Abstract: A technique provides a field service tool (FST) that allows customers to view and store engine performance data, including faults, in a convenient manner. The technique allows customers to gain insights into performance anomalies while preventing customers from changing engine parameters except for a limited set of parameters selected to avoid the need for service visits while having no effect on safety or compliance.

Abstract: The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof, and the related products including N-(fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N-(fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azolate salt, an N-silylazole, or a combination thereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azolate salts, or N-silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, an N-silylazole, or a combination thereof in one pot.

Abstract: A pipette tip carrier assembly suitable for storing elongate pipette tips in a biochemical analyser is described. The pipette tip carrier assembly comprises one or more holding elements each adapted to hold, in use, a respective pipette tip oriented such that the elongate dimension of the held pipette tip is parallel to a first axis. The pipette tip carrier assembly also includes a light source arranged to produce, at a position distal to the one or more holding elements along the first axis, light directed towards each of the one or more holding elements so as to be intercepted by one or more pipette tips held in 10 use by the one or more holding elements.

Abstract: There is provided a sterilisation assembly for a molecular diagnostic assay analyse. The assembly comprising: an enclosure having a passage therethrough, the passage being arranged in use to allow an assay sample set to pass through the enclosure, the enclosure defining a barrier adapted in use to restrict fluid communication across the enclosure to communication through the passage; and a decontaminator located within the passage, the decontaminator is arranged in use to sterilise contamination in the passage.

Abstract: An assay cartridge (31) for use in a molecular diagnostics assay comprising: an assay region (32), possibly containing a plurality of reagent wells (34); a first end comprising a first engagement member (35), such as a lip or protrusion, for engaging with a support housing; and a second end comprising a second engagement member (36) for engaging with a support housing; wherein the second engagement member comprises a clip, the clip being formed by a resilient element extending from the second end of the cartridge and a fastening element extending from said resilient element; wherein the clip comprises a release element extending from the resilient element actuatable to release the clip from a caddy or support housing in use.

Abstract: Methods for producing triflazoles or related derivatives thereof, and the resulting products are provided. For example, triflazoles can be prepared by reaction of trifluoromethanesulfonyl fluoride with an azole or azolate salt. Yields up to 78% are obtained. Triflazoles can be prepared by the reaction of a trifluoromethanesulfonyl fluoride with an N-silylazole in the presence of a basic catalyst. Yields up to 97% are obtained.

Abstract: There is provided a pipette tip disposal assembly. The assembly comprises a receiving element adapted to support an end of at least one pipette tip, the at least one pipette tip being toppled in use from the receiving element along a first direction; and a container positioned to receive the at least one toppled pipette tip, the at least one pipette tip falling towards a base of the container on being received by the container. The base of the container has a first linear dimension aligned with the first direction corresponding to the length of a pipette tip.

Abstract: Methods for producing triflazoles or related derivatives thereof, and the resulting products are provided. For example, triflazoles can be prepared by reaction of trifluoromethanesulfonyl fluoride with an azole or azolate salt. Yields up to 78% are obtained. Triflazoles can be prepared by the reaction of a trifluoromethanesulfonyl fluoride with an N-silylazole in the presence of a basic catalyst. Yields up to 97% are obtained.

Abstract: The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof; and the related products including N-(fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N-(fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azole anion compound, a silylazole, or a combination thereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azole anion compounds, or silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, a silylazole, or a combination thereof in one pot.

Abstract: The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof, and the related products including N-(fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N-(fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azolate salt, an N-silylazole, or a combination thereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azolate salts, or N-silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, an N-silylazole, or a combination thereof in one pot.

Abstract: The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof; and the related products including N-(fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N-(fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azole anion compound, a silylazole, or a combination thereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azole anion compounds, or silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, a silylazole, or a combination thereof in one pot.

Abstract: Dimethylamine (Me2NH) is reacted with sulfuryl fluoride (SO2F2) to form at least a first phase comprising N-(fluorosulfonyl) dimethylamine (FSO2NMe2), tetramethylsulfamide (SO2(NMe2)2), or a combination thereof. A second phase, which may include dimethylamine hydrofluoride (Me2NH2F), may be also formed and separated from the first phase. FSO2NMe2 or SO2(NMe2)2 is then isolated from the first phase. For example, the first phase may be a liquid phase, and FSO2NMe2 and SO2(NMe2)2 are separated by distillation, optionally under reduced pressure.

