Patents by Inventor Martin Lovmar
Martin Lovmar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11976316Abstract: Phenotyping of cells involves loading a biological sample into a microfluidic device (1, 100) comprising cell compartments (20, 120) to capture biological material, including target cells, in the sample in the cell compartments (20, 120). A subset (20A) of the cell compartments (20, 120) is identified as comprising target cells exhibiting target phenotype characteristic(s) as determined based on monitoring biological material in the cell compartments (20, 120) prior to addition of a test agent. The biological material is exposed to a test agent and a phenotypic response of the target cells to the test agent is determined based on monitoring target cells in the identified subset (20A) of the cell compartments (20, 120). The phenotyping of the target cells is thereby not overshadowed by the response of other cells and non-cell material present in the biological sample.Type: GrantFiled: March 19, 2018Date of Patent: May 7, 2024Assignee: ASTREGO DIAGNOSTICS ABInventors: Johan Elf, Michael Read, Özden Baltekin, Martin Lovmar, Petter Hammar, Elias Amselem, Mikael Olsson, Ove Öhman
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Patent number: 11958049Abstract: A sample loading cartridge (1) for a microfluidic device comprises a cartridge body (10) with a sample reservoir (20) configured to house a volume of a liquid sample (3) and a sample port (30) in connection with the sample reservoir (20). The cartridge (1) also comprises an output channel (40) extending from the sample reservoir (20) and a feedback channel (50) connected to the sample reservoir (20) and to the sample port (30). The cartridge body (10) comprises a detection portion (60) aligned with the feedback channel (50) to enable detection of any sample (3) in the feedback channel (50). The flow resistance of the feedback channel (50) is lower than the flow resistance of the output channel (40) to cause liquid sample (3) received in the sample port (30) to enter the feedback channel (50) with substantially no liquid sample (3) entering the output channel (40).Type: GrantFiled: September 20, 2019Date of Patent: April 16, 2024Assignee: ASTREGO DIAGNOSTICS ABInventors: Johan Öhman, Martin Lovmar, Lovisa Söderberg, Mikael Olsson
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Patent number: 11946029Abstract: A microfluidic device (1) comprises a substrate (10) having a flow input channel (30) in fluid connection with a first fluid port (31) and a flow output channel (40) in fluid connection with a third fluid port (41) and cell channels (20) disposed between the flow input channel (30) and the flow output channel (40). The cell channels (20) comprise a respective obstruction (25) designed to prevent the target cells from passing the respective obstruction (25) and into the flow output channel (40). The microfluidic device (1) also comprises a pre-filter (50) with a filter channel (60) in fluid connection with a first filter port (61) and pre-filter channels (70) adapted to accommodate the target cells. A respective first end (72) of the pre-filter channels (70) is in fluid connection with the filter channel (60) and a respective second end (74) of the pre-filter channels (70) is in fluid connection with the flow input channel (30).Type: GrantFiled: February 15, 2019Date of Patent: April 2, 2024Assignee: ASTREGO DIAGNOSTICS ABInventors: Özden Baltekin, Ove Öhman, Martin Lovmar, Johan Elf, Mikael Olsson
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Publication number: 20240075243Abstract: A reusable urinary catheter assembly comprises a storage container defining a cavity, a hydration liquid and a reusable urinary catheter. The hydration liquid includes a disinfection medium and a hydrophilic polymer. The viscosity of the hydration liquid is 40 cP or lower. The reusable urinary catheter includes a shaft, and at least a part of the shaft is provided with a hydrophilic surface. During storage, the shaft is enclosed within the cavity in a storage position. The hydration fluid hydrates and regenerates the hydrophilic surface and disinfects the catheter. The catheter is configured to be repeatedly inserted into and removed from the storage container.Type: ApplicationFiled: October 31, 2023Publication date: March 7, 2024Inventor: Martin LOVMAR
