Patents by Inventor Martin R. Prince

Martin R. Prince has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070287907
    Abstract: Described is a robust electrocardiogram (ECG) ordering technique of k-space for breath hold contrast enhanced magnetic resonance angiography (CE-MRA) that acquires the central part of k-space in a motion-free portion of diastole and fills in from the periphery of k-space at all other times. To make maximal use of the contrast enhancement, data is acquired continuously even when the ECG signal is lost. The ECG signal is monitored in real time. The ECG ordering technique allows a flexible acquisition matrix and is robust against ECG signal imperfections. The ECG ordering technique allows thoracic and pulmonary magnetic resonance angiography with a higher resolution when compared to the conventional gated sequence.
    Type: Application
    Filed: April 20, 2007
    Publication date: December 13, 2007
    Applicant: CORNELL RESEARCH FOUNDATION, INC.
    Inventors: Pascal Spincemaille, Yi Wang, Martin R. Prince
  • Patent number: 7110806
    Abstract: The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: September 19, 2006
    Inventor: Martin R. Prince
  • Patent number: 7003343
    Abstract: Current bolus chase magnetic resonance angiography is limited by the imaging time for each station. Tailoring the density of k-space sampling along the anterior-posterior direction of the coronal station allows a substantial decrease in scan time that leads to greater contrast bolus sharing among stations and consequently a significant improvement in image quality. Fast arterial-venous transit in the carotid arteries requires accurate, reliable timing of the acquisition to the bolus transit to maximize arterial signal and minimize venous artifacts. The rising edge of the bolus is not utilized in conventional elliptical-centric view ordering because the critical k-space center must be acquired with full arterial enhancement. The invention provides a recessed elliptical-centric view ordering scheme is introduced in which the k-space center is acquired a few seconds following scan initiation. The recessed view ordering is shown to be more robust to timing errors in a patient studies.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: February 21, 2006
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Richard Watts, Yi Wang, Martin R. Prince
  • Patent number: 6937883
    Abstract: A magnetic resonance imaging system is disclosed to perform an imaging pulse sequence that acquires data to generate an image of at least a portion of the patient. The magnetic resonance imaging system comprises an acoustic transducer to irradiate an anatomic structure in the patient using ultrasonic energy. A receiver, in response to ultrasonic energy, generates echo signals. Using the echo signals, a signal analyzer generates a plurality of gating signals, including a first gating signal in response to a first period of motion of the anatomic structure and the second gating signal in response to a second period of motion of the structure. The magnetic resonance imaging system, in response to the first gating signal, acquires data from the center of k-space, and, in response to the second gating signal, acquires the periphery of k-space.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: August 30, 2005
    Inventor: Martin R. Prince
  • Patent number: 6889072
    Abstract: The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: May 3, 2005
    Inventor: Martin R. Prince
  • Patent number: 6879853
    Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume. This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: April 12, 2005
    Inventors: James F. M. Meaney, Martin R. Prince
  • Publication number: 20040210130
    Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data (for example, image data which is representative of the central portion of k-space) of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement.
    Type: Application
    Filed: March 25, 2004
    Publication date: October 21, 2004
    Inventor: Martin R. Prince
  • Publication number: 20040181147
    Abstract: The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus.
    Type: Application
    Filed: March 25, 2004
    Publication date: September 16, 2004
    Inventor: Martin R. Prince
  • Patent number: 6754521
    Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: June 22, 2004
    Inventor: Martin R. Prince
  • Patent number: 6741881
    Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: May 25, 2004
    Inventor: Martin R. Prince
  • Publication number: 20040068177
    Abstract: The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation.
    Type: Application
    Filed: August 26, 2003
    Publication date: April 8, 2004
    Inventor: Martin R. Prince
  • Patent number: 6662038
    Abstract: The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation.
    Type: Grant
    Filed: April 7, 2001
    Date of Patent: December 9, 2003
    Inventor: Martin R. Prince
  • Publication number: 20030163036
    Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins.
    Type: Application
    Filed: February 27, 2003
    Publication date: August 28, 2003
    Inventor: Martin R. Prince
  • Publication number: 20030135111
    Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies).
    Type: Application
    Filed: January 24, 2003
    Publication date: July 17, 2003
    Inventors: James F.M. Meaney, Martin R. Prince
  • Patent number: 6564085
    Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies).
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: May 13, 2003
    Inventors: James F.M. Meaney, Martin R. Prince
  • Publication number: 20030047083
    Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins.
    Type: Application
    Filed: August 5, 2002
    Publication date: March 13, 2003
    Inventor: Martin R. Prince
  • Publication number: 20030032877
    Abstract: Current bolus chase magnetic resonance angiography is limited by the imaging time for each station. Tailoring the density of k-space sampling along the anterior-posterior direction of the coronal station allows a substantial decrease in scan time that leads to greater contrast bolus sharing among stations and consequently a significant improvement in image quality. Fast arterial-venous transit in the carotid arteries requires accurate, reliable timing of the acquisition to the bolus transit to maximize arterial signal and minimize venous artifacts. The rising edge of the bolus is not utilized in conventional elliptical-centric view ordering because the critical k-space center must be acquired with full arterial enhancement. The invention provides a recessed elliptical-centric view ordering scheme is introduced in which the k-space center is acquired a few seconds following scan initiation. The recessed view ordering is shown to be more robust to timing errors in a patient studies.
    Type: Application
    Filed: April 1, 2002
    Publication date: February 13, 2003
    Applicant: Cornell Research Foundation, Inc.
    Inventors: Richard Watts, Yi Wang, Martin R. Prince
  • Patent number: 6463318
    Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g.
    Type: Grant
    Filed: April 7, 2001
    Date of Patent: October 8, 2002
    Inventor: Martin R. Prince
  • Publication number: 20020068865
    Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies).
    Type: Application
    Filed: October 23, 2001
    Publication date: June 6, 2002
    Inventors: James F.M. Meaney, Martin R. Prince
  • Publication number: 20020010397
    Abstract: The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus.
    Type: Application
    Filed: July 5, 2001
    Publication date: January 24, 2002
    Inventor: Martin R. Prince