Patents by Inventor Marlon D. Cowart

Marlon D. Cowart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclopropyl amine derivatives
    Publication number: 20080242653
    Abstract: Compounds of formula (I) wherein R1, R2, R3, R3a, R3b, R4, and R5 are defined in the description, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Application
    Filed: December 14, 2007
    Publication date: October 2, 2008
    Inventors: Huaqing Liu, Lawrence A. Black, Youssef L. Bennani, Marlon D. Cowart, Zhenping Tian, Paul J. Brackemeyer
  • Method for Pain Treatment
    Publication number: 20080194538
    Abstract: This invention discloses a method of treating pain by administering histamine H4 receptor ligands and compositions comprising the same.
    Type: Application
    Filed: September 28, 2007
    Publication date: August 14, 2008
    Inventors: Marlon D. Cowart, Robert J. Altenbach, Huaqing Liu, Irene Drizin, Neil Wishart, David J. Babinski, Robert J. Gregg, Arthur A. Hancock, Timothy A. Esbenshade, Gin C. Hsieh, Jorge D. Brioni, Marie P. Honore, Lawrence A. Black, Chen Zhao, Brian D. Wakefield, Kathryn J. Hancock
  • Macrocyclic Benzofused Pyrimidine Derivatives
    Publication number: 20080188452
    Abstract: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
    Type: Application
    Filed: September 28, 2007
    Publication date: August 7, 2008
    Inventors: Robert J. Altenbach, Huaqing Liu, Irene Drizin, Marlon D. Cowart, Neil Wishart, David J. Babinski, Robert J. Gregg, Arthur A. Hancock, Kathryn J. Hancock, Timothy A. Esbenshade, Gin C. Hsieh, Jorge D. Brioni, Marie P. Honore, Lawrence A. Black, Chen Zhao, Brian D. Wakefield
  • DETERMINATION OF HISTAMINE-3 BIOACTIVITY
    Publication number: 20080159958
    Abstract: The invention relates to an in vivo method for determining the bioactivity of chemical compounds as histamine-3 receptor (H3R) ligands, and provides animal models to determine such bioactivity. The invention further relates to methods for screening therapeutic compounds demonstrating a desired property, using such methods and models described.
    Type: Application
    Filed: December 5, 2007
    Publication date: July 3, 2008
    Applicant: Abbott Laboratories
    Inventors: Richard J. Radek, R. Scott Bitner, Marlon D. Cowart, Jorge D. Brioni, Timothy A. Esbenshade
  • Fused bicyclic-substituted amines as histamine-3 receptor ligands
    Patent number: 7358263
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: April 15, 2008
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Yi-Yin Ku, Sou-Jen Chang, Dilinie P. Fernando
  • Benzimidazoles that are useful in treating sexual dysfunction
    Patent number: 7351828
    Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: April 1, 2008
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Pramila A. Bhatia, Jerome F. Daanen, Andrew O. Stewart, Meena V. Patel, Teodozyj Kolasa, Jorge D. Brioni, Jeffrey Rohde
  • Azacyclosteroid histamine-3 receptor ligands
    Patent number: 7345034
    Abstract: Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: March 18, 2008
    Assignee: Abbott Laboratories
    Inventors: Chen Zhao, Minghua Sun, Marlon D. Cowart, Youssef L. Bennani
  • Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
    Patent number: 7244852
    Abstract: The invention relates to a process for preparing 2-methylpyrrolidine and, more particularly, specific enantiomers of 2-methylpyrrolidine. Novel intermediates also are described.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: July 17, 2007
    Assignee: Abbott Laboratories
    Inventors: Yi-Yin Ku, Marlon D. Cowart, Padam N. Sharma
  • Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
    Patent number: 7235661
    Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B1, are as described in the specification.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: June 26, 2007
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Steven P. Latshaw, Sherry L. Nelson, Andrew O. Stewart
  • Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
    Patent number: 7205316
    Abstract: Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X?, Y, Y?, Z, and Z? are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: April 17, 2007
    Assignee: Abbott Laboratories
