Abstract: Bile salts are steroid acids derived from cholesterol in the liver, are released into the gastrointestinal tract to aid in digestion and are thoroughly modified by the resident gut microbiota. Bile acids act as versatile signaling molecules with a variety of endocrine functions and are linked to several diseases. In particular, serum and urinary bile salts represent biomarkers for early diagnostics of liver dysfunction, yet their current detection methods are impractical and hard to scale. Here the inventors engineered engineered synthetic bile salt receptors using TcpP as sensing domains connected to E. coli CadC system which activates transcription upon dimerization. The performance of the system was assayed for various selection of promoters and they can show that fine tunable response that may be reached by changing expression levels of the bile salt receptor.

Abstract: The present invention relates to N-(3-(5-(pyrimidin-4-yl)thiazol-4-yl)phenylsulfonamide compounds which are useful as inhibitors of protein kinases, more specifically BRAF or mutant forms thereof, to pharmaceutical composition comprising such compounds, and to uses of such compounds in the treatment or prevention of diseases associated with deregulated protein kinase activity, such as cancer.

Abstract: The present disclosure is generally directed to methods of tracking stocked inventory, such as products or other items stocked on a store shelf or other storage space. The disclosure is also directed to devices and systems that may be utilized to carry out such methods.

Abstract: Apparatus, systems and methods for identifying products are described herein.

Abstract: The present disclosure is generally directed to methods of tracking stocked inventory, such as products or other items stocked on a store shelf or other storage space. The disclosure is also directed to devices and systems that may be utilized to carry out such methods.

Abstract: A method of reading and quantifying pressure points or bumps or a product outline to extract a pattern that, when decoded, uniquely defines a product or class of products by defining the theoretical centers of applied pressure, determining the spatial relationship between more than one center or a product outline to define which pattern belongs to which product, and correlating each pattern with templates of stored patterns to determine what product is represented by each respective pattern.

Abstract: The present disclosure is generally directed to methods of tracking stocked inventory, such as products or other items stocked on a store shelf or other storage space. The disclosure is also directed to devices and systems that may be utilized to carry out such methods.

Abstract: A system for managing application performance performs a learning phase and a monitoring phase. One embodiment of the learning phase comprises monitoring performance of multiple components of a software system to create first monitored component data for the multiple components and automatically identifying correlation between the components and a performance metric based on the first monitored data. The monitoring phase comprises monitoring performance of the multiple components of the software system to create second monitored component data for the multiple components, using the identified correlation to predict the performance metric, calculating the actual performance metric based on the second monitored component data, and reporting a performance problem if the actual performance metric differs from the predicted performance metric by more than a threshold.

Abstract: A synthesis process for making a benzoxazine compound containing at least one benzoxazine unit from aromatic amine containing at least one primary amino group, at least one phenolic compound with at least one ortho-hydrogen, and alkyl formcel. In one embodiment, the aromatic amine is reacted with alkyl formcel to generate an alkoxymethyl intermediate compound. Subsequently, the intermediate compound is reacted with a phenol to generate the benzoxazine compound. In another embodiment, the benzoxazine compound is formed by reacting aromatic amine with alkyl formcel and phenol in one reaction step. Also disclosed is a method for isolating the alkoxymethyl compound formed by reacting aromatic amine with alkyl formcel. The isolated alkoxymethyl compound is useful as a reactant in a subsequent reaction.

Abstract: A synthesis process for making a benzoxazine compound containing at least one benzoxazine unit from aromatic amine containing at least one primary amino group, at least one phenolic compound with at least one ortho-hydrogen, and alkyl formcel. In one embodiment, the aromatic amine is reacted with alkyl formcel to generate an alkoxymethyl intermediate compound. Subsequently, the intermediate compound is reacted with a phenol to generate the benzoxazine compound. In another embodiment, the benzoxazine compound is formed by reacting aromatic amine with alkyl formcel and phenol in one reaction step. Also disclosed is a method for isolating the alkoxymethyl compound formed by reacting aromatic amine with alkyl formcel. The isolated alkoxymethyl compound is useful as a reactant in a subsequent reaction.

Abstract: A method of reading and quantifying pressure points or bumps or a product outline to extract a pattern that, when decoded, uniquely defines a product or class of products by defining the theoretical centers of applied pressure, determining the spatial relationship between more than one center or a product outline to define which pattern belongs to which product, and correlating each pattern with templates of stored patterns to determine what product is represented by each respective pattern.

Abstract: Systems and methods for identifying one or more objects hung from a display peg are described herein. The system may include a display peg comprising a first and second electrically conductive terminal. An object comprising a resistive element may be hung from the display peg such that the resistive element is in electrical communication with the terminals. A source may be configured to provide a current that flows from the first terminal through the resistive element to the second terminal. An electronic device may be configured to detect the electrical current flowing from the second terminal. The system may be configured to identify the type of object depending on the detected electrical current.

Abstract: Apparatus, systems and methods for identifying products are described herein.

Abstract: A sanitizing product creation system employing electricity to produce products useful for sanitizing and disinfecting surfaces.

Abstract: A system for managing application performance performs a learning phase and a monitoring phase. One embodiment of the learning phase comprises monitoring performance of multiple components of a software system to create first monitored component data for the multiple components and automatically identifying correlation between the components and a performance metric based on the first monitored data. The monitoring phase comprises monitoring performance of the multiple components of the software system to create second monitored component data for the multiple components, using the identified correlation to predict the performance metric, calculating the actual performance metric based on the second monitored component data, and reporting a performance problem if the actual performance metric differs from the predicted performance metric by more than a threshold.

Abstract: The present disclosure is generally directed to methods of tracking stocked inventory, such as products or other items stocked on a store shelf or other storage space. The disclosure is also directed to devices and systems that may be utilized to carry out such methods.

Abstract: Input devices, particularly devices for entering data within three-dimensional space and converting that data into one or more commands, are provided.

Abstract: A synthesis process for making a benzoxazine compound containing at least one benzoxazine unit from aromatic amine containing at least one primary amino group, at least one phenolic compound with at least one ortho-hydrogen, and alkyl formcel. In one embodiment, the aromatic amine is reacted with alkyl formcel to generate an alkoxymethyl intermediate compound. Subsequently, the intermediate compound is reacted with a phenol to generate the benzoxazine compound. In another embodiment, the benzoxazine compound is formed by reacting aromatic amine with alkyl formcel and phenol in one reaction step. Also disclosed is a method for isolating the alkoxymethyl compound formed by reacting aromatic amine with alkyl formcel. The isolated alkoxymethyl compound is useful as a reactant in a subsequent reaction.

Abstract: An electronic device is provided. The electronic device may include components. The components may include a power source, a processor, a memory, circuitry, an input/output unit, a display unit configured to display data and/or color, and a communication unit configured to transmit and/or receive data. The electronic device may include a conductive material connecting at least two of the components to each other. At least a portion of the electronic device may be formed in one or more layers of a printed substrate, and/or at least one of the components may be formed from a conductive ink.

Abstract: Input devices for sensing and transmitting digital information imparted by human touch are generally described. The input devices may be one-dimensional or two-dimensional input devices for entering data from a flat surface. Associated systems and methods are also described.