Abstract: System and methods may be used for arc fluence optimization without iteration to arc sequence generation. A method may include defining a particle arc range for a radiotherapy treatment of a patient, and generating an arc sequence, including a set of parameters for delivering the radiotherapy treatment, without requiring a dose calculation. The method may include optimizing fluence of the arc sequence for the radiotherapy treatment without iterating back to arc sequence generation, and outputting the fluence optimized arc sequence for use in the radiotherapy treatment.

Abstract: A vaporizer has a main unit, an atomizer, a mouthpiece and a quick connect adapter. The quick connect adapter includes a housing, air flow path, a quick release connector and an adapter connector. The housing defines an inner channel. The inner channel has a first open end and a second open end. The air flow path is defined by the housing to allow vapor to flow from the atomizer to the mouthpiece. The quick release connector is coupled to, and located adjacent, the first end of the housing. The quick release connecter is configured to allow the mouthpiece to be releasably coupled to the main unit via the quick connect adapter. The adapter connector coupled to, and located adjacent, the second end of the housing. The adapter connector is configured to allow the quick connect adapter to be releasably coupled to the main unit.

Abstract: A dielectric wave guide cable (1) includes a tubular core (2) made from a low loss material having a certain permittivity. The tubular core (2) is encompassed by a cladding (3) having, compared to the tubular core (2), a lower permittivity. The tubular core (2) may be coated on the inside by a coating (3) having a higher permittivity. The cladding (3) may be encompassed by a jacket (4).

Abstract: A mobile operating table column comprising a base and a stability system for ensuring that the base rests securely on an uneven surface, wherein the stability system comprises: four retractable and extendable upright support elements arranged at four different corners of the base, as well as support surfaces and an actuator for retracting and extending each of the four upright support elements. Each upright support element is associated with a support surface and can be retracted and extended relative to the latter. Moreover, the stability system may assume at least two different operating states: i) a parked state, in which the base rests on the floor with at least three of the support surfaces and the upright support elements are retracted; and ii) a fixed stationary state, in which the base rests on the surface with at least three of the support surfaces and the support elements are extended such that they are in contact with the surface and thereby ensure that the base rests securely on the floor.

Abstract: A syringe pump is disclosed that includes a pressure sensor assembly, a plunger, first and second pressure sensors, and a processor. The pressure sensor assembly senses a force and includes the plunger having a sensing surface configured to receive the force, the first pressure sensor operatively coupled to the plunger and configured to estimate the force applied to the sensing surface, and the second pressure sensor operatively coupled to the plunger and configured to estimate the force applied to the sensing surface. The processor is coupled to the first and second pressure sensors to estimate a magnitude of the force.

Abstract: An electronic vaporizer includes a main unit, an atomizer and a mouthpiece. The atomizer is removably coupled to the main unit. The mouthpiece is removably coupled to the atomizer. The atomizer includes an atomizer base, a heating electrode coupled to the atomizer base, a temperature sensing electrode coupled to the atomizer base, a heating element electrically coupled to the heating electrode and the temperature sensing electrode, and a heating crucible thermally coupled to the heating element. The heating element includes a heating element base, a heating circuit encapsulated within the heating element base and a temperature sensing circuit encapsulated within the heating element base.

Abstract: The present disclosure relates to a mouthpiece (40) for delivering an aerosol supplied by a nebulizer (100) to a user, the mouthpiece (40) comprising a body (46) defining a fluid path (47) from an inlet port (41) connectable to the nebulizer (100) to an inhalation opening (42) to be received in the mouth of a user and a filter (30). The filter (30) has a filter base (31) in fluid communication with the fluid path (47), a filter top (33) detachably connected to the filter base (31) and a filter material (32) provided between the filter base (31) and the filter top (33). The filter top (33) has an exhalation opening (36) cooperating with a one-way valve (39) allowing exhaustion of fluid from the fluid path (47) through the filter material (32) to the outside of the mouthpiece upon exhalation of a patient through the inhalation opening (42). The body (46) and the filter base (31) are an integrated one-piece unit so as to provide for an easy to handle and comfortable mouthpiece (40).

Abstract: Modular autonomous mobile fence, delimiter of grazing areas. It consists of two structures (10, 20) arranged opposite and distant from each other. Each structure (10, 20) is composed of at least two movable towers, arranged at the ends of the very same row and structurally linked to each other to form a movable row. An electric wire conductor (14, 15) is arranged between these two rows (10, 20) and forms a closed quadrilateral that delimits a closed grazing area (16). Said rows with towers and the area delimited by the electric fence can be selectively moved from one lot to the next, together with the animals kept therein. Said electric fence must have means of separation (31, 32) of the electric conductor from the ground (14, 15) and at least one of the mentioned towers must have means of tensioning (34) the electric conductor.

