Abstract: The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.

Abstract: A device with one or more flow through reaction chambers for investigation of one or more probes on a sensor chip. The device has (a) a sensor chip (b) a number of probe arrays corresponding to a number of samples to be investigated, arranged on the sensor chip spatially separated from one another, (c) an upper portion (d) a number of spatially separated chambers disposed in the upper portion corresponding in number to the number of probe arrays. The chambers are each provided with an inlet opening and an outlet opening. The position and dimension of the probe arrays and the chambers is relatively determined so that, after a sandwich-like combination of the sensor chip with the upper portion a respective precise fit reaction chamber is formed over each probe array with an inlet opening and an outlet opening.

Abstract: A machine for treating bulk material of industrial volume parts, having a treatment drum which is arranged with a horizontal axis and can be driven in both directions of rotation around said axis, the treatment drum comprises a permanently open co-axial inlet aperture and a permanently open co-axial discharge aperture, the treatment drum comprises a set of worm-like inner blades which extend at least as far as the discharge aperture and which, in the first direction of rotation of the treatment drum, reposition the bulk material in the drum and, in the second direction of rotation of the treatment drum, convey the bulk material through the discharge aperture.

Abstract: A procedure for detecting microparticles released by at least one dispenser, encompassing the following steps: (a) triggering the dispenser over an oscillation target (20) with a sensor material (21), so that at least one microparticle hits the sensor material (21) and excites an acoustic wave, (b) detecting the acoustic wave with at least one oscillation sensor (31) connected with the sensor material (21), which emits an electrical sensor signal when the acoustic wave arrives, and (c) evaluating the sensor signal to determine the impact of the microparticle. The procedure is aimed at detecting the impact and/or impact positions of microparticles on a target. A detector for executing the procedure is also described.

Abstract: A method of estimating the concentration of residual exhaust gas in an internal combustion engine having variable cam phase control is based on engine dynamometer and engine simulator data. Since both the volumetric efficiency and the residual exhaust gas concentration of an engine vary monotonically in response to changes in cam phase, the simulated residual concentration data is deemed to be reliable if the simulated volumetric efficiency data matches volumetric efficiency data determined by engine dynamometer testing. Volumetric efficiency test data is compared to simulated volumetric efficiency data, and the simulation software is tuned until the simulated data matches the test data. At such point, the simulated residual concentration data is deemed to be reliable, and is used to calibrate a model relating residual concentration to cam phase angle, and such model is then used by an engine controller to estimate residual exhaust gas concentration during operation of the engine.

Abstract: The invention relates to seroreactive regions on the E1 and E2 proteins of human papillomavirus 16 (HPV 16). The invention also relates to a vaccine that contains peptides comprising at least one seroreactive region of the E1 and/or E2 proteins. The invention likewise embraces compositions for diagnostic purposes, which contain peptides with the seroreactive regions. Further, the invention relates to antibodies that bind to seroreactive regions of the E1 and/or E2 proteins of HPV 16, and compositions comprising such antibodies, which can be used for diagnostic purposes.

Abstract: For the detection of the position and/or velocity of microparticles which move from dispensers of a dispensing head (30) to a target, a detector target with two linear bound, electro-acoustic or electro-optic interactive areas which fix a target plane is used. When microparticles impact on the interactive areas, detector signals are determined from which along with the dispensing head position motion parameters of the microparticles are obtained.

Abstract: An improved method of dynamically estimating the concentration of recirculated exhaust gases in air/fuel mixture of an internal combustion engine equipped with an exhaust gas recirculation (EGR) system. The EGR concentration at engine intake ports is separately estimated with static and dynamic models, and the EGR concentration for control purposes is determined by adjusting the result of the dynamic model based on a deviation of the dynamic model from the static model. This method provides the total EGR concentration, but can alternatively provide the inert EGR concentration through the inclusion of an exhaust inert ratio model.

Abstract: A coin (1) with a metal surface (2, 3) has macroscopic reliefs (5) which serve for visually specifying the value of the coin and as an authenticity feature. Microscopically fine relief structures (8) with a diffraction effect are formed directly in at least one of the surfaces (2, 3). The relief structures (8) are preferably arranged in a recessed relationship and are covered with a lacquer (9). It is also advantageous if at least a part of the relief structures (8) entails an asymmetrical profile shape and/or the grating vectors in a radial orientation. The release structures (8) may also include a machine-readable coding which is recognized by inexpensive optical reading devices for installation in coin testers.

Abstract: For the detection of the position and/or velocity of microparticles which move from dispensers of a dispensing head (30) to a target, a detector target with two linear bound, electro-acoustic or electro-optic interactive areas which fix a target plane is used. When microparticles impact on the interactive areas, detector signals are determined from which along with the dispensing head position motion parameters of the microparticles are obtained.

