Patents by Inventor Martin Davies

Martin Davies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030143591
    Abstract: The invention comprises novel methods and strategies to detect and/or quantify nucleic acid analytes. The methods involve nucleic acid probes with covalently conjugated dyes, which are attached either at adjacent nucleotides or at the same nucleotide of the probe and novel linker molecules to attach the dyes to the probes. The nucleic acid probes generate a fluorescent signal upon hybridization to complementary nucleic acids based on the interaction of one of the attached dyes, which is either an intercalator or a DNA groove binder, with the formed double stranded DNA. The methods can be applied to a variety of applications including homogeneous assays, real-time PCR monitoring, transcription assays, expression analysis on nucleic acid microarrays and other microarray applications such as genotyping (SNP analysis). The methods further include pH-sensitive nucleic acid probes that provide switchable fluorescence signals that are triggered by a change in the pH of the medium.
    Type: Application
    Filed: October 21, 2002
    Publication date: July 31, 2003
    Applicant: PROLIGO, LLC
    Inventors: Martin Davies, Ian Bruce, Andreas Wolter
  • Patent number: 6599908
    Abstract: Fused polycyclic 2-aminopyrimidines of formula (1): wherein Ar is an optionally substituted aromatic or heteroaromatic group; X is a carbon or nitrogen atom; Y is a carbon or nitrogen atom; Z is a linker group; A together with X and Y forms an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof are described. The compounds are potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate p56lck and/or p59fyn activity is believed to have a role.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: July 29, 2003
    Assignee: Celltech R & D Limited
    Inventors: Jeremy Martin Davis, Peter David Davis, David Festus Charles Moffat, Mark James Batchelor
  • Patent number: 6600037
    Abstract: Pyrimidines of formla (1) are described: wherein R1 is a —XR6 group; R2 and R3 which may be the same or different is each a hydrogen or halogen atom or a group selected from an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, —OH, —OR10 [where R10 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group] —SH, —NO2, —CN, —SR10, —COR10, S(O)R10, —SO2R8, —SO2N(R8)(R9), —CO2R8, —CON(R8)(R9), —CSN(R8)(R9), —NH2 or substituted amino group; R4 is a X1R11 group where X1 is a covalent bond or a —C(R12)(R13)— [where each of R12 and R13 is a hydrogen or halogen atom or a hydroxyl, alkyl or haloalkyl group] or —C(O)— group and R11 is an optionally substituted phenyl, thienyl, thiazolyl or indolyl group; R5 is a halogen atom or an alkynyl group; and the salts, solv
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: July 29, 2003
    Assignee: Celltech R & D Limited
    Inventors: Jeremy Martin Davis, David Festus Charles Moffat
  • Patent number: 6594588
    Abstract: A system and method for handling laboratory information includes a graphical user interface with a plurality of windows. A palette of icons is provided in a first one of the windows, each icon representing a predetermined task to be executed by a processor in communication with the graphical user interface. The processor is also in communication with a database containing static laboratory data (such as the type of sample to be analysed) as well as dynamic laboratory data (such as the name of the specific sample to be tested and the results of that test). A user can select icons from the first window and “drag and drop” them into a second window. A sequence of tasks may thus be built up, in the form of a tree structure, and when run the processor executes the sequence of tasks in turn by reference to the static and dynamic laboratory data.
    Type: Grant
    Filed: May 7, 2001
    Date of Patent: July 15, 2003
    Assignee: Thermo Bio Analysis Corp.
