Publication number: 20050202519
Abstract: The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of
Type:
Application
Filed:
October 4, 2002
Publication date:
September 15, 2005
Inventors:
Christophe Barthe, Susan Branford, Amie Corbin, Brian Druker, Justus Duyster, Andreas Hochhaus, Timothy Hughes, Sebastian Kreil, Thibaut Leguay, Francois-Xavier Mahon, Gerald Marit, Martin Muller, Chriatian Peschel, Claude Preudhomme, Catherine Roche Lestienne, Zbigniew Rudzki
Publication number: 20050155162
Abstract: The present invention relates to a proces for producing colored oxide layers on aluminum or on aluminum alloys by dyeing in an aqueous dye bath, rinsing with water and sealing, wherein there is used for the dyeing at least one dye of the general formula wherein m is a value from 1 to 8, especially from 1 to 4, n is a value from 0 to 7, especially from 1 to 4, the sum of m and n being less than or equal to 8, A is the radical of a chromophore of the 1-aminoanthraquinone, anthraquinone, anthrapyrimidine, azo, azomethine, benzodifuranone, quinacridone, quinacridonequinone, quinophthalone, diketopyrrolopyrrole, dioxazine, flavanthrone, indanthrone, indigo, isoindoline, isoindolinone, isoviolanthrone, perinone, perylene, phthalocyanine, pyranthrone or thioindigo series, B is a hydrogen atom, a branched or straight-chain C1-8alkyl, C2-8alkenyl or C2-8alkynyl radical, an aryl radical, an N—, O— or S-containing 5- or 6-membered heterocyclic ring, or a C1-8alkyl-arylene, aryl-C1-8alkylene or aryl-L-arylene radi
Type:
Application
Filed:
January 28, 2003
Publication date:
July 21, 2005
Inventors:
Hans-Thomas Schacht, Gibert Moegle, Didier Bauer, Leonhard Feiler, Olof Wallquist, Martin Muller