Patents by Inventor Martin Davies
Martin Davies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030143591Abstract: The invention comprises novel methods and strategies to detect and/or quantify nucleic acid analytes. The methods involve nucleic acid probes with covalently conjugated dyes, which are attached either at adjacent nucleotides or at the same nucleotide of the probe and novel linker molecules to attach the dyes to the probes. The nucleic acid probes generate a fluorescent signal upon hybridization to complementary nucleic acids based on the interaction of one of the attached dyes, which is either an intercalator or a DNA groove binder, with the formed double stranded DNA. The methods can be applied to a variety of applications including homogeneous assays, real-time PCR monitoring, transcription assays, expression analysis on nucleic acid microarrays and other microarray applications such as genotyping (SNP analysis). The methods further include pH-sensitive nucleic acid probes that provide switchable fluorescence signals that are triggered by a change in the pH of the medium.Type: ApplicationFiled: October 21, 2002Publication date: July 31, 2003Applicant: PROLIGO, LLCInventors: Martin Davies, Ian Bruce, Andreas Wolter
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Patent number: 6599908Abstract: Fused polycyclic 2-aminopyrimidines of formula (1): wherein Ar is an optionally substituted aromatic or heteroaromatic group; X is a carbon or nitrogen atom; Y is a carbon or nitrogen atom; Z is a linker group; A together with X and Y forms an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof are described. The compounds are potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate p56lck and/or p59fyn activity is believed to have a role.Type: GrantFiled: March 2, 2000Date of Patent: July 29, 2003Assignee: Celltech R & D LimitedInventors: Jeremy Martin Davis, Peter David Davis, David Festus Charles Moffat, Mark James Batchelor
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Patent number: 6600037Abstract: Pyrimidines of formla (1) are described: wherein R1 is a —XR6 group; R2 and R3 which may be the same or different is each a hydrogen or halogen atom or a group selected from an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, —OH, —OR10 [where R10 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group] —SH, —NO2, —CN, —SR10, —COR10, S(O)R10, —SO2R8, —SO2N(R8)(R9), —CO2R8, —CON(R8)(R9), —CSN(R8)(R9), —NH2 or substituted amino group; R4 is a X1R11 group where X1 is a covalent bond or a —C(R12)(R13)— [where each of R12 and R13 is a hydrogen or halogen atom or a hydroxyl, alkyl or haloalkyl group] or —C(O)— group and R11 is an optionally substituted phenyl, thienyl, thiazolyl or indolyl group; R5 is a halogen atom or an alkynyl group; and the salts, solvType: GrantFiled: October 19, 2000Date of Patent: July 29, 2003Assignee: Celltech R & D LimitedInventors: Jeremy Martin Davis, David Festus Charles Moffat
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Patent number: 6594588Abstract: A system and method for handling laboratory information includes a graphical user interface with a plurality of windows. A palette of icons is provided in a first one of the windows, each icon representing a predetermined task to be executed by a processor in communication with the graphical user interface. The processor is also in communication with a database containing static laboratory data (such as the type of sample to be analysed) as well as dynamic laboratory data (such as the name of the specific sample to be tested and the results of that test). A user can select icons from the first window and “drag and drop” them into a second window. A sequence of tasks may thus be built up, in the form of a tree structure, and when run the processor executes the sequence of tasks in turn by reference to the static and dynamic laboratory data.Type: GrantFiled: May 7, 2001Date of Patent: July 15, 2003Assignee: Thermo Bio Analysis Corp.Inventors: Joseph Martin Peden, Morgan Nicholas Skinner, Robin Dylan Jones, Andrew Martin Davis, Philip Ian Holt, Graham Stuart Taylor
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Patent number: 6579983Abstract: Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R1 is a hydrogen atom or a straight or branched chain alkyl group; R2 is a —X1—R3 group where X1 is a direct bond or a linker atom or group, and R3 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR Kinase and/or FGFr Kinase inhibitors and are of use in the prophylaxis and treatment of disease states assoicated with angiogenesis.Type: GrantFiled: June 16, 2000Date of Patent: June 17, 2003Assignee: Celltech R&D LimitedInventors: Mark James Batchelor, David Festus Charles Moffat, Jeremy Martin Davis, Martin Clive Hutchings