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Publication number: 20240009422Abstract: A urinary catheter assembly is described which includes a urinary catheter having a catheter shaft, and an introducer device. The introducer device includes a splitable tubular sheath, and is arranged to accommodate at least a part of the catheter shaft for insertion into the urethra, and subsequent removal. At least a part of an outer surface of the tubular sheath is provided with a hydrophilic coating or surface.Type: ApplicationFiled: July 7, 2023Publication date: January 11, 2024Inventors: Jan UTAS, Martin LOVMAR, Hans TÖRNEROOS, Niall GALLOWAY
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Publication number: 20230355123Abstract: A disposable medical device assembly for measuring a physiological parameter in a urinary or gastrointestinal tract of a mammal being is disclosed, comprising a probe, such as a catheter, for insertion into a bodily opening of the mammal being. The probe comprises at least one sensor, such as a pressure sensor. The medical device further comprises an energy source, in the form of a biofuel cell, connected to the at least one sensor.Type: ApplicationFiled: May 9, 2023Publication date: November 9, 2023Inventors: Jan UTAS, Martin LOVMAR, Henrik CLAESSON, Gabriel D’ESPINDULA, Marie BERTHUEL, Lisa GUILBAUD, Jules HAMMOND, Sébastien SOLAN, Aleksandrs SERGEJEVS, Alban THIERRY
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Publication number: 20220305233Abstract: A reusable urinary catheter assembly comprises a storage container defining a cavity, a hydration liquid and a reusable urinary catheter. The hydration liquid includes a disinfection medium and a hydrophilic polymer. The viscosity of the hydration liquid is 40 cP or lower. The reusable urinary catheter includes a shaft, and at least a part of the shaft is provided with a hydrophilic surface. During storage, the shaft is enclosed within the cavity in a storage position. The hydration fluid hydrates and regenerates the hydrophilic surface and disinfects the catheter. The catheter is configured to be repeatedly inserted into and removed from the storage container.Type: ApplicationFiled: March 23, 2022Publication date: September 29, 2022Inventor: Martin LOVMAR
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Patent number: 11414552Abstract: An antibacterial device is disclosed that includes a substrate and an antibacterial coating or antibacterial surface being provided on at least a part of the substrate's surface. The antibacterial coating or surface includes Angstrom scale flakes, where the Angstrom scale flakes are arranged in a standing position on the substrate surface and are attached to the substrate surface via edge sides thereof. The Angstrom scale flakes can, for example, be graphene flakes, or graphite flakes having a thickness of a few atom layers. It has been found that such standing flakes are efficient in killing prokaryotic cells but do not harm eukaryotic cells.Type: GrantFiled: February 11, 2021Date of Patent: August 16, 2022Assignee: DENTSPLY IH ABInventors: Martin Lovmar, Santosh Pandit, Venkata R. S. S. Mokkapati, Jie Sun
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Publication number: 20220032302Abstract: A sample loading cartridge (1) for a microfluidic device comprises a cartridge body (10) with a sample reservoir (20) configured to house a volume of a liquid sample (3) and a sample port (30) in connection with the sample reservoir (20). The cartridge (1) also comprises an output channel (40) extending from the sample reservoir (20) and a feedback channel (50) connected to the sample reservoir (20) and to the sample port (30). The cartridge body (10) comprises a detection portion (60) aligned with the feedback channel (50) to enable detection of any sample (3) in the feedback channel (50). The flow resistance of the feedback channel (50) is lower than the flow resistance of the output channel (40) to cause liquid sample (3) received in the sample port (30) to enter the feedback channel (50) with substantially no liquid sample (3) entering the output channel (40).Type: ApplicationFiled: September 20, 2019Publication date: February 3, 2022Inventors: Johan ÖHMAN, Martin LOVMAR, Lovisa SÖDERBERG, Mikael OLSSON
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Publication number: 20210386926Abstract: An irrigation system, for irrigation of a hollow body organ, comprises a reusable part and a disposable part. The reusable part comprises a liquid container with a first opening and a first connection interface. The disposable part comprises a protective cover comprising a tubular part, a one-way valve in the tubular part, and a protective skirt connected to and encircling the tubular part. The tubular part is provided with a second connection interface which is releasably connectable to the first connection interface.Type: ApplicationFiled: June 8, 2021Publication date: December 16, 2021Inventor: Martin LOVMAR
