Abstract: The invention refers to an implant device, in particular to a pubic symphysis implant device, and to an implant system comprising two such implant devices. The implant device of the invention comprises a bent body comprising a curved middle portion and two lateral arms extending away from the middle portion and being mutually joined by the middle portion, and at least one guiding element defining at least one guiding path along which a tensioning element can be guided. The invention further refers to method of fixating together a first bone or bone part and a second bone or bone part, for example for re-joining a disjoined pubic symphysis, using such an implant system, in particular by placing each of the two implant devices on corresponding bones or bone parts and by pulling the two implant devices towards each other by tensioning a tensioning element guided along the at least one guiding path of each of the two implant devices.

Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: Herein is reported a method for determining the concentration of a therapeutic antibody in a tissue of an experimental animal to whom the therapeutic antibody had been administered, wherein the interference from residual blood in a tissue sample of the experimental animal, which is used for determining the concentration of the therapeutic antibody in said tissue, is reduced by applying an inert reference antibody that does not penetrate into said tissue, whereby the inert reference antibody is administered 2 to 10 minutes prior to obtaining the tissue and blood sample.

Abstract: Described is a rotation limitation module for a steer-by-wire steering system. Said rotation limitation module comprises a housing in which a shaft portion is received. Furthermore, a limiter disk by way of a sliding guide is coupled in a rotationally fixed manner to the shaft portion and by way of an external thread is driven into an internal thread of the housing. Provided on the housing are detent geometries and on the limiter disk counter-detent geometries which, for limiting a rotation of the shaft portion in a first rotation direction and a second rotation direction, counter to said first rotation direction, are configured for contacting a respectively assigned detent geometry. A steering wheel module for a steer-by-wire steering system, which comprises such a rotation limitation module, is also disclosed.

Abstract: The disclosure specifies a gear assembly for an electric-motor assisted steering system, comprising an electric motor, a worm shaft which can be driven by the electric motor and which meshes with a worm wheel. The worm shaft has a recess on an end face which faces the electric motor, in which recess there is arranged an elastic element which applies an axial force to the worm shaft in the direction away from the electric motor. In the axial direction, the elastic element is supported by one end on an adjustment element, which is formed in such a way that it permits expansion of the elastic element in the axial direction when the axial force on the worm shaft exceeds a defined threshold value, and limits expansion of the elastic element when the axial force on the worm shaft lies below the defined threshold value.

Abstract: Described is a rotation limitation module for a steer-by-wire steering system. Said rotation limitation module comprises a housing in which a shaft portion is received. Furthermore, a limiter disk by way of a sliding guide is coupled in a rotationally fixed manner to the shaft portion and by way of an external thread is driven into an internal thread of the housing. Provided on the housing are detent geometries and on the limiter disk counter-detent geometries which, for limiting a rotation of the shaft portion in a first rotation direction and a second rotation direction, counter to said first rotation direction, are configured for contacting a respectively assigned detent geometry. A steering wheel module for a steer-by-wire steering system, which comprises such a rotation limitation module, is also disclosed.

Abstract: A rotation-limiting assembly for a steer-by-wire steering system is described. The rotation-limiting assembly comprises a housing, in which a shaft portion rotatable about a center axis is accommodated, wherein the shaft portion is coupled to the housing via a threaded pair, a sliding guide, and a force fit or a further sliding guide. The force fit couples the shaft portion to the housing in such a manner that, when a predefined breakaway torque is exceeded, the shaft portion is rotatable in relation to the housing. Furthermore, a first stop disk is provided on a first axial side of a sliding guide external contour of the sliding guide and a second stop disk is provided on a second axial side. Moreover, a steering wheel assembly for a steer-by-wire steering system, having such a rotation-limiting assembly is presented.

Abstract: Described is a rotation limitation module for a steer-by-wire steering system. Said rotation limitation module comprises a housing in which a shaft portion that is rotatable about a central axis and is able to be rotatably coupled to a steering wheel shaft or is configured as a portion of the steering wheel shaft is received. Furthermore provided is a limiter disk which by way of a sliding guide is coupled in a rotationally fixed and axially displaceable manner to the shaft portion and has an external thread which is driven into an internal thread of the housing. Moreover, the rotation limitation module comprises a first detent ring having a first detent wing, and a second detent ring having a second detent wing, both detent wings for limiting a rotation of the shaft portion being able to cooperate with the limiter disk. A steering wheel module for a steer-by-wire steering system is also disclosed, which comprises such a rotation limitation module.

