Abstract: Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases. Based on these observations, the present invention provides methods for treating diseases such as cancer and a HIV infection. The present invention also relates to methods of determining when a therapy to treat a disease characterized by the production of regulator cells should be administered to a patient.

Abstract: Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases. Based on these observations, the present invention provides methods for treating diseases such as cancer and a HIV infection. The present invention also relates to methods of determining when a therapy to treat a disease characterized by the production of regulator cells should be administered to a patient.

Abstract: Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases. Based on these observations, the present invention provides methods for treating diseases such as cancer and a HIV infection. The present invention also relates to methods of determining when a therapy to treat a disease characterized by the production of regulator cells should be administered to a patient.

Abstract: A method of reducing the time taken to manufacture a bitemporal relational database is disclosed. The method involves designing business database tables with relational rules stored in a relational kernel or referential rule dictionary, and designing those tables so as to be without start date and end date columns for start of valid time and end of valid time for entities, and designing the system to be without history tables recording the history of relationships between entities in the database; the system being designed as a current view with primary key and unique key constraints, and time-related issues being taken care of by the S$, T$, and E$ tables automatically generated as the data structure of the system is populated with data.

Abstract: Embodiments of the use case-based management system enable non-technical users to manage devices, resources, and services that are remote to the premises where their integrated system management devices, applications, or appliances are located. This permits users to subscribe to remote voice, data, and other services without having to first configure their local equipment to ensure proper acceptance of these services. The users can simply select the desired remote services in the use case-based management system, enter a minimum amount of non-technical information such as account information provided by the service provider, and enable the service. The use case-based management system automatically creates generalized system management requests and passes them externally to the proper remote service, resource, or device managers, which then translate and broker these requests into proper low-level commands.

Abstract: The present invention relates to computer-implemented methods and system for analysing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analysing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.

Abstract: Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases. Based on these observations, the present invention provides methods for treating diseases such as cancer and a HIV infection. The present invention also relates to methods of determining when a therapy to treat a disease characterized by the production of regulator cells should be administered to a patient.

Abstract: Embodiments provide systems and methods for managing converged workspaces that go beyond storing related files and additionally include other features such as identity and security management; membership and hierarchy management; file and data storage; and data, voice, and potentially other communications services. Workspaces may be personal or shared. A personal workspace may include a number of data and voice services such as a personal file share, an email account, and telephone service. A personal workspace may be a member of a shared workspace for a team, department, company, or organization. Associated voice services can handle incoming calls in a call flow process. Call flows have multiple levels through which calls are routed when they are un-answered, so that an incoming call is successively routed to the next call flow destination(s) until the call is answered or reaches a terminating destination such as voice messaging or an auto attendant.

Abstract: A database having data entries with attributes having values that can vary over system time (the time according to a computer clock) and also over valid time (the start time and end time of an interval during which the values of the attributes are true). All logical operations of updates and deletes of values are performed by insert operations that insert new entries into the database, so that all old entries that were present at previous systems still exist and still include their previously-assigned start times and end times for the value of the attribute.

Abstract: Embodiments of the use case-based management system enable non-technical users to manage complex integrated systems based on familiar languages and workflows, and thus reduce the costs of installing and managing these integrated systems. The dynamic use cases respond to the users' input as well as the continuous feedback of system status and health. Based on these input and feedback, the use case-based management system then subscribes to and authorizes services, manages services and resources, and configures and provisions services, resources, and devices.

Abstract: A database having data entries with attributes having values that can vary over system time (the time according to a computer clock) and also over valid time (the start time and end time of an interval during which the values of the attributes are true). All logical operations of updates and deletes of values are performed by insert operations that insert new entries into the database, so that all old entries that were present at previous systems still exist and still include their previously-assigned start times and end times for the value of the attribute.

Abstract: The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.

Abstract: A cap (11), which is suitable to be applied in a shaving head of a shaving apparatus, has a skin contacting surface (21) which comprises at least two annular corrugations (22, 23, 24). The shape of the skin contacting surface (21) of the cap (11) is adapted to realizing a high feeling of comfort for a user of a shaving apparatus which is equipped with at least one shaving head comprising the cap (11). A factor contributing to the feeling of comfort is that an annular central surface (22a) of an outmost corrugation (22) has an orientation which is out of line with an expected course of an imaginary smooth flowing plane (30) following the at least one central surface (23a, 24a) of the at least one other corrugation (23, 24), wherein a drooping configuration of the central surface (22a) of the outmost corrugation (22) with respect to the at least one central surface (23a, 24a) of the at least one other corrugation (23, 24) is realized.

Abstract: The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.

Abstract: The present inventor has noted that at least two populations of immune cells are produced in response to retroviruses which infect mammals. More particularly, the immune system of a mammal infected with a retrovirus is capable of mounting an immune response against the virus through a group of cells herein generally referred to as “effector cells”, however, a second population of cells are also produced which regulate the “effector cells”, herein generally referred to as “regulator cells” (or suppressor cells), limiting the mammal's ability to effectively control or eradicate the retroviral infection. Accordingly, the present invention utilizes these observations to provide methods for treating a mammal with a retroviral infection.

Abstract: The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.

Abstract: The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

Abstract: Numerous diseases have been linked to the production of effector cells. The present invention relates to the realization that effector cells are cycling in these diseases. In addition, the present invention relates to the determination that regulator cells are cycling in degenerative diseases. Based on these realizations, the present invention provides methods for treating conditions such as autoimmune diseases, degenerative diseases, and graft-versus-host disease. The present invention also relates to methods of determining when therapy should be administered to a patient.

Abstract: A database having data entries with attributes having values that can vary over system time (the time according to a computer clock) and also over valid time (the start time and end time of an interval during which the values of the attributes are true). All logical operations of updates and deletes of values are performed by insert operations that insert new entries into the database, so that all old entries that were present at previous systems still exist and still include their previously-assigned start times and end times for the value of the attribute.

Abstract: A database having data entries with attributes having values that can vary over system time (the time according to a computer clock) and also over valid time (the start time and end time of an interval during which the values of the attributes are true). All logical operations of updates and deletes of values are performed by insert operations that insert new entries into the database, so that all old entries that were present at previous system times still exist and still include their previously-assigned start times and end times for the value of the attribute.