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Patent number: 6550558Abstract: A method of mounting a radiator onto a support member in a vehicle includes the steps of securing to the radiator a resilient mounting bush having a first annular groove in its outer surface, providing a second annular groove in the inner surface of a radiator mounting bore formed in the support member, positioning a spring clip in one of the two annular grooves and inserting the bush into the bore, the spring clip being compressed radially during insertion of the bush into the bore and being released when the annular grooves are axially aligned with one another to lock the bush within the bore.Type: GrantFiled: September 18, 2001Date of Patent: April 22, 2003Assignee: New Holland North America, Inc.Inventors: Graeme J. Yorwarth, William P. Starkey, Martin Davies
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Publication number: 20020147339Abstract: Pyrimidines of formula (1) are described 1Type: ApplicationFiled: May 20, 2002Publication date: October 10, 2002Inventors: Mark James Batchelor, David Festus Charles Moffat, Jeremy Martin Davis, Martin Clive Hutchings
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Publication number: 20020079150Abstract: A method of mounting a radiator onto a support member in a vehicle comprises the steps of securing to the radiator a resilient mounting bush having a first annular groove in its outer surface, providing a second annular groove in the inner surface of a radiator mounting bore formed in the support member, positioning a spring clip in one of the two annular grooves and inserting the bush into the bore, the spring clip being compressed radially during insertion of the bush into the bore and being released when the annular grooves are axially aligned with one another to lock the bush within the bore.Type: ApplicationFiled: September 18, 2001Publication date: June 27, 2002Inventors: Graeme J. Yorwarth, William P. Starkey, Martin Davies
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Patent number: 6329196Abstract: A biological process is enhanced by a method and apparatus used to contact a biomass with a gas and with a nutrient liquid. A resiliently compressible porous matrix system containing the biomass is mounted in a reaction vessel containing a body of the nutrient liquid and a body of the gas above the body of the liquid. The body of liquid having an upper surface exposed to the body of gas and defining a liquid-gas interface. The resiliently compressible porous matrix system is located in a position in the reaction vessel so that compressible porous matrix system is partly immersed in the nutrient liquid and partly extends above the upper surface of the liquid into the body of gas.Type: GrantFiled: May 26, 1999Date of Patent: December 11, 2001Inventors: William Nevil Heaton Johnson, Martin Davies, Charles Joseph Banks
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Publication number: 20010011367Abstract: A machine control system (130) includes a computer (132) that generates, edits and displays a continuous multi-block flowchart representing a program and compiles the program from the flowchart to control the operations of a machine (140). The system (130) also includes a debugger (146) for displaying the flowchart in a debugger window (170) for runtime execution control of the program.Type: ApplicationFiled: March 20, 2001Publication date: August 2, 2001Inventors: Frank G. Logan, Kenneth W. Bunch, Teddy Martin Davis, Jeffrey M. Achesinski
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Patent number: 6243857Abstract: A machine control system (130) includes a computer (132) that generates, edits and displays a continuous multi-block flowchart representing a program and compiles the program from the flowchart to control the operations of a machine (140). The system (130) also includes a debugger (146) for displaying the flowchart in a debugger window (170) for runtime execution control of the program.Type: GrantFiled: February 17, 1998Date of Patent: June 5, 2001Assignee: NemaSoft, Inc.Inventors: Frank G. Logan, III, Kenneth W. Bunch, Teddy Martin Davis, Jeffrey M. Achesinski