    Inventors: Joseph Martin Peden, Morgan Nicholas Skinner, Robin Dylan Jones, Andrew Martin Davis, Philip Ian Holt, Graham Stuart Taylor
  • Patent number: 6579983
    Abstract: Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R1 is a hydrogen atom or a straight or branched chain alkyl group; R2 is a —X1—R3 group where X1 is a direct bond or a linker atom or group, and R3 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR Kinase and/or FGFr Kinase inhibitors and are of use in the prophylaxis and treatment of disease states assoicated with angiogenesis.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: June 17, 2003
    Assignee: Celltech R&D Limited
    Inventors: Mark James Batchelor, David Festus Charles Moffat, Jeremy Martin Davis, Martin Clive Hutchings
  • Patent number: 6550558
    Abstract: A method of mounting a radiator onto a support member in a vehicle includes the steps of securing to the radiator a resilient mounting bush having a first annular groove in its outer surface, providing a second annular groove in the inner surface of a radiator mounting bore formed in the support member, positioning a spring clip in one of the two annular grooves and inserting the bush into the bore, the spring clip being compressed radially during insertion of the bush into the bore and being released when the annular grooves are axially aligned with one another to lock the bush within the bore.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: April 22, 2003
    Assignee: New Holland North America, Inc.
    Inventors: Graeme J. Yorwarth, William P. Starkey, Martin Davies
  • Publication number: 20020147339
    Abstract: Pyrimidines of formula (1) are described 1
    Type: Application
    Filed: May 20, 2002
    Publication date: October 10, 2002
    Inventors: Mark James Batchelor, David Festus Charles Moffat, Jeremy Martin Davis, Martin Clive Hutchings
  • Publication number: 20020079150
    Abstract: A method of mounting a radiator onto a support member in a vehicle comprises the steps of securing to the radiator a resilient mounting bush having a first annular groove in its outer surface, providing a second annular groove in the inner surface of a radiator mounting bore formed in the support member, positioning a spring clip in one of the two annular grooves and inserting the bush into the bore, the spring clip being compressed radially during insertion of the bush into the bore and being released when the annular grooves are axially aligned with one another to lock the bush within the bore.
    Type: Application
    Filed: September 18, 2001
    Publication date: June 27, 2002
    Inventors: Graeme J. Yorwarth, William P. Starkey, Martin Davies
  • Patent number: 6329196
    Abstract: A biological process is enhanced by a method and apparatus used to contact a biomass with a gas and with a nutrient liquid. A resiliently compressible porous matrix system containing the biomass is mounted in a reaction vessel containing a body of the nutrient liquid and a body of the gas above the body of the liquid. The body of liquid having an upper surface exposed to the body of gas and defining a liquid-gas interface. The resiliently compressible porous matrix system is located in a position in the reaction vessel so that compressible porous matrix system is partly immersed in the nutrient liquid and partly extends above the upper surface of the liquid into the body of gas.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: December 11, 2001
    Inventors: William Nevil Heaton Johnson, Martin Davies, Charles Joseph Banks
  • Publication number: 20010011367
    Abstract: A machine control system (130) includes a computer (132) that generates, edits and displays a continuous multi-block flowchart representing a program and compiles the program from the flowchart to control the operations of a machine (140). The system (130) also includes a debugger (146) for displaying the flowchart in a debugger window (170) for runtime execution control of the program.
    Type: Application
    Filed: March 20, 2001
    Publication date: August 2, 2001
    Inventors: Frank G. Logan, Kenneth W. Bunch, Teddy Martin Davis, Jeffrey M. Achesinski
  • Patent number: 6243857
    Abstract: A machine control system (130) includes a computer (132) that generates, edits and displays a continuous multi-block flowchart representing a program and compiles the program from the flowchart to control the operations of a machine (140). The system (130) also includes a debugger (146) for displaying the flowchart in a debugger window (170) for runtime execution control of the program.
    Type: Grant
    Filed: February 17, 1998
    Date of Patent: June 5, 2001
    Assignee: NemaSoft, Inc.
