Abstract: The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: The invention relates to a device (2) for injecting spin-polarized electrons and for reflecting light, comprising at least one lattice structure (3) having a plurality of recesses (4), wherein the lattice structure (3) is designed to reflect the light, and wherein a respective injection contact (5, 6) for injecting spin-polarized electrons is arranged in at least some of the recesses (4).

Abstract: A vehicle radar system (3) which, for each one of a plurality of radar cycles, is arranged to, provide a measured azimuth angle (?m) and radial velocity (vdm) for a first plurality of detections (9, 20). For each one of the plurality of radar cycles, the radar system (3) is arranged to select one of these detections for each one of two velocity components (vx, vy) in a set of components (vx, vy, ax, ay; a) to be determined; select one detection from a second plurality of detections (9, 20) for each one of at least one corresponding acceleration component (ax, ay; a); calculate the components (vx, vy, ax, ay; a) for the selected detections; determine a calculated radial velocity (vdc) for each one of at least a part of the other detections in the first plurality of detections (9, 20) using the calculated components (vx, vy, ax, ay; a); determine an error between each calculated and measured radial velocity (vdc, vdm); and determine the number of inliers.

Abstract: A monitoring device is provided for analytical measurement of reaction fluid produced in a reaction vessel in a spectrometer with a monitoring cell. The distribution apparatus includes at least four supply and return lines that open into the distribution apparatus, wherein the distribution apparatus comprises a distribution device for distributing reaction fluid to the supply and return lines. The distribution apparatus comprises a distribution vessel in which the distribution device and an electrically controllable pump device for pumping of the reaction fluid are provided, wherein the distribution device comprises an electrically controllable valve device for distributing the reaction fluid to the lines that open into the distribution vessel.

Abstract: The invention relates to an assembly for a vehicle brake system, which comprises at least one brake cylinder and an electromechanical brake booster, having a drive arrangement for driving at least one actuating device designed for actuating a brake cylinder, wherein the drive arrangement has at least one electric motor and a gear mechanism for coupling the electric motor to the at least one actuating device, wherein at least one fastening device is provided for fastening the assembly to a vehicle, said fastening device defining a fastening plane. According to the invention the rotary shaft of the electric motor is arranged perpendicular to the longitudinal axis of the actuating device and at an angle of between 60° and 120° to the fastening plane.

Abstract: An apparatus for collecting liquid fractions from a separation/reaction apparatus (1). A capillary (2) guides an extracted liquid fraction to a branching unit (3), a collection arrangement (4) carries a plurality of target vessels (5) receiving the liquid fraction from the capillary and a fluid line (6) is flow-connected to a fluid pump (7) and opens into the branching unit. The capillary and the fluid line each have outlet openings in the direct vicinity of one another at their end facing a target vessel such that liquid emerging from the outlet opening (2?) of the capillary transitions into the outlet opening (6?) of the fluid line. This precludes back mixing with earlier/later liquid fractions, precludes uncontrolled dripping of sample substance at the transfer point, speeds displacement of the target vessels in the collection arrangement, facilitates automation of the fraction processing procedure, and results in a more compact fraction collection apparatus.

Abstract: A system including an NMR spectrometer (1) with a flow cell (2) analyzing a first liquid test sample (P1), a distributing device (3) with a multi-way valve, plural assemblies interconnected via fluid lines through the distributing device, a cannula (5) taking test samples from a storage vessel (5a), a sample loop (6) temporarily storing a further test sample (P2), and a pump device (7) pumping liquid (S) into the system. The valve arrangement a) decouples the sample loop with the temporarily stored further test sample and, simultaneously, b) decouples the flow cell with the first test sample from all fluid lines to the distributing device; and c) connects the cannula to the pump device for a simultaneous purging step or to the flow cell for removing the first test sample into a receiving vessel (5b; 5c) or to the sample loop for receiving a subsequent test sample.

Abstract: A system including an NMR spectrometer (1) with a flow cell (2) analyzing a first liquid test sample (P1), a distributing device (3) with a multi-way valve, plural assemblies interconnected via fluid lines through the distributing device, a cannula (5) taking test samples from a storage vessel (5a), a sample loop (6) temporarily storing a further test sample (P2), and a pump device (7) pumping liquid (S) into the system. The valve arrangement a) decouples the sample loop with the temporarily stored further test sample and, simultaneously, b) decouples the flow cell with the first test sample from all fluid lines to the distributing device; and c) connects the cannula to the pump device for a simultaneous purging step or to the flow cell for removing the first test sample into a receiving vessel (5b; 5c) or to the sample loop for receiving a subsequent test sample.

