Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: A center console for a vehicle, has at least one storage chamber, laterally delimited on both sides by two side walls, and at least one dividing element, arranged in the storage chamber and which serves for subdividing the storage chamber. In order to provide a center console having a storage chamber which can be adapted to articles that are to be stored, the center console has at least two upwardly open holding slots which are arranged in the storage chamber and are mutually spaced in a transverse direction of the center console and which are arranged mutually oppositely on the side walls such that the dividing element can, at edges, be at least partially inserted into the holding slots from above.

Abstract: A method of treating a brine composition includes hydrolyzing a metal halide salt in the brine composition to form a hydrolysis product including a hydrohalic acid. The metal includes an alkaline earth metal or an alkali metal.

Abstract: Methods, systems and devices are disclosed that provide, among other benefits, an adequate and effective pain management that can be implemented as part of surgical planning, pain management, and other applications. An example methodology for reducing post-operative pain of a subject includes administering, daily, for a first number of days before a surgery on the subject and according to a first pre-arranged schedule of administrations, light with one or more wavelengths in the range between approximately 515 nm and approximately 535 nm to the subject. The method further includes administering, daily, for a second number of days following the surgery and according to a second pre-arranged schedule of administrations, light with one or more wavelengths in the range between approximately 515 nm and approximately 535 nm. The light is administered for a time period during each day of the light administration.

Abstract: Disclosed herein are base-modified nucleoside-5?-oligophosphates (bm-N5OP) that include a positively charged moiety at least at one position of the base, compositions comprising the same, compositions made from the same, methods of making the same, and methods of using the same. The bm-N5OP disclosed herein are useful, for example, as tagged nucleotides for use in nanoSBS methods and for generating primers and/or templates for use in nanoSBS methods. When incorporated into a polynucleotide, the disclosed bm-N5OPs can neutralize at least a portion of the negative charge of the overall polynucleotide molecule.

Abstract: Methods and system are provided to select a battery control strategy for a hybrid battery of a hybrid electric vehicle. The methods comprise receiving forecast weather information at a first location, determining an operational parameter of the hybrid battery, and selecting a first battery control strategy based on the forecast weather information and the operational parameter of the hybrid battery, wherein the control strategy comprises a state of charge target for the hybrid battery required for a next start sequence.

Abstract: The invention provides arylthioether acetamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as bacterial infections, and in inhibiting LpxA activity.

Abstract: An actuation device for a motor vehicle, in particular for specifying a braking and/or acceleration request, with a first and a second housing portion is disclosed. The first housing portion includes an actuating surface on a top surface facing away from the second housing portion, or a cover with the actuating surface is arranged on the top surface. The housing portions are connected to each other by a hinge. An axis of rotation of the hinge is arranged laterally spaced apart from the actuating surface.

Abstract: The invention relates to a process for preparing heterocyclic amide derivatives, to novel polymorphic forms obtained from said process and the use of said polymorphic forms for use in the treatment and prophylaxis of cancer.

Abstract: A method of reducing rollback of a electric vehicle, including determining a position baseline of the electric vehicle; determining a position compensated speed of the electric vehicle based on the position baseline; determining a hold torque as a function of the position compensated speed; and generating a command to apply the hold torque to the motor-generator of the electric vehicle.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures include, in at least one aspect, a fully automatic method of converting a generative design into an editable, watertight B-Rep by leveraging the generative solver input and representation to: (1) embed the exact input solid boundary surfaces where the design coincides with the input, (2) approximate everywhere else the design boundary with globally smooth, editable “organic” surfaces, and (3) join all surfaces to form a generative design output B-Rep.

Abstract: The present disclosure provides, inter alia, a composition and method to make the composition comprising a therapeutic protein expressing microorganism, one or more disaccharides, one or more oligosaccharides, one or more antioxidants, one or more fatty alcohol, and colloidal oatmeal and/or alkaline oatmeal extract.

