Abstract: The present invention relates to a bispecific polypeptide molecule comprising a first polypeptide chain and a second polypeptide chain providing a binding region derived from a T cell receptor (TCR) being specific for a major histocompatibility complex (MHC)-associated peptide epitope, and a binding region derived from an antibody capable of recruiting human immune effector cells by specifically binding to a surface antigen of said cells, as well as methods of making the bispecific polypeptide molecule, and uses thereof.

Abstract: The present invention relates to a bispecific polypeptide molecule comprising a first polypeptide chain and a second polypeptide chain providing a binding region derived from a T cell receptor (TCR) being specific for a major histocompatibility complex (MHC)-associated viral peptide epitope, and a binding region derived from an antibody capable of recruiting human immune effector cells by specifically binding to a surface antigen of said cells, as well as methods of making the bispecific polypeptide molecule, and uses thereof.

Abstract: A vehicle radar system (3) and related method including at least one transceiver arrangement (7) arranged to generate and transmit radar signals (4), and to receive reflected radar signals (5). The radar signals form a plurality of sensing sectors or sensing bins (8a-8g), that together form a transceiver coverage (9), For each sensing bin (8a-8g) the radar system (3) is arranged to obtain a target angle (?) and a target range (r) to possible target objects (10a-10j). The radar system (3) is further arranged to determine an unoccupied domain border (11) and a corresponding unoccupied domain (12) for the radar transceiver coverage (9).

Abstract: The invention relates to an assembly for a vehicle brake system, which comprises at least one brake cylinder and an electromechanical brake booster, having a drive arrangement for driving at least one actuating device designed for actuating a brake cylinder, wherein the drive arrangement has at least one electric motor and a gear mechanism for coupling the electric motor to the at least one actuating device, wherein at least one fastening device is provided for fastening the assembly to a vehicle, said fastening device defining a fastening plane. According to the invention the rotary shaft of the electric motor is arranged perpendicular to the longitudinal axis of the actuating device and at an angle of between 60° and 120° to the fastening plane.

Abstract: The disclosed electromechanical brake booster for a vehicle brake system comprises a driving arrangement for driving at least one actuation device designed to actuate a brake cylinder. The driving arrangement includes at least one electric motor and a gear mechanism for coupling the electric motor to the at least one actuation device. The gear mechanism comprises at least one first spur gear and at least one second spur gear, the electric motor driving the first spur gear directly and the second gear via at least one intermediate gear.

Abstract: The electromechanical brake force booster for a vehicle brake system comprises a drive arrangement for driving at least one actuating device which is designed for actuating a brake cylinder. The drive arrangement has at least one electric motor and a gearing for coupling the electric motor to the at least one actuating device. The gearing comprises at least one second spur gear and at least one first spur gear. Furthermore, the gearing has an intermediate gearing stage. The intermediate gearing stage couples the electric motor to the second spur gear and to the first spur gear in torque-transmitting fashion. The intermediate gearing stage drives the second spur gear directly and the first spur gear via at least one intermediate gear.

Abstract: A monitoring device is provided for analytical measurement of reaction fluid produced in a reaction vessel in a spectrometer with a monitoring cell. The distribution apparatus includes at least four supply and return lines that open into the distribution apparatus, wherein the distribution apparatus comprises a distribution device for distributing reaction fluid to the supply and return lines. The distribution apparatus comprises a distribution vessel in which the distribution device and an electrically controllable pump device for pumping of the reaction fluid are provided, wherein the distribution device comprises an electrically controllable valve device for distributing the reaction fluid to the lines that open into the distribution vessel.

Abstract: A vacuum brake booster for a motor vehicle brake system, comprising a housing having axially opposing end wall regions which are connected together via a peripheral region, wherein the end wall regions each comprise at least one receiving opening for receiving components introducing braking force or releasing braking force, wherein at least one reinforcing rib is formed in at least one end wall region. According to the invention, the reinforcing rib extends outside of an inner circle arranged concentric to the receiving opening and spans an inner circle segment which encloses an angle of at least approximately 60° and at most approximately 180°.

