Abstract: A system for analyzing the concentration of a first component in a sample fluid is described. The system provides a mixture of sample fluid and control fluid to a fluid concentration measuring apparatus in a controlled ratio. The system stores flow change model, representing the variation in time of the flow of the sample fluid through the system between a valving and the fluid concentration measuring apparatus in response to a variation of the controlled rate by the valving. The system estimates the concentration of the first component in the sample fluid based at least in part on the controlled ratio, and the flow change model.

Abstract: The present invention provides a chimeric protein that has a modular structure and comprises a receptor binding domain (RBD) from the spike protein (S) of coronaviruses, a segment able to bind the core antigen from the Hepatitis B Virus (HBcAg), a segment including six consecutive histidine residues (HHHHHH), and two spacer segments. In this chimeric protein the aforementioned segments are arranged in a specific order, and the protein is able to form hybrid nanoparticles with HBcAg. The chimeric protein is part of vaccine compositions used for the prevention of coronavirus infections. Therefore, the invention discloses a method for the prevention of coronavirus infections, whereby a vaccine composition comprising said chimeric protein is administered.

Abstract: Systems, methods, and computer program products are provided for directing cash flows associated with a mortgage-backed security to back other securities without collapsing the original mortgage-backed security. A mortgage-backed security/an/or a set of loans is analyzed to identify cash flows from mortgages having specific desirable characteristics, and the cash flows are directed to subgroups or pools that support new mortgage-backed securities. The new securities make the desirable cash flows available to an issuer or prospective investor without collapsing the original mortgage-backed security.

Abstract: A printer head for three-dimensional printing of a continuous fiber-reinforced thermoset composite may include a deposition syringe, a fiber housing, and a feeding tube. The deposition syringe may define a resin reservoir, an air chamber, and a first inlet port configured to deliver a first flow of air to the air chamber. The deposition syringe may include a syringe body and a piston. The syringe body may include an inlet section, a needle section, and a converging section disposed between the inlet section and the needle section. The fiber housing may define a fiber chamber and a second inlet port configured to deliver a second flow of air to the fiber chamber. The feeding tube may extend from the fiber chamber to the needle section and may be configured to receive the second flow of air therein and to guide a fiber from the fiber chamber to the needle section.

Abstract: An apparatus, system, and method for healthcare provider scoring is described, including a first computing device, the first computing device associated with an owner identifier, a second computing device, a data storage repository, a data records, a first data field, a first data element, a first owner identifier, a first collaboration data set associated with the first owner identifier, the first collaboration data set comprising a first collaboration score, the first collaboration score being determined as a function of a first at least three of a group of collaboration score factors comprising: response timeous, notification timeous, accuracy, engagement, and contactability, wherein each of the first at least three of the group of collaboration score factors is weighted relative to one another, and a code segment for determining a collaboration score associated with the owner identifier, wherein the collaboration score is a function of the first collaboration data set.

Abstract: System and methods for three-dimensional printing are provided. In accordance with one aspect, a method for multimaterial fabrication of three-dimensional (3D) printed structures includes lifting a printing platform having a 3D printed structure formed thereon to remove the 3D printed structure from a plate through which radiation was transmitted to fabricate the 3D printed structure and activating a blast of an air jet focused on the surface of the plate under the printing platform to remove waste material left on the surface of the plate when the printing platform is lifted. In accordance with another aspect, method for three-dimensional (3D) printing includes photopolymerizing a photocurable resin to form a fabricated structure and programmed thermal treating of the fabricated structure for transesterification of material of the fabricated structure.

Abstract: Systems, methods, and computer program products are provided for directing cash flows associated with a mortgage-backed security to back other securities without collapsing the original mortgage-backed security. A mortgage-backed security/an/or a set of loans is analyzed to identify cash flows from mortgages having specific desirable characteristics, and the cash flows are directed to subgroups or pools that support new mortgage-backed securities. The new securities make the desirable cash flows available to an issuer or prospective investor without collapsing the original mortgage-backed security.

Abstract: The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused infections. Likewise, the invention disclosed a method for treating infections caused by this virus.

Abstract: The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused infections. Likewise, the invention disclosed a method for treating infections caused by this virus.

Abstract: An improved electromechanical apparatus for injecting or purging fluids on demand is disclosed. Also disclosed are systems and methods for using the apparatus, including automatic fertilizer injection/injecting and water line purging systems for use in lawn maintenance. The apparatus can be located in a main water line before the distribution valves of an irrigation system, for example, where it can be activated or deactivated without interfering with the normal usage of the system.

Abstract: An improved electromechanical apparatus for injecting or purging fluids on demand is disclosed. Also disclosed are systems and methods for using the apparatus, including automatic fertilizer injection/injecting and water line purging systems for use in lawn maintenance. The apparatus can be located in a main water line before the distribution valves of an irrigation system, for example, where it can be activated or deactivated without interfering with the normal usage of the system.

Abstract: The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family.

Abstract: Systems, methods, and computer program products are provided for directing cash flows associated with a mortgage-backed security to back other securities without collapsing the original mortgage-backed security. A mortgage-backed security/an/or a set of loans is analyzed to identify cash flows from mortgages having specific desirable characteristics, and the cash flows are directed to subgroups or pools that support new mortgage-backed securities. The new securities make the desirable cash flows available to an issuer or prospective investor without collapsing the original mortgage-backed security.

Abstract: The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.

Abstract: The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.

Abstract: The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family.

Abstract: The present invention is related to the field of the pharmaceutical industry, and describes a conserved area on the surface of the E protein that can be used for the development of wide-spectrum antiviral molecules to be employed in the prophylaxis and/or treatment of infections due to Dengue Virus serotypes 1-4 and other flaviviruses. The invention also covers chimeric proteins to be used as vaccines or as a prophylactic or therapeutic treatment against the four serotypes of Dengue Virus and other flaviviruses.

Abstract: A semiconductor device which displays an oscillating voltage due to the creation of charge domains which includes a plurality of semiconductor layers and at least two electrodes spaced from one another in the direction of the layers, an upper of which has a composition and/or dimensions predetermined so that a charge therein balances a depletion from a surface charge of the upper layer on application of a potential difference across said electrodes. The electrodes may be in contact solely with the upper layer. A method of manufacturing the device is also provided.

Abstract: Method for the insertion of protein antigens, of recombinant or synthetic origin, in outer membrane vesicles of Gram-negative bacteria without disruption of the vesicle structure, therefore maintaining the immunogenicity and immunostimulatory properties of said vesicles, and with the reported advantage that the immune response generated against the incorporated antigen is superior to the one generated when the antigen is administered alone. The resultant vaccine formulations are useful to increase protective capacity of existing vaccines and allow to extend it against different pathogens, in diseases of bacterial, viral, cancerous or other etiology. The referred formulations are applicable in the pharmaceutical industry as vaccines for therapeutic and preventive use in humans.

Abstract: A bird feeder having an elongate bird feed container open at opposed ends thereof. The bird feed container defines a longitudinal axis A and has a plurality of feeding ports provided in a sidewall of the bird feed container to facilitate eating by a bird. A removable cover covers the top end of the bird feed container, and the cover has both an open position, in which the cover is spaced from the top end to facilitate supplying bird feed into the bird feed container, and a closed position, in which the cover engages with and covers the top end of the bird feed container. A handle member connected to the bird feed container for hanging the bird feeder. A removable base engages with the bottom end of the bird feed container. The removable base has a closed position, for sealing the open bottom end of the bird feed container, and an open position in which the base is removed from the bird feed container to facilitate cleaning of the bird feed container and the base.