Abstract: A rotating sorting device for sorting packaged goods has one or more linear supply conveyors and a plurality of removal locations arranged circularly about a central axle. One or more linear removal conveyors are positioned between the central axle and the removal locations and are arranged substantially radially. The linear removal conveyor rotates continuously about the central axle. The linear supply conveyor is positioned above or below the linear removal conveyor and has an end portion in a conveying direction of the linear supply conveyor. The end portion has an incline extending downwardly or upwardly toward the linear removal conveyor. A distribution control device controls the linear supply conveyor, the linear removal conveyor, and the removal locations.

Abstract: The invention relates to an actuator assembly for a vehicle brake with a drive which is connected with an input side of a transmission. An output side of the transmission is adapted for the actuation of at least one friction element of the vehicle brake, with the transmission being a knee lever arrangement with two arms.

Abstract: Stress relieving of an age hardenable aluminium alloy product after solution heat treatment and quenching, is carried out by a permanent cold plastic deformation applied by the steps: (a) applying a stress-relieving cold mechanical stretch to said product, and (b) applying a stress-relieving cold compression to said product. This combined treatment gives improved strength and toughness and at least comparable distortion after machining.

Abstract: An improved method of dynamically estimating the concentration of recirculated exhaust gases in air/fuel mixture of an internal combustion engine equipped with an exhaust gas recirculation (EGR) system. The EGR concentration at engine intake ports is separately estimated with static and dynamic models, and the EGR concentration for control purposes is determined by adjusting the result of the dynamic model based on a deviation of the dynamic model from the static model. This method provides the total EGR concentration, but can alternatively provide the inert EGR concentration through the inclusion of an exhaust inert ratio model.

Abstract: A device for applying microdroplets to a substrate includes a dosing head having a nozzle orifice and a liquid storage area in fluid communication with the orifice. A drive applies an acceleration to the dosing head. A quantity of liquid in the storage area cannot follow the acceleration due to its inertia. This inertia causes microdroplets to be driven out of the nozzle onto the substrate. In one embodiment, the dosing head includes a plurality of nozzle orifices each having an associated liquid storage area, so that a plurality of different analytes are deposited on the substrate.

Abstract: An improved engine torque management control that coordinates engine throttle, spark and EGR under predefined highly throttled conditions so as to maximize the fuel economy improvement of EGR without degrading engine performance. Under the predefined conditions, EGR is increased to a level that maximizes the fuel economy improvement without causing combustion instability, and the throttle position and spark timing are controlled to compensate for the anticipated torque loss while increasing volumetric efficiency and reducing pumping losses. During idle and steady state cruising operation, EGR is increased, and engine throttle position is controlled to regulate the estimated engine output torque in accordance with the driver requested output torque. During transient torque increases, throttle control alone is used to regulate the output torque, while in transient torque decreases, the throttle position is maintained and spark timing is used to regulate the output torque.

Abstract: Papillomavirus-like particles (VLPs) comprising truncated L1 proteins are provided wherein the L1 proteins have one or more carboxy terminal amino acid residues deleted.

Abstract: A pedal arrangement for a footwell of a motor vehicle. The pedal arrangement includes a bearing bracket operatively connected to a front wall of the motor vehicle. A pedal pivot shaft is provided on the bearing bracket at an upper bracket segment. The upper bracket segment is capable of being torn off from the remainder of the bearing bracket. At least one pedal lever is arranged pivotally on the pivot shaft. A tear-off lever element is capable of being engaged with an abutment attached to the motor vehicle and spaced from a floor and the front wall of the motor vehicle. In the event of a collision, the upper bracket segment is at least partially torn away from the remainder of the bearing bracket such that the at least one pedal lever is displaced away from the driver reducing the possibility of injury to the driver.

Abstract: The invention concerns a device for processing frequency signals with a power limiter (10), in which the power limiter (10) has a first signal path (12), the power limiter (10) has a second signal path (14), the first signal path (12) has means (16) for analog signal processing, the second signal path (14) has means (18) for digital signal processing, the means (18) for digital signal processing have means for selective suppression of specific frequency regions and an output of the first signal path (12) and an output of the second signal path (14) are connected to means (22) for combination of signals. The invention also concerns a method that can advantageously be executed with the device according to the invention.

Abstract: The invention relates to seroreactive epitopes on proteins of human papillomavirus HPV18. In addition, the invention relates to peptides which have amino-acid sequences which coincide in whole or in part with the sequences of the seroreactive epitopes, and to vaccines which contain such peptides.