements, within the data processing pipeline, executing the second processing element on the first output and the context to generate a second output, and storing the second output in memory.

Abstract: An example operation may include one or more of executing a first processing element among a sequence of processing elements within a data processing pipeline on input data to generate a first output, transferring the first output and context associated with the first processing element from the first processing element to a second processing element among the sequence of processing elements, within the data processing pipeline, executing the second processing element on the first output and the context to generate a second output, and storing the second output in memory.

Abstract: A device, system, or method for changing the center of gravity of a bicycle, in particular an electric bicycle, to suit the situation, with: an actuator for changing the center of gravity of the bicycle, at least one sensor that monitors the riding status of the bicycle, a control unit which receives and processes data from the sensor, determines a center of gravity of the bicycle adapted to the situation and outputs corresponding control signals to the actuator in order to carry out the change in center of gravity. According to the invention, an adjustment speed of the change in the center of gravity can be adapted to a riding state of the bicycle.

Abstract: The invention relates to a damping apparatus (10) comprising a hollow housing (19) containing a damping fluid, wherein the housing (19) comprises an opening (21), a rod (13) partially inserted through the opening (21) into the hollow housing (19), wherein the rod (13) is guided slidably along a stroke axis (A) relative to the hollow housing (19), and a piston package (16) fixed to an end of the rod (13) residing within the hollow housing (19), wherein the piston package (16) separates an upper chamber (191) of the hollow housing (19) adjacent to the opening (21) from a lower chamber (192) of the hollow housing (19). The rod (13) comprises an inner volume (131) containing a compensation fluid, wherein the inner volume (131) is connected to the lower chamber (192) in a manner conducting the damping fluid. The invention further relates to a solar panel array comprising multiple solar panels and a damping apparatus (10) according to the invention.

Abstract: An apparatus for dispensing a mixture of a diluent and an additive for sanitation, cosmetic or cleaning applications. The apparatus includes a mixing unit for creating a mixture of the diluent and the additive, a diluent supply supplying the diluent to the mixing unit, an additive supply supplying the additive to the mixing unit, an outlet for dispensing the mixture. The diluent supply includes a pump arranged to increase the pressure of the diluent before the diluent enters the mixing unit.

Abstract: The invention relates to crystalline folate salts. The salt consists of a folate anion and an organic cation. The folate anion is 5-methyl-(6S)-tetrahydrofolic acid, and the cation is an organic compound which is an alkanolamine selected from the group consisting of choline, N-methylaminoethanol, 2-amino-2-methylpropanol and 2-dimethylaminoethanol.

Abstract: A universal quantum computing system uses electro-nuclear wavefunctions of rare-earth ions embedded in an insulating solid state matrix. Each rare-earth ion represents a nuclear qubit that can be selectively operated as a passive or active qubit. The passive qubit is a passive electronic doublet at a non-degenerate ground state that stores the quantum information in the two different nuclear spin states possible in the non-degenerate ground state causing two different passive-state electro-nuclear wavefunctions. The active qubit is an active electronic doublet at a non-degenerate excited state that stores the quantum information in the two different nuclear spin states possible in the non-degenerate excited state. A laser source generates laser pulses to optically excite the rare-earth ions from the non-degenerate ground state into the non-degenerate excited state and vice versa, to locally control the electronic dipolar interaction in a tunable manner among at least two active qubits.

Abstract: A fluid damper for modulating a retaining force of a seat belt is provided. The fluid damper includes an outer cylinder and an inner cylinder. The inner cylinder encloses an inner space. The fluid damper includes a piston shiftable in the inner space. The fluid damper includes a duct. The duct conductively connects a front fluid chamber disposed in front of the piston to a rear fluid chamber disposed behind the piston and/or a reservoir for the damping fluid. The duct includes an outer duct portion and an inner duct portion. The inner cylinder is deflectable from a rest position by a force acting on the piston so that the deflection of the inner cylinder causes an adjustment of an overlap of the outer duct portion and the inner duct portion depending on the magnitude of the force.

Abstract: A damping system is provided including at least one fluid damper including a damping volume containing a damping fluid, and a fluid reservoir including a reservoir piston partitioning an inner volume of the fluid reservoir into a damping chamber containing the damping fluid and a recoil chamber containing a recoil fluid. The damping volume of the at least one fluid damper is connected to the damping chamber of the fluid reservoir in a fluid-conducting manner. The reservoir piston is movable in a compression direction increasing a volume of the damping chamber and decreasing a volume of the recoil chamber. The reservoir piston is movable in a dilatation direction decreasing the volume of the damping chamber and increasing the volume of the recoil chamber. The reservoir piston includes a damping chamber surface facing the damping chamber and a recoil chamber surface facing the recoil chamber.

Abstract: A self-regulating damper unit comprising a cylinder having a first working chamber and a second working chamber, a piston, a piston rod, and a through-hole between the first working chamber and the second working chamber. The damper unit also comprises a shiftable weight which modifies a passage cross-section of the through-hole. The shiftable weight is movably mounted such that retardation of the piston causes enlargement of the passage cross-section. A seat belt unit comprises a seat belt and the damper unit.

Abstract: A power semiconductor arrangement has a switching facility, a housing, having a load connection facility for connecting in an electrically conductive manner to an external supply line and having a first plug-in connecting facility for plug-in connecting to an external second plug-in connecting facility. The housing has a first opening through which a connecting facility for connecting the load connection facility and the associated external supply line is accessible. A cover facility for covering the first opening is on the housing so as to be mechanically movable from a first end position into a second end position and has a first locking facility which cooperates with the external second plug-in connecting facility, whereby the first opening is closed with the cover facility as long as it is in its first end position, as long as the external second plug-in connecting facility is inserted into the first plug-in connecting facility.