Abstract: A communications device configured to transmit data to an infrastructure equipment of a wireless communications network is provided. The communications device is configured to periodically switch between an active operating mode and a reduced power operating mode in accordance with a discontinuous reception, DRX, operation. The communications device comprises transceiver circuitry configured to transmit signals and receive signals via a wireless access interface provided by the wireless communications network, and controller circuitry configured to control the transceiver circuitry to monitor for signals transmitted by the infrastructure equipment to the communications device, to receive, from the infrastructure equipment, a dynamic DRX indicator, DDI, the DDI indicating that the DRX operation should be updated by the communications device, and to update the DRX operation in accordance with the received DDI.

Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Abstract: A method for supplying a mobile usage unit with a consumable delivered by a movable delivery connection of a maintenance station to a supply inlet of the mobile usage unit includes identifying via a sensor system a supply inlet of the mobile usage unit, the sensor system providing data to a control unit, fluidly connecting via the control unit the delivery connection to the identified supply inlet, delivering via the control unit the consumable to the supply inlet, and after the delivery of the consumable has terminated, fluidly separating via the control unit the delivery connection from the supply inlet.

Abstract: Methods and apparatuses to non-destructively and periodically sample a small quantity of intracellular proteins and mRNA from the same single cell or cells for an extended period of time. Specifically, describe herein are non-perturbative methods for time-resolved, longitudinal extraction and quantitative measurement of intracellular proteins and nucleic acids from a variety of cell types using systems including nanostraws.

Abstract: There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3 and X have meanings provided in the description, which compounds are useful in the treatment of cancers.

Abstract: An AHP is disclosed having a topsheet, a backsheet joined with the topsheet, an absorbent core, disposed between the topsheet and the backsheet, and a poly(acrylic acid)-based superabsorbent polymer (SAP), partly derived from recycled resources. The SAP exhibits defined Saline Flow Conductivity and Absorption Against Pressure values. Methods for making the aforementioned AHP are also disclosed.

Abstract: Various aspects of the present disclosure are directed to a cylinder head for an internal combustion engine. In one example embodiment, the cylinder head includes at least one spark plug having at least one earth electrode, a precombustion chamber accommodating the at least one spark plug, and a fuel channel which leads into the precombustion chamber. The fuel channel having a flow axis at an outlet that is oriented in the direction of the at least one earth electrode. An axis of rotation of the at least one spark plug has an offset with respect to the flow axis between 0 and 15% of the greatest precombustion chamber diameter.

Abstract: A patient support apparatus includes a deck to support a mattress and a patient on the mattress, the deck including a head deck section articulatable about an axis to change an angle of the head deck section, and a control system in communication with a user interface, with the control system configured to adjust the angle of the head deck section and to adjust the height of the deck in response to input at the user interface. The control system is in communication with a display and generates a GUI (graphical user interface) at the display to display a deck icon representative of the deck and a height icon representative of the height.

Abstract: In example implementations, an apparatus is provided. The apparatus includes a first low voltage control block, a second low voltage control block, a primitive level shifter coupled to the first low voltage control block, a plurality of nozzle level shifters coupled to the primitive level shifter and a second low voltage control block, and a high side switch (HSS) control coupled to each one of the plurality of nozzle level shifters and the second low voltage control block. The plurality of nozzle level shifters are communicatively coupled to each other. The primitive shifter is to enable a selected nozzle level shifter to fire a respective HSS control circuit of the selected nozzle level shifter and to direct a tail current from the selected nozzle level shifter.

Abstract: A photovoltaic module includes at least one solar cell, an encapsulant encapsulating the at least one solar cell, a frontsheet juxtaposed with the encapsulant, and backsheet juxtaposed with the encapsulant. The frontsheet includes a glass layer, a polymer layer attached to the glass layer, and an adhesive layer attaching the polymer layer to the glass layer. The backsheet includes a single-layer, moisture-resistant, fire-retardant membrane.

Abstract: A modular toy system comprising a plurality of separate electronic toy modules, each electronic toy module comprising a function device operable to perform a user-perceptible function and a control circuit for controlling the function device; wherein at least a first electronic toy module of the plurality of electronic toy modules comprises a first control circuit, a first function device and a sensor system configured for contactless detection of respective coordinate values of at least two coordinates, each coordinate being indicative of a position or an orientation of at least a second electronic toy module of the plurality of electronic toy modules relative to the first electronic toy module; and wherein the first control circuit is configured to control operation of the first function device based on one or more of the detected coordinate values.

Abstract: A nickel-base alloy for high-temperature applications, preferably for gas turbines, and a process. A selective choice of alloy elements permits the provision of an alloy which can be used to produce components devoid of cracking.