Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: A hair styling accessory comprises a body supporting a pair of jaws defining a clamping space between them for receiving a tress of hair. The accessory is configured so that at least one of the jaws is movable to releasably clamp the tress of hair between the jaws. The movable jaw is actuated by air pressure. At least one of the jaws is configured to deliver a jet of air from the body to the clamping space.

Abstract: Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic E. coli. (ExPEC).

Abstract: A modular toy system comprising a plurality of separate electronic toy modules, each electronic toy module comprising a function device operable to perform a user-perceptible function and a control circuit for controlling the function device; wherein at least a first electronic toy module of the plurality of electronic toy modules comprises a first control circuit, a first function device and a sensor system configured for contactless detection of respective coordinate values of at least two coordinates, each coordinate being indicative of a position or an orientation of at least a second electronic toy module of the plurality of electronic toy modules relative to the first electronic toy module; and wherein the first control circuit is configured to control operation of the first function device based on one or more of the detected coordinate values.

Abstract: Systems and methods are provided for a combined defuel and priority panel for a fueling station. The defuel and priority panel is configured to defuel a compressed natural gas (CNG) vehicle and direct the defueled gas to fuel other CNG vehicles at the panel fueling and defueling site. The defuel and priority panel is also configured to store defueled gas in defuel storage tanks, which can then be used to later fuel CNG vehicles.

Abstract: The present invention relates to a process for the production of purified O-polysaccharide-Exoprotein A (O-EPA) bioconjugates. In particular, the process comprises a purification of said bioconjugate comprising the steps of a first anion exchange chromatography prior to a hydroxyapatite chromatography followed by a hydrophobic interaction chromatography and subsequently a second anion exchange chromatography.

Abstract: A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).

Abstract: A modular toy system comprising a plurality of separate electronic toy modules, each electronic toy module comprising a function device operable to perform a user-perceptible function and a control circuit for controlling the function device; wherein at least a first electronic toy module of the plurality of electronic toy modules comprises a first control circuit, a first function device and a sensor system configured for contactless detection of respective coordinate values of at least two coordinates, each coordinate being indicative of a position or an orientation of at least a second electronic toy module of the plurality of electronic toy modules relative to the first electronic toy module; and wherein the first control circuit is configured to control operation of the first function device based on one or more of the detected coordinate values.

Abstract: Systems and methods are provided for a combined defuel and priority panel for a fueling station. The defuel and priority panel is configured to defuel a compressed natural gas (CNG) vehicle and direct the defueled gas to fuel other CNG vehicles at the panel fueling and defueling site. The defuel and priority panel is also configured to store defueled gas in defuel storage tanks, which can then be used to later fuel CNG vehicles.

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: Techniques and architecture are described for validating and verifying iPXE scripts prior to execution during a booting process. During the booting process of a network device, right after the UEFI/BIOS stage of the booting process, a trusted iPXE script may make a request to a network server for the ownership voucher and owner certificate of the network device. The ownership voucher and owner certificate may then be stored in a trusted platform module (TPM) on the network device. In configurations, the retrieved owner certificate may be validated by the ownership voucher. The owner certificate may be used to validate iPXE scripts. Once validated, the iPXE scripts may be executed and the booting process may be continued to the kernel loading step and the application loading step. During a subsequent booting process of the network device, the ownership voucher and owner certificate may be retrieved from the TPM.

Abstract: The present invention relates to a method of controlling an ensemble of interacting toy construction models. The interacting toy construction models include toy construction elements having functional toy construction elements, the toy construction elements include coupling members configured for detachably interconnecting the toy construction elements with each other. The functional toy construction elements may perform a function in compliance with a configuration defining a functional behaviour. The method includes configuring the functional toy construction elements in the interacting toy construction models based on information on further functional toy construction elements in said interacting toy construction model to coordinate their functional behaviour in a model-behaviour; and further adapting the model-behaviour based on information on further interacting toy construction models in the ensemble.

Abstract: A toy system comprising a plurality of toy construction elements, having detachably interconnecting coupling members for creating coherent spatial structures. The plurality of toy construction elements include: an energy source device comprising a housing and an energy transfer circuit therein; and energy distribution devices to provide respective external conductive loops extending outside the housing and defining a respective external energy transfer zone in a proximity of the respective external conductive loops. The energy source device is configured to be brought into operational connection with the energy distribution devices.

Abstract: The present invention relates to a compound according to Formula (1a) or (1b): wherein R1; R2; R3 X and Y are defined herein, and their use in methods of nucleic acid synthesis.

Abstract: Automated jackstand systems and methods deploy a jackstand to support a front end of a trailer parked at an automated loading dock. The jackstand prevents collapse of the trailer's landing gear and prevents upending of the trailer during loading and unloading. Advantageously, by deploying the jackstand automatically, presence of personnel in the yard where tractors and trailers are moving is not required.

Abstract: The present invention relates to a compound according to Formula (1a) or (1b): wherein R1; R3; Y and X are defined herein, and their use in methods of nucleic acid synthesis.

Abstract: A fuel tank comprises an interior wall, a sump, and a baffle that comprises a center fitting, a full-length containment petal, a partial-length containment petal, a dump tube. The full-length containment petal comprises a full-length side edge, extending radially outward from the center fitting. The partial-length containment petal comprises a partial-length side edge, extending radially outward from the center fitting. The dump tube is connected to the sump. The full-length side edge of the full-length containment petal is longer than the partial-length side edge of the partial-length containment petal. All of the partial-length side edge of the partial-length containment petal is attached to a linear portion of the full-length side edge of the full-length containment petal.

Abstract: A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).

Abstract: Techniques and architecture are described for validating and verifying iPXE scripts prior to execution during a booting process. During the booting process of a network device, right after the UEFI/BIOS stage of the booting process, a trusted iPXE script may make a request to a network server for the ownership voucher and owner certificate of the network device. The ownership voucher and owner certificate may then be stored in a trusted platform module (TPM) on the network device. In configurations, the retrieved owner certificate may be validated by the ownership voucher. The owner certificate may be used to validate iPXE scripts. Once validated, the iPXE scripts may be executed and the booting process may be continued to the kernel loading step and the application loading step. During a subsequent booting process of the network device, the ownership voucher and owner certificate may be retrieved from the TPM.

Abstract: An interactive toy comprising a function device for performing user-perceptible, controllable functions. The interactive toy also includes a rechargeable power source and a charging circuit for contactless receipt of electrical energy and for charging the rechargeable power source when the interactive toy is positioned in a charging zone of a contactless charging device. The interactive toy is adapted to determine a charging rate at respective positions relative to the charging device and to generate a user-perceptible output indicative of the determined charging rate.