Abstract: A piston-cylinder assembly includes a cylinder having a cylinder interior filled with a fluid and divided by a piston, which is axially displaceable in cylinder, into a first working space and a second working space. A piston rod is arranged on piston and is guided through second working space and through an end-side second closure in a manner sealed off to the outside at the second end of the cylinder. The retraction stroke of piston and piston rod is restricted by a stop which is arranged in cylinder and against which piston comes to bear directly or indirectly, wherein the axial position of the stop in cylinder is variably adjustable by an adjustment device.

Abstract: A rail brake damper includes a cylinder-piston arrangement. A damping device assigned to the piston comprises at least one damping valve having at least one piston channel, which passes through the piston, connecting the two operating chambers of the cylinder, and a closure element assigned to the piston channel. The closure element is spring pre-loaded with the effect of closing the piston channel and is acted on by the hydraulic pressure which prevails in the operating chamber facing away from the piston rod with the effect of opening the damping valve.

Abstract: A method adjusts parameters of a hearing system which has a hearing aid device and a communication device, which is separate from the hearing aid device. A component for acoustic coupling of the hearing aid device to the ear of a hearing-aid wearer is fitted to the hearing aid device. A camera of the communication device is used to capture at least one image of the component used for acoustic coupling. A product identity of the component is identified from the captured image and acoustic transfer characteristics are assigned to the previously identified component. The parameters of the hearing system are adjusted on the basis of these acoustic transfer characteristics.

Abstract: The invention relates to amorphous folate salt. The salt consists of a folate anion and an organic cation. The folate anion is selected from the group consisting of 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, (6S)-tetrahydrofolic acid, 5,10-Methylene-(6R)-tetrahydrofolic acid, and its oxidized derivatives JK12A and Mefox, and the cation is an organic compound selected from the group arginine, choline, acetylcholine, 1,1-dimethyl-biguanidin and phenylethylbiguanidin. The cation is an organic compound with a complementary pharmacological activity.

Abstract: A turbine has a turbine housing with a receiving region, a turbine wheel which is disposed in the receiving region, a duct formed by the turbine housing, through which exhaust gas of an internal combustion engine can flow and which opens into the receiving region, and a tongue slide which has a tongue which is assigned to the duct and which can be displaced relative to the turbine housing about the rotational axis such that a flow cross section of the duct can be set. The exhaust gas which flows through the duct can be guided via the flow cross section into the receiving region and can be fed to the turbine wheel. The turbine is configured as a half-axial flow turbine in which a respective flow direction runs obliquely with respect to the axial direction and obliquely with respect to the radial direction of the turbine wheel.

Abstract: A nebulizer includes a replaceable container with fluid to be nebulized. The container includes an inseparable indicator device. The container and the indicator device are axially moved during nebulization and tensioning of the nebulizer. The indicator device controls locking of the nebulizer against further use if a predetermined number of uses has been reached or exceeded.

Abstract: A nebulizer is proposed which receives a container with a fluid and an indicator device. The indicator device stops further use of the container in a locked state when a predetermined number of uses has been reached or exceeded. In the locked state, a locking device locks the nebulizer against rotation in a partially tensioned state and, thus, against further use. After replacement of the container including the indicator device, the nebulizer can be used again.

Abstract: The present invention relates to the identification of a genomic integration site for heterologous polynucleotides in Chinese Hamster Ovary (CHO) cells resulting in high RNA and/or protein production. More specifically it relates to CHO cells comprising at least one heterologous polynucleotide stably integrated into the 5100A gene cluster of the CHO genome and to methods for the production of said CHO cells. Further, the invention relates to a method for the production of a protein of interest using said CHO cell and to the use of said CHO cell for producing a protein of interest at high yield. Integration within these specific target regions leads to reliable, stable and high yielding production of an RNA and/or protein of interest, encoded by the heterologous polynucleotide.

Abstract: An apparatus for dispensing a mixture of a diluent and an additive for sanitation, cosmetic or cleaning applications. The apparatus includes a mixing unit for creating a mixture of the diluent and the additive, a diluent supply supplying the diluent to the mixing unit, an additive supply supplying the additive to the mixing unit, an outlet for dispensing the mixture. The diluent supply includes a pump arranged to increase the pressure of the diluent before the diluent enters the mixing unit.

Abstract: Damper includes a housing having proximal and distal ends, a first attachment point proximate the distal end of the housing, a rod having proximal and distal ends at least partially disposed within the housing and moveable relative to the housing between an extended position and a compressed position, a second attachment point proximate the proximal end of the rod, a piston joined to the rod within the housing proximate the distal end of the rod, the piston including a bypass groove having a flow area defined therein to allow fluid to flow from a first side of the piston to an opposing side of the piston, and a first washer disposed proximate a first end of the piston and at least partially covering the flow area of the bypass groove.

Abstract: The invention relates to flat dosage forms that disintegrate or dissolve in an aqueous environment and release at least one active ingredient in a body orifice or body cavity. The inventive dosages are formed from a polymer matrix in the form of a solidified foam having cavities and contain at least one pharmaceutical active ingredient. The inventive dosage forms further have a high mass per unit area in the region of 50 to 350 g/m2. Despite their high mass per unit area and the resulting high active ingredient loading during administration, these dosage forms exhibit a substantially improved mouthfeel in comparison to conventional film dosage forms. The invention also relates to methods for producing a dosage form of this type.

