Patents by Inventor Martin Karl Russel Burnham

Martin Karl Russel Burnham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • mecB
    Patent number: 6124119
    Abstract: The invention provides mecB polypeptides and polynucleotides encoding mecB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mecB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: September 26, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Deborah Jaworski, Elizabeth Lawlor, Martin Rosenberg, Lisa Kathleen Shilling, Min Wang, Judith Ward, Martin Karl Russel Burnham, Andrew Fosberry, John Hodgson
  • infB
    Patent number: 6110685
    Abstract: The invention provides infB polypeptides and polynucleotides encoding in polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing infB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: August 29, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, Richard Lloyd Warren, Magdalena Zalacain, Chi Young So, Christopher M Traini, David John Holmes, Karen Anne Ingraham, Thomas B Mathie
  • Histidinol dehydrogenase
    Patent number: 6107071
    Abstract: The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: August 22, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Chromosomal DNA fragments encoding enzymes for encoding .beta.-lactam biosynthetic enzymes, and vectors and transformants for their expression
    Patent number: 6066468
    Abstract: DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthesis of penicillin and cephalosporin .beta.-lactams and such enzymes are expressed by hosts into which the recombinant vectors are transformed. The DNA and the enzymes encoded thereby have utility in the preparation of penicillins and cephalosporins, both known and novel, possessing pharmacological, especially antimicrobial, activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 23, 2000
    Assignee: Beecham Group plc
    Inventors: Martin Karl Russel Burnham, Ian David Normansell, John Edward Hodgson
  • Fibronectin binding protein; monoclonal antibody and their use in preventing bacterial adhesion
    Patent number: 6054572
    Abstract: A monoclonal antibody (Mab), or a fragment thereof, that binds to one or more epitopes of a matrix binding protein and an isolated D1-D4 polypeptide from a Staphylococcus aureus Fbp and their use in the prevention of adhesion of bacteria, in particular gram positive bacteria, to extracellular matrix proteins on in-dwelling devices or to matrix proteins in wounds.
    Type: Grant
    Filed: August 3, 1995
    Date of Patent: April 25, 2000
    Assignee: SmithKline Beecham Corporation, p.l.c.
    Inventors: Martin Karl Russel Burnham, Ian Chopra, Ian Alfred Critchley, David Justin Charles Knowles
  • Glucose kinase from Streptococcus pneumoniae
    Patent number: 6025175
    Abstract: The invention provides Glucose Kinase polypeptides and DNA (RNA) encoding Glucose Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glucose Kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 6, 1998
    Date of Patent: February 15, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard O Nicholas, Robert King Stodola, Martin Karl Russel Burnham
  • 3-dehydroquinate synthase
    Patent number: 6020159
    Abstract: The invention provides 3-DEHYDROQUINATE SYNTHASE polypeptides and DNA (RNA) encoding 3-DEHYDROQUINATE SYNTHASE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing 3-DEHYDROQUINATE SYNTHASE polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: February 1, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham, Martin Rosenberg, Julie M Pratt, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Sugar kinase
    Patent number: 6008030
    Abstract: The invention provides sugar kinase polypeptides and DNA (RNA) encoding sugar kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing sugar kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: December 28, 1999
    Assignee: SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Phosphoribosyl transferase
    Patent number: 6001603
    Abstract: The invention provides phosphoribosyl transferase polypeptides and DNA (RNA) encoding phosphoribosyl transferase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phosphoribosyl transferase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: December 14, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Martin Karl Russel Burnham, Michael Arthur Lonetto, Patrick Vernon Warren
  • Regulator
    Patent number: 5994096
    Abstract: The invention provides regulator polypeptides and DNA (RNA) encoding regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing regulator polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: November 30, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Martin Karl Russel Burnham, Michael Arthur Lonetto, Patrick Vernon Warren
  • DNA encoding spo-rel polypeptides
    Patent number: 5989864
    Abstract: Spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spo-rel for the treatment of infection, particularly bacterial infections. Antagonists against such spo-rel and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spo-rel nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding the relA/spoT gene family and for detecting the polypeptide in a host.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: November 23, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Martin Karl Russel Burnham, Daniel Robert Gentry, John Edward Hodgson, Elizabeth Jane Lawlor
  • DNA encoding phoH polypeptides
    Patent number: 5965402
    Abstract: The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: October 12, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Fibronectin binding protein polypeptides
    Patent number: 5955078
    Abstract: A monoclonal antibody (Mab), or a fragment thereof, that binds to one or more epitopes of a matrix binding protein and an isolated D1-D4 polypeptide (SEQ ID NO. 6, 7, and 8) from a Staphylococcus aureus Fbp and their use in the prevention of adhesion of bacteria, in particular gram positive bacteria, to extracellular matrix proteins on in-dwelling devices or to matrix proteins in wounds.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 21, 1999
    Assignee: Smithkline Beecham p.l.c.
    Inventors: Martin Karl Russel Burnham, Ian Chopra, Ian Alfred Critchley, David Justin Charles Knowles
  • DNA strand resolution
    Patent number: 5948642
    Abstract: The invention provides DNA strand resolution polypeptides and DNA (RNA) encoding DNA strand resolution polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing DNA strand resolution polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: September 7, 1999
    Assignee: Smithkline Beecham p.l.c.
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • IgA Fc binding protein
    Patent number: 5928895
    Abstract: The invention provides IgA Fc binding protein polypeptides and DNA (RNA) encoding IgA Fc binding protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing IgA Fc binding protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: July 27, 1999
    Assignee: SmithKline Beecham Corporation
    Inventor: Martin Karl Russel Burnham
  • Tetracycline resistance protein
    Patent number: 5891670
    Abstract: The invention provides tetracycline resistance protein polypeptides and DNA (RNA) encoding tetracycline resistance protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tetracycline resistance protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: April 6, 1999
    Assignee: Smithkline Beecham Corporation
    Inventors: Martin Karl Russel Burnham, Michael Arthur Lonetto, Patrick Vernon Warren
  • gbpA
    Patent number: 5885805
    Abstract: The invention provides gbpA polypeptides and DNA (RNA) encoding gbpA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gbpA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: March 23, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Arthur Lonetto, Patrick Vernon Warren, Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward
  • Ferrichrome transport ATP-binding protein
    Patent number: 5882891
    Abstract: The invention provides Ferrichrome transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Ferrichrome transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Ferrichrome transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: March 16, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakly Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Glycogen phosphorylase
    Patent number: 5882885
    Abstract: The invention provides glycogen phosphorylase polypeptides and DNA (RNA) encoding glycogen phosphorylase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing glycogen phosphorylase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: March 16, 1999
    Assignee: Smithkline Beecham Corporation
    Inventor: Martin Karl Russel Burnham
  • yitJ
    Patent number: 5882897
    Abstract: The invention provides yitJ polypeptides and DNA (RNA) encoding yitJ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yitJ polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: March 16, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham, p.l.c.
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren