Abstract: The present invention relates to the field of methods for providing pharmaceutical compositions comprising poorly water-soluble drugs. In particular the present invention relates to compositions comprising stable, amorphous hybrid nanoparticles, comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix-forming component, useful in pharmaceutical compositions and in therapy.

Abstract: Devices, systems, methods, and/or computer-implemented methods that can facilitate protection of a substrate in a qubit device using sacrificial material are provided. According to an embodiment, a device can comprise a superconducting lead provided on a pillar of a sacrificial material provided on a substrate. The device can further comprise a collapsed superconducting junction provided on the substrate and coupled to the superconducting lead.

Abstract: A tool for thermoforming a container having a base and an upstanding sidewall walls or walls. The tool includes a mould having a profile shaped to form the exterior shape of the container and a plug adapted to be inserted in the mould to define the interior of the container. The plug has a lower face adapted to define the profile of the base of the container. The profile of the lower face of the plug has at least one groove therein defining, in use, a rib upstanding in the interior of the base of the container.

Abstract: The invention relates to an orthopedic joint device having an upper part and a lower part which is hinged about a pivot axis to said upper part, having a flexion moment-controlled retainer device that is positioned between the upper part and the lower part, blocks a flexion and releases the flexion when a predefined flexion moment is exceeded, wherein a control element is associated with the retainer device and is coupled to a delaying element.

Abstract: The invention relates to an exhaust gas turbocharger having a hydrodynamic plain bearing or a hydrodynamic plain bearing, comprising a rotor (10) and a counter-bearing part (50) assigned to the rotor (10), wherein a rotor bearing surface of the rotor (10) and a counterface of the counter-bearing part (50) face each other to form the hydrodynamic plain bearing in the form of a combined journal—thrust bearing, having a continuous hydrodynamically load bearing gap formed between the rotor bearing surface and the counterface, wherein the rotor bearing surface and/or the counterface, when cut longitudinally and through the axis of rotation (R) in sectional view, form(s) a bearing contour forming merging contour sections (17.1 to 17.3; 44.1 to 44.3; 53.1 to 53.3) to generate hydrodynamic load capacities in both the radial and the axial direction, wherein a contour section (17.3; 44.3; 53.

Abstract: The invention relates to various aspects of a ?-LED or a ?-LED array for augmented reality or lighting applications, in particular in the automotive field. The ?-LED is characterized by particularly small dimensions in the range of a few ?m.

Abstract: In certain aspects, a quasi-rigorous electromagnetic simulation, such as a domain decomposition-based simulation, is applied to an area of interest of a lithographic mask to produce an approximate prediction of the electromagnetic field from the area of interest. This is then applied as input to a machine learning model, which improves the electromagnetic field prediction from the quasi-rigorous simulation, thus yielding results which are closer to a fully-rigorous Maxwell simulation but without requiring the same computational load.

Abstract: A method of making superabsorbent polymer material and comprising the step of providing soluble polyacrylic acid polymers. The soluble polyacrylic acid polymers have a molar percent of carbon-to-carbon double bonds of at least 0.03. The soluble polyacrylic acid polymers may be obtained from pre-existing recycled post-consumer superabsorbent polymer material, and/or from pre-existing recycled post-industrial superabsorbent polymer material. Superabsorbent polymer material obtained by the method, and absorbent articles comprising these materials are also provided.

Abstract: The present invention is related to an aqueous post treatment composition for providing a post treatment layer on at least a part of a passivation layer, which is covering at least a part of a zinc layer being on at least a part of an iron containing substrate, characterized in that the aqueous post treatment composition comprises at least one chromium (III) ion source and at least one compound containing the chemical element silicon; wherein a molar ratio of silicon versus chromium is given in said composition, with the proviso that said molar ratio is ranging from 2600:1 to 1:1 for the zinc layer obtained by an electrolytic acid zinc deposition process; or that said molar ratio is ranging from 5200:1 to 1:1 for the zinc layer obtained by an electrolytic alkaline zinc deposition process.

Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Abstract: Disclosed are super-hydrophobic, super oleophilic membranes comprising a metal mesh comprising copper, a coating comprising a carbohydrate derivative, wherein the carbohydrate derivative is covalently or ionically bonded to a metal mesh surface and methods of preparation thereof. The disclosed membranes are useful for wastewater treatment in the oil industry, in particular for oil/water separation processes.

