Abstract: The present invention relates to compounds that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with MALT1.

Abstract: Systems and methods for publication and external interfacing for a unified document surface are disclosed. An example system may include a document serving circuit structured to access a document data, the document data comprising data for a unified document surface, and provide at least a portion of the document data to a client serving circuit. The client serving circuit may be structured to implement a unified document surface interface in response to the at least a portion of the document data, implement an extension creation interface, provide a pack implementation value to the document serving circuit in response to user interactions with the extension creation interface, and determine an executable object in response to the pack implementation value.

Abstract: A method at an electronic device with a display includes: displaying a user interface having a first region and a second region; receiving, and displaying in the first region of the user interface, a live video stream of a physical environment captured by a remote video camera; displaying, in the second region, a timeline corresponding to a timespan for a first portion of a duration during which the live video stream may have been recorded; in response to receiving a user interaction to move the timespan to a second portion of the duration, transitioning the displayed timeline to a new timeline that corresponds to the timespan for the second portion, and while transitioning, displaying, in the first region, a subset of video frames representing the first and/or second portion of the duration.

Abstract: A manually operated pump exhibiting numerous improvement over existing such 5 pumps is described. The pump can include a cylinder that is removeably mounted to a molded valve box of unitary construction. The valve box can feature a valve plate covering a valve chamber and housing an inlet valve and an outlet valve. In some instances, the pump includes a molded piston of unitary construction to which a pair of opposing piston cups is mounted. In some cases, the pump includes a filler cap forming an inlet adapted to deliver a priming fluid 10 into the cylinder. In some cases, the pump includes a stopper cap adapted to prevent a pump shaft from being fully pulled out of the cylinder.

Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.

Abstract: A method of treating polyester during the laundry process, wherein a fabric conditioner composition comprising: a) 2 to 30 wt. % quaternary ammonium compound; and b) natural oil; is added to the rinse stage of the laundry process.

Abstract: Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. Also provided are derivative cells having stable and functional genome editing that delivers improved or enhanced therapeutic effects. Also provided are therapeutic compositions and the use thereof comprising the functionally enhanced derivative effector cells alone, or with antibodies or checkpoint inhibitors in combination therapies.

Abstract: A method of producing a compound formula (I) the method comprising: reacting a compound of formula (II) with a compound of formula (III) wherein, R3 is hydrogen or halogen; R1 and R2 are each independently C1-C6alkoxy, or R1 and R2 together are ?O or —OCH2CH2O— or —OCH2CH2CH2O—; and optionally whereby the reaction is carried out in the presence of an oxidizer.

Abstract: Systems and methods for publication and external interfacing for a unified document surface are disclosed. An example system may include a document serving circuit structured to access a document data, the document data including data for a unified document surface, and to provide at least a portion of the document data to a client serving circuit; the client serving circuit structured to implement a unified document surface interface in response to the at least a portion of the document data; the client serving circuit further structured to implement an extension creation interface, and to provide a pack implementation value to the document serving circuit in response to user interactions with the extension creation interface; and wherein the document serving circuit is further structured to determine a pack definition value in response to the pack implementation value.

Abstract: A compound: and double bond regioisomers thereof.

Abstract: A benefit agent delivery particle comprising a core-shell structure in which a shell entraps a core containing benefit agent, wherein said shell comprises polyester.

Abstract: An ancillary laundry composition comprising an ester oil, which is a polyol comprising at least two ester linkages, free perfume and 0 to 0.85 wt. % anionic and/or cationic surfactant. A method of laundering clothes, wherein said composition is added in the wash or rinse stage. A method of preventing colour fade over (10) laundry cycles, wherein fabrics are treated with said composition during each consecutive laundry cycle. The use of said composition to provide an improved colour maintenance or reduced colour fade over consecutive laundry cycles, preferably (10), more preferably (5) laundry cycles.

Abstract: An aqueous fabric spray composition comprising: an ester oil; and free perfume.

Abstract: A method of preventing or reducing colour fade of fabrics over multiple laundry cycles wherein a composition comprising fabric softening active, pentaerythritol ester oil and perfume is used during the rinse stage of the laundry process. Method of preparing the composition.

Abstract: A benefit agent delivery particle comprising a core-shell structure in which a shell of polymeric material entraps a core containing benefit agent, wherein said benefit agent comprises an ester oil.

Abstract: An ancillary laundry composition comprising 0.25 to 10 wt. % ester oil, free perfume and 0 to 4 wt. % anionic and/or cationic surfactant. A method of laundering clothes, wherein said composition is added in the wash or rinse stage. A method of preventing colour fade over (10) laundry cycles, wherein fabrics are treated with said composition during each consecutive laundry cycle. Use of said composition to provide an improved colour maintenance or reduced colour fade over consecutive laundry cycles, preferably (10), more preferably (5) laundry cycles.

Abstract: Method for softening knitted cotton, wherein knitted cotton is treated with an ancillary laundry composition comprising: a. Soil release polymer b. Silicone c. less than 4 w.t. % surfactant; and d. Water wherein the method comprises delivering the ancillary laundry composition into the wash or rise stage and comprises the steps of: a. Pouring a laundry product into a washing receptacle, a washing machine drawer, or a dosing shuttle b. Pouring the ancillary laundry composition on top of the laundry product. Use of the method for softening knitted cotton.

Abstract: Systems and methods include a document serving circuit structured to access a document data, the document data comprising data for a unified document surface, and to provide at least a portion of the document data to a client serving circuit. The client serving circuit is structured to implement a unified document surface interface in response to the at least a portion of the document data, implement an extension creation interface, and to provide a pack implementation value to the document serving circuit in response to user interactions with the extension creation interface. The document serving circuit is further structured to determine a pack definition value in response to the pack implementation value.

Abstract: An example system may include a document snapshot circuit structured to generate a document snapshot configured to capture a state of a document at a time marker and a document sharding circuit structured to analyze the document snapshot, and generate a first plurality of shard documents capturing the state of the document at the time marker. The system may include a document serving circuit structured to access the first plurality of shard documents, and provide at least a subset of the first plurality of shard documents to a client serving circuit structured to implement a unified document surface interface in response to the at least a subset of the first plurality of shard documents. The document serving circuit is configured to provide the subset of the first plurality of shard documents in an order determined to prioritize shards related to a last accessed location of the document.