Abstract: A vacuum brake booster for a motor vehicle brake system, comprising a displaceable force input member that is coupled to or can be coupled to a brake pedal, a chamber arrangement arranged in a booster housing having at least one working chamber and at least one vacuum chamber, which are separated from one another via at least one movable wall, a control valve assembly that can be actuated by the force input member, and a force output member for transmitting an operating force to a downstream brake system. The at least one working chamber can be fluidically connected optionally to a negative pressure source or the atmosphere by way of the control valve assembly. The control valve assembly comprises a control valve housing, in which an actuating piston that is coupled with the force input member s displaceably arranged, and a first valve seat, and a second valve seat.

Abstract: A method for displaying at least one parameter concerning the operation of a vehicle in the vehicle by a display device with a display surface wherein, in a first display mode of the display device, the display surface generates a display element with a first boundary and an area lying within the first boundary. The area is divided into at least a first sub-area and a second sub-area and the first sub-area includes a scale by which a state variable of the vehicle is displayed. The current value of the state variable is displayed in the first display mode by a graphical element which extends from the second sub-area in the first sub-area to the scale. Also disclosed is a device for displaying at least one parameter concerning the operation of a vehicle in the vehicle.

Abstract: A pipetting device (2) for removing fluid from a sample vessel (52) includes a pipetting needle (4) and an auxiliary cannula (18) for piercing a septum, designed to guide the pipetting needle axially through the auxiliary cannula. The pipetting device has a guide arm (6), on the lower end (10) of which is arranged an end plate (12) that is axially displaceable along the guide arm against a resilient resistance. A centering device (14) inserts into the end plate of the guide arm, and at least three centering fingers (26) with conical bevels (34) are constructed on the radial outside of the centering device, distributed around the circumference thereof, and forming a holding-down device for the sample vessel. The disclosed construction makes possible to reliably pierce the septum of a sample vessel and to easily pull the pipetting needle out of the septum again even with thin pipetting needles.

Abstract: A pipetting device (2) for removing fluid from a sample vessel (52) includes a pipetting needle (4) and an auxiliary cannula (18) for piercing a septum, designed to guide the pipetting needle axially through the auxiliary cannula. The pipetting device has a guide arm (6), on the lower end (10) of which is arranged an end plate (12) that is axially displaceable along the guide arm against a resilient resistance. A centering device (14) inserts into the end plate of the guide arm, and at least three centering fingers (26) with conical bevels (34) are constructed on the radial outside of the centering device, distributed around the circumference thereof, and forming a holding-down device for the sample vessel. The disclosed construction makes possible to reliably pierce the septum of a sample vessel and to easily pull the pipetting needle out of the septum again even with thin pipetting needles.

Abstract: Monitoring cell (100) for performing an NMR measurement of a reaction fluid. The monitoring cell (100) has a hollow NMR sample probe (110) for receiving the reaction fluid. Inlet and outlet transport capillaries (112, 123) transport the reaction fluid to and from the sample probe (110). A feed line (306) and return line transport a temperature control fluid to and from the monitoring cell (100). An adapter head (108) couples the transport capillaries (112, 123) to the sample probe (110) and removably connects the sample probe (110) to an adapter section (106). The transport capillaries (112, 123) are positioned within the feed line (306) in parallel to one another. The feed and the return lines (306, 358) are attached to the adapter section (106) such that a reversal of the temperature control fluid stream occurs in the adapter section (106).

Abstract: Monitoring cell (100) for performing an NMR measurement of a reaction fluid. The monitoring cell (100) has a hollow NMR sample probe (110) for receiving the reaction fluid. Inlet and outlet transport capillaries (112, 123) transport the reaction fluid to and from the sample probe (110). A feed line (306) and return line transport a temperature control fluid to and from the monitoring cell (100). An adapter head (108) couples the transport capillaries (112, 123) to the sample probe (110) and removably connects the sample probe (110) to an adapter section (106). The transport capillaries (112, 123) are positioned within the feed line (306) in parallel to one another. The feed and the return lines (306, 358) are attached to the adapter section (106) such that a reversal of the temperature control fluid stream occurs in the adapter section (106).

