Patents by Inventor Martin G. Pomper

Martin G. Pomper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11021450
    Abstract: Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: June 1, 2021
    Assignee: The Johns Hopkins University
    Inventors: Martin G. Pomper, Ronnie C. Mease, Ying Chen, Sangeeta Ray
  • Patent number: 11007251
    Abstract: The present disclosure relates to methods and compositions for treating and/or preventing autoimmune fibrosis, such as systemic sclerosis (SSc; scleroderma). The method includes administering to a subject in need thereof an effective amount of a death receptor agonist. Suitable death receptor agonists include tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL), agonistic death receptor antibodies, and variants, analogues, or derivatives thereof. The administration of the death receptor agonist blocks fibroblast or profibrogenic cell activation, and/or reduces or depletes myofibroblasts, thereby reducing or preventing systemic sclerosis.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: May 18, 2021
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Seulki Lee, Martin G. Pomper, Jong-Sung Park, Yumin Oh, Magdalena Scully, Maureen Horton
  • Patent number: 10947197
    Abstract: Methods, and related compositions, for the improved synthesis of [18F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [18F]DCFPyL so produced.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: March 16, 2021
    Assignee: The Johns Hopkins University
    Inventors: Hayden T. Ravert, Daniel P. Holt, Ying Chen, Ronnie C. Mease, Hong Fan, Martin G. Pomper, Robert F. Dannals
  • Publication number: 20210040126
    Abstract: PSMA-targeted PET/SPECT agents for imaging PSMA-positive cancer and or tumor neovasculature and PSMA-targeted radiotherapeutic agent for the treatment of PSMA-positive cancer or tumor neovasculature are disclosed. Methods of imaging PSMA expressing tumors, or cells and kits also are disclosed.
    Type: Application
    Filed: July 21, 2020
    Publication date: February 11, 2021
    Inventors: Martin G. Pomper, Ronnie C. Mease, Sangeeta Ray
  • Patent number: 10912850
    Abstract: Radiofluorinated FNDP for PET imaging of soluble epoxide hydrolase (sEH) and method of using the same are disclosed.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: February 9, 2021
    Assignees: The Johns Hopkins University, Oregon Health & Science University
    Inventors: Andrew Horti, Martin G. Pomper, Nabil J. Alkayed
  • Patent number: 10898594
    Abstract: PAMAM dendrimer based CEST imaging agents, pharmaceutical compositions comprising the same and methods of uses thereof are disclosed.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: January 26, 2021
    Assignee: The Johns Hopkins University
    Inventors: Wojciech Lesniak, Sridhar Nimmagadda, Nikita Oskolkov, Michael McMahon, Xiaolei Song, Martin G. Pomper
  • Patent number: 10857246
    Abstract: Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: December 8, 2020
    Assignee: The Johns Hopkins University
    Inventors: Xing Yang, Il Minn, Steven Rowe, Sangeeta Ray, Ronnie C. Mease, Michael Gorin, Mohamad Allaf, Martin G. Pomper
  • Publication number: 20200360542
    Abstract: Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 19, 2020
    Inventors: Martin G. Pomper, Ronnie C. Mease, Sangeeta Ray, Ying Chen, Xing Yang
  • Publication number: 20200347464
    Abstract: Methods, reporter gene constructs, and kits for using prostate-specific membrane antigen (PSMA) as an imaging reporter to image a variety of cells and tissues are provided.
    Type: Application
    Filed: July 21, 2020
    Publication date: November 5, 2020
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Mark Castanares, Il Minn, Shawn Lupold
  • Publication number: 20200330613
    Abstract: Salicylic acid-based polymeric CEST contrast agents targeting prostate-specific membrane antigen, pharmaceutical composition comprising the same and methods of use thereof are disclosed.
    Type: Application
    Filed: June 22, 2020
    Publication date: October 22, 2020
    Inventors: Sangeeta Ray, Xing Yang, Xiaolei Song, Michael T. McMahon, Martin G. Pomper
  • Publication number: 20200330624
    Abstract: Imaging and radiotherapeutics agents targeting fibroblast-activation protein-? (FAP-?) and their use in imaging and treating FAP-? related diseases and disorders are disclosed.
    Type: Application
    Filed: October 23, 2018
    Publication date: October 22, 2020
    Inventors: Xing Yang, Sridhar Nimmagadda, Steven Rowe, Stephanie Slania, Martin G. Pomper
  • Publication number: 20200306391
    Abstract: Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer are disclosed.
    Type: Application
    Filed: May 30, 2018
    Publication date: October 1, 2020
    Inventors: Sangeeta Ray, Martin G. Pomper
  • Publication number: 20200297693
    Abstract: Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.
    Type: Application
    Filed: June 11, 2020
    Publication date: September 24, 2020
    Inventors: JUN LIU, QINGLI HE, MARTIN G. POMPER, IL MINN, BIAO YU, QIAOLING WANG
  • Publication number: 20200290982
    Abstract: Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific T1-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 17, 2020
    Inventors: Sangeeta Ray, Martin G. Pomper, Thomas J. Meade, Ronnie C. Mease, Ying Chen, Xing Yang, Matthew Rotz
  • Publication number: 20200282083
    Abstract: Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
    Type: Application
    Filed: November 5, 2019
    Publication date: September 10, 2020
    Inventors: Martin G. Pomper, Ronnie Charles Mease, Ying Chen
  • Publication number: 20200283412
    Abstract: Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.
    Type: Application
    Filed: June 15, 2018
    Publication date: September 10, 2020
    Inventors: Martin G. Pomper, Ronnie C. Mease, Ying Chen, Sangeeta Ray
  • Patent number: 10736974
    Abstract: Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: August 11, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Ronnie C. Mease, Sangeeta Ray, Ying Chen, Xing Yang
  • Publication number: 20200231614
    Abstract: PPSMA binding scaffolds with radioiodinated, radiobrominated and radioastatinated labeled prosthetic groups are disclosed. Pharmaceutical compositions and methods of treating PSMA expressing cells or tumors also are disclosed.
    Type: Application
    Filed: October 21, 2016
    Publication date: July 23, 2020
    Inventors: MARTIN G. POMPER, RONNIE C. MEASE, YING CHEN, SANGEETA RAY, MICHAEL ZALUTSKY, GANESAN VAIDYANATHAN
  • Patent number: 10717750
    Abstract: PSMA-targeted PET/SPECT agents for imaging PSMA-positive cancer and or tumor neovasculature and PSMA-targeted radiotherapeutic agent for the treatment of PSMA-positive cancer or tumor neovasculature are disclosed. Methods of imaging PSMA expressing tumors, or cells and kits also are disclosed.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: July 21, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Ronnie C. Mease, Sangeeta Ray
  • Publication number: 20200216402
    Abstract: Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 9, 2020
    Inventors: Martin G. Pomper, Ronnie C. Mease, Ying Chen, Sangeeta Ray