Abstract: The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: The electromechanical brake force booster for a vehicle brake system comprises a drive arrangement for driving at least one actuating device which is designed for actuating a brake cylinder. The drive arrangement has at least one electric motor and a gearing for coupling the electric motor to the at least one actuating device. The gearing comprises at least one second spur gear and at least one first spur gear. Furthermore, the gearing has an intermediate gearing stage. The intermediate gearing stage couples the electric motor to the second spur gear and to the first spur gear in torque-transmitting fashion. The intermediate gearing stage drives the second spur gear directly and the first spur gear via at least one intermediate gear.

Abstract: The present disclosure relates to a bearing arrangement for supporting a shaft, in particular a shaft of a gearing mechanism for an electromechanical brake booster, having: at least one bearing, a shaft, which is at least section-wise accommodated in the at least one bearing and has a protruding, rounded region on at least one of its axial end surfaces, at least one spring element, that engages the protruding, rounded region in order to prestress the shaft in the axial direction.

Abstract: The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: A vacuum brake booster for a motor vehicle brake system, comprising a housing having axially opposing end wall regions which are connected together via a peripheral region, wherein the end wall regions each comprise at least one receiving opening for receiving components introducing braking force or releasing braking force, wherein at least one reinforcing rib is formed in at least one end wall region. According to the invention, the reinforcing rib extends outside of an inner circle arranged concentric to the receiving opening and spans an inner circle segment which encloses an angle of at least approximately 60° and at most approximately 180°.

Abstract: A bushing comprises an insulating body having a first body end portion, a second body end portion, and a body center portion connecting the first body end portion and the second body end portion, and a bushing conductor coaxially extending within and mechanically coupled to the insulating body. The bushing conductor includes a first connecting portion having a first end face at the first body end portion, a second connecting portion having a second end face at the second body end portion, and a center portion electrically and mechanically connecting the first connecting portion and the second connecting portion. The first connecting portion is elastically deformable with respect to the first body end portion along a radial direction and/or the second connecting portion is elastically deformable with respect to the second body end portion along the radial direction.

Abstract: A vehicle environment detection system (2) that includes at least one radar sensor arrangement (3) and at least one processing unit (4), where the radar sensor arrangement (3) is arranged to detect at least two radar detections (9, 10, 11) during at least two radar cycles. For each radar cycle, the processing unit (4) generates a detection list ({Dit}t=t0, . . . ,t0?N) including range (ri), azimuth angle (?i) and Doppler velocity (vi) for each of the radar detections (9, 10, 11). The processing unit (4) is further arranged to aggregate and store detection lists ({Dit}t=t0, . . . ,t0?N) from the radar cycles in a detection memory (12), and then to group the radar detections (9, 10, 11) in the detection lists ({Dit}t=t0, . . . ,t0?N) into consistently moving motion subsets (40, 41, 42) in a segmentation procedure. Each motion subset (40, 41, 42) corresponds to a certain target object (6, 7, 8).

Abstract: A bushing adapter comprises an insert having a bore extending through the insert along a length direction of the insert and a fastening member extending through the bore. The insert is configured to be attached to a bushing conductor of a bushing. The fastening member has an operating portion positioned outside of the bore at a bushing internal end of the fastening member and a fastening portion positioned outside of the bore at a bushing external end of the fastening member.

Abstract: A vacuum brake booster for a motor vehicle brake system, comprising a displaceable force input member that is coupled to or can be coupled to a brake pedal, a chamber arrangement arranged in a booster housing having at least one working chamber and at least one vacuum chamber, which are separated from one another via at least one movable wall, a control valve assembly that can be actuated by the force input member, and a force output member for transmitting an operating force to a downstream brake system. The at least one working chamber can be fluidically connected optionally to a negative pressure source or the atmosphere by way of the control valve assembly. The control valve assembly comprises a control valve housing, in which an actuating piston that is coupled with the force input member s displaceably arranged, and a first valve seat, and a second valve seat.

Abstract: The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: The present invention relates to a bispecific polypeptide molecule comprising a first polypeptide chain and a second polypeptide chain providing a binding region derived from a T cell receptor (TCR) being specific for a major histocompatibility complex (MHC)-associated peptide epitope, and a binding region derived from an antibody capable of recruiting human immune effector cells by specifically binding to a surface antigen of said cells, as well as methods of making the bispecific polypeptide molecule, and uses thereof.

Abstract: The present invention relates to a bispecific polypeptide molecule comprising a first polypeptide chain and a second polypeptide chain providing a binding region derived from a T cell receptor (TCR) being specific for a major histocompatibility complex (MHC)-associated peptide epitope, and a binding region derived from an antibody capable of recruiting human immune effector cells by specifically binding to a surface antigen of said cells, as well as methods of making the bispecific polypeptide molecule, and uses thereof.