Abstract: A method for analyzing wine proposes puncturing the closure (60) of a wine bottle (61) containing wine (62) with a disposable cannula (3) having a lateral cannula opening (32) and a female Luer connection (30), and filling a disposable syringe (4) having a male Luer connection (41) with an inert gas. At least part (69) of the wine sample (65) is transferred into an analytical spectrometer (68) and spectrometric analysis of the wine sample (65) is carried out. An inexpensive method is thereby proposed that is easy to perform for analyzing a wine sample from a sealed wine bottle without impairing the quality or storage stability of the wine remaining in the wine bottle due to withdrawal of a wine sample from the wine bottle, in particular, wherein the volume of the removed wine sample can be easily controlled.

Abstract: A method for displaying at least one parameter concerning the operation of a vehicle in the vehicle by a display device with a display surface wherein, in a first display mode of the display device, the display surface generates a display element with a first boundary and an area lying within the first boundary. The area is divided into at least a first sub-area and a second sub-area and the first sub-area includes a scale by which a state variable of the vehicle is displayed. The current value of the state variable is displayed in the first display mode by a graphical element which extends from the second sub-area in the first sub-area to the scale. Also disclosed is a device for displaying at least one parameter concerning the operation of a vehicle in the vehicle.

Abstract: A method for analyzing wine proposes puncturing the closure (60) of a wine bottle (61) containing wine (62) with a disposable cannula (3) having a lateral cannula opening (32) and a female Luer connection (30), and filling a disposable syringe (4) having a male Luer connection (41) with an inert gas. At least part (69) of the wine sample (65) is transferred into an analytical spectrometer (68) and spectrometric analysis of the wine sample (65) is carried out. An inexpensive method is thereby proposed that is easy to perform for analyzing a wine sample from a sealed wine bottle without impairing the quality or storage stability of the wine remaining in the wine bottle due to withdrawal of a wine sample from the wine bottle, in particular, wherein the volume of the removed wine sample can be easily controlled.

Abstract: The present invention relates to anti-FLT3 antibodies with a modified Fc region comprising the amino acid substitutions 239D and 332E to enhance antibody-dependent cell cytotoxicity (ADCC) of these antibodies. The invention further relates to pharmaceutical compositions containing these antibodies, nucleic acids encoding these antibodies as well as methods of using such antibodies.

Abstract: The invention relates to a device (1, 21, 31, 41, 64) for the preparation and measurement of a nuclear spin resonance (NMR) measurement sample (10), including—a flow-through NMR probehead (2), with a first tube (3) and a second tube (14) each for the supply and removal of a liquid NMR measurement sample (10),—at least one chamber (4, 22, 32) which is connected to one of the tubes (3, 14),—a sample inlet (5) for introducing the liquid measurement sample (10) into the device (1, 21, 31, 41, 64), wherein at least one chamber (4, 22, 32) has at least one connection for increasing (9, 24, 25, 42, 43, 46, 47) and releasing (8, 23, 27, 48a, 48b) the gas pressure, and in which at least one chamber (4, 22, 32) comprises means for mixing the liquid measurement sample (10) contained in the chamber (4, 22, 32) with a gas With the inventive device it is possible to reduce the measurement sample consumption when doing an NMR spectroscopic measurement on liquid measurement samples to which spin order can be catalytically tr

Abstract: The present invention relates to anti-FLT3 antibodies with a modified Fc region comprising the amino acid substitutions 239D and 332E to enhance antibody-dependent cell cytotoxicity (ADCC) of these antibodies. The invention further relates to pharmaceutical compositions containing these antibodies, nucleic acids encoding these antibodies as well as methods of using such antibodies.