    Inventors: Robert J. Altenbach, Lawrence A. Black, Marlon D. Cowart, Huaqing Liu
  • Bicyclic-substituted amines as histamine-3 receptor ligands
    Patent number: 7153889
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: December 26, 2006
    Assignee: Abbott Laboratories
    Inventors: Robert J. Altenbach, Lawrence A. Black, Sou-Jen Chang, Marlon D. Cowart, Ramin Faghih, Gregory A. Gfesser, Yi-Yin Ku, Huaqing Liu, Kirill A. Lukin, Diana L. Nersesian, Yu-ming Pu, Padam N. Sharma, Youssef L. Bennani, Michael P. Curtis
  • Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
    Patent number: 7098222
    Abstract: Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X?, Y, Y?, Z, Z?, R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: August 29, 2006
    Assignee: Abbott Laboratories
    Inventors: Robert J. Altenbach, Lawrence A. Black, Sou-Jen Chang, Marlon D. Cowart, Ramin Faghih, Gregory A. Gfesser, Yi-Yin Ku, Huaqing Liu, Kirill A. Lukin, Diana L. Nersesian, Yu-ming Pu, Michael P. Curtis
  • Fused bicyclic-substituted amines as histamine-3 receptor ligands
    Patent number: 7094790
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: August 22, 2006
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Yi-Yin Ku, Sou-Jen Chang, Dilinie P. Fernando, Timothy A. Grieme, Robert J. Altenbach
  • Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
    Patent number: 7057042
    Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B1 are as described in the specification.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: June 6, 2006
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Steven P. Latshaw, Sherry L. Nelson, Andrew O. Stewart
  • Benzimidazoles that are useful in treating male sexual dysfunction
    Patent number: 7022728
    Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: April 4, 2006
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Pramila A. Bhatia, Jerome F. Daanen, Andrew O. Stewart, Meena V. Patel, Teodozyj Kolasa, Jorge D. Brioni, Jeffrey Rohde
  • Amines as histamine-3 receptor ligands and their therapeutic applications
    Patent number: 6969730
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: November 29, 2005
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Youssef L. Bennani, Ramin Faghih, Gregory A. Gfesser, Lawrence A. Black
  • Benzimidazoles that are useful in treating sexual dysfunction
    Patent number: 6960589
    Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein L is C1-4 alkyl; RA, RB, RC, RD, and RE, are as described in the specification; Z is selected from the group consisting of N, C and CH; and A is aryl and heteroaryl as described in the specification.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: November 1, 2005
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Pramila A. Bhatia, Jerome F. Daanen, Andrew O. Stewart, Meena V. Patel, Teodozyj Kolasa, Jorge D. Brioni, Jeffrey Rohde, Kenneth M. Engstrom
  • Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
    Publication number: 20040260100
    Abstract: The invention relates to a process for preparing 2-methylpyrrolidine and, more particularly, specific enantiomers of 2-methylpyrrolidine. Novel intermediates also are described.
    Type: Application
    Filed: February 27, 2004
    Publication date: December 23, 2004
    Inventors: Yi-Yin Ku, Marlon D. Cowart, Padam N. Sharma
  • Fused bicyclic-substituted amines as histamine-3 receptor ligands
    Publication number: 20040248899
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: April 30, 2004
    Publication date: December 9, 2004
    Inventors: Marlon D. Cowart, Yi-Yin Ku, Sou-Jen Chang, Dilinie P. Fernando, Timothy A. Grieme, Robert J. Altenbach
  • Process for preparing amine-substituted benzofurans
    Patent number: 6822101
    Abstract: The present invention relates to processes for preparing amine substituted benzofurans, and more particularly 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile, and salts thereof. Compounds prepared by the processes of the invention have demonstrated activity as histamine-3 receptor ligands.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: November 23, 2004
    Assignee: Abbott Laboratories
    Inventors: Yi-Yin Ku, Yu-Ming Pu, Marlon D. Cowart, Timothy A. Grieme, Ashok K. Gupta, Daniel J. Plata