Abstract: A receiver for receiving a combination signal having two separate signal portions whose pulses are shifted relative to each other and/or whose carrier waves have a phase difference is configured to obtain a first series of samples using a first sampling and to obtain a second series of samples using a second sampling. The first sampling is adjusted to a symbol phase of the first signal portion, the second sampling is adjusted to a symbol phase of the second signal portion.

Abstract: A method for checking a fault status of a mobile utility unit by a maintenance station includes generating via control electronics status data representing a fault status of the mobile utility unit, storing the status data as fault data in a fault memory via the control electronics, classifying via a data processing unit the fault data under different fault classes to identify an applicable fault class, and initiating via the data processing unit a procedural measure for the mobile utility unit according to the identified fault class.

Abstract: A method for breaking down a mixture, which is present in the form of solid particles, consisting of: (A) 0 to 99% by weight of metallic ruthenium, (B) 0 to 50% by weight of at least one element other than ruthenium, which is present in elementary form, selected from the group of elements of the atomic numbers 13, 21-30, 39-42, 45-52, and 72-83, (C) 0 to 99% by weight of ruthenium oxide, (D) 0 to 70% by weight of at least one solid element oxide other than ruthenium, (E) 0 to 30% by weight of at least one inorganic substance other than (A) to (D), and (F) 0 to 3% by weight of at least one organic substance, wherein the sum of the % by weight of the compounds (A) to (F) is 100% by weight and the ruthenium content of the mixture is 2 to 99% by weight, and wherein the method comprises the steps of: (1) optionally mixing said mixture with alkali carbonate by forming a blend, (2) alkaline oxidizing breakdown of the mixture or of the blend, respectively, formed in optional step (1) into molten potassium hydroxide u

Abstract: The present invention relates to a method for reducing wear of an energy storage device in an energy storage system connected to a load, the energy storage system comprising at least two energy storage devices. The method comprising: connecting (S1) the energy storage system to an electrical energy source, and electrically powering (S2) the load via the energy storage system by connecting at least one of the energy storage devices to transfer electrical energy from the electrical energy source to the load, and disconnecting at least one other energy storage device to not transfer any electrical energy from the electrical energy source to the load.

Abstract: A three-dimensional (3D) measuring instrument includes a registration camera and a surface measuring system having a projector and an autofocus camera. For the instrument in a first pose, the registration camera captures a first registration image of first registration points. The autofocus camera captures a first surface image of first light projected onto the object by the projector and determines first 3D coordinates of points on the object. For the instrument in a second pose, the registration camera captures a second registration image of second registration points. The autofocus camera adjusts the autofocus mechanism and captures a second surface image of second light projected by the projector. A compensation parameter is determined based at least in part on the first registration image, the second registration image, the first 3D coordinates, the second surface image, and the projected second light.

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.

Abstract: An auto-injector may include a housing having a longitudinal axis and a transverse axis, the housing having a shorter dimension along the transverse axis than along the longitudinal axis, wherein the transverse axis is perpendicular to the longitudinal axis; a flowpath having a first end and a second end; and a container enclosing a first fluid, the container extending from a first end toward a second end along or parallel to the longitudinal axis and being movable from a first position to a second position along or parallel to the longitudinal axis, the container being fluidly isolated from the flowpath in the first position and fluidly connected to the flowpath in the second position.

Abstract: A digitally printed security document includes: a security document substrate; a first digitally printed print working on a first surface of the substrate in a first region, the first print working including a first array of printed elements arranged according to a first grid of lattice points having a first pitch; and a second digitally printed print working on the first surface of the substrate in a second region, the second print working including a second array of printed elements arranged across a second grid of lattice points having a second pitch different from the first pitch.

Abstract: A measurement input circuit for a measurement device for measuring an electric signal in a device under test comprises a signal input that receives the electronic signal from the device under test and provides the received electronic signal at a signal node, a direct signal coupling path that is coupled between the signal node an electrical ground and comprises a first impedance value, an alternating signal coupling path that is coupled between the signal node and the electrical ground , and comprises a second impedance value that is lower than the first impedance value, and a signal output that is coupled to the signal node and outputs the received electronic signal.