    Inventors: Frank G. Logan, III, Kenneth W. Bunch, Teddy Martin Davis, Jeffrey M. Achesinski
  • Patent number: 6235746
    Abstract: Compounds of general formula (1) are described: wherein R1 is a hydrogen or halogen atom or an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group or a group selected from hydroxyl (—OH), substituted hydroxyl, thiol (—SH), substituted thiol, amino (—NH2), or substituted amino; R2 and R3, which may be the same or different, is each an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; R4 is a hydrogen atom or a straight or branched chain alkyl group; R5 is a hydrogen atom or an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; R6 is a hydrogen or halogen atom or an amino (—NH2), substituted amino, nitro, carboxyl (—CO2H) or esterified carboxyl group or a group —X1—R6a where X1 is a direct bond or a linker atom or group and R6a is an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; X is a direct bond or a linker atom or
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: May 22, 2001
    Assignee: Celltech Therapeutics, Limited
    Inventors: Peter David Davis, David Festus Charles Moffat, Jeremy Martin Davis, Martin Clive Hutchings
  • Patent number: 6133257
    Abstract: Fused polycyclic 2-aminopyrimidines of formula (1) are described: whereinR.sup.1 is a group --L.sup.1 R.sup.2 where L.sup.1 is a covalent bond or a linker atom or group and R.sup.2 is a group --(Alk).sub.m L.sup.2 R.sup.3 where Alk is an optionally substituted aliphatic or heteroaliphatic chain, m is zero or the integer 1, L.sup.2 is a covalent bond or a linker atom or group and R.sup.3 is an optionally substituted cycloaliphatic or heterocycloaliphatic group provided that when m is zeroL.sup.2 is a covalent bond;Ar is an aryl or heteroaryl group;X is a carbon or nitrogen atom;Y is a carbon or nitrogen atom;Z is a linker group;A together with X and Y forms an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group;and the salts, solvates, hydrates and N-oxides thereof.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: October 17, 2000
    Assignee: Celltech Therapeutics Limited
    Inventors: Mark James Batchelor, Jeremy Martin Davis, David Festus Charles Moffat, Peter David Davis
  • Patent number: 6057329
    Abstract: Fused polycyclic 2-aminopyrimidines of formula (1): ##STR1## wherein Ar is an optionally substituted aromatic or heteroaromatic group;X is a carbon or nitrogen atom;Y is a carbon or nitrogen atom;Z is a linker group;A together with X and Y forms an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group;and the salts, solvates, hydrates and N-oxides thereof are described. The compounds are potent and selective inhibitors of the protein tyrosine kinases p56.sup.lck and p59.sup.fyn and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate p56.sup.lck and/or p59.sup.fyn activity is believed to have a role.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: May 2, 2000
    Assignee: Celltech Therapeutics Limited
    Inventors: Jeremy Martin Davis, Peter David Davis, David Festus Charles Moffat, Mark James Batchelor
  • Patent number: 5971320
    Abstract: A model helicopter creates lift using rotor propellers mounted to the rotor arms of a gyroscopic rotor assembly. A controller converts front-back, and left-right inputs into speed control signals used to vary the speeds of the rotor propellers at selected positions of the rotor assembly as it rotates. The varying speed of the rotor propellers at selected rotor positions produces thrust vectors at those positions. The resultant thrust vector determines the direction of the helicopter's flight and enables it to pitch and roll in response to the front-back and left-right inputs. The rotor assembly can have two or more rotor arms, each with a propeller. The helicopter provides left-right yaw control with a yaw propeller on the helicopter body. Electric motors, or motors using other conventional power and speed control methods, can be used to drive the rotor and yaw propellers.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: October 26, 1999
    Inventors: Phillip Matthew Jermyn, Steven Martin Davis
  • Patent number: 5958935
