Abstract: A method for the detection of the presence of or the risk of cancer in a patient, comprising, with reference to a normal control, the step of: (i) detecting the expression level of a gene characterised by any of the nucleotide sequences identified herein as SEQ ID No. 1 to SEQ ID No. 10, in a sample isolated from a patient, wherein an increased expression level of the gene characterised by any of SEQ ID Nos. 1 to 6 and 10, or a decreased expression level of the gene characterised by any of SEQ ID Nos. 7 to 9, indicates the presence of or the risk of cancer in the patient from whom the sample was isolated.

Abstract: A strain-responsive visual indicator comprises a pair of overlapping shutter strips (1, 2) adapted to be mounted to a substrate such that strain in the substrate causes relative movement M between them. Each shutter strip comprises an alternating set of windows (5) or (6) and bars (7) or (8) and the distal strip (2) is backed by a strip (3) of a different colour exposed through its windows (6), or the distal strip can instead be printed with a set of alternating colours in place of its windows and bars. The effect is that under different strain conditions different colour indications from the distal strip (2) will be visible through the windows (5) of the proximal strip (1), in accordance with the relative positions of the two strips. The indicator can be incorporated e.g. in the shaft of a toothbrush to give a visual warning in response to flexure of the shaft if excessive brushing pressure is applied. Numerous other applications and the use of different types of indicia are indicated in the specification.

Abstract: An artificial amorphous semiconductor material, and a junction made from the material, has a plurality of crystalline semiconductor material quantum dots substantially uniformly distributed and regularly spaced in three dimensions through a matrix of dielectric material or thin layers of dielectric materials. The material is formed by first forming a plurality of layers of dielectric material comprising a compound of a semiconducting material, and forming alternating layers as layers of stoichiometric dielectric material and layers of semiconductor rich dielectric material respectively. The material is then heated causing quantum dots to form in the semiconductor rich layers of dielectric material in a uniform and regularly spaced distribution in three dimensions through the dielectric material.

Abstract: A vehicle includes at least one reconfigurable system having a plurality of selectively variable parameters, and a controller that is operatively connected to the at least one reconfigurable system to control the values of the plurality of selectively variable parameters. The controller is also configured to receive data indicative of physical characteristics of a person from at least one data storage medium, and configured to determine values of the selectively variable parameters according to a predetermined algorithm based on the data indicative of physical characteristics of a person. The controller is also configured to cause the selectively variable parameters to assume the determined values.

Abstract: An apparatus useful for electrostatic deposition (ESD) of aerosol particles and methods of depositing the aerosol particles onto a substrate are disclosed. The ESD apparatus and the method of the present invention are useful for electrostatically depositing nanoparticles produced by gas-phase synthesis onto a substrate where the velocity of the flow of aerosol can be controlled.

Abstract: A system useful for electrostatic deposition (ESD) of aerosol particles and methods of depositing the aerosol particles onto a substrate are disclosed. The ESD system and the method of the present invention are useful for electrostatically depositing nanoparticles produced by gas-phase synthesis, using an induction particle generator, onto a substrate. Direct current may be used with minimized corona leakage in the system, which would otherwise be damaging to the induction particle generator.

Abstract: The present invention relates generally to an apparatus for small particle and nanoparticle synthesis. A durable particle generator capable of high temperature particle synthesis is disclosed. The particle generator is configured as to minimize susceptor degradation associated with harsh reaction conditions.

Abstract: The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides are derived from a C-terminal region of p21 and display selectivity for cyclin/CDK2 inhibition over cyclin/CDK4 inhibition. Variants of such peptides particularly involving certain alanine replacements are shown to be particularly potent.

Abstract: The present invention relates to a compound of formula I, or a variant thereof, A-(B)m-C-(D)n-E??(I) wherein m and n are each independently 0 or 1 and A, B, C, D and E are each independently linked to the respective adjacent residue by a linker group independently selected from carboxamide, reduced carboxamide, sulfonamide, imine, semicarbazone, oxime and ethanolamine; A is (i) a natural or unnatural amino acid residue having a side chain comprising at least one H-bond acceptor moiety and at least one H-bond donor moiety, or a derivative thereof; or (ii) R(CO), wherein R is a C1-C24 hydrocarbyl group comprising at least one H-bond acceptor moiety and optionally one or more H-bond donor moieties, and where R optionally contains one or more heteroatoms selected from S, O, and N, and is optionally substituted by one or more substituents selected from halogen, OMe, CN, CF3, and NO2; each of B and D is independently an amino acid residue selected from arginine, 4-(guanidinyl)phenylalanine (4-(Gu)Phe), piperidi

Abstract: A method of manufacturing a Coriolis flowmeter for the measurement of a process material requiring an ultra high level of purity. This is achieved by forming the entire flow path of the Coriolis flow meter from a PFA plastic material that does not transfer ions from the Coriolis flowmeter to the process material flowing through the flowmeter.