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Publication number: 20210260333Abstract: Improved urinary catheters are described. One example urinary catheter includes a catheter shaft with an internal lumen, extending between a distal discharge opening and a proximal drainage opening, arranged at a proximal tip of the catheter shaft. An overcoat layer encircles a portion of the catheter shaft, forming a closed deformable fluid filled cavity intermediate the overcoat layer and the outer surface of the shaft. The overcoat layer is elastically deformable to allow for movement of the fluid within the cavity during deployment. At least a portion at the proximal end is arranged to be compressed to a smaller diameter during insertion, and upon continued insertion of the catheter shaft through the urethra into at least the bladder neck, arranged to expand back toward a greater diameter, as the fluid is caused to flow toward the proximal end of the fluid filled cavity.Type: ApplicationFiled: May 7, 2021Publication date: August 26, 2021Inventor: Martin LOVMAR
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Publication number: 20210179862Abstract: An antibacterial device is disclosed that includes a substrate and an antibacterial coating or antibacterial surface being provided on at least a part of the substrate's surface. The antibacterial coating or surface includes Angstrom scale flakes, where the Angstrom scale flakes are arranged in a standing position on the substrate surface and are attached to the substrate surface via edge sides thereof. The Angstrom scale flakes can, for example, be graphene flakes, or graphite flakes having a thickness of a few atom layers. It has been found that such standing flakes are efficient in killing prokaryotic cells but do not harm eukaryotic cells.Type: ApplicationFiled: February 11, 2021Publication date: June 17, 2021Inventors: Martin Lovmar, Santosh Pandit, Venkata R.S.S. Mokkapati, Jie Sun
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Patent number: 11020564Abstract: An insertion aid for catheter manipulation is disclosed. The insertion aid can be used for urinary catheters, such as hydrophilic urinary catheters for intermittent use. The insertion aid includes first and second plate-like arms arranged overlying each other and with a separation distance there between. The insertion aid also includes a resilient hinge connecting adjacent marginal edges of the plate-like arms together. At least one of the plate-like arms includes a groove on its clamping inner surface for holding a catheter shaft. The groove extends at least partly in the same direction as, and essentially parallel to, the resilient hinge, and is arranged at a distance both from the resilient hinge and from the marginal edge of the plate-like arm. Corresponding catheter set and catheter assembly are also disclosed.Type: GrantFiled: October 13, 2017Date of Patent: June 1, 2021Assignee: DENTSPLY IH ABInventors: Peter Madlung, Martin Lovmar, Evelina Gustavsson
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Patent number: 10974025Abstract: A urinary catheter and a method of its manufacture are disclosed. The urinary catheter comprises a tubular shaft extending between an insertion end and a discharge end, the tubular shaft being formed of at least two materials having different properties. The materials are arranged substantially separated from each other in distinct zones, wherein at least one of the width and thickness of said zones varies over the length of the tubular shaft, to form two or more uniform sections of the tubular shaft having various relative amounts of said materials, and wherein at least one transition between two such uniform sections is formed by at least one transition section providing a gradual transition between the uniform sections. The catheter can e.g. be produced by intermittent extrusion.Type: GrantFiled: June 28, 2017Date of Patent: April 13, 2021Assignee: DENTSPLY IH ABInventors: Jan Utas, Niklas Dahlberg, Martin Lovmar
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Patent number: 10920092Abstract: An antibacterial device is disclosed that includes a substrate and an antibacterial coating or antibacterial surface being provided on at least a part of the substrate's surface. The antibacterial coating or surface includes Angstrom scale flakes, where the Angstrom scale flakes are arranged in a standing position on the substrate surface and are attached to the substrate surface via edge sides thereof. The Angstrom scale flakes can, for example, be graphene flakes, or graphite flakes having a thickness of a few atom layers. It has been found that such standing flakes are efficient in killing prokaryotic cells but do not harm eukaryotic cells.Type: GrantFiled: May 4, 2018Date of Patent: February 16, 2021Assignee: DENTSPLY IH ABInventors: Martin Lovmar, Santosh Pandit, Venkata R. S. S. Mokkapati, Jie Sun