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Patent number: 6235746Abstract: Compounds of general formula (1) are described: wherein R1 is a hydrogen or halogen atom or an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group or a group selected from hydroxyl (—OH), substituted hydroxyl, thiol (—SH), substituted thiol, amino (—NH2), or substituted amino; R2 and R3, which may be the same or different, is each an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; R4 is a hydrogen atom or a straight or branched chain alkyl group; R5 is a hydrogen atom or an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; R6 is a hydrogen or halogen atom or an amino (—NH2), substituted amino, nitro, carboxyl (—CO2H) or esterified carboxyl group or a group —X1—R6a where X1 is a direct bond or a linker atom or group and R6a is an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; X is a direct bond or a linker atom orType: GrantFiled: February 16, 1999Date of Patent: May 22, 2001Assignee: Celltech Therapeutics, LimitedInventors: Peter David Davis, David Festus Charles Moffat, Jeremy Martin Davis, Martin Clive Hutchings
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Patent number: 6133257Abstract: Fused polycyclic 2-aminopyrimidines of formula (1) are described: whereinR.sup.1 is a group --L.sup.1 R.sup.2 where L.sup.1 is a covalent bond or a linker atom or group and R.sup.2 is a group --(Alk).sub.m L.sup.2 R.sup.3 where Alk is an optionally substituted aliphatic or heteroaliphatic chain, m is zero or the integer 1, L.sup.2 is a covalent bond or a linker atom or group and R.sup.3 is an optionally substituted cycloaliphatic or heterocycloaliphatic group provided that when m is zeroL.sup.2 is a covalent bond;Ar is an aryl or heteroaryl group;X is a carbon or nitrogen atom;Y is a carbon or nitrogen atom;Z is a linker group;A together with X and Y forms an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group;and the salts, solvates, hydrates and N-oxides thereof.Type: GrantFiled: June 18, 1998Date of Patent: October 17, 2000Assignee: Celltech Therapeutics LimitedInventors: Mark James Batchelor, Jeremy Martin Davis, David Festus Charles Moffat, Peter David Davis
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Patent number: 6057329Abstract: Fused polycyclic 2-aminopyrimidines of formula (1): ##STR1## wherein Ar is an optionally substituted aromatic or heteroaromatic group;X is a carbon or nitrogen atom;Y is a carbon or nitrogen atom;Z is a linker group;A together with X and Y forms an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group;and the salts, solvates, hydrates and N-oxides thereof are described. The compounds are potent and selective inhibitors of the protein tyrosine kinases p56.sup.lck and p59.sup.fyn and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate p56.sup.lck and/or p59.sup.fyn activity is believed to have a role.Type: GrantFiled: December 22, 1997Date of Patent: May 2, 2000Assignee: Celltech Therapeutics LimitedInventors: Jeremy Martin Davis, Peter David Davis, David Festus Charles Moffat, Mark James Batchelor
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Patent number: 5971320Abstract: A model helicopter creates lift using rotor propellers mounted to the rotor arms of a gyroscopic rotor assembly. A controller converts front-back, and left-right inputs into speed control signals used to vary the speeds of the rotor propellers at selected positions of the rotor assembly as it rotates. The varying speed of the rotor propellers at selected rotor positions produces thrust vectors at those positions. The resultant thrust vector determines the direction of the helicopter's flight and enables it to pitch and roll in response to the front-back and left-right inputs. The rotor assembly can have two or more rotor arms, each with a propeller. The helicopter provides left-right yaw control with a yaw propeller on the helicopter body. Electric motors, or motors using other conventional power and speed control methods, can be used to drive the rotor and yaw propellers.Type: GrantFiled: August 26, 1997Date of Patent: October 26, 1999Inventors: Phillip Matthew Jermyn, Steven Martin Davis
