Patents by Inventor Martin Oft

Martin Oft has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Interleukin-10 Production of Antigen-Specific CD8+ T Cells and Methods of Use of Same
    Publication number: 20190032134
    Abstract: The present disclosure provides methods and compositions relating to isolated CD8+ T cells expressing a disease antigen-specific T cell receptor, as well as nucleic acids encoding the V? and V? polypeptide pairs of T cell receptors (TCRs) of such disease antigen-specific T cells. Such disease antigen-specific CD8+ T cells are obtainable from the periphery (e.g., blood) of a subject having a disease amenable to treatment with an IL-10 agent. The present disclosure also contemplates therapeutic methods and compositions relating to administration of isolated disease antigen-specific CD8+ T cells to a subject, as well as therapeutic methods and compositions relating to CD8+ T cells genetically modified to express a disease antigen-specific TCR and/or chimeric antigen receptor.
    Type: Application
    Filed: January 10, 2017
    Publication date: January 31, 2019
    Inventors: John Brian Mumm, Ivan Ho Chan, Scott McCauley, Scott Ogg, Martin Oft
  • Methods of using interleukin-10 for treating diseases and disorders
    Patent number: 10143726
    Abstract: Methods of treating subjects having a disease or disorder responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: December 4, 2018
    Assignee: Armo Biosciences, Inc.
    Inventor: Martin Oft
  • Methods of Using Interleukin-10 for Treating Diseases and Disorders
    Publication number: 20180250364
    Abstract: Methods of treating subjects having a disease or disorder responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 6, 2018
    Inventor: Martin Oft
  • Methods of modulating cytokine activity; related reagents
    Patent number: 9970944
    Abstract: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: May 15, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jochen Schmitz, Martin Oft, Robert A. Kastelein, J. Fernando Bazan
  • METHODS OF MODULATING CYTOKINE ACTIVITY; RELATED REAGENTS
    Publication number: 20180128837
    Abstract: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 10, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jochen Schmitz, Martin Oft, Robert A. Kastelein, J. Fernando Bazan
  • Methods of using pegylated interleukin-10 for treating cancer
    Patent number: 9943568
    Abstract: Methods of treating subjects having a disease or disorder responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: April 17, 2018
    Assignee: ARMO BioSciences, Inc.
    Inventor: Martin Oft
  • Use of Pegylated IL-10 to Treat Cancer
    Publication number: 20180085467
    Abstract: Provided are methods of treatment for tumors. In particular, methods are provided for use of a chemically modified IL-10 to treat tumors.
    Type: Application
    Filed: November 3, 2017
    Publication date: March 29, 2018
    Inventors: Martin Oft, Catherine Sheppard, John Brian Mumm, Lingling Wu
  • Use of pegylated IL-10 to treat cancer
    Patent number: 9833514
    Abstract: Provided are methods of treatment for tumors. In particular, methods are provided for use of a chemically modified IL-10 to treat tumors.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: December 5, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Martin Oft, Catherine Sheppard, John Brian Mumm, Lingling Wu
  • Methods of Using Interleukin-10 for Treating Diseases and Disorders
    Publication number: 20170246252
    Abstract: Methods of treating subjects having a disease or disorder responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided.
    Type: Application
    Filed: October 20, 2015
    Publication date: August 31, 2017
    Inventor: Martin OFT
  • Methods of Using Interleukin-10 for Treating Diseases and Disorders
    Publication number: 20160375101
    Abstract: Methods for determining dosing parameters associated with subcutaneous administration of IL-10 useful for the treatment and/or prevention of a cholesterol-related disease, disorder or condition, and pharmaceutical compositions associated therewith, are provided herein. Certain embodiments are directed to means for establishing a therapeutic range of an IL-10 agent in a subject. In some embodiments, particular parameters (e.g., hematological parameters) are monitored to provide an indication of the upper limit of the therapeutic range such that any untoward adverse effects are avoided.
    Type: Application
    Filed: January 9, 2015
    Publication date: December 29, 2016
    Inventor: Martin Oft
  • Use of Pegylated IL-10 to Treat Cancer
    Publication number: 20160367689
    Abstract: Provided are methods of treatment for tumors. In particular, methods are provided for use of a chemically modified IL-10 to treat tumors.
    Type: Application
    Filed: May 16, 2016
    Publication date: December 22, 2016
    Inventors: Martin Oft, Catherine Sheppard, John Brian Mumm, Lingling Wu
  • Methods of Using Interleukin-10 for Treating Diseases and Disorders
    Publication number: 20160243196
    Abstract: Methods of treating subjects having diseases, disorders, or conditions, including cancer and immune- and inflammatory-related disorders, via the administration of IL-10 in combination with one or more additional agents, and methods and models associated therewith, are provided.
    Type: Application
    Filed: November 7, 2014
    Publication date: August 25, 2016
    Inventors: John Brian Mumm, Ivan Ho Chan, Martin Oft
  • Method of treatment of lymphoma with pegylated IL-10
    Patent number: 9364517
    Abstract: Provided are methods of treatment for tumors. In particular, methods are provided for use of a chemically modified IL-10 to treat tumors.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: June 14, 2016
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Martin Oft, Catherine Sheppard, John Brian Mumm, Lingling Wu
  • Methods of Using Interleukin-10 for Treating Diseases and Disorders
    Publication number: 20160058838
    Abstract: Methods of treating subjects having a disease or disorder responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided.
    Type: Application
    Filed: April 15, 2014
    Publication date: March 3, 2016
    Inventor: Martin Oft
  • Use of Pegylated IL-10 to Treat Cancer
    Publication number: 20150079031
    Abstract: Provided are methods of treatment for tumors. In particular, methods are provided for use of a chemically modified IL-10 to treat tumors.
    Type: Application
    Filed: September 12, 2014
    Publication date: March 19, 2015
    Inventors: Martin Oft, Catherine Sheppard, John Brian Mumm, Lingling Wu
  • USES OF MAMMALIAN CYTOKINES AND AGONISTS; RELATED REAGENTS
    Publication number: 20140370025
    Abstract: Provided are methods of treatment for tumors. In particular, provided are methods of using of a cytokine molecule and its receptor.
    Type: Application
    Filed: August 29, 2014
    Publication date: December 18, 2014
    Inventor: Martin Oft
  • Method of treating solid cancers with pegylated IL-10
    Patent number: 8865652
    Abstract: Provided are methods of treatment for tumors. In particular, methods are provided for use of a chemically modified IL-10 to treat tumors.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: October 21, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Martin Oft, Catherine Sheppard, John Mumm, Lingling Wu
  • Uses of mammalian cytokines and agonists; related reagents
    Patent number: 8822405
    Abstract: The present invention relates generally to uses of TSLP in the treatment of cancer.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: September 2, 2014
    Assignee: Merck, Sharp & Dohme Corp.
    Inventor: Martin Oft
  • METHODS OF MODULATING CYTOKINE ACTIVITY; RELATED REAGENTS
    Publication number: 20140140954
    Abstract: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.
    Type: Application
    Filed: February 3, 2014
    Publication date: May 22, 2014
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jochen Schmitz, Martin Oft, Robert A. Kastelein, J. Fernando Bazan
  • USES OF IL-23 AGONISTS AND ANTAGONISTS; RELATED REAGENTS
    Publication number: 20120034219
    Abstract: Provided are methods of treatment for tumors. In particular, methods are provided for modulating activity of a cytokine molecule and its receptor.
    Type: Application
    Filed: October 10, 2011
    Publication date: February 9, 2012
    Applicant: Schering Corporation
    Inventors: Martin Oft, Terrill K. McClanahan