Abstract: A method for measuring wear of a rail (20) comprises detecting a first set of wheel signals (SW1) by a wheel sensor (21) mounted to the rail (20), determining a first average wheel signal (AV1) of the first set of wheel signals (SW1), detecting at least one second set of wheel signals (SW2) by the wheel sensor (21), where the second set of wheel signals (SW2) is detected after detecting the first set of wheel signals (SW1), determining a second average wheel signal (AV2) of the second set of wheel signals (SW2), and determining a difference signal (DIF) given by the difference between the second average wheel signal (AV2) and the first average wheel signal (AV1), wherein a wheel signal is detected when a wheel (22) of a rail vehicle passes the wheel sensor (21). Furthermore, an evaluation system (23) for measuring wear of a rail (20) is provided.

Abstract: A monitoring unit for monitoring a linear asset includes a connection to a data output of a distributed sensor arranged along the linear asset, where the linear asset has a length which is different from the length of the distributed sensor, and a processing unit which is configured to receive a data signal provided by the distributed sensor, to apply a transfer function, to evaluate the data signal and to provide a tracking output signal. Evaluating the data signal includes running an evaluation algorithm, the transfer function is applied to the data signal or to the evaluation algorithm, and by applying the transfer function, the data signal or the evaluation algorithm is normalized. Furthermore, a method for monitoring a linear asset is provided.

Abstract: A method for the production of a sol-gel based matrix resulting in a sol-gel based matrix with high stability and high porosity. The sol-gel based material may be used for the production of a composite or sensor suitable for monitoring analytes.

Abstract: Provided are cyclic peptide dimers. The cyclic peptide dimer include a first cyclic peptide attached to a second cyclic peptide. The present disclosure also provides compositions containing the cyclic peptide dimers. Also provided are methods of using the cyclic peptide dimers and/or compositions thereof to inhibit the growth of malignant cells in, for example, tumors.

Abstract: An evaluation unit 10 for a sensor arrangement for railway monitoring is described, the evaluation unit 10 comprising a connection to a position sensor 11 and a connection to a tracking sensor 12. The position sensor 11 is capable of detecting rail vehicles 19 passing over the position of the position sensor 11 on a railway track 14 and provides a position output signal 15. The tracking sensor 12 comprises a fibre optic sensor 16, which is capable of detecting the position of noise along the railway track 14 and the tracking sensor 12 provides a tracking output signal 18. The evaluation unit 10 provides an output signal 13 that depends on the position output signal 15 and the tracking output signal 18. Further, a sensor arrangement for railway monitoring and a method for evaluation of railway monitoring signals are described.

Abstract: The present invention relates to a new class of substituted aza-triangulenium fluorescent dyes having a hydroxy group attached to an aryl as quenching group. The new substituted aza-triangulenium fluorescent dyes may be attached to a linker, conjugated to carrier molecule such as e.g. a protein, a nucleic acid, a lipid, or a saccharide, or deposited or immobilized on solid support materials. The substituted aza-triangulenium fluorescent dyes are useful for various purposes, including use in sensors for monitoring or determining the concentration of analytes, such as H+(pH), Na+, K+, Ca2+, O2, CO2, H2O2, ionic strength, redox potentials, metal ions, and metabolites.

Abstract: A method for the production of a sol-gel based matrix resulting in a sol-gel based matrix with high stability and high porosity. The sol-gel based material may be used for the production of a composite or sensor suitable for monitoring analytes.

Abstract: The present invention relates to a method for the production of a sol-gel based matrix. The method comprises the steps of: a) providing a first alkoxysilane of the general formula: R1—Si(OR2)3 and a second alkoxysilane of the general formula (I): b) preparing a first sol-gel component by polymerization of the first alkoxysilane in the presence of an acid catalyst, c) preparing a second sol-gel component by polymerization of the second alkoxysilane in the presence of an Lewis acid catalyst, d) Mixing the first sol-gel component and the second sol-gel component for the preparation of a sol-gel based matrix. The above method results in a sol-gel based matrix with high stability and high porosity. The sol-gel based material may be used for the production of a composite or sensor suitable for monitoring analytes. Methods for preparing these composites or sensors are provided as well.

