Patents by Inventor Marlon D. Cowart

Marlon D. Cowart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF OSTEOARTHRITIS PAIN
    Publication number: 20100273778
    Abstract: This invention discloses a method of treatment of osteoarthritis pain by administration of a histamine H3 receptor antagonist, described herein, a salt thereof, or a composition comprising such compound or salt.
    Type: Application
    Filed: April 26, 2010
    Publication date: October 28, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Marlon D. Cowart, Gin C. Hsieh, Jorge D. Brioni, James P. Sullivan
  • Fused bicyclic-substituted amines as histamine-3 receptor ligands
    Patent number: 7807697
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: October 5, 2010
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Yi-Yin Ku, Sou-Jen Chang, Dilinie P. Fernando, Timothy A. Grieme, Robert J. Altenbach
  • OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES
    Publication number: 20100222358
    Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
    Type: Application
    Filed: March 2, 2010
    Publication date: September 2, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Marlon D. Cowart, Chen Zhao, Minghua Sun, Lawrence A. Black, Guo Zhu Zheng, Robert J. Gregg, Geoff G.Z. Zhang, Ahmad Y. Sheikh, Xiaochun Lou, Rodger F. Henry, David M. Barnes, Lawrence Kolaczkowski, Anthony R. Haight, Sou-Jen Chang, Steven J. Wittenberger, Michael G. Fickes
  • Octahydro-pyrrolo[3,4-b]pyrrole derivatives
    Patent number: 7728031
    Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands, Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: June 1, 2010
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Chen Zhao, Minghua Sun, Lawrence A. Black, Guo Zhu Zheng, Robert J. Gregg, Lawrence Kolaczkowski
  • AMINO HETEROCYCLIC LINKED PYRIMIDINE DERIVATIVES
    Publication number: 20100016344
    Abstract: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
    Type: Application
    Filed: July 10, 2009
    Publication date: January 21, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Brian D. Wakefield, Robert J. Altenbach, Lawrence A. Black, Marlon D. Cowart, Irene Drizin, Huaqing Liu
  • HETEROARYL-FUSED MACROCYCLIC PYRIMIDINE DERIVATIVES
    Publication number: 20100004256
    Abstract: Heteroaryl-fused macrocyclic 2,4-diaminopyrimidine compounds of formula (I) wherein W, G1, G2, A1 and R1 are defined in the description, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.
    Type: Application
    Filed: May 5, 2009
    Publication date: January 7, 2010
    Applicant: Abbott Laboratories
    Inventors: Huaqing Liu, Irene Drizin, Marlon D. Cowart, Robert J. Altenbach
  • BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES
    Publication number: 20090326222
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Application
    Filed: June 22, 2009
    Publication date: December 31, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Marlon D. Cowart, Minghua Sun, Chen Zhao, Guo Zhu Zheng
  • SUBSTITUTED PYRIMIDINE DERIVATIVES
    Publication number: 20090270364
    Abstract: The present application describes substituted pyrimidine compounds of formula (I) wherein X, A1, R1, R2, R3, R4, R5, R6, R7, R8, R9, p, q, r, v, and w are defined in the specification, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: April 27, 2009
    Publication date: October 29, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Huaqing Liu, Irene Drizin, Marlon D. Cowart, Robert J. Altenbach
  • MACROCYCLIC PYRIMIDINE DERIVATIVES
    Publication number: 20090253678
    Abstract: Macrocyclic pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.
    Type: Application
    Filed: March 27, 2009
    Publication date: October 8, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Huaqing Liu, Irene Drizin, John R. Koenig, Marlon D. Cowart, Chen Zhao, Brian D. Wakefield, Lawrence A. Black, Robert J. Altenbach
  • Macrocyclic Spiro Pyrimidine Derivatives
    Publication number: 20090233904
    Abstract: Macrocyclic spiro pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.
