Abstract: The present invention relates to computer-implemented methods and system for analysing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analysing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.

Abstract: A design optimization and manufacturing approach for the creation of complex 3D curved rod structures with spatially variable material distributions that exhibit active deformation behavior is provided. The framework optimizes the cross-sectional properties of a rod structure, in particular the Young's modulus, such that under given loading conditions the rod structure may obtain one or more target shapes resulting from geometrically nonlinear deformation, from which the structure can then actively deform back to the original shape due to the shape memory effect. A novel algorithm is provided to generate physical realizations from the computational design model, which allows their direct fabrication via printing of shape memory composites with voxel-level compositional control with a multi-material 3D printer. The design and manufacture digital toolchain allows the continuous variation of multiple active materials as a route to optimize mechanical as well as active behavior of a structure.

Abstract: A cable that includes outer cable jacketing located about a conductor layer. The conductor layer includes cable elements that are resistant to compression and a plurality of compression-resistant members.

Abstract: Systems and methods for increasing robustness of a system with a remote server are provided. Some methods can include a first system remotely controlling a second system, detecting a failure in the first system or in a communication link between the first system and the second system, and temporarily removing control of the second system from the first system.

Abstract: Systems and methods of communicating data from an alarm system to emergency services personnel are provided. Some methods can include receiving information from a monitoring system in a monitored region via a first communications link, where the information relates to a detected event in the monitored region. Upon receiving the information, some methods can also include transmitting the information to a communications module via a second, different communications link.

Abstract: A monitoring system is continuously coupled to and in communication with a selected network. The system monitors characteristics of the network and characteristics of assets of the network. Removal of assets can be detected and alarm indicating messages can be generated locally at the monitoring system or at a wireless communication device.

Abstract: A cap for a shaving head of a shaving apparatus has a skin contacting surface including at least two annular corrugations. The shape of the skin contacting surface of the cap is adapted to realizing a high feeling of comfort for a user of the shaving apparatus. A factor contributing to the feeling of comfort is that an annular central surface of an outermost corrugation has an orientation that is out of line with an expected course of an imaginary smooth flowing plane following a central surface of an adjacent corrugation, where a drooping configuration of the central surface of the outermost corrugation with respect to the central surface of the adjacent corrugation is realized.

Abstract: Systems and methods for increasing robustness of a system with a remote server are provided. Some methods can include a first system remotely controlling a second system, detecting a failure in the first system or in a communication link between the first system and the second system, and temporarily removing control of the second system from the first system.

Abstract: A monitoring system is continuously coupled to and in communication with a selected network. The system monitors characteristics of the network, and also characteristics of assets of the network. Removal of assets can be detected and alarm indicating messages generated locally at the monitoring system, or at a wireless communication device.

Abstract: Systems and methods for increasing robustness of a system with a remote server are provided. Some methods can include a first system remotely controlling a second system, detecting a failure in the first system or in a communication link between the first system and the second system, and temporarily removing control of the second system from the first system.

Abstract: The present invention relates to computer-implemented methods and system for analyzing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analyzing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.

Abstract: The present invention relates to computer-implemented methods and system for analyzing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analyzing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.

Abstract: Systems and methods of communicating data from an alarm system to emergency services personnel are provided. Some methods can include receiving information from a monitoring system in a monitored region via a first communications link, where the information relates to a detected event in the monitored region. Upon receiving the information, some methods can also include transmitting the information to a communications module via a second, different communications link.

Abstract: Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases. Based on these observations, the present invention provides methods for treating diseases such as cancer and a HIV infection. The present invention also relates to methods of determining when a therapy to treat a disease characterized by the production of regulator cells should be administered to a patient.

Abstract: A cable that includes outer cable jacketing located about a conductor layer. The conductor layer includes cable elements that are resistant to compression and a plurality of compression-resistant members.

Abstract: The present invention relates to computer-implemented methods and system for analyzing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analyzing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.

Abstract: Numerous diseases have been linked to the production of effector cells. The present invention relates to the realization that effector cells are cycling in these diseases. In addition, the present invention relates to the determination that regulator cells are cycling in degenerative diseases. Based on these realizations, the present invention provides methods for treating conditions such as autoimmune diseases, degenerative diseases, and graft-versus-host disease. The present invention also relates to methods of determining when therapy should be administered to a patient.

Abstract: Systems and methods for increasing robustness of a system with a remote server are provided. Some methods can include a first system remotely controlling a second system, detecting a failure in the first system or in a communication link between the first system and the second system, and temporarily removing control of the second system from the first system.

Abstract: A method of reducing the time taken to manufacture a bitemporal relational database is disclosed. The method involves designing business database tables with relational rules stored in a relational kernel or referential rule dictionary, and designing those tables so as to be without start date and end date columns for start of valid time and end of valid time for entities, and designing the system to be without history tables recording the history of relationships between entities in the database; the system being designed as a current view with primary key and unique key constraints, and time-related issues being taken care of by the S$, T$, and E$ tables automatically generated as the data structure of the system is populated with data.

Abstract: Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases. Based on these observations, the present invention provides methods for treating diseases such as cancer and a HIV infection. The present invention also relates to methods of determining when a therapy to treat a disease characterized by the production of regulator cells should be administered to a patient.