Abstract: The disclosure specifies a gear assembly for an electric-motor assisted steering system, comprising an electric motor, a worm shaft which can be driven by the electric motor and which meshes with a worm wheel. The worm shaft has a recess on an end face which faces the electric motor, in which recess there is arranged an elastic element which applies an axial force to the worm shaft in the direction away from the electric motor. In the axial direction, the elastic element is supported by one end on an adjustment element, which is formed in such a way that it permits expansion of the elastic element in the axial direction when the axial force on the worm shaft exceeds a defined threshold value, and limits expansion of the elastic element when the axial force on the worm shaft lies below the defined threshold value.

Abstract: The present invention relates to methods and compositions for modulating mannosylation profile of recombinant proteins expressed by mammalian host cells during the cell culture process, using a polyether ionophore.

Abstract: A method to manufacture electric power steering systems is proposed. First, an electric motor having a drive shaft, a coupling device, and a worm gear having a worm shaft are provided. Then, an adjusting sleeve is provided, and an individual axial position of each adjusting sleeve in its associated opening is determined in order to achieve a specific axial preloading force on the worm shaft. The adjusting sleeve is press-fitted into the axial opening in the determined axial position, and a spring element is installed in the adjusting sleeve so that the spring element is supported on one end axially on the drive shaft and on its other end it is supported axially on the adjusting sleeve, and said spring element acts upon the worm shaft with the preloading force in the axial direction via the adjusting sleeve.

Abstract: A cooking system (10) for a space restricted environment includes at least one cooking unit (12) having at least one cooking hob (11) movable between a stowed position and a deployed position such that in the stowed position the cooking hob (11) is located either behind or below an corresponding surface of a countertop (22), cabinet, wall or the like and in the deployed position the cooking hob (11) upwardly extends through an opening (28) in the corresponding surface

Abstract: The present invention relates to a method of increasing biosimilarity of a TNF ? binding protein to a reference TNF ? binding protein by modifying the charge profile of the binding protein produced by cell culture in a cell culture medium, by making an adjustment to a cell culture condition The adjustment is an increase in the concentration of a metal ion in the cell culture medium and the adjustment occurs on one or more days during the cell culture method, whereby the adjustment in the cell culture condition results in the modification of the charge profile of the binding protein. The present invention also relates to a biosimilar protein obtainable by such a process.

Abstract: The present invention relates to methods and compositions for modulating glycosylation profile, such as the galactosylation profile, of recombinant proteins expressed by mammalian host cells during the cell culture process by supplementing cell culture media with a peracetyl galactose.

Abstract: The present invention relates to a method for controlling the afucosylation level of a glycoprotein composition. The method comprises the control of the afucosylation level by selecting the appropriate temperature and/or pH. The invention also relates to glycoprotein compositions produced according to the method of the invention.

Abstract: The present invention relates to methods and compositions for modulating mannosylation profile of recombinant proteins expressed by mammalian host cells during the cell culture process, using a polyether ionophore.

Abstract: The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of a triazine dye or supplemented with an effective amount of a triazine dye, whereby production of said protein is increased relative to cells grown without said triazine dye or any other inducer.

Abstract: The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of 4,4?diisothiocyanostilbene-2,2?-disulfonic acid (DIDS) or supplemented with an effective amount of DIDS, whereby production of said protein is increased relative to cells grown without DIDS.

Abstract: A method to manufacture electric power steering systems is proposed. First, an electric motor having a drive shaft, a coupling device, and a worm gear having a worm shaft are provided. Then, an adjusting sleeve is provided, and an individual axial position of each adjusting sleeve in its associated opening is determined in order to achieve a specific axial preloading force on the worm shaft. The adjusting sleeve is press-fitted into the axial opening in the determined axial position, and a spring element is installed in the adjusting sleeve so that the spring element is supported on one end axially on the drive shaft and on its other end it is supported axially on the adjusting sleeve, and said spring element acts upon the worm shaft with the preloading force in the axial direction via the adjusting sleeve.