    Type: Application
    Filed: March 10, 2009
    Publication date: September 17, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Huaqing Liu, John R. Koenig, Marlon D. Cowart, Lawrence A. Black
  • CYCLOBUTYL AMINE DERIVATIVES
    Publication number: 20090227593
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Application
    Filed: May 21, 2009
    Publication date: September 10, 2009
    Applicant: Abbott Laboratories
    Inventors: Huaqing Liu, Arthur A. Hancock, Kathryn J. Hancock, Marlon D. Cowart
  • COMPOSITIONS FOR TREATMENT OF COGNITIVE DISORDERS
    Publication number: 20090221648
    Abstract: The present invention relates to compositions for treatment of cognitive deficits. Such compositions can have a nicotinic acetylcholine receptor ligand, of either ?4?2 subtype or ?7 nicotinic acetylcholine subtype, and a histamine-3 receptor ligand, a method of using the same, and a related article of manufacture. Combinations of such active agents with psychostimulants or monoamine reuptake inhibitors also is contemplated.
    Type: Application
    Filed: December 18, 2008
    Publication date: September 3, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Lynne E. Rueter, Gerald B. Fox, Kaitlin E. Browman, James P. Sullivan, Jorge D. Brioni, Marlon D. Cowart, Ramin Faghih, Gregory A. Gfesser, Kathleen H. Mortell, Murali Gopalakrishnan
  • Benzothiazole cyclobutyl amine derivatives
    Patent number: 7576110
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: August 18, 2009
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Minghua Sun, Chen Zhao, Guo Zhu Zheng
  • Cyclobutyl amine derivatives
    Patent number: 7553964
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: June 30, 2009
    Assignee: Abbott Laboratories
    Inventors: Huaqing Liu, Kathryn J. Hancock, legal representative, Marlon D. Cowart, Arthur A. Hancock
  • BENZOTHIAZOLE AND BENZOOXAZOLE DERIVATIVES AND METHODS OF USE
    Publication number: 20090163464
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
    Type: Application
    Filed: December 17, 2008
    Publication date: June 25, 2009
    Applicant: Abbott Laboratories
    Inventors: Lawrence A. Black, Marlon D. Cowart, Gregory A. Gfesser, Brian D. Wakefield, Robert J. Altenbach, Huaqing Liu, Chen Zhao, Gin C. Hsieh
  • Amines as histamine-3 receptor ligands and their therapeutic applications
    Patent number: 7538138
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: May 26, 2009
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Youssef L. Bennani, Ramin Faghih, Gregory A. Gfesser, Lawrence A. Black
  • OCTAHYDRO-PYRROLO[3,4-B]PYRROLE N-OXIDES
    Publication number: 20090105267
    Abstract: The invention relates to octahydro-pyrrolo[3,4-b]pyrrole N-oxides as prodrugs of CNS-active compounds, compositions comprising such compounds, methods for making the compounds, salts, and polymorphs, and methods of treating conditions and disorders using such compounds and compositions. Octahydro-pyrrolo[3,4-b]pyrrole N-oxides of formula (I) are prodrugs of histamine-3 antagonists, and are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole N-oxide compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
    Type: Application
    Filed: September 11, 2008
    Publication date: April 23, 2009
    Applicant: Abbott Laboratories
    Inventors: Marlon D. Cowart, Kennan C. Marsh, Huaqing Liu, Jae Y. Lee, Maria G. Beconi, Jill M. Wetter, Lawrence A. Black, Thomas C. Custer
  • BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS
    Publication number: 20090054420
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Application
    Filed: August 21, 2008
    Publication date: February 26, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Robert J. Altenbach, Lawrence A. Black, Sou-Jen Chang, Marlon D. Cowart, Ramin Faghih, Gregory A. Gfesser, Yi-Yin Ku, Huaqing Liu, Kirill A. Lukin, Diana L. Nersesian, Yu-ming Pu, Padam N. Sharma, Youssef L. Bennani, Michael P. Curtis
  • Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
    Patent number: 7470691
    Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B1 are as described in the specification.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: December 30, 2008
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Steven P. Latshaw, Sherry L. Nelson, Andrew O. Stewart
  • Bicyclic-substituted amines as histamine-3 receptor ligands
    Patent number: 7456196
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: November 25, 2008
    Assignee: Abbott Laboratories
    Inventors: Robert J. Altenbach, Marlon D. Cowart, Huaqing Liu