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Publication number: 20210008554Abstract: A capturing of target cells from a biological sample is achieved by inducing a flow of the biological sample in a flow channel (30, 60) of an upstream microfluidic device (1). Target cells present in the biological sample are captured in cell channels (20) of the upstream microfluidic device(1). Once at least a minimum number of target cells are captured in the cell channels (20), the flow of the biological sample in the flow channel is reduced and are verse flow is applied at the upstream microfluidic device (1) to release the target cells captured in the cell channels (20) of the upstream microfluidic device (1) and enable transfer the target cells into cell channels (120) of a downstream microfluidic device (100).Type: ApplicationFiled: February 15, 2019Publication date: January 14, 2021Inventors: Özden BALTEKIN, Ove ÖHMAN, Martin LOVMAR, Johan ELF, Mikael OLSSON
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Publication number: 20200407671Abstract: A microfluidic device (1) comprises a substrate (10) having a flow input channel (30) in fluid connection with a first fluid port (31) and a flow output channel (40) in fluid connection with a third fluid port (41) and cell channels (20) disposed between the flow input channel (30) and the flow output channel (40). The cell channels (20) comprise a respective obstruction (25) designed to prevent the target cells from passing the respective obstruction (25) and into the flow output channel (40). The microfluidic device (1) also comprises a pre-filter (50) with a filter channel (60) in fluid connection with a first filter port (61) and pre-filter channels (70) adapted to accommodate the target cells. A respective first end (72) of the pre-filter channels (70) is in fluid connection with the filter channel (60) and a respective second end (74) of the pre-filter channels (70) is in fluid connection with the flow input channel (30).Type: ApplicationFiled: February 15, 2019Publication date: December 31, 2020Inventors: Özden BALTEKIN, Ove ÖHMAN, Martin LOVMAR, Johan ELF, Mikael OLSSON
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Publication number: 20200316600Abstract: A microfluidic device (1) comprises a substrate (10) having spatially defined and separated cell compartments (20) configured to accommodate cells. A respective first end (22) of the spatially defined and separated cell compartments (20) is in fluid connection with a flow input channel (30). The microfluidic device (1) comprises at least one identification surface (60, 61) comprising immobilized affinity molecules configured to capture cells of a species or serotype or of a group of species or serotypes.Type: ApplicationFiled: October 30, 2018Publication date: October 8, 2020Inventors: Johan ELF, Ove ÖHMAN, Martin LOVMAR, Özden BALTEKIN
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Publication number: 20200131557Abstract: Phenotyping of cells involves loading a biological sample into a microfluidic device (1, 100) comprising cell compartments (20, 120) to capture biological material, including target cells, in the sample in the cell compartments (20, 120). A subset (20A) of the cell compartments (20, 120) is identified as comprising target cells exhibiting target phenotype characteristic(s) as determined based on monitoring biological material in the cell compartments (20, 120) prior to addition of a test agent. The biological material is exposed to a test agent and a phenotypic response of the target cells to the test agent is determined based on monitoring target cells in the identified subset (20A) of the cell compartments (20, 120). The phenotyping of the target cells is thereby not overshadowed by the response of other cells and non-cell material present in the biological sample.Type: ApplicationFiled: March 19, 2018Publication date: April 30, 2020Inventors: Johan ELF, Michael READ, Özden BALTEKIN, Martin LOVMAR, Petter HAMMAR, Elias AMSELEM, Mikael OLSSON, Ove ÖHMAN
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Patent number: D886280Type: GrantFiled: July 19, 2019Date of Patent: June 2, 2020Assignee: DENTSPLY IH ABInventor: Martin Lovmar