Abstract: A system for preventing and/or extinguishing a fire in an enclosed target area in a vehicle. The system having a central compressed air source for supplying compressed air to a load circuit. A supply of compressed air is provided in a compressed air buffer tank is supplied to a gas separation device from the compressed air buffer tank. A nitrogen-enriched gas mixture is provided at an outlet of the gas separation device, and introduced into the target area. An inlet of the compressed air buffer tank is at least temporarily fluidically connected to an outlet of a central compressed air source, wherein compressed air can be supplied to the compressed air buffer tank. A fluidic connection is provided between the central compressed air source and the compressed air buffer tank if a load circuit is not drawing any compressed air from the central compressed air source.

Abstract: A device for the fine machining of a circumferential workpiece surface arranged eccentrically relative to an axis of a workpiece. The device comprises a pressure mechanism configured to press a fine-machining tool against the circumferential workpiece surface. The device also includes a drive unit configured to drive an active section of the pressure mechanism via a first drive and a second drive. The first drive drives the active section in a movement plane that runs crosswise to the workpiece axis along a first movement trajectory. The second drive drives the active section along a second movement trajectory that is at an angle to the first movement trajectory.

Abstract: A guide vane for a diffuser of a radial compressor which is arranged downstream of a receiving area for a compressor wheel is disclosed. The guide vane has a skeleton line where the skeleton line is elliptical at least in a sub-region.

Abstract: This invention relates to a hearing aid comprising at least one electroacoustic transducer; a signal processing circuitry, configured to receive from the at least an electroacoustic transducer an electrical input signal and/or to provide said at least an electroacoustic transducer with an electrical output signal; and power supply means configured to provide power to the electroacoustic transducer and to said signal processing circuitry; wherein the hearing aid further comprises at least one electroosmotic porous membrane configured to transport liquid and/or vapor outside of the hearing aid, or away from a component thereof.

Abstract: The invention relates to a method for monitoring operating parameters of an actuator (10), wherein the method comprises: providing the actuator (10), providing at least two detection units (26, 28, 30, 32, 34, 36) which are designed to detect different operating parameters of the actuator (10), detecting operating parameters of the actuator (10) via the detection units (26, 28, 30, 32, 34, 36), outputting data relating to the measured operating parameters to an evaluation unit, combining the measured operating parameters into a state information, which indicates whether or not the technical state of the actuator (10) is in a predetermined standard state.

Abstract: This invention relates to a method for the purification of nucleic acids, preferably DNA, from biological samples, comprising the steps (a) optional lysis of said sample, (b) optional heat incubation of said sample, (c) enzymatic digestion of non-nucleic acid components in the product of step (a) or (b), (d) heat inactivation of one or more enzyme(s) used in step (c), (e) transfer of the product of step (d) onto a resin capable of retaining non-nucleic acid components, while the nucleic acids pass through the resin, thereby purifying the nucleic acids.

Abstract: Provided is a method for the production of a nozzle piston for arrangement in a damping space of a damper, which contains a damping fluid, wherein the piston divides the damping space into a first fluid chamber and a second fluid chamber. Also provided is a production method with the method according to the invention for a damper. Also provided is a nozzle piston for arrangement in a damping space of a damper, which contains a damping fluid, wherein the nozzle piston can be obtained by means of ultra-short pulse lasering of the recess from a piston blank. Also provided is a damper having a nozzle piston according to the invention. Also provided is a production plant for the production of a damper having at least one ultra-short pulse laser station for machining a piston blank for the damper by ultra-short pulse lasering.

Abstract: A turbine has a turbine housing with a receiving region, a turbine wheel which is disposed in the receiving region, a duct formed by the turbine housing, through which exhaust gas of an internal combustion engine can flow and which opens into the receiving region, and a tongue slide which has a tongue which is assigned to the duct and which can be displaced relative to the turbine housing about the rotational axis such that a flow cross section of the duct can be set. The exhaust gas which flows through the duct can be guided via the flow cross section into the receiving region and can be fed to the turbine wheel. The turbine is configured as a half-axial flow turbine in which a respective flow direction runs obliquely with respect to the axial direction and obliquely with respect to the radial direction of the turbine wheel.

Abstract: A cutting machine for cutting slices of in particular strand-shaped cutting material includes: a machine housing; a drive motor; a cutting blade, driven in rotation by the drive motor in a cutting plane, for cutting off slices; a stop plate, displaceable parallel to the cutting plane, for setting a desired slice thickness; a carriage, movable back and forth parallel to the cutting plane, having a supporting plate and a bearing wall, the supporting plate and the bearing wall forming a holding device for the cutting material, the carriage including a pivoting device for moving the supporting plate between a starting position and a pivoted-up position, the supporting plate in the starting position and in the pivoted-up position forming a right angle with the cutting plane; and a fixing plate arranged orthogonal to the supporting plate and being rigidly connected to the supporting plate, the fixing plate including a slotted link.