Abstract: Dimethylamine (Me2NH) is reacted with sulfuryl fluoride (SO2F2) to form at least a first phase comprising N-(fluorosulfonyl) dimethylamine (FSO2NMe2), tetramethylsulfamide (SO2(NMe2)2), or a combination thereof. A second phase, which may include dimethylamine hydrofluoride (Me2NH2F), may be also formed and separated from the first phase. FSO2NMe2 or SO2(NMe2)2 is then isolated from the first phase. For example, the first phase may be a liquid phase, and FSO2NMe2 and SO2(NMe2)2 are separated by distillation, optionally under reduced pressure.

Abstract: Dimethylamine (Me2NH) is reacted with sulfuryl fluoride (SO2F2) to form at least a first phase comprising N-(fluorosulfonyl) dimethylamine (FSO2NMe2), tetramethylsulfamide (SO2(NMe2)2), or a combination thereof. A second phase, which may include dimethylamine hydrofluoride (Me2NH2F), may be also formed and separated from the first phase. FSO2NMe2 or SO2(NMe2)2 is then isolated from the first phase. For example, the first phase may be a liquid phase, and FSO2NMe2 and SO2(NMe2)2 are separated by distillation, optionally under reduced pressure.

Abstract: Dimethylamine (Me2NH) is reacted with sulfuryl fluoride (SO2F2) to form at least a first phase comprising N-(fluoro sulfonyl) dimethylamine (FSO2NMe2), tetramethylsulfamide (SO2(NMe2)2), or a combination thereof. A second phase, which may include dimethylamine hydrofluoride (Me2NH2F), may be also formed and separated from the first phase. FSO2NMe2 or SO2(NMe2)2 is then isolated from the first phase. For example, the first phase may be a liquid phase, and FSO2NMe2 and SO2(NMe2)2 are separated by distillation, optionally under reduced pressure.

Abstract: The present invention is directed to methods for preparing a fluorosulfonate ester or a salt thereof, through a reaction of a dissolved sulfonyl fluoride (RFSO2F) with alkoxide anion (RO?) optionally in the presence of an aprotic base (B), where RF is fluorine or a C1-C8 perfluoroalkyl group, and R is a primary alkyl or alkoxyalkyl. Alkoxide anion (RO?) can be generated from a precursor such as an alcohol or silyl ester.

Abstract: The present invention is directed to methods comprising adding ammonia, either as an ammonium salt or as a gas at pressures below 0.01 MPa, to a sulfuryl fluoride solution to form the anion of bis(fluorosulfonyl)amine under conditions well suited for large-scale production. The bis(fluorosulfonyl)amine so produced can be isolated by methods described in the prior art, or isolated as an organic ion pair, such as an alkylammonium solid salt, or as an ionic liquid.

Abstract: The present invention is directed to methods comprising adding ammonia, either as an ammonium salt or as a gas at pressures below 0.01 MPa, to a sulfuryl fluoride solution to form the anion of bis(fluorosulfonyl)amine under conditions well suited for large-scale production. The bis(fluorosulfonyl)amine so produced can be isolated by methods described in the prior art, or isolated as an organic ion pair, such as an alkylammonium solid salt, or as an ionic liquid.

Abstract: The present invention is directed to methods for preparing a fluorosulfonate ester or a salt thereof, through a reaction of a dissolved sulfonyl fluoride (RFSO2F) with alkoxide anion (RO?) optionally in the presence of an aprotic base (B), where RF is fluorine or a C1-C8 perfluoroalkyl group, and R is a primary alkyl or alkoxyalkyl. Alkoxide anion (RO?) can be generated from a precursor such as an alcohol or silyl ester.

Abstract: The present invention is directed to methods comprising adding ammonia, either as an ammonium salt or as a gas at pressures below 0.01 MPa, to a sulfuryl fluoride solution to form the anion of bis(fluorosulfonyl)amine under conditions well suited for large-scale production. The bis(fluorosulfonyl)amine so produced can be isolated by methods described in the prior art, or isolated as an organic ion pair, such as an alkylammonium solid salt, or as an ionic liquid.