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Patent number: 5958935Abstract: 2-Anilinopyrimidines, processes for their preparation, pharmaceutical compositions containing them, their use in medicine. In a preferred embodiment, the compounds have the general formula (1): ##STR1## wherein R.sup.1 is preferably methoxy; R.sup.2 and R.sup.3 are preferably methyl; R.sup.4 is preferably a hydrogen atom; R.sup.5 is a hydrogen atom or an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; R.sup.6 is a hydrogen or halogen atom or an amino (--NH.sub.2), substituted amino, nitro, carboxyl (--CO.sub.2 H), esterified carboxyl or --X.sup.1 R.sup.6a where X.sup.1 is a direct bond or a linker atom or group and R.sup.6a is an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; X is a direct bond or a linker atom or group; and R.sup.7 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group.Type: GrantFiled: November 19, 1996Date of Patent: September 28, 1999Assignee: Celltech Therapeutics LimitedInventors: Peter David Davis, David Festus Charles Moffat, Jeremy Martin Davis, Martin Clive Hutchings
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Patent number: 5922741Abstract: Compounds of general formula (1) are described: ##STR1## wherein Ar is an optionally substituted aromatic or heteroaromatic group;X.sup.1 is an oxygen or sulphur atom;R.sup.1 is a hydrogen atom or a methyl group;R.sup.2 is a hydrogen atom or a group --Alk.sup.1 or --X.sup.2 Alk.sup.1 where Alk.sup.1 is an optionally substituted aliphatic or heteroaliphatic group and X.sup.2 is a --C(O)--, --C(S)--, or --S(O).sub.n group where n is an integer 1 or 2;R.sup.3 is a hydrogen atom or a group --Alk.sup.2, ?where Alk.sup.2 is as defined for Alk.sup.1 !, --X.sup.2 Alk.sup.2, --Ar.sup.1 ?where Ar.sup.1 is an optionally substituted aromatic or heteroaromatic group!, --Alk.sup.2 Ar.sup.1, or --X.sup.2 Alk.sup.2 Ar.sup.1 ;and the salts, solvates, hydrates and N-oxides thereof.The compounds are selective inhibitors of the protein tyrosine kinase p56.sup.lck and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate p56.sup.Type: GrantFiled: April 22, 1997Date of Patent: July 13, 1999Assignee: Celltech Therapeutics Ltd.Inventors: Peter David Davis, Jeremy Martin Davis, David Festus Charles Moffat
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Patent number: 5737545Abstract: A method and system are designed to guarantee availability of ownership of an ISA bus by a bus mastering or a direct memory access device in a system also including a PCI bus. This is accomplished by placing a lock on the PCI bus through a bridge device to a configuration read of a PCI configuration space register. Once the lock is established, other PCI devices are prevented from locking any other resource on the PCI bus. The PCI configuration space exists outside of the memory or I/O ranges to which an ISA resident device can generate access. Consequently, whenever the ISA resident device generates its access, it is to a device known not to be in a locked state. Consequently, the bus transaction is capable of completion within the time limit expected by the ISA resident device.Type: GrantFiled: May 21, 1996Date of Patent: April 7, 1998Assignee: VLSI Technology, Inc.Inventors: Philip Wszolek, Barry Martin Davis, Brian Neil Fall, Richard Demers
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Patent number: 5726426Abstract: A container for use in connection with the exposure of edible matter to microwave radiation. The container comprises a base tray and a lid. The lid is formed from a sheet of material which absorbs microwave radiation and is heated by it, and has a plurality of openings formed in it to allow escape of moisture during heating of the product. The lid is so folded or constructed that the distance through the openings from one side to the other side of the lid is greater then the thickness of the material of the lid.Type: GrantFiled: June 26, 1996Date of Patent: March 10, 1998Assignee: Ranks Hovis McDougall LimitedInventors: Jeffrey Martin Davis, Peter Bowler, Kenneth David Woods
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Patent number: 4052148Abstract: A process in which a substance undergoes endothermic change within a predetermined temperature range in at least one stage of the process and is subsequently subjected to a substantially higher temperature in a further stage of the process, characterised in that effluent heat from said further stage is augmented and the resultant supply of heat is applied partly to the generation of power, and partly to said endothermic change.Type: GrantFiled: March 4, 1976Date of Patent: October 4, 1977Assignee: The Associated Portland Cement Manufacturers LimitedInventors: Anthony Robin Pennell, Peter Leslie Dover, William Martin Davies