Abstract: A flow meter pickoff assembly for nulling a flow meter zero offset is provided. The flow meter pickoff assembly includes a mounting device affixed to a first flow meter portion of a flow meter and a first pickoff sensor half adjustably affixed to the mounting device and configured to interact with a second pickoff sensor half affixed to a second flow meter portion. At least one relative angle of the first pickoff sensor half in relation to the second pickoff sensor half can be adjusted by adjusting the first pickoff sensor half to the mounting device according to at least one adjustment axis. The flow meter pickoff assembly further includes an adjustment means for enabling the first pickoff sensor half to adjust with respect to the mounting device along the at least one adjustment axis in order to adjust the at least one relative angle.

Abstract: The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides are derived from a C-terminal region of p21 and display selectivity for cyclin/CDK2 inhibition over cyclin/CDK4 inhibition. Variants of such peptides particularly involving certain alanine replacements are shown to be particularly potent.

Abstract: The present invention provides methods for treating sinus-evoked headaches using botulinum toxin injected or applied in multiple subcutaneous locations over divisions of the trigeminal nerve in soft tissues and dermatomes overlying the corresponding effected sinuses implicated in the etiology of the pain.

Abstract: A Coriolis flowmeter for the measurement of a process material requiring an ultra high level of purity. This is achieved by forming the entire Coriolis flowmeter of a PFA plastic material that does not transfer ions from the Coriolis flowmeter to the process material flowing through the flowmeter.

Abstract: A method of crystallizing amorphous silicon on a glass substrate relies on deliberately heating the glass substrate above its strain point during processing, making low temperature glasses, such as soda lime glasses, ideal for such use. Since the glass is plastic above this temperature while the silicon remains elastic, the glass is forced to conform to the shape defined by the silicon once this temperature is exceeded. This process relaxes any stresses which might otherwise be created in the glass or film, as long as the glass temperature is above the strain point. As the glass temperature is reduced back below the strain point, the glass becomes progressively more rigid and stresses will begin to build up in the film and glass. When cooled slowly, the stress in the film and the glass can be controlled by appropriate selection of a thermal expansion coefficient of the glass relative to that of silicon, particularly those with linear expansion coefficients in the range 4-10 ppm/° C.

Abstract: A device (30) for treating aneurysms comprises a bag (31) removably attached to the distal end of a catheter (14), the bag being arranged to be inserted in an aneurysm (20) and being of flexible and stretchable material and being permeable to blood components. Once the bag is inserted, individual GD coils (18) are introduced therein. The bag is inserted by a shoulder (42) or a widened portion (50) of a guide wire (40) engaging a marker ring (46). The bag material may encourage clotting. In another embodiment the bag (131) is located around the end of the catheter (114) during insertion. When insertion is completed, electrolysable struts (32, 172) are removed to separate the bag from the catheter.

Abstract: A method of publishing information on the Internet, includes the step of a publishing service provider establishing an Internet publishing site. A person who wishes to publish information accesses the Internet publishing site and registers as a client. During the registration process, the client chooses: (a) to provide details of the client's existing Internet site; and/or (b) to request the publishing service provided to provide an Internet site for the client, or (c) not to utilize a “traditional” Internet web site. The information to be published is transferred from the client to the Internet publishing site. Software on the Internet publishing site automatically converts the information into a content item in a format suitable for placing on an Internet site, automatically allocates a URL (uniform resource locater) to the content item, and automatically enables the content item to be visible on the Internet.

Abstract: A Coriolis flowmeter for the measurement of a process material requiring an ultra high level of purity. This is achieved by forming the entire Coriolis flowmeter of a PFA plastic material that does not transfer ions from the Coriolis flowmeter to the process material flowing through the flowmeter.

Abstract: A method of manufacturing a Coriolis flowmeter for the measurement of a process material requiring an ultra high level of purity. This is achieved by forming the entire flow path of the Coriolis flow meter from a PFA plastic material that does not transfer ions from the Coriolis flowmeter to the process material flowing through the flowmeter.

Abstract: A thin film silicon solar cell is provided on a glass substrate, the glass having a textured surface, including larger scale surface features and smaller scale surface features. Over the surface is deposited a thin barrier layer which also serves as an anti-reflection coating. The barrier layer may be a silicon nitride layer for example and will be 70 nm±20% in order to best achieve its anti-reflection function. Over the barrier layer is formed an essentially conformal silicon film having a thickness which is less than the dimensions of the larger scale features of the glass surface and of a similar dimension to the smaller scale features of the glass surface.