Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: A method for obtaining an improved plasticized material results from two differentiated steps: an esterification reaction for synthesizing a polycarboxylic acid ester oligomer in the presence of excess polyol and a catalyst, and a second step of gelatinization and plasticization at temperatures above 90° C. involving a starch mixed with water and with the polycarboxylic acid ester oligomer with excess polyol obtained in the previous step, and a coadjuvant. The catalyst used in the esterification reaction is the same as the coadjuvant used in the gelatinization and plasticization reaction. The plasticized material obtained with this method has a higher stability and a lower migration rate than known plasticized materials.

Abstract: Described herein is a genetically modified plant or non-human animal having reduced expression of an endogenous target gene.

Abstract: The disclosure relates to a substrate support assembly for reducing the evacuation time when using argon gas. In one embodiment, a substrate support assembly includes a porous plug within the substrate support assembly. The porous plug includes a first cylindrical section with a first volume and axial length, a second cylindrical section with a second volume and axial length. The first cylindrical section has a larger volume than the second cylindrical section. The first cylindrical section and second cylindrical section have a volume ratio between about 2 and about 12. The first cylindrical section axial length and second cylindrical section axial length have a length ratio between about 2 and about 10.

Abstract: Novel Fusidic Acid (FA) based compounds that have equivalent potency against clinical isolates of Staphylococcus aureus (S. aureus) and Enterococcus faecium (E. faecium) as well as an improved resistance profile in vitro when compared to FA. Importantly, the new compounds display efficacy against a FA-resistant strain of Staphylococcus aureus in a soft-tissue murine infection model. This disclosure delineates the structural features of FA necessary for potent antibiotic activity and demonstrates that the resistance profile can be improved for this scaffold and target.

Abstract: The present invention discloses a design for a measurement device with improved power measurement accuracy, involving the measurement of the temperature using a highly accurate device that can be installed coupled to the protectors, the device comprising: an essentially rectangular parallelepiped-shaped casing with a plurality of slots in the lateral surfaces, one or more openings, and at least one electrical connection rod; a motherboard (PCB) on the inside of the casing, comprising a first face having at least one Shunt resistor and its own power supply, and a second face, opposite the first face, having—a communication module consisting of a microcontroller that is connected to the measurement module, —a temperature sensor disposed on the second face (PCB) and on the side opposite the Shunt resistor, and—electrically isolated communication ports; and an analogue-to-digital converter.

Abstract: A method and apparatus for cooling a semiconductor chamber are described herein. A semiconductor chamber component, includes a powered region, a grounded region, and a fluid conduit disposed within the semiconductor chamber component and passing through the powered region and grounded region, the fluid conduit comprising a ceramic material.

Abstract: The disclosure relates to a substrate support assembly and apparatus for measuring the temperature of a substrate disposed on the support assembly. In one embodiment, a substrate temperature measurement apparatus includes a substrate support assembly, a probe assembly, and a probe target. The substrate support assembly includes an electrostatic chuck and one or more plates. The probe assembly within the substrate support assembly extends through one or more of the one or more plates. The probe assembly includes an optical probe sensor, an optical fiber coupled to the optical probe sensor, and an insulating sheath surrounding the optical fiber. The probe target includes a phosphor coating, is in contact with the electrostatic chuck, and is spaced from the probe assembly.

Abstract: Disclosed subject matter relates generally to graphics processing, and relates more particularly to processing graphics vertex content.

Abstract: The present embodiments generally describe a monolithic, e.g., integral, box unit and methods of manufacturing monolithic box units. The monolithic box unit has a ring portion and a body portion, both of which are molded and set simultaneously. The method proceeds with filling a female oriented cavity with a Polymer mixture, allowing both the ring portion and body portion to fill and cure at the same time. Once ejected from the cavity, the entire unit can be trimmed and then add hardware and cover to complete the box.

Abstract: The present disclosure provides methods and compositions for inhibiting corrosion of metallic surfaces and dissolving iron sulfide deposits in aqueous systems. A method may include adding a composition to the aqueous medium. The composition may include malic acid or a salt thereof. The composition may optionally include an organic solvent and/or a corrosion inhibitor.

Abstract: A floating platform for high-power wind turbines, comprising a concrete substructure, said concrete substructure forming the base of the platform, which remains semi-submerged in the operating position, and consisting of a square lower slab on which a series of beams and five hollow reinforced concrete cylinders are constructed, distributed at the corners and the center of said lower slab; a metal superstructure supported on the concrete substructure and forming the base for connection with the wind turbine tower, said tower being coupled at the center thereof; and metal covers covering each of the cylinders, on which the metal superstructure is supported and to which vertical pillars are secured, linked together by beams, which join at the central pillar by an element whereon the base of the wind turbine tower is secured.