Abstract: A dryer has a drum for laundry items to be dried, a supply air channel, an exhaust air channel, a recirculated air channel branching off therefrom and discharging into the supply air channel upstream of a drum inlet, a blower, a heat pump having a condenser disposed in the supply air channel, an evaporator disposed in the exhaust air channel, a throttle, a compressor, a controller and a heater. The dryer is configured such that moist warm air flows out of the drum in an exhaust air channel part, substantially in the same direction as the supply air in an inlet part of the supply air channel containing the condenser. The process air leaving the drum has a relative air humidity Frel, to which Frelmin?Frel?Frelmax applies, wherein Frelmin is a predetermined minimum value and Frelmax is a maximum value of the relative air humidity.

Abstract: The invention relates to powder coating compositions suitable for low temperature powder coating crosslinking typically at curing temperature is between 75 and 140° C. which can be used for powder coating temperature-sensitive substrates like MDF, wood, plastic or temperature sensitive metal alloys.

Abstract: A method of operating a wind turbine, in particular plural wind turbines of a wind park, includes: receiving, by the wind turbine or a wind park controller, safety relevant information from an external source external to the wind turbine; activating, by the wind turbine or the wind park controller, a safe operation mode depending on the received information, wherein the external source is different from a wind park controller.

Abstract: A process for the production of a propylene homopolymer or a propylene-ethylene copolymer includes polymerizing propylene and optional ethylene comonomers in the presence of a catalyst, wherein the catalyst is obtainable by a process of A) providing a Ziegler-Natta procatalyst including contacting a magnesium-containing support with i) a halogen-containing titanium compound, ii) ethylbenzoate as an activator, iii) and as internal donor an aminobenzoate compound according to formula B preferably 4-[benzoyl(methyl)amino]pentan-2-yl benzoate (AB); and B) contacting the Ziegler-Natta procatalyst obtained in step A) with a co-catalyst and a Selectivity Control Agent (SCA) in combination with an Activity Limiting Agent (ALA) to obtain the catalyst.

Abstract: The present invention relates to a catalytic article for purifying an exhaust gas containing nitrogen oxides, which comprises a first region containing a vanadium-based SCR catalyst, a second region containing a metal-promoted molecular sieve catalyst, and a third region containing a vanadium-based SCR catalyst, wherein at least part of the second region is located downstream of at least part of the first region and upstream of at least part of the third region in the exhaust gas flow direction, provided that no part of the second region is located upstream of the first region or downstream of the third region. The present invention also relates to a method and a system for treatment of an exhaust gas containing nitrogen oxides by selective catalytic reduction using the catalytic article.

Abstract: Disclosed herein is a method of pretreatment of a metallic substrate for a subsequent metal cold forming process. The method includes at least steps (1) and (2), namely providing at least one substrate having at least one surface at least partially made of at least one metal (step (1)), contacting the at least one surface of the substrate provided in step (1) with an aqueous lubricant composition (B) (step (2)), where the aqueous lubricant composition (B) includes besides water at least constituents (b1) to (b4) and optionally (b5). Further disclosed herein are a pretreated metallic substrate obtained by the method, a method of cold forming of a metallic substrate, and an aqueous lubricant composition (B).

Abstract: The disclosure includes systems and devices for collaborative moving of a push-cable. Such systems and devices include cable-storage drum devices used to store and dispense/retract a push-cable, generally via motors or like machine-driven force, and cable-storage drum devices used to direct and impart machine-driven force in moving the push-cable as well as push-cable moving systems employing a cable-storage drum device and a cable-storage drum device. The cable-storage drum devices and cable-handling devices as well as systems of the present invention may be communicatively linked in generating corresponding movements of the push-cable. The disclosure further includes methods associated with such push-cable moving systems and a cleaning element apparatus that may be used in a cable-storage drum device, push-cable handling device, or both in cleaning a push-cable prior to retraction.

Abstract: An apparatus for sampling landfill gas from a landfill flowing through a pipe. The apparatus may comprise: an enclosure configured to receive a section of the pipe; a gas sampling port in the section of the pipe; at least one sensor device disposed in a region of the enclosure, the at least one sensor being coupled to the section of the pipe through the gas sampling port; and thermal insulation positioned to retain heat from the section of the pipe in the region of the enclosure. A method of operating a landfill gas recovery system. The method may comprise: flowing gas from a well riser pipe through a sampling subsystem to a collection system; and heating a portion of the sampling subsystem with the gas flowing from the well riser pipe to the collection system.