Abstract: The present invention relates to a method for the production of a sol-gel based matrix. The method comprises the steps of: a) providing a first alkoxysilane of the general formula: R1—Si(OR2)3 and a second alkoxysilane of the general formula (I): b) preparing a first sol-gel component by polymerisation of the first alkoxysilane in the presence of an acid catalyst, c) preparing a second sol-gel component by polymerisation of the second alkoxysilane in the presence of an Lewis acid catalyst, d) Mixing the first sol-gel component and the second sol-gel component for the preparation of a sol-gel based matrix. The above method results in a sol-gel based matrix with high stability and high porosity. The sol-gel based material may be used for the production of a composite or sensor suitable for monitoring analytes. Methods for preparing these composites or sensors are provided as well.

Abstract: The present invention relates to a new class of substituted aza-triangulenium fluorescent dyes having a hydroxy group attached to an aryl as quenching group. The new substituted aza-triangulenium fluorescent dyes may be attached to a linker, conjugated to carrier molecule such as e.g. a protein, a nucleic acid, a lipid, or a saccharide, or deposited or immobilised on solid support materials. The substituted aza-triangulenium fluorescent dyes are useful for various purposes, including use in sensors for monitoring or determining the concentration of analytes, such as H+(pH), Na+, K+, Ca2+, O2, CO2, H2O2, ionic strength, redox potentials, metal ions, and metabolites.

Abstract: In a method for reducing a mechanical stress of a component of a drive train of a motor vehicle with at least two wheels, of which at least one wheel is a drive wheel, wherein the motor vehicle has an anti-lock braking system and an electric machine which is coupled to the drive wheel, wherein each wheel of the motor vehicle has a dedicated friction brake, the anti-lock braking system operates individually on each friction brake. During activation of the anti-lock braking system, mechanical stress of an articulated shaft connecting the electric machine and the coupled drive wheel is determined, and the electric machine coupled to the drive wheel is controlled so as to counteract the mechanical stress. A motor vehicle making use of the method si also disclosed.

Abstract: In a method for reducing a mechanical stress of a component of a drive train of a motor vehicle with at least two wheels, of which at least one wheel is a drive wheel, wherein the motor vehicle has an anti-lock braking system and an electric machine which is coupled to the drive wheel, wherein each wheel of the motor vehicle has a dedicated friction brake, the anti-lock braking system operates individually on each friction brake. During activation of the anti-lock braking system, mechanical stress of an articulated shaft connecting the electric machine and the coupled drive wheel is determined, and the electric machine coupled to the drive wheel is controlled so as to counteract the mechanical stress. A motor vehicle making use of the method si also disclosed.

Abstract: A method for minimizing tread damage and profile wear of wheels of a railway vehicle is provided. The railway vehicle includes two sets of wheels, or a bogie of a railway vehicle with two sets of wheels, wherein setpoint values for parameters characterizing the position of a wheel relative to the track are determined based on measured values of a variable parameter relevant for the creation of tread damage and profile wear during the movement of the railway vehicle, on condition that the tread damage and profile wear on the wheels of the railway vehicle are minimized, wherein the position of one set of wheels is adjusted according to the setpoint values by means of actuation, control, or a combination of both.

Abstract: A method for minimizing tread damage and profile wear of wheels of a railway vehicle is provided. The railway vehicle includes two sets of wheels, or a bogie of a railway vehicle with two sets of wheels, wherein setpoint values for parameters characterizing the position of a wheel relative to the track are determined based on measured values of a variable parameter relevant for the creation of tread damage and profile wear during the movement of the railway vehicle, on condition that the tread damage and profile wear on the wheels of the railway vehicle are minimized, wherein the position of one set of wheels is adjusted according to the setpoint values by means of actuation, control, or a combination of both.

Abstract: The present invention relates to compositions and methods to assess gene expression in cells. In particular, the present invention provides compositions and methods to assess expression from an exogenous gene and an endogenous version of the same gene in induced pluripotent stem cells.

Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Abstract: Disclosed herein are isolated, purified peptides, biologically active fragments and analogs of the peptides having anti-tumor activity in mammals, pharmaceutical formulations comprising the peptides, fragments and analogs and methods of treating mammals suffering from tumors using such materials.

Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Abstract: Disclosed herein are isolated, purified peptides, biologically active fragments and analogs of the peptides having anti-tumor activity in mammals, pharmaceutical formulations comprising the peptides, fragments and analogs and methods of treating mammals suffering from tumors using such materials.