Abstract: The present disclosure provides a method for managing a multi-kitchen order comprising: receiving a delivery order comprising: a plurality of order items each associated with a kitchen, preparation time for each order item, location data of each kitchen, a delivery order destination, and requested delivery time; identifying a plurality of kitchens within a predetermined geolocation; defining an area for pickup of the order items; analyzing the following to determine a consolidation viability of pickup and delivery of each of the delivery orders: distance information between the localized area and the delivery order destination, preparation time associated with each of the order items, and the requested delivery time of the delivery order; assigning a delivery provider in proximity of the localized area to pick up the order items; determining an optimized route operative to satisfy the requested delivery time of delivery order; and transmitting, to the delivery provider, the optimized route.

Abstract: An electrically conductive adhesive composition, free of metals and metal salts, includes an adhesive polymer component selected from polyethylene-vinyl acetate, polyolefin elastomers, polyvinyl butyral, poly(acrylic acid), polyacrylates and poly(methyl methacrylate) from 5% to 40% by weight, an electrically conductive component including acetylene or carbon black nanoparticles, carbon nanotubes, and flakes or plates of graphene or graphene derivatives from 60% to 95% by weight, percentages by weight of the adhesive polymer component and electrically conductive component, the electrically conductive component consisting of acetylene or carbon black nanoparticles from 15% to 45% by weight, carbon nanotubes from 5% to 25% by weight, and flakes or plates of graphene or graphene derivatives from 35% to 70% by weight, percentages by weight of the electrically conductive component, and a solvent compatible with the adhesive polymer component from 50% to 90% by weight of the electrically conductive adhesive composit

Abstract: A pallet top deck, a bottom deck, and spaced apart support blocks coupled between the top and bottom decks. Each support block includes an inner wall surrounding an interior opening, an outer wall surrounding the inner wall, and a plurality of ribs extending between the inner and outer walls. First and second upper tabs extend outwards from upper surfaces of the inner wall, with each upper tab comprising an angled contact surface for engaging the top deck. The angled contact surfaces of the first and second upper tabs are oriented in a first direction. First and second lower tabs extend outwards from lower surfaces of the ribs, with each tab comprising an angled contact surface for engaging the bottom deck. The angled contact surfaces of the first and second lower tabs are oriented in a second direction that is orthogonal to the first direction.

Abstract: A pallet top deck, a bottom deck, and spaced apart support blocks coupled between the top and bottom decks. Each support block includes an inner wall surrounding an interior opening, an outer wall surrounding the inner wall, and a plurality of ribs extending between the inner and outer walls. First and second upper tabs extend outwards from upper surfaces of the inner wall, with each upper tab comprising an angled contact surface for engaging the top deck. The angled contact surfaces of the first and second upper tabs are oriented in a first direction. First and second lower tabs extend outwards from lower surfaces of the ribs, with each tab comprising an angled contact surface for engaging the bottom deck. The angled contact surfaces of the first and second lower tabs are oriented in a second direction that is orthogonal to the first direction.

Abstract: The present disclosure provides a method for managing a multi-kitchen order comprising: receiving a delivery order comprising: a plurality of order items each associated with a kitchen, preparation time for each order item, location data of each kitchen, a delivery order destination, and requested delivery time; identifying a plurality of kitchens within a predetermined geolocation; defining a localized area for pickup of the order items; analyzing the following to determine a consolidation viability of pickup and delivery of each of the delivery orders: distance information between the localized area and the delivery order destination, preparation time associated with each of the order items, and the requested delivery time of the delivery order; assigning a delivery provider in proximity of the localized area to pick up the order items; determining an optimized route operative to satisfy the requested delivery time of delivery order; and transmitting, to the delivery provider, the optimized route.

Abstract: A Laterally Diffused Metal Oxide Semiconductor (LDMOS) transistor with implant alignment spacers includes a gate stack comprising a first nitride layer. The first nitride layer is formed on a silicon layer. The gate stack is separated from a substrate by a first oxide layer. The gate stack includes a polysilicon layer formed from the silicon layer, and a second oxide layer is formed on a sidewall of the polysilicon layer. A drain region of the LDMOS transistor is implanted with a first implant aligned to a first edge formed by the second oxide layer. A second nitride layer conformingly covers the second oxide layer. A nitride etch-stop layer conformingly covers the second nitride layer.

Abstract: According to one aspect, a method for improved kitchen production is provided, the method comprising: receiving a request for one or more order items to be prepared in a kitchen, each of the one or more order items comprising: a recipe requiring: one or more resources for preparation, one or more processes for preparation, and an estimated preparation time, and a requested pickup time; retrieving a kitchen production capacity comprising a plurality of resources of the kitchen and a plurality of processes of the kitchen; projecting kitchen availability comprising: resource availability at a timeframe, process availability at the predetermined timeframe, current order items being prepared in the kitchen, and order items awaiting preparation in the kitchen; assessing the kitchen production capacity and the kitchen availability in view of the recipes of the one or more order items; and scheduling, based on the comparing, production the one or more order items.

Abstract: The present invention relates to a method for the preparation of a molecular sieve of the CHA-type as well as catalytic applications thereof.