Abstract: The present invention is directed to methods for preparing a fluorosulfonate ester or a salt thereof, through a reaction of a dissolved sulfonyl fluoride (RFSO2F) with alkoxide anion (RO?) optionally in the presence of an aprotic base (B), where RF is fluorine or a C1-C8 perfluoroalkyl group, and R is a primary alkyl or alkoxyalkyl. Alkoxide anion (RO?) can be generated from a precursor such as an alcohol or silyl ester.

Abstract: The present invention is directed to methods comprising adding ammonia, either as an ammonium salt or as a gas at pressures below 0.01 MPa, to a sulfuryl fluoride solution to form the anion of bis(fluorosulfonyl)amine under conditions well suited for large-scale production. The bis(fluorosulfonyl)amine so produced can be isolated by methods described in the prior art, or isolated as an organic ion pair, such as an alkylammonium solid salt, or as an ionic liquid.

Abstract: A golf shot recordal system permits images of a golfer's shot to be recorded. The system comprises a tee unit adjacent to the tee comprising a tee camera and a green unit in the golf hole on the green comprising a green camera. The tee unit further comprises a radio frequency video receiver to receive and decode signals corresponding to the image from the green camera and a video encoder to receive signals corresponding to the image from the tee camera and signals corresponding to the green images from the radio frequency receiver. The green unit further comprises a pin located in the golf hole, wherein the green camera is mounted on the pin, and a radio frequency video transmitter to send signals to the radio frequency video receiver in the tee unit. Also provided is a method of recording video images of a golfer's shot using the recordal system.

Abstract: A golf shot recordal system that permits images of a golfer's shot to be recorded comprises: (a) a tee unit that comprises a tee camera, which can provide a video image of the golfer and the golf ball at the tee, and down the fairway towards the green, the tee unit being locatable adjacent to the tee; and (b) a green unit that comprises a green camera, which can provide a video image of the golf ball when it has been hit onto the green, the green unit being locatable in the golf hole on the green. The tee unit further comprises: (i) a radio frequency video receiver which can receive and decode signals corresponding to the image from the green camera; and (ii) a video encoder that can receive signals corresponding to the tee images from the tee camera and that can receive signals corresponding to the green images from the radio frequency receiver.

Abstract: The present invention relates to a structural protein of adeno-associated virus (AAV) which comprises at least one modification which brings about a reduction in the antigenicity, its production and use.

Abstract: A reactor for the oxidation of a precursor to an aromatic carboxylic acid or ester thereof in a liquid phase reaction mixture is disclosed. The reactor comprises an elongate vessel, substantially vertical in use, having an upper mixing element and a lower mixing element, characterised in that the upper mixing element is an axial pumping impeller and the lower mixing element is a radial pumping impeller. A process of producing a carboxylic acid or ester thereof in a reactor of the invention is also disclosed. In use, the configuration of mixing elements leads to three highly turbulent mixing zones. In a preferred embodiment of the process of the present invention oxidant, from one inlet, and solvent, precursor and catalyst, are introduced directly into a mixing zone. The highly turbulent mixing zones lead to rapid mass transfer suppressing the formation of unwanted, coloured by-products and reduced reactor fouling.

Abstract: A reactor for the oxidation of a precursor to an aromatic carboxylic acid or ester thereof in a liquid phase reaction mixture is disclosed. The reactor comprises an elongate vessel, substantially vertical in use, having an upper mixing element and a lower mixing element, characterised in that the upper mixing element is an axial pumping impeller and the lower mixing element is a radial pumping impeller. A process of producing a carboxylic acid or ester thereof in a reactor of the invention is also disclosed. In use, the configuration of mixing elements leads to three highly turbulent mixing zones. In a preferred embodiment of the process of the present invention oxidant, from one inlet, and solvent, precursor and catalyst, are introduced directly into a mixing zone. The highly turbulent mixing zones lead to rapid mass transfer suppressing the formation of unwanted, coloured by-products and reduced reactor fouling.

Abstract: The invention relates to a method for identifying substances which are suitable to be used as medicaments for treating virus infections or for testing the effectiveness of such substances. The invention also relates to the use of a corresponding method for observing the infection route and/or the infection mechanism of viruses in cells, especially viruses that are provided for gene transfers for gene expression or as vectors and/or for gene therapy.