    Abstract: 2-Anilinopyrimidines, processes for their preparation, pharmaceutical compositions containing them, their use in medicine. In a preferred embodiment, the compounds have the general formula (1): ##STR1## wherein R.sup.1 is preferably methoxy; R.sup.2 and R.sup.3 are preferably methyl; R.sup.4 is preferably a hydrogen atom; R.sup.5 is a hydrogen atom or an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; R.sup.6 is a hydrogen or halogen atom or an amino (--NH.sub.2), substituted amino, nitro, carboxyl (--CO.sub.2 H), esterified carboxyl or --X.sup.1 R.sup.6a where X.sup.1 is a direct bond or a linker atom or group and R.sup.6a is an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; X is a direct bond or a linker atom or group; and R.sup.7 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: September 28, 1999
    Assignee: Celltech Therapeutics Limited
    Inventors: Peter David Davis, David Festus Charles Moffat, Jeremy Martin Davis, Martin Clive Hutchings
  • Patent number: 5922741
    Abstract: Compounds of general formula (1) are described: ##STR1## wherein Ar is an optionally substituted aromatic or heteroaromatic group;X.sup.1 is an oxygen or sulphur atom;R.sup.1 is a hydrogen atom or a methyl group;R.sup.2 is a hydrogen atom or a group --Alk.sup.1 or --X.sup.2 Alk.sup.1 where Alk.sup.1 is an optionally substituted aliphatic or heteroaliphatic group and X.sup.2 is a --C(O)--, --C(S)--, or --S(O).sub.n group where n is an integer 1 or 2;R.sup.3 is a hydrogen atom or a group --Alk.sup.2, ?where Alk.sup.2 is as defined for Alk.sup.1 !, --X.sup.2 Alk.sup.2, --Ar.sup.1 ?where Ar.sup.1 is an optionally substituted aromatic or heteroaromatic group!, --Alk.sup.2 Ar.sup.1, or --X.sup.2 Alk.sup.2 Ar.sup.1 ;and the salts, solvates, hydrates and N-oxides thereof.The compounds are selective inhibitors of the protein tyrosine kinase p56.sup.lck and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate p56.sup.
    Type: Grant
    Filed: April 22, 1997
    Date of Patent: July 13, 1999
    Assignee: Celltech Therapeutics Ltd.
    Inventors: Peter David Davis, Jeremy Martin Davis, David Festus Charles Moffat
  • Patent number: 5737545
    Abstract: A method and system are designed to guarantee availability of ownership of an ISA bus by a bus mastering or a direct memory access device in a system also including a PCI bus. This is accomplished by placing a lock on the PCI bus through a bridge device to a configuration read of a PCI configuration space register. Once the lock is established, other PCI devices are prevented from locking any other resource on the PCI bus. The PCI configuration space exists outside of the memory or I/O ranges to which an ISA resident device can generate access. Consequently, whenever the ISA resident device generates its access, it is to a device known not to be in a locked state. Consequently, the bus transaction is capable of completion within the time limit expected by the ISA resident device.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: April 7, 1998
    Assignee: VLSI Technology, Inc.
    Inventors: Philip Wszolek, Barry Martin Davis, Brian Neil Fall, Richard Demers
  • Patent number: 5726426
    Abstract: A container for use in connection with the exposure of edible matter to microwave radiation. The container comprises a base tray and a lid. The lid is formed from a sheet of material which absorbs microwave radiation and is heated by it, and has a plurality of openings formed in it to allow escape of moisture during heating of the product. The lid is so folded or constructed that the distance through the openings from one side to the other side of the lid is greater then the thickness of the material of the lid.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: March 10, 1998
    Assignee: Ranks Hovis McDougall Limited
    Inventors: Jeffrey Martin Davis, Peter Bowler, Kenneth David Woods
  • Patent number: 4052148
    Abstract: A process in which a substance undergoes endothermic change within a predetermined temperature range in at least one stage of the process and is subsequently subjected to a substantially higher temperature in a further stage of the process, characterised in that effluent heat from said further stage is augmented and the resultant supply of heat is applied partly to the generation of power, and partly to said endothermic change.
    Type: Grant
    Filed: March 4, 1976
    Date of Patent: October 4, 1977
    Assignee: The Associated Portland Cement Manufacturers Limited
    Inventors: Anthony Robin Pennell, Peter Leslie Dover, William Martin Davies